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EP2773913B1 - Gefriertrocknungsanlage mit einer be- und entladevorrichtung - Google Patents

Gefriertrocknungsanlage mit einer be- und entladevorrichtung Download PDF

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Publication number
EP2773913B1
EP2773913B1 EP12786840.4A EP12786840A EP2773913B1 EP 2773913 B1 EP2773913 B1 EP 2773913B1 EP 12786840 A EP12786840 A EP 12786840A EP 2773913 B1 EP2773913 B1 EP 2773913B1
Authority
EP
European Patent Office
Prior art keywords
drying
freeze
drying chamber
carriage
loading
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP12786840.4A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2773913A1 (de
Inventor
Martin Christ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MARTIN CHRIST GEFRIERTROCKNUNGSANLAGEN GmbH
Original Assignee
MARTIN CHRIST GEFRIERTROCKNUNGSANLAGEN GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by MARTIN CHRIST GEFRIERTROCKNUNGSANLAGEN GmbH filed Critical MARTIN CHRIST GEFRIERTROCKNUNGSANLAGEN GmbH
Priority to EP16191639.0A priority Critical patent/EP3144618B2/de
Publication of EP2773913A1 publication Critical patent/EP2773913A1/de
Application granted granted Critical
Publication of EP2773913B1 publication Critical patent/EP2773913B1/de
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Classifications

    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/001Handling, e.g. loading or unloading arrangements
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Definitions

  • the invention relates to a freeze-drying plant according to the preamble of claim 1.
  • Freeze-drying plants are designed in many cases for discontinuous operation and consist predominantly of a drying chamber and a connected thereto via a closable opening condenser chamber, wherein the material to be dried is received in a plurality of drying vessels, vials, ampoules or trays to carry out drying on a footprint within a drying chamber.
  • a plurality of such shelves are arranged vertically displaceable one above the other in a frame at a distance.
  • a freeze-drying plant in which the drying vessels are transported on a conveyor belt in a position in front of the inlet opening of the housing of this system, to be subsequently introduced in rows in a direction perpendicular to the feed direction of the conveyor belt for the purpose of carrying out the drying process in the housing.
  • a device which consists of two on either side of a located in a loading position extending guides mounted, interconnected by a sliding bar carriage, the sliding bar both set up for insertion of the drying vessels and for pushing out the drying vessels after drying is.
  • the sliding bar is thus first pivoted to the inactive position, retracted above the drying vessels in the housing and finally pivoted on the opposite side of the input opening back of the group of drying vessels in its active position, in which it is available for pushing out .
  • the problem due to the running over of the drying vessels, in particular due to unavoidable abrasion, is the maintenance of aseptic conditions.
  • a slider for rowwise insertion into the housing of the first on a conveyor belt drying vessels in a direction perpendicular to the feed direction of the conveyor belt, a slider is provided, wherein additionally a sliding bar is arranged, which extends parallel to the slide and by means of two laterally along the guided in the loading and unloading position guided chain hoists in the housing and is extendable from this.
  • the sliding bar is in turn at its ends between a lowered active, that is, to rest against the group of upstanding drying vessels applied position and a raised inactive, that is intended to run over the group position about a horizontal axis pivotable.
  • a further freeze-drying plant in which a series is inserted into the housing through the input opening slide for serial insertion of drying vessels in the system, wherein the inserted into the housing group of drying vessels during insertion abuts a retractable also in the housing beam, which causes a stabilization of the upright position of the drying vessels.
  • the beam is supported at both ends on a respective carriage and at this pivotable between a lower active, applied to the drying vessel position and an upper inactive, for driving over the group of drying vessels position determined.
  • the slider and the bar can be moved completely out of the housing.
  • the beam acts as an ejector, whereas the slide performs a stabilizing function.
  • FR 2 918 653 A1 is a freeze-drying plant in which in a, having a closable opening housing a drying chamber is set up .
  • a drying chamber In the drying chamber is an arrangement provided by shelves.
  • the shelves are slidably disposed in their height position in a frame and intended for setting up drying vessels.
  • a pushing out of the drying vessels from the drying chamber via a push rod which can be hung in unused condition on pins of a rear wall of the drying chamber.
  • telescoping arms can be moved from outside the drying chamber side of the drying vessels in the drying chamber.
  • the telescopic arms can be performed with the retraction into the drying chamber on the shelves.
  • the arms can be coupled via end coupling means with the push rod.
  • this coupled state can then be moved out of the drying chamber with a contracting of the telescopic arms, the push rod, whereby a pushing out of the drying vessels takes place.
  • the arms are introduced under the guidance of the lowest footprint in the drying chamber and coupled with the push rod with subsequent ejection of the drying vessels.
  • the support arms are moved back into the drying chamber, the push rod is suspended from the rear wall of the drying chamber with subsequent extension of the arms from the drying chamber.
  • the second lowest floor space can then be lowered into the unloading level.
  • the telescopic arms are now introduced back into the drying chamber and coupled there with the push rod, whereby the second lowest floor space can be unloaded.
  • a displacement plane which may be an empty shelf, the pressure plate of the arrangement of shelves or the space below the pressure plate.
  • the floor space to be unloaded is initially undercut and then lowered into the displacement plane, whereupon the unloading process follows.
  • an empty shelf level can be brought into which the carriage can be moved.
  • the guides intended for supporting the carriage are arranged in a fixed height position and define the position of the displacement plane.
  • a conveyor belt forms according to the features of claim 3, a part of the loading and unloading, the conveying direction is transverse to the input or Ausschubraum.
  • a conveyor belt and a trolley may be used, the size of which depends on the footprint and the next to said guides also has a designated for the carriage parking position.
  • Such a trolley has no conveyor belt.
  • the loading and unloading device comprises according to the features of claim 4, a loading bridge whose guides interact during storage of the carriage with the guides within the drying chamber.
  • claims 5 and 6 are directed to the second limit position of the carriage located outside the drying chamber. This position can be used as parking position during the drying process. It is set up starting from the drying chamber beyond the conveyor belt if it is also to be used for loading at the same time. In other cases, it can also be set up on the dock leveler.
  • claims 7 to 10 are directed to different variants of a drive of the carriage.
  • an electric drive is used, which may also be a linear drive.
  • a preferably inductive charging station may be arranged in the second limit position.
  • claims 1 and 12 are directed to further embodiments of the drive including the associated therewith guides.
  • a traction with the guides is thereafter preferably mediated via a toothed belt, which surrounds a plurality of wheels and in this way is also suitable for driving over gaps in segments of the guides.
  • the drive has a flat-building, all components including a control receiving housing whose height corresponds to that of the guides.
  • the housing of the carriage is preferably designed as a hermetically sealed, in particular watertight unit, which is accessible within the drying chamber a CIP cleaning process (clean in place).
  • a second, a counter-holding function fulfilling and otherwise identical carriage provided, which is also included in the guides. Both carriages can have a parking position on the loading and unloading device and it can be spent in the sliding plane always one of the two carriages in a sliding position and the other in a suitable position for performing a counter holding function.
  • An advantage may be the exercise of a counter holding function in drying vessels with a low resistance to riot.
  • claims 14 and 15 are directed to the particular intended for receiving the carriage guides. These are segmented in the longitudinal direction and displaceable relative to each other. They can simultaneously be designed as lateral guide edges for the drying vessels, so that in conjunction with an additional displaceable arrangement perpendicular to their longitudinal extension a simple adaptation to different dimensions of the drying vessels is possible, thus mediating a safe Aufstandposition this in the transverse direction to a pushing in or pushing out and at the same time preventing jamming and wedging, thus producing less rejects at the drying vessels.
  • the guides depending on the shape of the drying vessels, eg. As in a shell drying, a gap remain that corresponds to the space required for the suspension of the shelves.
  • the guides must therefore not necessarily be moved to a frontal investment position. Also, as previously stated, the carriage is to some extent suitable for traversing spaces between segments of the guides.
  • vacuum-tight encapsulated gear units are provided, which are arranged outside the drying chamber arranged drive units.
  • the displacement movement of said segments can also be represented structurally in a different manner, for example linked to the drive of the carriage.
  • an intermediate space between two segments can be bridged by moving telescopically extendable intermediate elements in these intermediate spaces.
  • a certain for Auflagerung the loading and unloading assembly is provided, which is arranged in the direction of the drying chamber and away from this, thus movable parallel to the direction of a pushing in or out.
  • This embodiment can be used particularly advantageously for maintenance purposes.
  • This assembly may be arranged displaceably on rails, for example.
  • freeze dryer has been described above in connection with a drying chamber that is loaded and unloaded through only one orifice. According to the features of claim 18, the subject invention is also useful in such a system, which is designed for a pass-through operation and is therefore provided with two opposing openings, each associated with a loading and unloading.
  • the further embodiment of the freeze-drying plant according to the features of claim 19 is directed to the per se known representation of a system of conditions for the located in the displacement plane footprint. This allows for independent height positioning of the displacement plane in the drying chamber and is exemplified by an arrangement of bolts, which is fulfilled between an active position in which a support function is fulfilled and an inactive position in which no support function, relative to the footprint in the Moving plane are movable.
  • a freeze-drying plant referred to, inter alia, consisting of a housing 3 arranged in a drying chamber 2 and a slidably mounted on rails 4 in the direction of arrows 5, a loading and unloading device carrying unit 6 is.
  • the assembly 6 together with rails and the housing 3 are arranged on a common base plate 7 and it is the assembly 6 - apart from maintenance - usually firmly docked to the housing.
  • a guide unit 14 which carries on the top side two guides 16 receiving parallel to one another, a carriage 15 to be described in greater detail below.
  • a loading bridge 17 which also carries guides 18 on the upper side, the function of which will be explained below.
  • the carriage 15 can be moved along the mutually identical guides 16, 18.
  • the guides 16, 18 are dimensioned and arranged in conjunction with the displaceability of the guide unit 14 and the loading bridge 17 in the direction of the arrows 5 with the proviso that the carriage 15 in a front-side limit position or loading position on the side facing away from the housing 3 Conveyor belt 8 is displaceable.
  • the drying chamber 2 is equipped in a manner known per se with an arrangement of mutually parallel, horizontally extending shelves 19, which in a frame 20 are held vertically movable and each serve to set up a drying substance to be dried drying vessels and are to be led out of the drying chamber 2 after completion of the drying process.
  • each of the shelves is movable in this displacement plane.
  • This is the height position within the drying chamber in which, with the door open, 12 drying vessels can be introduced or carried out into the drying chamber 2 in a manner which will be explained below, by means of the slide 15.
  • the top view according Fig. 2 as well as the representation according to Fig. 3 show an adjusting plate 19, which is located in the loading position.
  • this displacement plane there are further guides 21, 22, the nature of which corresponds to that of the guides 16, 18.
  • the guides 21, 22 are slidably disposed within the housing 3 in its longitudinal direction, whereas their height position is fixed.
  • the in Fig. 4 shown, laterally held in the guides 16 carriage 15 is characterized on its front side 23 and on this opposite in the direction of the arrows 5 back 24 by mutually identical guide surfaces, which are intended to bear on the on orparticularlyschiebenden drying vessels.
  • the Auflagerung of the carriage 15 in the guides 16 is effected by wheels 25 which are connected by a toothed belt 26 with each other, wherein the toothed belt 26 additionally has an outer toothing, with a corresponding Profileing of the guides 16 and other guides 18, 21, 22 is engaged. All drive and control components of the carriage 15 are housed in a flat housing 27 whose height corresponds approximately to that of the guides 16 and thus less than that of a drying vessel fails.
  • a battery-powered electric drive can be used, to charge it in the loading position a non-contact, z.
  • B. inductively effective charging station 28 is set up. ( Fig. 1 )
  • the width of the surface available for standing up should correspond to an integer multiple of the diameter or a comparable dimension of a drying vessel.
  • the individual, pushed onto the loading bridge 17 rows of drying vessels should be laterally offset by half a diameter measure to each other to achieve optimum packing density. In this way, a mutual support effect of the drying vessels can be represented with each other.
  • Fig. 5 the loading bridge 17 with side guides 29 and the footprint 19 with side guides 30, 31 equipped. These each form lateral guide edges for the drying vessels and are arranged so as to be displaceable transversely to the insertion direction, thus in the direction of the arrows 32, so that insofar adjustment to different dimensions of the drying vessels is possible.
  • each drives are provided for the lateral adjustment of the side guides 29 to 31.
  • Each of the shelves 19 is provided in the corner region of its rectangular base with outstanding also rectangular, extending in the plane of the respective footprint 19 lugs 33, each with an approximately semicircular, is provided to the peripheral outside open recess 34. These recesses 34 serve in conjunction with vertically extending rods 35 of the frame 20 of the vertical guidance of the shelves 19. In this way, an exact vertical guidance of the shelves 19 is shown.
  • the longitudinal displaceability of the guides 21, 22 given in this way is set up with the proviso that in an in Fig. 6 shown first boundary position, the opposite end faces of two successive guides 21, 22 are spaced from each other, whereas in a second limit position these end faces lie directly against each other, thus forming a continuous approximately continuous guide path for the carriage 15.
  • the first limit position is characterized in that the shelves 19 are vertically freely displaced.
  • the second limit position is characterized in that a footprint 19 is located in the above-mentioned loading and unloading or displacement plane and is secured in this form-fitting manner.
  • Fig. 8 shows the carriage 36 in the first limit position, wherein it can be seen that a vertical movement of the shelves 19 is not hindered by the bolt 41.
  • Fig. 10 shows the carriage in the second limit position, wherein it can be seen that now the bolt 41 facing portion of a projection 33 rests on the bolt 41, thus preventing further downward movement of the adjusting plate 19.
  • FIGS. 11 to 17 the movements will be described of a working cycle of the freeze-drying plant 1, beginning with the insertion of drying vessels in rows into the freeze-drying plant and ending with the pushing out of the drying vessels after completion of the drying process from the plant.
  • Fig. 11 the door 12 of the housing 3 has been moved vertically to its open position, wherein, as Fig. 12 shows, the guides 21, 22 are shifted to their second limit position, thus frontally adjacent to each other and forming a continuous guide for the carriage 15 within the drying chamber 2.
  • the guide unit 14 is also displaced together with the loading bridge 17 in the direction of the arrows 5, with the proviso that the loading bridge 17 and thus their guides 18 abut the end face on the guides 21 within the drying chamber 2, so that the loading bridge 17 partially into the drying chamber. 2 has been moved into it.
  • a first row of drying vessels 42 passes via the conveyor belt 8 into a position in front of the carriage 15, which is thus located on the side of the conveyor belt 8 facing away from the housing 3.
  • Fig. 15 is then the carriage 15 in the rearward direction, that is moved from the on the latter footprint 19 away, and then this process is repeated after transfer of the next footprint 19 in the loading position until all shelves 19 are loaded to the initial lowest and after Retraction of the loading bridge 17 from the drying chamber 2 and closing the door 12, the method of freeze-drying can be carried out in a conventional manner.
  • the guides 18, 21, 22 are pushed together in the longitudinal direction, in turn, based on a continuous displacement possibility for the carriage 15. This is then retracted into this empty rack level, this case thus the loaded shelves 19 underfahrend, and indeed to its rear, the door 12 opposite limit position within the drying chamber. 2 Subsequently, the loading surface 19 located directly above the initially empty insertion level is lowered into the displacement plane and secured in this position in a form-fitting manner by displacement of the guides 16, 18 in its second limit position. The carriage 15 is now on the back of the group of drying vessels 42, which the door 12 is opposite. This position of the carriage is in Fig. 16 shown.
  • the carriage 15 is now driven for the purpose of pushing out the drying vessels on the loading bridge 17 on the conveyor belt 8, on which the treated by freeze drying drying vessels 42 discharged in the direction of the arrow 9 become.
  • the carriage 15 is then retracted after emptying the bottom shelf 19 along a now empty shelf 19 again in the drying chamber 2 to its rear end position, in this case the next to be unloaded footprint 19 underfahrend.
  • the latter footprint is then lowered into the unloading position and secured in this form-fitting, whereupon the unloading process is continued with the cooperation of the carriage 15 and the conveyor belt 8.
  • the shelves 19 are thus unloaded successively by means of only one carriage, wherein the carriage 15 is always under loaded loading surfaces 19, so that in this respect aseptic conditions are respected.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Drying Of Solid Materials (AREA)
EP12786840.4A 2011-11-04 2012-11-03 Gefriertrocknungsanlage mit einer be- und entladevorrichtung Active EP2773913B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP16191639.0A EP3144618B2 (de) 2011-11-04 2012-11-03 Gefriertrocknungsanlage

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011117628.8A DE102011117628B4 (de) 2011-11-04 2011-11-04 Gefriertrockungsanlage mit einer Be- und Entladevorrichtung
PCT/EP2012/004595 WO2013064266A1 (de) 2011-11-04 2012-11-03 Gefriertrocknungsanlage mit einer be- und entladevorrichtung

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP16191639.0A Division EP3144618B2 (de) 2011-11-04 2012-11-03 Gefriertrocknungsanlage
EP16191639.0A Division-Into EP3144618B2 (de) 2011-11-04 2012-11-03 Gefriertrocknungsanlage

Publications (2)

Publication Number Publication Date
EP2773913A1 EP2773913A1 (de) 2014-09-10
EP2773913B1 true EP2773913B1 (de) 2017-03-01

Family

ID=47178567

Family Applications (2)

Application Number Title Priority Date Filing Date
EP12786840.4A Active EP2773913B1 (de) 2011-11-04 2012-11-03 Gefriertrocknungsanlage mit einer be- und entladevorrichtung
EP16191639.0A Active EP3144618B2 (de) 2011-11-04 2012-11-03 Gefriertrocknungsanlage

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP16191639.0A Active EP3144618B2 (de) 2011-11-04 2012-11-03 Gefriertrocknungsanlage

Country Status (6)

Country Link
US (2) US11236942B2 (es)
EP (2) EP2773913B1 (es)
CN (1) CN103857969B (es)
DE (2) DE102011117628B4 (es)
ES (2) ES2624146T3 (es)
WO (1) WO2013064266A1 (es)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
EP3499160A1 (de) 2017-12-15 2019-06-19 Martin Christ Gefriertrocknungsanlagen GmbH Gefriertrockner, gefriertrocknungsanlage, verfahren zum betrieb eines gefriertrockners und neue verwendung eines schlittens
US10982896B2 (en) 2017-10-20 2021-04-20 Martin Christ Gefriertrocknungsanlagen Gmbh Method for a pressure-based determining of a product parameter in a freeze dryer, freeze dryer and software product

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EP3938741B1 (en) 2019-03-14 2024-05-01 Terumo BCT Biotechnologies, LLC Lyophilization container fill fixture, system and method of use
CN110159721A (zh) * 2019-06-04 2019-08-23 深圳市时代高科技设备股份有限公司 传动机构及粉体干燥加热炉
CN110220370B (zh) * 2019-06-26 2023-11-17 东莞市德瑞精密设备有限公司 货架式锂电池烘烤设备
CN111219978B (zh) * 2020-03-18 2024-09-03 无锡先导智能装备股份有限公司 中转装置及烘干设备
CN113803984B (zh) * 2021-08-16 2023-02-17 上海奥星制药技术装备有限公司 一种原料药自动进出料装置
CN114294929B (zh) * 2022-01-14 2023-03-10 深圳市信亿德科技有限公司 一种具有升降机构的快速均匀烘烤的工业用烤箱
DE102022103429B3 (de) 2022-02-14 2023-05-04 Martin Christ Gefriertrocknungsanlagen Gmbh Be- und Entladeeinrichtung für einen Gefriertrockner, Verfahren und Gefriertrocknungsanlage
CN117589670B (zh) * 2024-01-18 2024-04-09 江苏永成汽车零部件股份有限公司 用于汽车门饰板的喷漆表面质量检测系统

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10982896B2 (en) 2017-10-20 2021-04-20 Martin Christ Gefriertrocknungsanlagen Gmbh Method for a pressure-based determining of a product parameter in a freeze dryer, freeze dryer and software product
EP3499160A1 (de) 2017-12-15 2019-06-19 Martin Christ Gefriertrocknungsanlagen GmbH Gefriertrockner, gefriertrocknungsanlage, verfahren zum betrieb eines gefriertrockners und neue verwendung eines schlittens

Also Published As

Publication number Publication date
ES2638237T5 (es) 2021-01-18
ES2638237T3 (es) 2017-10-19
US20170059246A1 (en) 2017-03-02
EP3144618B1 (de) 2017-06-21
EP2773913A1 (de) 2014-09-10
CN103857969B (zh) 2016-03-09
EP3144618A1 (de) 2017-03-22
ES2624146T3 (es) 2017-07-13
DE202012013409U1 (de) 2016-11-09
DE102011117628B4 (de) 2015-10-22
EP3144618B2 (de) 2020-04-01
DE102011117628A1 (de) 2013-05-08
US11236943B2 (en) 2022-02-01
WO2013064266A1 (de) 2013-05-10
US11236942B2 (en) 2022-02-01
US20140230265A1 (en) 2014-08-21
CN103857969A (zh) 2014-06-11

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