[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EP1490090A4 - Wirkstoff-abgabesystem und verfahren zum schutz und zur verabreichung von wirkstoffen - Google Patents

Wirkstoff-abgabesystem und verfahren zum schutz und zur verabreichung von wirkstoffen

Info

Publication number
EP1490090A4
EP1490090A4 EP03713634A EP03713634A EP1490090A4 EP 1490090 A4 EP1490090 A4 EP 1490090A4 EP 03713634 A EP03713634 A EP 03713634A EP 03713634 A EP03713634 A EP 03713634A EP 1490090 A4 EP1490090 A4 EP 1490090A4
Authority
EP
European Patent Office
Prior art keywords
protecting
methods
delivery systems
agent delivery
administering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP03713634A
Other languages
English (en)
French (fr)
Other versions
EP1490090A2 (de
Inventor
Thomas Piccariello
Randal J Kirk
Lawrence P Olon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire LLC
Original Assignee
New River Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/156,527 external-priority patent/US7060708B2/en
Application filed by New River Pharmaceuticals Inc filed Critical New River Pharmaceuticals Inc
Priority to EP10183239A priority Critical patent/EP2316468A1/de
Priority to EP10183256A priority patent/EP2266590A3/de
Priority to EP10183210A priority patent/EP2316469A1/de
Publication of EP1490090A2 publication Critical patent/EP1490090A2/de
Publication of EP1490090A4 publication Critical patent/EP1490090A4/de
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP03713634A 2002-02-22 2003-02-24 Wirkstoff-abgabesystem und verfahren zum schutz und zur verabreichung von wirkstoffen Ceased EP1490090A4 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP10183239A EP2316468A1 (de) 2002-02-22 2003-02-24 Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
EP10183256A EP2266590A3 (de) 2002-02-22 2003-02-24 Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen
EP10183210A EP2316469A1 (de) 2002-02-22 2003-02-24 Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US35838102P 2002-02-22 2002-02-22
US358381P 2002-02-22
US36625802P 2002-03-22 2002-03-22
US366258P 2002-03-22
US156527 2002-05-29
US10/156,527 US7060708B2 (en) 1999-03-10 2002-05-29 Active agent delivery systems and methods for protecting and administering active agents
PCT/US2003/005524 WO2003079972A2 (en) 2002-02-22 2003-02-24 Active agent delivery systems and methods for protecting and administering active agents

Publications (2)

Publication Number Publication Date
EP1490090A2 EP1490090A2 (de) 2004-12-29
EP1490090A4 true EP1490090A4 (de) 2006-09-20

Family

ID=28457706

Family Applications (4)

Application Number Title Priority Date Filing Date
EP10183239A Withdrawn EP2316468A1 (de) 2002-02-22 2003-02-24 Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
EP03713634A Ceased EP1490090A4 (de) 2002-02-22 2003-02-24 Wirkstoff-abgabesystem und verfahren zum schutz und zur verabreichung von wirkstoffen
EP10183256A Withdrawn EP2266590A3 (de) 2002-02-22 2003-02-24 Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen
EP10183210A Withdrawn EP2316469A1 (de) 2002-02-22 2003-02-24 Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP10183239A Withdrawn EP2316468A1 (de) 2002-02-22 2003-02-24 Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP10183256A Withdrawn EP2266590A3 (de) 2002-02-22 2003-02-24 Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen
EP10183210A Withdrawn EP2316469A1 (de) 2002-02-22 2003-02-24 Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin

Country Status (8)

Country Link
EP (4) EP2316468A1 (de)
JP (1) JP4625637B2 (de)
KR (1) KR20040088519A (de)
CN (1) CN1649614A (de)
AU (2) AU2003217676B2 (de)
CA (1) CA2477088A1 (de)
IL (1) IL163666A0 (de)
WO (1) WO2003079972A2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1436012T3 (en) 2001-10-18 2018-01-22 Nektar Therapeutics Polymer Conjugates of Opioid Antagonists
JP2010229140A (ja) * 2002-02-22 2010-10-14 Shire Llc 活性物質送達系及び活性物質を保護し投与する方法
KR102008768B1 (ko) 2002-09-06 2019-08-08 인설트 테라페틱스, 인코퍼레이티드 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체
ES2445585T3 (es) 2003-12-16 2014-03-04 Nektar Therapeutics Composiciones monodispersas de naloxol PEGilado
US20060182692A1 (en) 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
CN101137352A (zh) * 2005-01-21 2008-03-05 诺瓦制药公司 药物配制剂及其用法
TWI528976B (zh) * 2006-12-13 2016-04-11 斯茹林製藥公司 用於醫物傳遞之以環糊精為基之聚合物
US20080176958A1 (en) * 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
AU2009210570B2 (en) * 2008-01-30 2014-11-20 Indiana University Research And Technology Corporation Ester-based insulin prodrugs
AU2009327418A1 (en) 2008-12-19 2010-06-24 Indiana University Research And Technology Corporation Amide based glucagon superfamily peptide prodrugs
WO2011035305A1 (en) * 2009-09-21 2011-03-24 Forest Laboratories Holdings Limited Compositions and methods for treating bacterial infections using ceftaroline
CA2927380C (en) * 2009-12-31 2017-07-04 Kempharm, Inc. Amino acid conjugates of quetiapine, process for making and using the same
WO2011112657A1 (en) 2010-03-11 2011-09-15 Kempharm, Inc. Fatty acid conjugates of quetiapine, process for making and using the same
AU2011270832B2 (en) * 2010-06-24 2016-05-12 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
TWI432204B (zh) * 2011-06-03 2014-04-01 Taiwan Hopax Chems Mfg Co Ltd 對抗自由基的醫藥組合物
CN106928369B (zh) 2012-08-21 2021-04-02 奥索临床诊断有限公司 喹硫平的抗体及其用途
CN104736564B (zh) 2012-08-21 2019-02-05 詹森药业有限公司 喹硫平半抗原的抗体及其用途
CA2882595C (en) * 2012-08-21 2019-06-04 Ortho-Clinical Diagnostics, Inc. Antibodies to olanzapine haptens and use thereof
US9664700B2 (en) 2012-08-21 2017-05-30 Janssen Pharmaceutica Nv Antibodies to risperidone and use thereof
EP2888234B1 (de) 2012-08-21 2017-12-06 Janssen Pharmaceutica NV Haptene von aripiprazol und deren verwendung in immunoassays
US20140057297A1 (en) 2012-08-21 2014-02-27 Janssen Pharmaceutica Nv Antibodies to Paliperidone Haptens and Use Thereof
CN104736565B (zh) 2012-08-21 2019-03-12 詹森药业有限公司 利培酮半抗原的抗体及其用途
EP2888285B1 (de) 2012-08-21 2024-04-17 Janssen Pharmaceutica NV Antikörper gegen aripiprazol-haptene und verwendung davon
PL2888373T3 (pl) 2012-08-21 2018-08-31 Janssen Pharmaceutica Nv Przeciwciała dla arypiprazolu i ich zastosowanie
CA2882490A1 (en) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc. Antibodies to paliperidone and use thereof
ES2807902T3 (es) 2012-08-21 2021-02-24 Janssen Pharmaceutica Nv Anticuerpos para olanzapina y uso de los mismos
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
AU2014306759B2 (en) 2013-08-12 2018-04-26 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
WO2015095391A1 (en) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
CN104817612A (zh) * 2014-01-30 2015-08-05 陈光健 寡肽cd07及其制备方法和应用
US9707184B2 (en) 2014-07-17 2017-07-18 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
ES2947409T3 (es) * 2014-09-24 2023-08-08 Univ Indiana Res & Tech Corp Profármacos de insulina a base de amida lipídica
CA2964628A1 (en) 2014-10-20 2016-04-28 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
SG11201703896QA (en) * 2014-11-21 2017-06-29 Biohaven Pharm Holding Co Ltd Sublingual formulation of riluzole
WO2017068577A1 (en) 2015-10-18 2017-04-27 Ariel-University Research And Development Company Ltd. Peptide-based multiple-drug delivery vehicle
US10444250B2 (en) 2015-12-17 2019-10-15 Janssen Pharmaceutica Nv Antibodies to risperidone and use thereof
CA3008812A1 (en) 2015-12-17 2017-06-22 Janssen Pharmaceutica Nv Antibodies to quetiapine and use thereof
US11433136B2 (en) 2015-12-18 2022-09-06 The General Hospital Corporation Polyacetal polymers, conjugates, particles and uses thereof
CA3018193C (en) * 2016-03-18 2023-04-04 Caregen Co., Ltd. Conjugate of finasteride with peptide
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
EP3583944A4 (de) * 2017-02-16 2021-03-03 Caregen Co., Ltd. Konjugat aus salicylsäure und peptid
WO2019006426A2 (en) 2017-06-30 2019-01-03 Massachusetts Institute Of Technology RAMIFIED MULTIFUNCTIONAL MACROMONOMERS AND RELATED POLYMERS AND USES THEREOF
WO2019112630A1 (en) * 2017-12-06 2019-06-13 Bailey Steven W Peptide compositions for slowing degradation of vitamin-mineral supplements, foods, pharmaceuticals, and cosmetics
KR20210022575A (ko) * 2018-05-23 2021-03-03 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 심장-특이적 표적화-펩티드 (ctp), 조성물, 및 그의 용도
WO2020037236A1 (en) 2018-08-17 2020-02-20 Massachusetts Institute Of Technology Degradable polymers of a cyclic silyl ether and uses thereof
JP2022500437A (ja) * 2018-09-14 2022-01-04 ジャンイン ユスン ファーマシューティカル カンパニー,リミテッド モンテルカストおよびペプチドの新規接合体
JP2020054487A (ja) * 2018-09-28 2020-04-09 Spiber株式会社 酸放出体
AU2020278465A1 (en) 2019-05-20 2021-12-09 Dana-Farber Cancer Institute, Inc. Boronic ester prodrugs and uses thereof
WO2021141662A1 (en) 2020-01-10 2021-07-15 Massachusetts Institute Of Technology Proteolysis targeting chimeric molecules (protacs) with functional handles and uses thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997036616A2 (en) * 1996-04-02 1997-10-09 The University Of Birmingham Anti-tumour agent
WO2000052078A1 (en) * 1999-03-05 2000-09-08 Innovative Technologies, Llc Use of protein conformation for the protection and release of chemical compounds
WO2000053233A1 (en) * 1999-03-10 2000-09-14 Lotus Biochemical Corporation Use of protein conformation for the protection and release of chemical compounds
WO2002034237A1 (en) * 2000-08-22 2002-05-02 New River Pharmaceuticals, Inc. Active agent delivery systems and methods for protecting and administering active agents
WO2002051432A1 (en) * 2001-11-16 2002-07-04 New River Pharmaceuticals Inc. A novel pharmaceutical compound and methods of making and using same
WO2003020200A2 (en) * 2000-11-16 2003-03-13 New River Pharmaceuticals Inc. A novel pharmaceutical compound and methods of making and using same
WO2003034980A2 (en) * 2000-11-14 2003-05-01 New River Pharmaceuticals Inc. A novel pharmaceutical compound containing abacavir sulfate and methods of making and using same
WO2003072047A2 (en) * 2002-02-22 2003-09-04 New River Pharmaceuticals Inc. Idothyronine compositions
WO2003101476A1 (en) * 2002-05-29 2003-12-11 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents

Family Cites Families (314)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2507631A (en) 1944-01-19 1950-05-16 Ciba Pharm Prod Inc Pyridine and piperidine compounds and process of making same
MC370A1 (fr) 1961-10-24 1963-03-28 American Cyanamid Co Procédé de préparation des aminotétracyclines substituées
GB993584A (de) 1962-01-24
US3352912A (en) 1963-07-24 1967-11-14 Du Pont Adamantanes and tricyclo[4. 3. 1. 1 3.8] undecanes
GB1206403A (en) 1966-12-15 1970-09-23 Wyeth John & Brother Ltd Oxazoles
US3674836A (en) 1968-05-21 1972-07-04 Parke Davis & Co 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
GB1285035A (en) 1968-11-09 1972-08-09 Conveyancer Ltd A power driven vehicle
US5562925A (en) 1970-04-20 1996-10-08 Research Corporation Tech. Inc. Anti-tumor method
NL173848C (nl) 1970-06-01 1984-03-16 Janssen Pharmaceutica Nv Werkwijze ter bereiding van 2.2-diaryl 4-piperidino butyramiden; werkwijze ter bereiding van therapeutisch werkzame preparaten en de door toepassing daarvan verkregen gevormde voortbrengselen.
CH616691A5 (en) 1970-12-17 1980-04-15 Glaxo Lab Ltd Process for the preparation of steroid compounds and their use.
US3843681A (en) 1971-06-01 1974-10-22 American Home Prod 1-carboxamido pyrano(thiopyrano)(3,4-6)indole derivatives
DE2815926A1 (de) 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB1415256A (en) 1972-02-05 1975-11-26 Yamanouchi Pharma Co Ltd Alpha-aminomethylbenzyl alcohol derivatives
CH570401A5 (de) 1972-05-09 1975-12-15 Wander Ag Dr A
FI54128C (fi) 1972-12-09 1978-10-10 Akzo Nv Foerfarande foer framstaellning av nya 11,11-alkylidensteroider ur oestran- och 19-norpregnanserien med foerbaettrad hormonell verkan
US4314081A (en) 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
US3965143A (en) 1974-03-26 1976-06-22 G. D. Searle & Co. 16-Oxygenated prostanoic acid derivatives
NL7503310A (nl) 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
GB1559811A (en) 1975-07-28 1980-01-30 Sandoz Ltd Pharmaceutically active benzothiadiazole derivatives
US4026894A (en) 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4108880A (en) 1975-11-03 1978-08-22 Johnson & Johnson Esters of retinoic acid
DE2644265C2 (de) 1976-09-30 1983-02-10 Bayer Ag, 5090 Leverkusen Chinazoline
GB1548022A (en) 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
CH639659A5 (de) 1978-12-18 1983-11-30 Sandoz Ag Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung.
FI64938C (fi) 1977-06-20 1984-02-10 Sandoz Ag Foerfarande foer framstaellning av nya terapeutiskt anvaendbara bensoxa- och bensotiadiazolyl-1,4-dihydropyridinderivat
GB1604739A (en) 1977-07-28 1981-12-16 Yamanouchi Pharma Co Ltd 7-methoxy-7-(1,3-dithietane-2-carboxamide) cephalosporanic acid derivatives
GB1591490A (en) 1977-08-04 1981-06-24 Abbott Lab 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
US4820738A (en) 1977-08-15 1989-04-11 American Cyanamid Company 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4278689A (en) 1978-07-11 1981-07-14 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
GB2007656B (en) 1977-11-05 1982-05-19 Pfizer Ltd Therapeutic agents
US4166182A (en) 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
CA1140119A (en) 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
DE2815578C2 (de) 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
SE429652B (sv) 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
US4323581A (en) 1978-07-31 1982-04-06 Johnson & Johnson Method of treating carcinogenesis
US4307100A (en) 1978-08-24 1981-12-22 Agence Nationale De Valorisation De La Recherche (Anvar) Nor bis-indole compounds usable as medicaments
US4356166A (en) * 1978-12-08 1982-10-26 University Of Utah Time-release chemical delivery system
DE2909439A1 (de) 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
US4642384A (en) 1979-03-19 1987-02-10 Riker Laboratories, Inc. Process for the preparation of derivatives of pyrrolidine and piperidine
US4254129A (en) 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
DD151309A5 (de) 1979-06-01 1981-10-14 Wellcome Found Verfahren zur herstellung von substituierten aminotriazinen
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4988731A (en) 1979-08-20 1991-01-29 Abbott Laboratories Sodium hydrogen divalproate oligomer
US5212326A (en) 1979-08-20 1993-05-18 Abbott Laboratories Sodium hydrogen divalproate oligomer
FR2465486A1 (fr) 1979-09-21 1981-03-27 Roussel Uclaf Nouvelle application utilisant la lh-rh ou des agonistes
US5389613A (en) 1979-09-21 1995-02-14 Roussel Uclaf Method of treating prostate adenocarcinoma, prostate benign hypertrophia and endometriosis
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
CY1327A (en) 1979-11-27 1986-06-27 Sandoz Ag Novel polypeptides,processes for their production,pharmaceutical compositions comprising said polypeptides and their use
EP0030360B2 (de) 1979-12-11 1988-09-28 Eisenwerk-Gesellschaft Maximilianshütte mbH Stahlerzeugungsverfahren
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
JPS56110665A (en) 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Sulfamoyl-substituted phenetylamine derivative and its preparation
GB2088877B (en) 1980-02-15 1984-07-04 Glaxo Group Ltd Androstane 17 carbothioates
GB2078719B (en) 1980-06-02 1984-04-26 Ici Ltd Heterocyclic compounds
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
US4301146A (en) 1980-07-29 1981-11-17 G. D. Searle & Co. Stabilization of 16-oxygenated prostanoic acid derivatives
JPS5746986A (en) 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
US4670444B1 (en) 1980-09-03 1999-02-09 Bayer Ag and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
US5264446A (en) 1980-09-09 1993-11-23 Bayer Aktiengesellschaft Solid medicament formulations containing nifedipine, and processes for their preparation
US4486425A (en) 1980-09-30 1984-12-04 Sankyo Company Limited 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
FR2492258A1 (fr) 1980-10-17 1982-04-23 Pharmindustrie Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
US4329356A (en) 1980-10-31 1982-05-11 Eli Lilly And Company Treatment of hypertension with fluoxetine and l-5-hydroxytryptophane
GR75395B (de) 1980-11-14 1984-07-13 Lilly Co Eli
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4384123A (en) 1980-12-04 1983-05-17 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4337201A (en) 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4308264A (en) 1981-01-28 1981-12-29 Abbott Laboratories Stabilized, dilute aqueous preparation of 1α,25-dihydroxycholecalciferol for neonatal administration
NO155805C (no) 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
US4526892A (en) 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4418068A (en) 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4355032B2 (en) 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4507305A (en) 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4423050A (en) 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
EP0069442B1 (de) 1981-06-06 1985-02-20 Pfizer Limited Fungizide Mittel, Verfahren zu deren Herstellung, und diese enthaltende pharmazeutische Zusammenstellungen
US4962115A (en) 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US4410520A (en) 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
DK161312C (da) 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
IT1201087B (it) 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
GR79215B (de) 1982-06-07 1984-10-22 Glaxo Group Ltd
US4519801A (en) 1982-07-12 1985-05-28 Alza Corporation Osmotic device with wall comprising cellulose ether and permeability enhancer
DE3372965D1 (en) 1982-07-23 1987-09-17 Ici Plc Amide derivatives
JPS5951288A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規な9−ニトロカンプトテシン及びその製造法
DK162718C (da) 1982-09-30 1992-05-11 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af 7-substitueret-3-vinyl-3-cephemforbindelser
DE3364536D1 (en) 1982-11-08 1986-08-21 Nyegaard & Co As X-ray contrast agents
US4535186A (en) 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
US4520022A (en) 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins
US5053432A (en) 1983-04-14 1991-10-01 Burroughs Wellcome Co. Naphthoquinone derivatives
CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
US5082668A (en) 1983-05-11 1992-01-21 Alza Corporation Controlled-release system with constant pushing source
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
US4567264A (en) 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
CA1237079A (en) 1983-05-23 1988-05-24 Arthur Simon Antiarrhythmic class iii process
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
USRE33994E (en) 1983-08-16 1992-07-14 Burroughs Wellcome Co. Pharmaceutical delivery system
CH656884A5 (de) 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
JPS6051189A (ja) 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
US4513006A (en) 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives
AU575854B2 (en) 1983-10-04 1988-08-11 Shionogi & Co., Ltd. 7beta-(carboxyalkenamido) cephalosporins
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
SE8306367L (sv) 1983-11-18 1985-05-19 Ferring Ab Antidiuretiskt verkande farmaceutiskt preparat
US5238924A (en) 1984-05-03 1993-08-24 Merck & Co., Inc. Treatment of renal diseases with ace inhibitors
US4551552A (en) 1984-05-23 1985-11-05 E. I. Du Pont De Nemours And Company Process for preparing rimantadine
GB8419575D0 (en) 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
US4639338A (en) 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
EP0182024B1 (de) 1984-09-20 1991-04-03 Beecham Group Plc Purin-Derivate und ihre pharmazeutische Verwendung
DE3581471D1 (de) 1984-10-19 1991-02-28 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
DE3572485D1 (en) 1984-12-22 1989-09-28 Thomae Gmbh Dr K Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs
US4772475A (en) 1985-03-08 1988-09-20 Yamanouchi Pharmaceutical Co., Ltd. Controlled-release multiple units pharmaceutical formulation
NZ215486A (en) 1985-03-16 1988-09-29 Wellcome Found 3'-azido-3'-deoxythymidine antiretroviral compositions (zidovudine, azt)
US4724232A (en) 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
US4665098A (en) 1985-03-28 1987-05-12 Mcneilab, Inc. Pharmaceutical composition of N-(4-hydroxyphenyl) retinamide having increased bioavailability
NO166131C (no) 1985-06-20 1991-06-05 Daiichi Seiyaku Co Analogifremgangsmaate for fremstilling av s(-)-pyridobenzoksazinforbindelser.
US4642346A (en) 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
DK288385D0 (da) 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
DE3529529A1 (de) 1985-08-17 1987-02-19 Boehringer Mannheim Gmbh Verfahren zur herstellung einer stabilen modifikation von torasemid
US5254539A (en) 1985-08-26 1993-10-19 U.S. Government, Dept. Of Health And Human Services, C/O National Institutes Of Health Method of treating HIV with 2',3'-dideoxyinosine
JPS62501712A (ja) 1985-08-26 1987-07-09 アメリカ合衆国 2′、3′―ジデオキシイノシン、2′,3′―ジデオキシグアノシンまたは2′,3′―ジデオキシアデノシンを含有する抗htlv―3/lav剤
US5246937A (en) 1985-09-18 1993-09-21 Beecham Group P.L.C. Purine derivatives
GB8524663D0 (en) 1985-10-07 1985-11-13 Fujisawa Pharmaceutical Co Quinazoline derivatives
EP0223403B1 (de) 1985-10-25 1993-08-04 Beecham Group Plc Piperidinderivat, seine Herstellung und seine Verwendung als Arzneimittel
DE3543999A1 (de) 1985-12-13 1987-06-19 Bayer Ag Hochreine acarbose
IT1188212B (it) 1985-12-20 1988-01-07 Paolo Colombo Sistema per il rilascio a velocita' controllata di sostanze attive
AU588080B2 (en) 1986-01-16 1989-09-07 Schering Corporation Fused benzazepines
US5286754A (en) 1986-01-21 1994-02-15 Bayer Aktiengesellschaft Pharmaceutical formulations of ciprofloxacin
GB8607684D0 (en) 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
SE8601624D0 (sv) 1986-04-11 1986-04-11 Haessle Ab New pharmaceutical preparations
US4826868A (en) 1986-05-29 1989-05-02 Ortho Pharmaceutical Corporation 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
USRE36481E (en) 1986-06-23 2000-01-04 Merck & Co., Inc. HMG-CoA reductase inhibitors
US4940727A (en) 1986-06-23 1990-07-10 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US5138069A (en) 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
DE3623620A1 (de) 1986-07-12 1988-01-21 Boehringer Mannheim Gmbh Spritzfertige, waessrige, alkalische injektionsloesungen von torasemid und verfahren zu ihrer herstellung
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
IE60588B1 (en) 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
IN165717B (de) 1986-08-07 1989-12-23 Battelle Memorial Institute
DE3639353A1 (de) 1986-11-18 1988-05-19 Huels Chemische Werke Ag Ester von 3-tert.butyl- bzw. 3-tert.butyl-5-alkyl-4-hydroxyphenyl-(alkan-)carbonsaeuren mit oxethylaten von polythiolen, verfahren zu ihrer herstellung und ihre verwendung als stabilisatoren
KR880007441A (ko) 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
US4978655A (en) 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
KR880007433A (ko) 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
US4753935A (en) 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
IL84305A (en) 1987-02-06 1992-01-15 Fisons Corp 2-aminoacetamide derivatives
US4826860A (en) 1987-03-16 1989-05-02 Warner-Lambert Company Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
GB8708886D0 (en) 1987-04-14 1987-05-20 Akzo Nv 2beta-morpholino-androstane derivatives
US4808411A (en) 1987-06-05 1989-02-28 Abbott Laboratories Antibiotic-polymer compositions
DE3720757A1 (de) 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
DK172696B1 (da) 1987-08-13 1999-05-31 Glaxo Group Ltd Indolderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende forbindelserne
GB8719367D0 (en) 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
ZA885709B (en) 1987-08-19 1989-04-26 Fujisawa Pharmaceutical Co Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid(syn isomer)
FR2619713B1 (fr) 1987-08-25 1990-08-31 Rhone Poulenc Sante Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement des troubles du sommeil et de la depression
US5232917A (en) 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
IE60311B1 (en) 1987-09-24 1994-06-29 American Home Prod Sustained release etodolac
US4797405A (en) 1987-10-26 1989-01-10 Eli Lilly And Company Stabilized pergolide compositions
CA1327358C (en) 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
US5004758A (en) 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
US5382600A (en) 1988-01-22 1995-01-17 Pharmacia Aktiebolag 3,3-diphenylpropylamines and pharmaceutical compositions thereof
DE68918878T2 (de) 1988-02-02 1995-02-23 Johnson Matthey Inc Pt(IV) Komplexe.
US5047407A (en) 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
GB8815265D0 (en) 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
DE3901814A1 (de) 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
GB8819477D0 (en) 1988-08-16 1988-09-21 Wellcome Found Medicaments
US5114976A (en) 1989-01-06 1992-05-19 Norden Michael J Method for treating certain psychiatric disorders and certain psychiatric symptoms
US5246925A (en) 1989-03-09 1993-09-21 Wisconsin Alumni Research Foundation 19-nor-vitamin D compounds for use in treating hyperparathyroidism
CA1333616C (en) 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US5696270A (en) 1989-05-23 1997-12-09 Abbott Laboratories Intermediate for making retroviral protease inhibiting compounds
US5354866A (en) 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
US5770564A (en) 1989-06-16 1998-06-23 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5538739A (en) 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
PH30995A (en) 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US5006344A (en) 1989-07-10 1991-04-09 E. R. Squibb & Sons, Inc. Fosinopril tablet formulations
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
HU225965B1 (en) 1989-09-18 2008-01-28 Stanford Res Inst Int Process for producing medicaments containing 1,2,4-benzotriazine oxides as radiation sensitizers and/or selective cytotoxic agents
FR2653017B1 (fr) 1989-10-17 1995-05-05 Delalande Sa Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique.
US5114948A (en) 1989-10-19 1992-05-19 Eli Lilly And Company Stabilized pergolide compositions
GB8924528D0 (en) 1989-10-31 1989-12-20 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
US4962128A (en) 1989-11-02 1990-10-09 Pfizer Inc. Method of treating anxiety-related disorders using sertraline
GB8927913D0 (en) 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
IL96531A (en) 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
IT1237904B (it) 1989-12-14 1993-06-18 Ubaldo Conte Compresse a rilascio a velocita' controllata delle sostanze attive
GB9002375D0 (en) 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
MY107937A (en) 1990-02-13 1996-06-29 Takeda Chemical Industries Ltd Prolonged release microcapsules.
DE122007000050I1 (de) 1990-02-19 2007-11-08 Novartis Ag Acylverbindungen
US5229382A (en) 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
WO1991016895A1 (en) 1990-05-03 1991-11-14 G.D. Searle & Co. Pharmaceutical composition
PT97888B (pt) 1990-06-07 1998-12-31 Zeneca Ltd Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
US5212176A (en) 1990-06-29 1993-05-18 Abbott Laboratories R(+)-terazosin
GR1001529B (el) 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
DE69103503T2 (de) * 1990-09-28 1995-01-05 Mercian Corp Adriamycinderivate.
US5238714A (en) 1990-10-02 1993-08-24 Board Of Regents, The University Of Texas System Efficient microcapsule preparation and method of use
US5565473A (en) 1990-10-12 1996-10-15 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5177080A (en) 1990-12-14 1993-01-05 Bayer Aktiengesellschaft Substituted pyridyl-dihydroxy-heptenoic acid and its salts
SK278998B6 (sk) 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
WO1992016484A1 (en) 1991-03-19 1992-10-01 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
AU654331B2 (en) 1991-03-30 1994-11-03 Kissei Pharmaceutical Co. Ltd. Succinic acid compounds
DK58291D0 (da) 1991-04-02 1991-04-02 Novo Nordisk As Krystalinsk stof og dets fremstilling
US5605897A (en) 1991-04-23 1997-02-25 Eli Lilly And Company 2-methyl-thieno-benzodiazepine
GB9111902D0 (en) 1991-06-03 1991-07-24 Glaxo Group Ltd Chemical compounds
RU2086544C1 (ru) 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
CA2068402C (en) 1991-06-14 1998-09-22 Michael R. Hoy Taste mask coatings for preparation of chewable pharmaceutical tablets
SG43036A1 (en) 1991-06-21 1997-10-17 Thomae Gmbh Dr K (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid
FR2678833B1 (fr) 1991-07-08 1995-04-07 Rhone Poulenc Rorer Sa Nouvelles compositions pharmaceutiques a base de derives de la classe des taxanes.
AU665562B2 (en) 1991-07-12 1996-01-11 Warner-Lambert Company Cholecystokinin antagonists useful in the treatment of panic attacks
CA2118938A1 (en) 1991-09-13 1993-04-01 Kelvin W. Gee Novel gabaa receptor with steroid binding sites
US5252602A (en) 1991-10-11 1993-10-12 Rafeul Alam Effects of misoprostol on allergic responses
NZ244986A (en) 1991-11-08 1995-10-26 Merck & Co Inc Hiv protease inhibitor and pharmaceutical compositions
US5413999A (en) 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
GB9202298D0 (en) 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CZ283425B6 (cs) 1992-04-02 1998-04-15 Smithkline Beecham Corporation Fenylové deriváty a farmaceutické prostředky s jejich obsahem
FR2689888B1 (fr) 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
GB9209599D0 (en) 1992-05-02 1992-06-17 Fisons Corp Novel therapy for the treatment of parkinsons disease
ES2121084T3 (es) 1992-05-11 2002-02-16 Merrell Pharma Inc Utilizacion de derivados de terfenadina como antihistaminicos en un paciente que padece de trastornos hepaticos.
RU2124503C1 (ru) 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
MY113693A (en) 1992-05-26 2002-05-31 Chugai Pharmaceutical Co Ltd Erythromycin derivatives having an enterokinesis stimulating action
US5534496A (en) * 1992-07-07 1996-07-09 University Of Southern California Methods and compositions to enhance epithelial drug transport
GB9215665D0 (en) 1992-07-23 1992-09-09 British Bio Technology Compounds
TW366342B (en) 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
SG47101A1 (en) 1992-07-31 1998-03-20 Us Bioscience Crystalline amifostine compositions and methods for the preparation and use of same
US5424471A (en) 1992-07-31 1995-06-13 U.S. Bioscience, Inc. Crystalline amifostine compositions and methods of the preparation and use of same
MX9304638A (es) 1992-07-31 1994-05-31 Neose Pharm Inc Composicion para tratar e inhibir las ulceras gastricas y duodenales.
CA2086874E (en) 1992-08-03 2000-01-04 Renzo Mauro Canetta Methods for administration of taxol
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5248699A (en) 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
JP3277342B2 (ja) 1992-09-02 2002-04-22 武田薬品工業株式会社 徐放性マイクロカプセルの製造法
EP1262183A1 (de) 1992-09-03 2002-12-04 Sepracor, Inc. Verwendung von Norastemizol zur Behandlung der allergischen Rhinitis
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
SE9203318D0 (sv) 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
ES2131560T3 (es) 1992-11-17 1999-08-01 Sankyo Co Derivado de carbapenem cristalino.
US5358941A (en) 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
AU671491B2 (en) 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
EP0674513B1 (de) 1992-12-29 1996-09-25 Abbott Laboratories Inhibitoren der retroviralen protease
WO1994016693A1 (en) 1993-01-19 1994-08-04 Warner-Lambert Company Stable oral ci-981 formulation and process of preparing same
US5298410A (en) * 1993-02-25 1994-03-29 Sterling Winthrop Inc. Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
US5378804A (en) 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5294615A (en) 1993-04-29 1994-03-15 Abbott Laboratories Terazosin polymorph and pharmaceutical composition
AU698834B2 (en) 1993-05-24 1998-11-12 Purdue Pharma Ltd. Methods and compositions for inducing sleep
US5891459A (en) * 1993-06-11 1999-04-06 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
EP0703902B1 (de) 1993-06-24 1998-12-16 Albany Molecular Research, Inc. Verfahren zur herstellung von piperidinderivaten
US5500413A (en) 1993-06-29 1996-03-19 Ferring Ab Process for manufacture of 1-deamino-8-D-arginine vasopressin
US5674850A (en) 1993-12-23 1997-10-07 Ferring Ab High purity desmopressin produced in large single batches
US5698226A (en) 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
US5496545A (en) 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
TW406020B (en) 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
US5457895A (en) 1993-10-01 1995-10-17 R. P. Scherer Corporation Method of identifying freeze-dried dosage forms
DK0725642T3 (da) 1993-10-27 2000-05-29 Upjohn Co Stabiliseret prostaglandin E1
HU225062B1 (en) 1993-12-21 2006-05-29 Schering Corp Tetrahydrofuran derivatives with antifungal- effect, pharmaceutical compositions containing them and process for their preparation
IL111991A (en) 1994-01-28 2000-07-26 Abbott Lab Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
US5811120A (en) 1994-03-02 1998-09-22 Eli Lilly And Company Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
US5972383A (en) 1994-03-02 1999-10-26 Eli Lilly And Company Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
CA2145614A1 (en) 1994-03-31 1995-10-01 Jeffrey A. Dodge Intermediates and processes for preparing benzothiophene compounds
US5466810A (en) 1994-06-10 1995-11-14 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
ZA956647B (en) 1994-08-10 1997-02-10 Wellcome Found Hypolipidaemic compounds.
CO4410191A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
US5629425A (en) 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US5681950A (en) 1994-09-28 1997-10-28 Universidad De Antioquia Withajardins
EP0788511B1 (de) 1994-10-07 2002-12-11 Fujisawa Pharmaceutical Co., Ltd. Zyklische hexapeptide mit antibiotischer aktivität
US5910569A (en) * 1994-11-22 1999-06-08 Lotus Biochemical Corporation Iodothyronine polymers
CA2163837C (en) 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates
US5856493A (en) 1995-02-06 1999-01-05 Smithkline Beecham Corporation Process for making novel form of paroxeting hydrochloride anhydrate
US5760069A (en) 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
CA2212836C (en) 1995-02-13 2003-08-12 G.D. Searle & Co. Substituted isoxazoles for the treatment of inflammation
GB9502858D0 (en) 1995-02-14 1995-04-05 British Biotech Pharm Novel use of matrix metalloproteinase inhibitors
KR19980702210A (ko) 1995-02-17 1998-07-15 폴락 돈나 엘 비척추골 골절의 위험률을 감소시키는 방법
ES2181868T3 (es) 1995-02-28 2003-03-01 Aventis Pharma Inc Composicion farmaceutica para compuestos de piperidinoalcanol.
EG23659A (en) 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
CR5278A (es) 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
US5614639A (en) 1995-03-31 1997-03-25 Eli Lilly And Company Process for preparing 2-substituted benzo[b]thiophene compounds and intermediates thereof
US5912268A (en) 1995-05-22 1999-06-15 Alza Corporation Dosage form and method for treating incontinence
US5674895A (en) 1995-05-22 1997-10-07 Alza Corporation Dosage form comprising oxybutynin
PT833643E (pt) 1995-06-06 2005-06-30 Merck & Co Inc Formulacoes de sal anidro de alendronato
IL118279A (en) 1995-06-07 2006-10-05 Abbott Lab Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
US5569772A (en) 1995-06-07 1996-10-29 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
US5659087A (en) 1995-06-07 1997-08-19 Eli Lilly And Company Diarylvinyl sulfoxides
US5514826A (en) 1995-06-07 1996-05-07 Eli Lilly And Company Vinyl sulfenic acid derivatives
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
IL128862A (en) 1995-07-17 2007-12-03 Warner Lambert Co [R - (R * R *)] - 2 - (4 - fluorophenyl) - ß, d - dihydroxy - 5 - (1 - methyl - ethyl) 3 - phenyl - 4 - [(phenamino) carbonyl)] - 1H - Pyrol - 1 - Patenoic acid Hydrogen salt Hydrogen crystalline (Atorostatin) Crystalline hydrate
US5762909A (en) 1995-08-31 1998-06-09 General Electric Company Tumor targeting with polymeric molecules having extended conformation
GB9518027D0 (en) 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
US5851536A (en) 1995-11-22 1998-12-22 University Of Washington Therapeutic delivery using compounds self-assembled into high axial ratio microstructures
US5922736A (en) 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US5646180A (en) 1995-12-05 1997-07-08 Vertex Pharmaceuticals Incorporated Treatment of the CNS effects of HIV
US5753653A (en) 1995-12-08 1998-05-19 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
EP0869974B1 (de) 1995-12-22 2009-03-04 Novo Nordisk A/S Verbindungen mit wachstumshormon-freisetzenden eigenschaften
US5731342A (en) 1996-02-22 1998-03-24 Eli Lilly And Company Benzothiophenes, formulations containing same, and methods
HU226646B1 (en) 1996-03-12 2009-05-28 Pg Txl Company Water soluble pharmaceutical compositions containing taxane derivatives
EP0966303A2 (de) * 1996-05-01 1999-12-29 Antivirals Inc. Polypeptidkonjugate zum transport von substanzen durch zellmembranen
US6030941A (en) * 1996-05-01 2000-02-29 Avi Biopharma, Inc. Polymer composition for delivering substances in living organisms
US5843984A (en) 1996-05-09 1998-12-01 Eli Lilly And Company Sulfated benzothiophene derivatives, methods of use and formulations containing same
US5763398A (en) 1996-06-20 1998-06-09 Ferring B.V. Nasal administration of desmopressin
US5952294A (en) * 1996-07-31 1999-09-14 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peptidyl prodrugs and methods of making and using the same
PL188173B1 (pl) 1996-09-04 2004-12-31 Abbott Lab Pochodne erytromycyny, sposób wytwarzania pochodnych erytromycyny i środek o działaniu przeciwbakteryjnym
US5948750A (en) 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
HRP970566A2 (en) * 1996-10-30 1998-08-31 Jones Deborah Defeo Conjugates useful in the treatment of prostate canser
US6113920A (en) 1996-10-31 2000-09-05 Glaxo Wellcome Inc. Pharmaceutical compositions
AU734827B2 (en) 1997-05-21 2001-06-21 Board Of Trustees Of The Leland Stanford Junior University Composition and method for enhancing transport across biological membranes
US5922877A (en) 1997-08-05 1999-07-13 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
US5994409A (en) 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
US6485514B1 (en) 1997-12-12 2002-11-26 Supergen, Inc. Local delivery of therapeutic agents
CH689805A8 (fr) 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
US6008207A (en) 1998-08-13 1999-12-28 Merck & Co., Inc. Anhydrous alendronate monosodium salt formulations
US6309633B1 (en) * 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US6051567A (en) 1999-08-02 2000-04-18 Abbott Laboratories Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol
CA2393535A1 (en) * 1999-12-07 2001-06-14 Krasnow Institute Adaptive electric field modulation of neural systems
JP2004523480A (ja) * 2000-08-22 2004-08-05 ニュー リバー ファーマシューティカルズ, インコーポレイテッド 活性作用物質送達系ならびに活性作用物質の保護および投与方法
JP2006516947A (ja) * 2000-11-16 2006-07-13 ニュー リバー ファーマシューティカルズ インコーポレイテッド 新規な医薬化合物およびその製造方法と使用方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997036616A2 (en) * 1996-04-02 1997-10-09 The University Of Birmingham Anti-tumour agent
WO2000052078A1 (en) * 1999-03-05 2000-09-08 Innovative Technologies, Llc Use of protein conformation for the protection and release of chemical compounds
WO2000053233A1 (en) * 1999-03-10 2000-09-14 Lotus Biochemical Corporation Use of protein conformation for the protection and release of chemical compounds
WO2002034237A1 (en) * 2000-08-22 2002-05-02 New River Pharmaceuticals, Inc. Active agent delivery systems and methods for protecting and administering active agents
WO2003034980A2 (en) * 2000-11-14 2003-05-01 New River Pharmaceuticals Inc. A novel pharmaceutical compound containing abacavir sulfate and methods of making and using same
WO2003020200A2 (en) * 2000-11-16 2003-03-13 New River Pharmaceuticals Inc. A novel pharmaceutical compound and methods of making and using same
WO2002051432A1 (en) * 2001-11-16 2002-07-04 New River Pharmaceuticals Inc. A novel pharmaceutical compound and methods of making and using same
WO2003072047A2 (en) * 2002-02-22 2003-09-04 New River Pharmaceuticals Inc. Idothyronine compositions
WO2003101476A1 (en) * 2002-05-29 2003-12-11 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents

Also Published As

Publication number Publication date
AU2003217676B2 (en) 2009-06-11
IL163666A0 (en) 2005-12-18
EP2266590A3 (de) 2011-04-20
EP1490090A2 (de) 2004-12-29
CN1649614A (zh) 2005-08-03
CA2477088A1 (en) 2003-10-02
EP2316468A1 (de) 2011-05-04
AU2009201958A1 (en) 2009-06-11
WO2003079972A3 (en) 2004-03-18
EP2316469A1 (de) 2011-05-04
WO2003079972A2 (en) 2003-10-02
EP2266590A2 (de) 2010-12-29
AU2003217676A1 (en) 2003-10-08
JP2005524677A (ja) 2005-08-18
JP4625637B2 (ja) 2011-02-02
KR20040088519A (ko) 2004-10-16

Similar Documents

Publication Publication Date Title
IL163666A0 (en) Active agent delivery systems and methods for protecting and administering active agents
AU2003240949A1 (en) Active agent delivery systems and methods for protecting and administering active agents
IL154583A0 (en) Active agent delivery systems and methods for protecting and administering active agents
HK1254943A1 (zh) 治療藥物遞送裝置和方法
AU2003258209A1 (en) Active agent delivery systems, medical devices, and methods
PL1543851T3 (pl) Wszczepialne urządzenie do podawania substancji czynnej
LT2000095A (en) Aerosolised active agent delivery
AU2003229084A1 (en) Methods and formulations for the delivery of pharmacologically active agents
AU2003286819A8 (en) Alternate delivery location methods and systems
EP1553899A4 (de) Verfahren und system für die intravesikuläre abgabe von therapeutischen mitteln
AU2003210843A1 (en) Agent delivery and aspiration device
AU2003213020A1 (en) Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
AU2003261100A1 (en) Devices delivering therapeutic agents and methods regarding the same
EP1183068A4 (de) Verfahren zur durch elektroporation erleichterte verabreichung aktiver substanzen
IL143962A0 (en) Polymeric delivery agents and delivery agent compounds
AU2003258206A1 (en) Active agent delivery system including a polyurethane, medical device, and method
AU2003281876A1 (en) Pharmaceutical delivery systems and methods for using same
AU6475901A (en) System and method for assessing the performance of a pharmaceutical agent delivery system
EP1392241A4 (de) System für die osmotische freisetzung von pharmazeutisch wirksamen mitteln
HK1096895A1 (en) Cryogranulation and storage method for active pharmaceutical agents
AU2003243439A8 (en) Medical device for intra-lumenal delivery of pharmaceutical agents
AU2003212962A8 (en) Transdermal drug delivery systems
AU2002351292A8 (en) Hemostatic agent delivery system
AU2003284885A8 (en) Device and methods for sequential, regional delivery of multiple cytotoxic agents
AU2002316200A1 (en) Compound and composition for delivering active agents

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20040914

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO

A4 Supplementary search report drawn up and despatched

Effective date: 20060821

17Q First examination report despatched

Effective date: 20071016

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SHIRE LLC

REG Reference to a national code

Ref country code: DE

Ref legal event code: R003

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20120611