|
TW321649B
(et)
*
|
1994-11-12 |
1997-12-01 |
Zeneca Ltd |
|
|
GB9424233D0
(en)
*
|
1994-11-30 |
1995-01-18 |
Zeneca Ltd |
Quinazoline derivatives
|
|
GB9508535D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivative
|
|
GB9508538D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
GB9508565D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quiazoline derivative
|
|
AU5343096A
(en)
*
|
1995-04-27 |
1996-11-18 |
Zeneca Limited |
Quinazoline derivatives
|
|
GB9508537D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
|
NZ330868A
(en)
|
1996-02-13 |
2000-01-28 |
Zeneca Ltd |
4-phenoxy, phenylthio or phenylamino substituted quinazoline derivatives ane medicaments useful as VEGF inhibitors
|
|
GB9603097D0
(en)
*
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline compounds
|
|
GB9603095D0
(en)
*
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
|
ES2169355T3
(es)
|
1996-03-05 |
2002-07-01 |
Astrazeneca Ab |
Derivados de 4-anilinoquinazolina.
|
|
GB9607729D0
(en)
*
|
1996-04-13 |
1996-06-19 |
Zeneca Ltd |
Quinazoline derivatives
|
|
US6498163B1
(en)
|
1997-02-05 |
2002-12-24 |
Warner-Lambert Company |
Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation
|
|
EP1806348A3
(en)
*
|
1997-02-05 |
2008-01-02 |
Warner-Lambert Company LLC |
Pyrido [2, 3 -d] pyrimidines and 4-amino-primidines as inhibitors of cellular proliferation
|
|
WO1998033798A2
(en)
*
|
1997-02-05 |
1998-08-06 |
Warner Lambert Company |
Pyrido[2,3-d]pyrimidines and 4-amino-pyrimidines as inhibitors of cell proliferation
|
|
US5945422A
(en)
*
|
1997-02-05 |
1999-08-31 |
Warner-Lambert Company |
N-oxides of amino containing pyrido 2,3-D! pyrimidines
|
|
GB9716231D0
(en)
*
|
1997-07-31 |
1997-10-08 |
Amersham Int Ltd |
Base analogues
|
|
EA003640B1
(ru)
|
1998-05-26 |
2003-08-28 |
Варнер-Ламберт Компани |
Бициклические пиримидины и бициклические 3,4-дигидропиримидины как ингибиторы клеточной пролиферации
|
|
EP1801112A1
(en)
*
|
1998-05-26 |
2007-06-27 |
Warner-Lambert Company LLC |
Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
|
|
CA2347474C
(en)
*
|
1998-10-23 |
2008-08-26 |
F. Hoffmann-La Roche Ag |
Bicyclic nitrogen heterocycles
|
|
AU776250B2
(en)
|
1999-10-21 |
2004-09-02 |
F. Hoffmann-La Roche Ag |
Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of P38 protein kinase
|
|
KR100537241B1
(ko)
|
1999-10-21 |
2005-12-19 |
에프. 호프만-라 로슈 아게 |
Ｐ38 단백질 키나제의 억제제로서의 알킬아미노 치환된이중고리 질소 헤테로고리 화합물
|
|
ATE398120T1
(de)
|
1999-11-05 |
2008-07-15 |
Astrazeneca Ab |
Neue quinazolin-derivate
|
|
WO2001042243A2
(en)
*
|
1999-12-08 |
2001-06-14 |
Advanced Medicine, Inc. |
Protein kinase inhibitors
|
|
US20020002169A1
(en)
|
1999-12-08 |
2002-01-03 |
Griffin John H. |
Protein kinase inhibitors
|
|
PT1417207E
(pt)
|
2000-08-04 |
2005-11-30 |
Warner Lambert Co |
Processo para a preparacao de 2-(4-piridil)amino-6-dialquiloxifenil-pirido(2,3-d)pirimidin-7-onas
|
|
JP2004505974A
(ja)
|
2000-08-04 |
2004-02-26 |
ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー |
２−（４−ピリジル）アミノ−６−ジアルキルオキシフェニルピリド〔２，３−ｄ〕ピリミジン−７−オン類の製造方法
|
|
US6506749B2
(en)
|
2000-08-31 |
2003-01-14 |
Syntex (U.S.A.) Llc |
7-oxo-pyridopyrimidines (I)
|
|
JP4146721B2
(ja)
*
|
2000-08-31 |
2008-09-10 |
エフ．ホフマン−ラ ロシュ アーゲー |
７−オキソ−ピリドピリミジン類
|
|
US6518276B2
(en)
|
2000-08-31 |
2003-02-11 |
Syntex (U.S.A.) Llc |
7-oxo-pyridopyrimidines (II)
|
|
MXPA03001821A
(es)
*
|
2000-08-31 |
2003-06-04 |
Hoffmann La Roche |
7-oxo-piridopirimidinas como inhibidores de prolieferacion celular.
|
|
RU2269527C2
(ru)
|
2001-02-12 |
2006-02-10 |
Ф.Хоффманн-Ля Рош Аг |
Производные пиридопиримидинов, способы их получения и фармацевтическая композиция на их основе
|
|
JP4508645B2
(ja)
*
|
2002-01-04 |
2010-07-21 |
ザ ロックフェラー ユニバーシティー |
アミロイド−βペプチド関連疾患の予防および治療用の組成物および方法
|
|
CA2473026C
(en)
|
2002-01-22 |
2011-05-03 |
Warner-Lambert Company Llc |
2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones
|
|
US6822097B1
(en)
|
2002-02-07 |
2004-11-23 |
Amgen, Inc. |
Compounds and methods of uses
|
|
PA8577501A1
(es)
|
2002-07-25 |
2004-02-07 |
Warner Lambert Co |
Inhibidores de quinasas
|
|
AU2003251661A1
(en)
|
2002-08-06 |
2004-02-25 |
F. Hoffmann-La Roche Ag |
6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors
|
|
MXPA05005547A
(es)
*
|
2002-11-28 |
2005-07-26 |
Schering Ag |
Pirimidinas inhibidoras de chk, pdk y akt, su produccion y uso como agentes farmaceuticos.
|
|
US7098332B2
(en)
*
|
2002-12-20 |
2006-08-29 |
Hoffmann-La Roche Inc. |
5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
|
|
CN100420687C
(zh)
*
|
2002-12-20 |
2008-09-24 |
霍夫曼-拉罗奇有限公司 |
作为选择性kdr和fgfr抑制剂的吡啶并[2,3-d]嘧啶衍生物
|
|
US6861422B2
(en)
|
2003-02-26 |
2005-03-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
|
|
US7160888B2
(en)
*
|
2003-08-22 |
2007-01-09 |
Warner Lambert Company Llc |
[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
|
|
JP4758349B2
(ja)
*
|
2003-10-08 |
2011-08-24 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
タンパク質キナーゼ阻害剤としての化合物および組成物
|
|
DE602004005238T2
(de)
|
2003-11-13 |
2007-11-08 |
F. Hoffmann-La Roche Ag |
Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7-one
|
|
EP1718645A1
(en)
*
|
2004-02-18 |
2006-11-08 |
Warner-Lambert Company LLC |
2-(pyridin-3-ylamino)-pyrido 2,3-d pyrimidin-7-ones
|
|
WO2005105097A2
(en)
*
|
2004-04-28 |
2005-11-10 |
Gpc Biotech Ag |
Pyridopyrimidines for treating inflammatory and other diseases
|
|
DE102004029784A1
(de)
|
2004-06-21 |
2006-01-05 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
|
|
DE102004033670A1
(de)
|
2004-07-09 |
2006-02-02 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
|
|
FR2873118B1
(fr)
|
2004-07-15 |
2007-11-23 |
Sanofi Synthelabo |
Derives de pyrido-pyrimidine, leur application en therapeutique
|
|
US7759485B2
(en)
|
2004-08-14 |
2010-07-20 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of dihydropteridinones
|
|
US20060035903A1
(en)
|
2004-08-14 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Storage stable perfusion solution for dihydropteridinones
|
|
US20060074088A1
(en)
|
2004-08-14 |
2006-04-06 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones for the treatment of cancer diseases
|
|
US20060058311A1
(en)
|
2004-08-14 |
2006-03-16 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation
|
|
US7728134B2
(en)
|
2004-08-14 |
2010-06-01 |
Boehringer Ingelheim International Gmbh |
Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
|
|
EP1630163A1
(de)
|
2004-08-25 |
2006-03-01 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
|
CA2575804A1
(en)
*
|
2004-08-26 |
2006-03-02 |
Boehringer Ingelheim International Gmbh |
Pteridinones used as plk (polo like kinase) inhibitors
|
|
DE102004058337A1
(de)
|
2004-12-02 |
2006-06-14 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
|
|
FR2887882B1
(fr)
|
2005-07-01 |
2007-09-07 |
Sanofi Aventis Sa |
Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
|
|
US7642270B2
(en)
|
2005-09-14 |
2010-01-05 |
Janssen Pharmaceutica N.V. |
5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
|
|
CN101300258A
(zh)
*
|
2005-09-14 |
2008-11-05 |
詹森药业有限公司 |
作为c-fms激酶抑制剂的5-氧代-5,8-二氢-吡啶并-嘧啶类
|
|
TW200800983A
(en)
|
2005-09-14 |
2008-01-01 |
Janssen Pharmaceutica Nv |
5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
|
|
DK1940839T3
(da)
*
|
2005-10-07 |
2013-10-14 |
Exelixis Inc |
Pyridopyrimidione Inhibitors of P13Ka
|
|
CN102746298A
(zh)
*
|
2005-10-07 |
2012-10-24 |
埃克塞里艾克西斯公司 |
PI3Kα的吡啶并嘧啶酮抑制剂
|
|
FR2896246B1
(fr)
*
|
2006-01-13 |
2008-08-15 |
Sanofi Aventis Sa |
Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
|
|
JP2009525292A
(ja)
|
2006-01-31 |
2009-07-09 |
エフ．ホフマン−ラ ロシュ アーゲー |
７ｈ−ピリド［３，４−ｄ］ピリミジン−８−オン、それらの製造及びプロテインキナーゼ阻害剤としての使用
|
|
US7439358B2
(en)
|
2006-02-08 |
2008-10-21 |
Boehringer Ingelheim International Gmbh |
Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
|
|
WO2007143146A2
(en)
*
|
2006-05-31 |
2007-12-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method of treating inflammatory diseases using tyroskine kinase inhibitors
|
|
EP2074122B9
(en)
|
2006-09-15 |
2013-09-11 |
Pfizer Products Inc. |
Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors
|
|
EP1914234A1
(en)
|
2006-10-16 |
2008-04-23 |
GPC Biotech Inc. |
Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
|
|
JO2985B1
(ar)
|
2006-12-20 |
2016-09-05 |
Takeda Pharmaceuticals Co |
مثبطات كينازmapk/erk
|
|
FR2910813B1
(fr)
|
2006-12-28 |
2009-02-06 |
Sanofi Aventis Sa |
Nouvelle utilisation therapeutique pour le traitement des leucemies
|
|
WO2008127678A1
(en)
*
|
2007-04-11 |
2008-10-23 |
Exelixis, Inc. |
Pyrido [2, 3-d] pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer
|
|
CN101711249A
(zh)
*
|
2007-04-11 |
2010-05-19 |
埃克塞里艾克西斯公司 |
作为PI3K-α的抑制剂用于治疗癌症的吡啶并[2,3-D]嘧啶-7-酮化合物
|
|
WO2009019205A1
(en)
|
2007-08-03 |
2009-02-12 |
Boehringer Ingelheim International Gmbh |
Crystalline form of a dihydropteridione derivative
|
|
EP2112150B1
(en)
|
2008-04-22 |
2013-10-16 |
Forma Therapeutics, Inc. |
Improved raf inhibitors
|
|
TW201018685A
(en)
|
2008-09-30 |
2010-05-16 |
Exelixis Inc |
Pyridopyrimidinone inhibitors of PI3Kα and mTOR
|
|
US8674095B2
(en)
|
2008-12-19 |
2014-03-18 |
Afraxis Holdings, Inc. |
Compounds for treating neuropsychiatric conditions
|
|
JP6166534B2
(ja)
|
2009-08-05 |
2017-07-19 |
イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． |
新規調節タンパク質および阻害剤
|
|
CA2776770A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Afraxis, Inc. |
8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders
|
|
FR2955109B1
(fr)
|
2010-01-08 |
2012-09-07 |
Sanofi Aventis |
Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique
|
|
US8901137B2
(en)
|
2010-02-09 |
2014-12-02 |
Exelixis, Inc. |
Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K and mTOR in combination with autophagy inhibitors
|
|
US8546566B2
(en)
|
2010-10-12 |
2013-10-01 |
Boehringer Ingelheim International Gmbh |
Process for manufacturing dihydropteridinones and intermediates thereof
|
|
US9358233B2
(en)
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
|
SG193291A1
(en)
|
2011-03-04 |
2013-10-30 |
Newgen Therapeutics Inc |
Alkyne substituted quinazoline compound and methods of use
|
|
US20140163026A1
(en)
*
|
2011-04-08 |
2014-06-12 |
Afraxis Holdings, Inc. |
8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of nervous system disorders and cancer
|
|
US9370535B2
(en)
|
2011-05-17 |
2016-06-21 |
Boehringer Ingelheim International Gmbh |
Method for treatment of advanced solid tumors
|
|
US9951088B2
(en)
*
|
2012-05-09 |
2018-04-24 |
Sunovion Pharmaceuticals Inc. |
D2 receptor modulators and methods of use thereof in the treatment of diseases and disorders
|
|
EP2872491B1
(en)
*
|
2012-07-11 |
2021-05-05 |
Blueprint Medicines Corporation |
Inhibitors of the fibroblast growth factor receptor
|
|
EP2900668A4
(en)
|
2012-09-26 |
2016-04-20 |
Mannkind Corp |
INHIBITORS OF MULTIPLE KINASE PATHWAYS
|
|
JP2016525532A
(ja)
|
2013-07-26 |
2016-08-25 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
骨髄異形成症候群の処置
|
|
AU2014339972B9
(en)
|
2013-10-25 |
2019-05-30 |
Blueprint Medicines Corporation |
Inhibitors of the fibroblast growth factor receptor
|
|
US9867831B2
(en)
|
2014-10-01 |
2018-01-16 |
Boehringer Ingelheim International Gmbh |
Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
|
|
CN106749173A
(zh)
*
|
2016-11-25 |
2017-05-31 |
吉林化工学院 |
一种嘧啶联吡啶类化合物的制备方法
|
|
US11174255B2
(en)
|
2017-05-15 |
2021-11-16 |
University Of Houston System |
Pyrido[2,3-d]pyrimidin-7-ones and related compounds as inhibitors of protein kinases
|
|
US20220194937A1
(en)
*
|
2019-05-16 |
2022-06-23 |
University Of Houston System |
Protein kinase inhibitors and uses thereof for the treatment of diseases and conditions
|
|
KR102329720B1
(ko)
*
|
2019-08-30 |
2021-11-23 |
한국과학기술연구원 |
단백질 키나아제 저해 활성을 갖는 신규한 피리미도[4,5-d]피리미딘-2-온 유도체
|
|
EP4065578A1
(en)
|
2019-11-26 |
2022-10-05 |
Theravance Biopharma R&D IP, LLC |
Fused pyrimidine pyridinone compounds as jak inhibitors
|
|
WO2023177356A2
(en)
*
|
2022-03-18 |
2023-09-21 |
Engine Biosciences Pte. Ltd. |
Compounds and method for pkmyt1 inhibition
|