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EA201890337A8 - Конструкции антитела к flt3 и cd3 - Google Patents

Конструкции антитела к flt3 и cd3

Info

Publication number
EA201890337A8
EA201890337A8 EA201890337A EA201890337A EA201890337A8 EA 201890337 A8 EA201890337 A8 EA 201890337A8 EA 201890337 A EA201890337 A EA 201890337A EA 201890337 A EA201890337 A EA 201890337A EA 201890337 A8 EA201890337 A8 EA 201890337A8
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody construct
present
flt3
indicated
polynucleotide
Prior art date
Application number
EA201890337A
Other languages
English (en)
Other versions
EA201890337A1 (ru
Inventor
Тобиас РАУМ
Йохен Пендциалек
Клаудиа БЛЮМЕЛЬ
Франциска Ботт
Кристоф Дальхофф
Патрик ХОФФМАНН
Элизабет Нарвольд
Маркус Муенз
Йоханнес Брози
Питер Куфер
Маттхиас Фриедрих
Бенно Раттел
Памела Богнер
Андреас Волф
Сорнелиус Помпе
Original Assignee
Эмджен Рисерч (Мюник) Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмджен Рисерч (Мюник) Гмбх filed Critical Эмджен Рисерч (Мюник) Гмбх
Publication of EA201890337A1 publication Critical patent/EA201890337A1/ru
Publication of EA201890337A8 publication Critical patent/EA201890337A8/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к конструкции биспецифического антитела, содержащей первый связывающий домен, который связывается с FLT3 человека на поверхности целевой клетки, и второй связывающий домен, который связывается с CD3 человека на поверхности Т-клетки. Кроме того, согласно настоящему изобретению предложен полинуклеотид, кодирующий указанную конструкцию антитела, вектор, содержащий указанный полинуклеотид, и клетка-хозяин, трансформированная или трансфицированная указанным полинуклеотидом или вектором. Кроме того, согласно настоящему изобретению предложен способ получения указанной конструкции антитела согласно настоящему изобретению, медицинское применение указанной конструкции антитела и набор, содержащий указанную конструкцию антитела.
EA201890337A 2015-07-31 2016-08-01 Конструкции антитела к flt3 и cd3 EA201890337A8 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562199944P 2015-07-31 2015-07-31
US201662290861P 2016-02-03 2016-02-03
PCT/EP2016/068319 WO2017021362A1 (en) 2015-07-31 2016-08-01 Antibody constructs for flt3 and cd3

Publications (2)

Publication Number Publication Date
EA201890337A1 EA201890337A1 (ru) 2018-07-31
EA201890337A8 true EA201890337A8 (ru) 2019-09-30

Family

ID=56800254

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890337A EA201890337A8 (ru) 2015-07-31 2016-08-01 Конструкции антитела к flt3 и cd3

Country Status (36)

Country Link
US (2) US11447567B2 (ru)
EP (2) EP3328891B1 (ru)
JP (2) JP7011574B2 (ru)
KR (1) KR20180030852A (ru)
CN (2) CN115925964A (ru)
AU (1) AU2016302580B2 (ru)
BR (1) BR112018001042A2 (ru)
CA (1) CA2991607A1 (ru)
CL (3) CL2018000269A1 (ru)
CO (1) CO2018000882A2 (ru)
CR (1) CR20180067A (ru)
CY (1) CY1126145T1 (ru)
DK (1) DK3328891T5 (ru)
EA (1) EA201890337A8 (ru)
ES (1) ES2943147T3 (ru)
FI (1) FI3328891T3 (ru)
HK (1) HK1248251A1 (ru)
HR (1) HRP20230401T1 (ru)
HU (1) HUE061579T2 (ru)
IL (2) IL289894B2 (ru)
JO (1) JO3792B1 (ru)
LT (1) LT3328891T (ru)
MD (1) MD3328891T2 (ru)
MX (1) MX2018001159A (ru)
MY (1) MY193235A (ru)
PE (1) PE20181082A1 (ru)
PH (1) PH12018500157A1 (ru)
PL (1) PL3328891T3 (ru)
PT (1) PT3328891T (ru)
RS (1) RS64184B1 (ru)
SG (1) SG10202000793XA (ru)
SI (1) SI3328891T1 (ru)
TN (1) TN2017000550A1 (ru)
TW (1) TWI829617B (ru)
UA (1) UA125717C2 (ru)
WO (1) WO2017021362A1 (ru)

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