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EA201691631A1 - Иммунотерапия рака с применением комбинации местной и системной иммунной стимуляции - Google Patents

Иммунотерапия рака с применением комбинации местной и системной иммунной стимуляции

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Publication number
EA201691631A1
EA201691631A1 EA201691631A EA201691631A EA201691631A1 EA 201691631 A1 EA201691631 A1 EA 201691631A1 EA 201691631 A EA201691631 A EA 201691631A EA 201691631 A EA201691631 A EA 201691631A EA 201691631 A1 EA201691631 A1 EA 201691631A1
Authority
EA
Eurasian Patent Office
Prior art keywords
local
combination
cancer immunotherapy
immune stimulation
systemic immune
Prior art date
Application number
EA201691631A
Other languages
English (en)
Other versions
EA035259B1 (ru
Inventor
Мелен Ян Хенрик Тер
Куэнка Карлос В. Пайя
Original Assignee
Иммьюн Дизайн Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Иммьюн Дизайн Корп. filed Critical Иммьюн Дизайн Корп.
Publication of EA201691631A1 publication Critical patent/EA201691631A1/ru
Publication of EA035259B1 publication Critical patent/EA035259B1/ru

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В настоящем изобретении предлагаются композиции и способы иммунотерапии раковых заболеваний, причем в указанных способах комбинируется системная вакцинация рекомбинантным экспрессионным вектором, кодирующим вирусный антиген и/или опухолевый(е) антиген(ы), специфический(е) к раку, с целью индуцирования активированных CD8 Т-клеток путем местной (например, внутриопухолевой) стимуляции иммунной системы с использованием стандартного или модифицированного применения агониста TLR для индуцирования местных воспалительных и врожденных иммунных ответов, которые вовлекают Т-клетки в опухоль.
EA201691631A 2014-02-14 2015-02-13 Иммунотерапия рака с применением комбинации местной и системной иммунной стимуляции EA035259B1 (ru)

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US201562101335P 2015-01-08 2015-01-08
PCT/US2015/015767 WO2015123496A1 (en) 2014-02-14 2015-02-13 Immunotherapy of cancer through combination of local and systemic immune stimulation

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WO2015123496A1 (en) 2015-08-20
EP3104878A1 (en) 2016-12-21
ES2738582T3 (es) 2020-01-23
SG11201606625RA (en) 2016-09-29
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JP2017506641A (ja) 2017-03-09
JP6581101B2 (ja) 2019-09-25
MX2016010565A (es) 2017-05-10
BR112016018521A2 (pt) 2017-10-17
EP3104878B1 (en) 2019-05-22
IL247066B (en) 2020-11-30
CA2939093A1 (en) 2015-08-20
US20160058852A1 (en) 2016-03-03
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