EA201591399A1 - РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА - Google Patents
РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗАInfo
- Publication number
- EA201591399A1 EA201591399A1 EA201591399A EA201591399A EA201591399A1 EA 201591399 A1 EA201591399 A1 EA 201591399A1 EA 201591399 A EA201591399 A EA 201591399A EA 201591399 A EA201591399 A EA 201591399A EA 201591399 A1 EA201591399 A1 EA 201591399A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- rappγ
- agonists
- sclerosis
- multidated
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Способы лечения рассеянного склероза (PC) при помощи агонистов РАППγ и, в частности, соединения формулы (I), известного как INT131.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361758641P | 2013-01-30 | 2013-01-30 | |
| PCT/US2014/012656 WO2014120538A1 (en) | 2013-01-30 | 2014-01-23 | PPARγ AGONISTS FOR TREATMENT OF MULTIPLE SCLEROSIS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201591399A1 true EA201591399A1 (ru) | 2015-12-30 |
| EA029216B1 EA029216B1 (ru) | 2018-02-28 |
Family
ID=51223587
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201591399A EA029216B1 (ru) | 2013-01-30 | 2014-01-23 | РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА |
| EA201792096A EA201792096A3 (ru) | 2013-01-30 | 2014-01-23 | РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201792096A EA201792096A3 (ru) | 2013-01-30 | 2014-01-23 | РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US9061020B2 (ru) |
| EP (1) | EP2950798B1 (ru) |
| JP (3) | JP5989921B2 (ru) |
| KR (2) | KR20150133182A (ru) |
| CN (1) | CN105228622B (ru) |
| AU (1) | AU2014212740B2 (ru) |
| BR (1) | BR112015018048A2 (ru) |
| CA (1) | CA2899187C (ru) |
| EA (2) | EA029216B1 (ru) |
| ES (1) | ES2883141T3 (ru) |
| HK (1) | HK1218510A1 (ru) |
| IL (2) | IL240051A (ru) |
| MX (1) | MX366765B (ru) |
| SG (2) | SG10201805896SA (ru) |
| WO (1) | WO2014120538A1 (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| KR20150133182A (ko) * | 2013-01-30 | 2015-11-27 | 인테크린 테라퓨틱스, 아이엔씨. | 다발성 경화증의 치료를 위한 PPARγ 작용제 |
| SG10202103552XA (en) | 2015-03-09 | 2021-05-28 | Intekrin Therapeutics Inc | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
| SG10202101500WA (en) * | 2016-08-18 | 2021-03-30 | Intekrin Therapeutics Inc | PPARγ AGONIST FOR TREATMENT OF BONE DISORDERS |
| JP2019524888A (ja) * | 2016-08-18 | 2019-09-05 | インテクリン セラピューティクス インコーポレイテッド | 血液がんの治療のためのＰＰＡＲγアゴニスト |
| AU2017326261A1 (en) * | 2016-09-13 | 2019-04-04 | Intekrin Therapeutics, Inc. | Treatment of multiple sclerosis with CHS-131 |
| SG11201909046XA (en) * | 2017-04-03 | 2019-10-30 | Coherus Biosciences Inc | PPARγ AGONIST FOR TREATMENT OF PROGRESSIVE SUPRANUCLEAR PALSY |
| EA201992364A1 (ru) * | 2018-04-02 | 2020-03-23 | Кохерус Байосайенсис Инк. | АГОНИСТ PPARγ ДЛЯ ЛЕЧЕНИЯ ПРОГРЕССИРУЮЩЕГО НАДЪЯДЕРНОГО ПАРАЛИЧА |
| US20220387393A1 (en) * | 2019-11-06 | 2022-12-08 | Board Of Regents, The University Of Texas System | Methods for the treatment of dysmyelinating/demyelinating diseases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030171399A1 (en) | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| US7223761B2 (en) * | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| EP1722789A2 (en) * | 2004-03-08 | 2006-11-22 | Amgen Inc. | Therapeutic modulation of ppar (gamma) activity |
| WO2009007673A2 (en) * | 2007-07-11 | 2009-01-15 | Cardoz Ab | Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and a ppar gamma agonist |
| EP2242747A1 (de) * | 2008-02-07 | 2010-10-27 | Sanofi-Aventis | Substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| US20100087481A1 (en) * | 2008-10-03 | 2010-04-08 | Lee Kathleen M | Oral pharmaceutical formulations for antidiabetic compounds |
| JP6084926B2 (ja) * | 2010-09-21 | 2017-02-22 | インテクリン・セラピユーテイクス・インコーポレイテツド | 抗糖尿病固体医薬組成物 |
| KR20150133182A (ko) * | 2013-01-30 | 2015-11-27 | 인테크린 테라퓨틱스, 아이엔씨. | 다발성 경화증의 치료를 위한 PPARγ 작용제 |
-
2014
- 2014-01-23 KR KR1020157023209A patent/KR20150133182A/ko active Application Filing
- 2014-01-23 MX MX2015009818A patent/MX366765B/es active IP Right Grant
- 2014-01-23 JP JP2015556062A patent/JP5989921B2/ja not_active Expired - Fee Related
- 2014-01-23 BR BR112015018048A patent/BR112015018048A2/pt not_active Application Discontinuation
- 2014-01-23 ES ES14746632T patent/ES2883141T3/es active Active
- 2014-01-23 CA CA2899187A patent/CA2899187C/en active Active
- 2014-01-23 SG SG10201805896SA patent/SG10201805896SA/en unknown
- 2014-01-23 EA EA201591399A patent/EA029216B1/ru unknown
- 2014-01-23 EP EP14746632.0A patent/EP2950798B1/en active Active
- 2014-01-23 SG SG11201505944QA patent/SG11201505944QA/en unknown
- 2014-01-23 KR KR1020167032282A patent/KR102056756B1/ko active IP Right Grant
- 2014-01-23 WO PCT/US2014/012656 patent/WO2014120538A1/en active Application Filing
- 2014-01-23 US US14/162,723 patent/US9061020B2/en active Active
- 2014-01-23 EA EA201792096A patent/EA201792096A3/ru unknown
- 2014-01-23 AU AU2014212740A patent/AU2014212740B2/en not_active Ceased
- 2014-01-23 CN CN201480006782.8A patent/CN105228622B/zh active Active
-
2015
- 2015-05-08 US US14/707,122 patent/US9539249B2/en active Active
- 2015-07-21 IL IL240051A patent/IL240051A/en active IP Right Grant
-
2016
- 2016-06-07 HK HK16106520.8A patent/HK1218510A1/zh unknown
- 2016-08-09 JP JP2016156171A patent/JP6224189B2/ja not_active Expired - Fee Related
- 2016-10-30 IL IL248594A patent/IL248594B/en unknown
-
2017
- 2017-01-10 US US15/402,941 patent/US9867816B2/en active Active
- 2017-10-03 JP JP2017193213A patent/JP6466540B2/ja not_active Expired - Fee Related
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