EA201792096A3 - РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА - Google Patents
РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗАInfo
- Publication number
- EA201792096A3 EA201792096A3 EA201792096A EA201792096A EA201792096A3 EA 201792096 A3 EA201792096 A3 EA 201792096A3 EA 201792096 A EA201792096 A EA 201792096A EA 201792096 A EA201792096 A EA 201792096A EA 201792096 A3 EA201792096 A3 EA 201792096A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- rappγ
- agonists
- sclerosis
- multidated
- treatment
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Способы лечения рассеянного склероза (PC) при помощи агонистов РАППγ и, в частности, соединения формулы (I), известного как INT131.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361758641P | 2013-01-30 | 2013-01-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201792096A2 EA201792096A2 (ru) | 2018-01-31 |
| EA201792096A3 true EA201792096A3 (ru) | 2018-05-31 |
Family
ID=51223587
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201591399A EA029216B1 (ru) | 2013-01-30 | 2014-01-23 | РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА |
| EA201792096A EA201792096A3 (ru) | 2013-01-30 | 2014-01-23 | РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201591399A EA029216B1 (ru) | 2013-01-30 | 2014-01-23 | РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US9061020B2 (ru) |
| EP (1) | EP2950798B1 (ru) |
| JP (3) | JP5989921B2 (ru) |
| KR (2) | KR20150133182A (ru) |
| CN (1) | CN105228622B (ru) |
| AU (1) | AU2014212740B2 (ru) |
| BR (1) | BR112015018048A2 (ru) |
| CA (1) | CA2899187C (ru) |
| EA (2) | EA029216B1 (ru) |
| ES (1) | ES2883141T3 (ru) |
| HK (1) | HK1218510A1 (ru) |
| IL (2) | IL240051A (ru) |
| MX (1) | MX366765B (ru) |
| SG (2) | SG10201805896SA (ru) |
| WO (1) | WO2014120538A1 (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| JP5989921B2 (ja) * | 2013-01-30 | 2016-09-07 | インテクリン・セラピユーテイクス・インコーポレイテツド | 多発性硬化症を治療するためのＰＰＡＲγアゴニスト |
| MX2017011586A (es) | 2015-03-09 | 2017-10-26 | Intekrin Therapeutics Inc | Metodos para el tratamiento de enfermedad de higado graso no alcoholico y/o lipodistrofia. |
| CA3033971A1 (en) * | 2016-08-18 | 2018-02-22 | Intekrin Therapeutics, Inc. | Ppar.gamma. agonist for treatment of bone disorders |
| EA201990512A1 (ru) * | 2016-08-18 | 2019-08-30 | Интекрин Терапьютикс, Инк. | АГОНИСТ PPARγ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙ КЛЕТОК КРОВИ |
| JP2019531286A (ja) * | 2016-09-13 | 2019-10-31 | インテクリン セラピューティクス インコーポレイテッド | Ｃｈｓ−１３１による多発性硬化症の治療 |
| CN110996951A (zh) * | 2017-04-03 | 2020-04-10 | 科赫罗斯生物科学股份有限公司 | 治疗进行性核上性麻痹的PPARγ激动剂 |
| EA201992364A1 (ru) * | 2018-04-02 | 2020-03-23 | Кохерус Байосайенсис Инк. | АГОНИСТ PPARγ ДЛЯ ЛЕЧЕНИЯ ПРОГРЕССИРУЮЩЕГО НАДЪЯДЕРНОГО ПАРАЛИЧА |
| WO2021092279A1 (en) * | 2019-11-06 | 2021-05-14 | Board Of Regents, The University Of Texas System | Methods for the treatment of dysmyelinating/demyelinating diseases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030171399A1 (en) | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| US7223761B2 (en) * | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| JP2007527918A (ja) * | 2004-03-08 | 2007-10-04 | アムジェン インコーポレイテッド | Ｐｐａｒガンマ活性の治療的調節 |
| EP2175845A2 (en) * | 2007-07-11 | 2010-04-21 | Cardoz AB | New combination for use in the treatment of inflammatory disorders |
| EP2242747A1 (de) | 2008-02-07 | 2010-10-27 | Sanofi-Aventis | Substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| US20100087481A1 (en) * | 2008-10-03 | 2010-04-08 | Lee Kathleen M | Oral pharmaceutical formulations for antidiabetic compounds |
| EP2618827B1 (en) * | 2010-09-21 | 2021-06-02 | Intekrin Therapeutics, Inc. | Antidiabetic solid pharmaceutical compositions |
| JP5989921B2 (ja) * | 2013-01-30 | 2016-09-07 | インテクリン・セラピユーテイクス・インコーポレイテツド | 多発性硬化症を治療するためのＰＰＡＲγアゴニスト |
-
2014
- 2014-01-23 JP JP2015556062A patent/JP5989921B2/ja not_active Expired - Fee Related
- 2014-01-23 MX MX2015009818A patent/MX366765B/es active IP Right Grant
- 2014-01-23 EA EA201591399A patent/EA029216B1/ru unknown
- 2014-01-23 AU AU2014212740A patent/AU2014212740B2/en not_active Ceased
- 2014-01-23 CN CN201480006782.8A patent/CN105228622B/zh active Active
- 2014-01-23 EA EA201792096A patent/EA201792096A3/ru unknown
- 2014-01-23 US US14/162,723 patent/US9061020B2/en active Active
- 2014-01-23 KR KR1020157023209A patent/KR20150133182A/ko active Application Filing
- 2014-01-23 BR BR112015018048A patent/BR112015018048A2/pt not_active Application Discontinuation
- 2014-01-23 EP EP14746632.0A patent/EP2950798B1/en active Active
- 2014-01-23 ES ES14746632T patent/ES2883141T3/es active Active
- 2014-01-23 SG SG10201805896SA patent/SG10201805896SA/en unknown
- 2014-01-23 CA CA2899187A patent/CA2899187C/en active Active
- 2014-01-23 WO PCT/US2014/012656 patent/WO2014120538A1/en active Application Filing
- 2014-01-23 KR KR1020167032282A patent/KR102056756B1/ko active IP Right Grant
- 2014-01-23 SG SG11201505944QA patent/SG11201505944QA/en unknown
-
2015
- 2015-05-08 US US14/707,122 patent/US9539249B2/en active Active
- 2015-07-21 IL IL240051A patent/IL240051A/en active IP Right Grant
-
2016
- 2016-06-07 HK HK16106520.8A patent/HK1218510A1/zh unknown
- 2016-08-09 JP JP2016156171A patent/JP6224189B2/ja not_active Expired - Fee Related
- 2016-10-30 IL IL248594A patent/IL248594B/en unknown
-
2017
- 2017-01-10 US US15/402,941 patent/US9867816B2/en active Active
- 2017-10-03 JP JP2017193213A patent/JP6466540B2/ja not_active Expired - Fee Related
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