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EA201491278A1 - Модифицированный коллаген - Google Patents

Модифицированный коллаген

Info

Publication number
EA201491278A1
EA201491278A1 EA201491278A EA201491278A EA201491278A1 EA 201491278 A1 EA201491278 A1 EA 201491278A1 EA 201491278 A EA201491278 A EA 201491278A EA 201491278 A EA201491278 A EA 201491278A EA 201491278 A1 EA201491278 A1 EA 201491278A1
Authority
EA
Eurasian Patent Office
Prior art keywords
collagen
modified collagen
modified
isolated
maturation
Prior art date
Application number
EA201491278A
Other languages
English (en)
Other versions
EA027745B1 (ru
Inventor
Александра Дитрих
Майкл Майерс
Original Assignee
Инноколл Текнолоджис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP20120150527 external-priority patent/EP2612888A1/en
Priority claimed from GBGB1220868.2A external-priority patent/GB201220868D0/en
Application filed by Инноколл Текнолоджис Лимитед filed Critical Инноколл Текнолоджис Лимитед
Publication of EA201491278A1 publication Critical patent/EA201491278A1/ru
Publication of EA027745B1 publication Critical patent/EA027745B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к модифицированному коллагену, который может быть получен обеспечением выделенного коллагена; замораживанием выделенного коллагена; обезвоживанием замороженного коллагена и созреванием обезвоженного коллагена. Также представлены способы получения модифицированного коллагена и его применение.
EA201491278A 2012-01-09 2013-01-09 Модифицированный коллаген EA027745B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20120150527 EP2612888A1 (en) 2012-01-09 2012-01-09 A modified collagen
GBGB1220868.2A GB201220868D0 (en) 2012-11-20 2012-11-20 A modified collagen
PCT/EP2013/050333 WO2013104687A2 (en) 2012-01-09 2013-01-09 A modified collagen

Publications (2)

Publication Number Publication Date
EA201491278A1 true EA201491278A1 (ru) 2015-01-30
EA027745B1 EA027745B1 (ru) 2017-08-31

Family

ID=47559477

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201491278A EA027745B1 (ru) 2012-01-09 2013-01-09 Модифицированный коллаген
EA201790763A EA037396B1 (ru) 2012-01-09 2013-01-09 Модифицированный коллаген

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201790763A EA037396B1 (ru) 2012-01-09 2013-01-09 Модифицированный коллаген

Country Status (21)

Country Link
US (4) US10487134B2 (ru)
EP (4) EP3901218A1 (ru)
JP (3) JP6494285B2 (ru)
AU (1) AU2013208952B2 (ru)
CA (1) CA2860552C (ru)
CY (3) CY1119524T1 (ru)
DK (3) DK3536748T3 (ru)
EA (2) EA027745B1 (ru)
ES (3) ES2645445T3 (ru)
HK (1) HK1244296B (ru)
HR (3) HRP20171635T1 (ru)
HU (3) HUE054838T2 (ru)
LT (3) LT3255106T (ru)
MX (1) MX368037B (ru)
NO (1) NO2802624T3 (ru)
PL (3) PL2802624T3 (ru)
PT (2) PT3255106T (ru)
RS (3) RS56564B1 (ru)
SI (3) SI2802624T1 (ru)
TR (1) TR201907156T4 (ru)
WO (1) WO2013104687A2 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2802624T3 (ru) * 2012-01-09 2017-12-30
US20180237259A1 (en) * 2017-02-22 2018-08-23 Otis Elevator Company Method for detecting trapped passengers in elevator car
RU2704248C1 (ru) * 2018-10-02 2019-10-25 Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет инженерных технологий" (ФГБОУ ВО "ВГУИТ") Способ получения пористого коллагенового материала
RU2760326C1 (ru) * 2021-03-04 2021-11-24 Общество с ограниченной ответственностью научно-производственное объединение «Велис» Способ получения пористого влагоемкого материала на коллагеновой основе
US20240226382A1 (en) 2021-04-12 2024-07-11 Innocoll Pharmaceuticals Limited Drug-release implant for laparoscopic surgery
CN113201569B (zh) * 2021-06-21 2022-08-30 江南大学 一种牛ⅰ型胶原蛋白的纯化方法
EP4376806A2 (en) * 2021-07-28 2024-06-05 Innocoll Pharmaceuticals Limited Bupivacaine-collagen drug delivery implant and methods of making and using thereof
WO2023084005A1 (en) * 2021-11-12 2023-05-19 Innocoll Pharmaceuticals Limited Resorbable collagen scaffold for dural repair
WO2024079289A1 (en) 2022-10-12 2024-04-18 Innocoll Pharmaceuticals Limited A kit for implanting a drug-release implant for laparoscopic surgery

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5246282B2 (ru) * 1972-11-15 1977-11-24
US4097234A (en) * 1976-12-10 1978-06-27 Nippi, Incorporated Method for preparing dispersion of collagen fiber
US4279812A (en) 1979-09-12 1981-07-21 Seton Company Process for preparing macromolecular biologically active collagen
US5206028A (en) 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
FR2720945B1 (fr) 1994-06-08 1996-08-30 Coletica Membrane collagénique anti-adhérence post-opératoire.
US5945125A (en) 1995-02-28 1999-08-31 Temple University Controlled release tablet
WO1998031403A1 (en) * 1997-01-16 1998-07-23 Cohesion Corporation Lyophilized collagen-based biomaterials, process of preparation and uses thereof
US20010014667A1 (en) * 1998-01-05 2001-08-16 Chen Charles C. Compositions with enhanced osteogenic potential, methods for making the same and therapeutic uses thereof
US20050208114A1 (en) * 1998-03-24 2005-09-22 Petito George D Composition and method for healing tissues
GB2345638A (en) * 1998-09-11 2000-07-19 Tissue Science Lab Limited Injectable collagen compositions
US6682760B2 (en) * 2000-04-18 2004-01-27 Colbar R&D Ltd. Cross-linked collagen matrices and methods for their preparation
EP2314293B1 (en) 2001-01-16 2017-01-04 Vascular Therapies, LLC Implantable device containing resorbable matrix material and rapamycin for preventing or treating vasuloproliferative diseases
US7098315B2 (en) * 2001-01-25 2006-08-29 Nycomed Pharma As Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge
JP2004099513A (ja) * 2002-09-09 2004-04-02 Toshiba Corp クラゲのコラーゲン回収方法及びクラゲのコラーゲン回収システム
WO2004090151A2 (en) * 2003-04-11 2004-10-21 Ecodynamic Biolab Inc. Method for extracting collagen comprising microbial fermentation
US7534422B2 (en) * 2004-07-09 2009-05-19 Viscofan, S.A. Universal fishing bait based on fibrous collagen and the procedure for its preparation
USRE47826E1 (en) * 2007-03-28 2020-01-28 Innocoll Pharmaceuticals Limited Drug delivery device for providing local analgesia, local anesthesia or nerve blockage
US8034368B2 (en) * 2007-03-28 2011-10-11 Innocoll Technologies Limited Drug delivery device for providing local analgesia, local anesthesia or nerve blockage
PL3085363T3 (pl) 2007-03-28 2019-08-30 Innocoll Pharmaceuticals Limited Urządzenie dostarczające lek dla zapewnienia miejscowej analgezji, miejscowego znieczulenia lub blokady nerwowej
US7820794B2 (en) 2008-09-11 2010-10-26 Sunmax Biotechnology Co., Ltd. Long-lasting collagen and manufacturing method thereof
IES20090859A2 (en) * 2008-11-06 2010-06-23 Innocoll Technologies Ltd Drug delivery implants and processes for their preparation
EP2459011B1 (en) * 2009-07-27 2016-04-13 National Cheng Kung University Preparation of high purity collagen
JP2011225462A (ja) * 2010-04-16 2011-11-10 Ihara Suisan Kk 多孔質コラーゲン、その製造方法およびその用途
US8951598B2 (en) 2010-05-07 2015-02-10 Empire Technology Development Llc Nanoscale collagen particles and membranes
EP2510929A1 (en) * 2011-04-11 2012-10-17 Innocoll Technologies Limited Methods for treating bacterial infection
NO2802624T3 (ru) * 2012-01-09 2017-12-30
US11623947B2 (en) * 2013-04-08 2023-04-11 Innocoll Pharmaceuticals Limited Collagen powder

Also Published As

Publication number Publication date
TR201907156T4 (tr) 2019-06-21
PT3255106T (pt) 2019-06-04
HUE043826T2 (hu) 2019-09-30
EA201790763A2 (ru) 2017-07-31
NO2802624T3 (ru) 2017-12-30
LT3255106T (lt) 2019-07-25
JP6494285B2 (ja) 2019-04-03
WO2013104687A3 (en) 2013-12-05
US20170022266A1 (en) 2017-01-26
SI2802624T1 (en) 2018-02-28
JP2019065017A (ja) 2019-04-25
EP3536748A1 (en) 2019-09-11
PL3536748T3 (pl) 2021-07-19
ES2870137T3 (es) 2021-10-26
EP3536748B1 (en) 2021-02-24
US20190359689A1 (en) 2019-11-28
CY1124160T1 (el) 2022-05-27
DK2802624T3 (da) 2017-11-13
HRP20210699T1 (hr) 2021-09-17
US20150011476A1 (en) 2015-01-08
PL3255106T3 (pl) 2019-09-30
CA2860552A1 (en) 2013-07-18
US20220213173A1 (en) 2022-07-07
LT2802624T (lt) 2017-12-27
HRP20171635T1 (hr) 2018-02-23
DK3255106T3 (da) 2019-05-20
MX368037B (es) 2019-09-17
HUE037043T2 (hu) 2018-08-28
JP2015508403A (ja) 2015-03-19
JP2020169188A (ja) 2020-10-15
PT2802624T (pt) 2017-11-10
RS61726B1 (sr) 2021-05-31
EA037396B1 (ru) 2021-03-24
EP3901218A1 (en) 2021-10-27
EP3255106B1 (en) 2019-04-24
AU2013208952B2 (en) 2016-09-15
PL2802624T3 (pl) 2018-02-28
CY1119524T1 (el) 2018-03-07
CA2860552C (en) 2020-06-16
DK3536748T3 (da) 2021-05-03
AU2013208952A1 (en) 2014-08-28
MX2014008327A (es) 2015-05-11
RS58935B1 (sr) 2019-08-30
US11746141B2 (en) 2023-09-05
SI3536748T1 (sl) 2021-08-31
HRP20190861T1 (hr) 2019-08-09
WO2013104687A2 (en) 2013-07-18
RS56564B1 (sr) 2018-02-28
JP6720279B2 (ja) 2020-07-08
EA027745B1 (ru) 2017-08-31
ES2728205T3 (es) 2019-10-22
EP3255106A1 (en) 2017-12-13
EP2802624B1 (en) 2017-08-02
ES2645445T3 (es) 2017-12-05
SI3255106T1 (sl) 2019-09-30
EP2802624A2 (en) 2014-11-19
LT3536748T (lt) 2021-08-10
HUE054838T2 (hu) 2021-10-28
JP7213205B2 (ja) 2023-01-26
US10487134B2 (en) 2019-11-26
HK1244296B (zh) 2020-06-05
CY1121643T1 (el) 2020-07-31
EA201790763A3 (ru) 2017-11-30

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