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EA201170257A1 - Новые соединения, полезные в лечении дегенеративных и воспалительных заболеваний - Google Patents

Новые соединения, полезные в лечении дегенеративных и воспалительных заболеваний

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Publication number
EA201170257A1
EA201170257A1 EA201170257A EA201170257A EA201170257A1 EA 201170257 A1 EA201170257 A1 EA 201170257A1 EA 201170257 A EA201170257 A EA 201170257A EA 201170257 A EA201170257 A EA 201170257A EA 201170257 A1 EA201170257 A1 EA 201170257A1
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EA
Eurasian Patent Office
Prior art keywords
diseases
compounds
cartilage
conditions
disease
Prior art date
Application number
EA201170257A
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English (en)
Other versions
EA018587B1 (ru
Inventor
Кристель Жанн Мари Мене
Люк Джулиан Корина Ван Ромпай
Стефен Роберт Флетчер
Хавьер Блан
Нолвен Жуанниго
Аластэр Джеймс Ходжес
Коэн Курт Смитс
Original Assignee
Галапагос Нв
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Publication date
Application filed by Галапагос Нв filed Critical Галапагос Нв
Publication of EA201170257A1 publication Critical patent/EA201170257A1/ru
Publication of EA018587B1 publication Critical patent/EA018587B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

Раскрывают соединения [1,2,4]триазоло[1,5-а]пиридина, которые имеют формулу, представленную формулой (I). Из соединений могут быть приготовлены фармацевтические композиции, и соединения могут быть использованы для предупреждения и лечения ряда состояний у млекопитающих, в том числе людей, включающих в качестве неограничивающего примера, заболевания, включающие деградацию хряща, деградацию кости и/или сустава, например, остеоартрит; и/или состояния, включающие воспаление или иммунные реакции, такие как болезнь Крона, ревматоидный артрит, псориаз, аллергия дыхательных путей (например, астма, ринит), ювенильный идиопатический артрит, колит, воспалительные заболевания кишечника, обусловленные действием эндотоксина болезненные состояния (например, осложнения после шунтирования или хронические обусловленные действием эндотоксина состояния, способствующие возникновению, например, хронической сердечной недостаточности), заболевания, включающие ухудшение ремоделирования хряща (например, заболевания, включающие анаболическую стимуляцию хондроцитов), врожденные мальформации хряща, заболевания, связанные с гиперсекрецией IL6, и отторжение трансплантата (например, отторжение пересаженного органа) и пролиферативные заболевания.
EA201170257A 2008-07-25 2009-07-24 ПРОИЗВОДНЫЕ 2-ЦИКЛОПРОПИЛКАРБОНИЛАМИНО-5-ФЕНИЛ[1,2,4]ТРИАЗОЛО[1,5-a]ПИРИДИНА ДЛЯ ЛЕЧЕНИЯ ДЕГЕНЕРАТИВНЫХ И ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ EA018587B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13592008P 2008-07-25 2008-07-25
US22068509P 2009-06-26 2009-06-26
PCT/EP2009/059604 WO2010010190A1 (en) 2008-07-25 2009-07-24 Novel compounds useful for the treatment of degenerative and inflammatory diseases

Publications (2)

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EA201170257A1 true EA201170257A1 (ru) 2011-08-30
EA018587B1 EA018587B1 (ru) 2013-09-30

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