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EA201170255A1 - Новые соединения, пригодные для лечения дегенеративных и воспалительных заболеваний - Google Patents

Новые соединения, пригодные для лечения дегенеративных и воспалительных заболеваний

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Publication number
EA201170255A1
EA201170255A1 EA201170255A EA201170255A EA201170255A1 EA 201170255 A1 EA201170255 A1 EA 201170255A1 EA 201170255 A EA201170255 A EA 201170255A EA 201170255 A EA201170255 A EA 201170255A EA 201170255 A1 EA201170255 A1 EA 201170255A1
Authority
EA
Eurasian Patent Office
Prior art keywords
conditions
diseases
endotoxin
transplant rejection
degenerative
Prior art date
Application number
EA201170255A
Other languages
English (en)
Other versions
EA018080B1 (ru
Inventor
Кристель Жанн Мари Мене
Хавьер Блан
Original Assignee
Галапагос Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Галапагос Нв filed Critical Галапагос Нв
Publication of EA201170255A1 publication Critical patent/EA201170255A1/ru
Publication of EA018080B1 publication Critical patent/EA018080B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

Описано новое соединение [1,2,4]триазоло[1,5-а]пиридина, которое имеет формулу, соответствующую формуле (I). Это соединение можно получать в виде фармацевтической композиции и можно использовать для предотвращения и лечения различных состояний у млекопитающих, включая людей, где состояния включают в качестве неограничивающего примера, заболевания, включающие деградацию хрящевой ткани, костной ткани и/или деградацию суставов, например остеоартрит; и/или состояния, включающие воспаление или иммунные ответы, такие как болезнь Крона, ревматоидный артрит, псориаз, заболевания, связанные с респираторной аллергией (например, астма, ринит), юношеский идиопатический артрит, колит, воспалительные заболевания кишечника, болезненные состояния, обусловленные эндотоксином (например, осложнения после шунтирования или хронические состояния, обусловленные эндотоксином, способствующим, например, хронической сердечной недостаточности), заболевания, включающие нарушение ремоделирования хрящевой ткани (например, заболеваний, включающих анаболическую стимуляцию хондроцитов), врожденные мальформации хрящевой ткани, заболевания, связанные с повышенной секрецией IL6 и отторжением трансплантата (например, отторжение органного трансплантата), и пролиферативные заболевания.
EA201170255A 2008-07-25 2009-07-24 Соединения, пригодные для лечения дегенеративных и воспалительных заболеваний EA018080B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13592008P 2008-07-25 2008-07-25
US22068509P 2009-06-26 2009-06-26
PCT/EP2009/059605 WO2010010191A1 (en) 2008-07-25 2009-07-24 Novel compounds useful for the treatment of degenerative and inflammatory diseases.

Publications (2)

Publication Number Publication Date
EA201170255A1 true EA201170255A1 (ru) 2011-08-30
EA018080B1 EA018080B1 (ru) 2013-05-30

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Application Number Title Priority Date Filing Date
EA201170255A EA018080B1 (ru) 2008-07-25 2009-07-24 Соединения, пригодные для лечения дегенеративных и воспалительных заболеваний
EA201170257A EA018587B1 (ru) 2008-07-25 2009-07-24 ПРОИЗВОДНЫЕ 2-ЦИКЛОПРОПИЛКАРБОНИЛАМИНО-5-ФЕНИЛ[1,2,4]ТРИАЗОЛО[1,5-a]ПИРИДИНА ДЛЯ ЛЕЧЕНИЯ ДЕГЕНЕРАТИВНЫХ И ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ

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AU2009273143B2 (en) 2014-01-23
US20110190260A1 (en) 2011-08-04

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