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CL2009001637A1 - N-(5-(4-((6-cianopiridin-3-il)metoxi)fenil)-[1,2,4]triazolo[1,5-a]piridin-2-il)ciclopropancarboxamida, inhibidor de jak, composicion farmaceutica; y su uso en el tratamiento y prevencion de enfermedades proliferativas e inflamatorias, tales como osteoartritis, enfermedad de crohn, artritis reumatoide, psoriasis, entre otras. - Google Patents

N-(5-(4-((6-cianopiridin-3-il)metoxi)fenil)-[1,2,4]triazolo[1,5-a]piridin-2-il)ciclopropancarboxamida, inhibidor de jak, composicion farmaceutica; y su uso en el tratamiento y prevencion de enfermedades proliferativas e inflamatorias, tales como osteoartritis, enfermedad de crohn, artritis reumatoide, psoriasis, entre otras.

Info

Publication number
CL2009001637A1
CL2009001637A1 CL2009001637A CL2009001637A CL2009001637A1 CL 2009001637 A1 CL2009001637 A1 CL 2009001637A1 CL 2009001637 A CL2009001637 A CL 2009001637A CL 2009001637 A CL2009001637 A CL 2009001637A CL 2009001637 A1 CL2009001637 A1 CL 2009001637A1
Authority
CL
Chile
Prior art keywords
disease
osteoarthritis
prevention
pharmaceutical composition
diseases
Prior art date
Application number
CL2009001637A
Other languages
English (en)
Inventor
Christel Jeanne Marie Menet
Javier Blanc
Original Assignee
Galapagos Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos Nv filed Critical Galapagos Nv
Publication of CL2009001637A1 publication Critical patent/CL2009001637A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

UN COMPUESTO QUE COMPRENDE LA FORMULA VIA O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO.<br /> UNA COMPOSICION  FARMACEUTICA QUE COMPRENDE UN PORTADOR  FARMACEUTICAMENTE ACEPTABLE Y UNA CANTIDAD FARMACEUTICAMENTE EFECTIVA DE DICHO COMPUESTO.<br /> USO DE DICHO COMPUESTO PARA EL TRATAMIENTO, PREVENCION O PRIFOLAXIS DE ENFERMEDADES QUE INVOLUCRAN LA DEGRADACION DEL CARTILAGO, LA DEGRADACION DE LAS ARTICULACIONES Y/O HUESO TALES COMO OSTEOARTRITIS Y/O AFECCIONES QUE INVOLUCRAN LA INFLAMACION O RESPUESTAS INMUNES, TALES COMO LA ENFERMEDAD DE CROHN, ARTRITIS REUMANOIDE , PSORIASIS, ENFERMEDAD ALERGICA DE LAS VIAS  RESPIRATORIAS  ( TALES COMO ASMA, RINITIS), ARTRITIS IDIOPATICA JUVENIL, COLITIS, ENFERMEDAD INFLAMATORIA INTESTINAL, ESTADOS  DE ENFERMEDAD CONDUCIDOS  POR ENDOTOXINA (TALES COMO COMPLICACIONES LUEGO DE CIRUGIA DE BYPASS O ESTADOS DE ENDOTOXINA CRONICOS  QUE CONTRIBUYEN A POR EJEMPLO INSUFICIENCIA  CARDIACA CRONICA ), ENFERMEDADES QUE INVOLUCRAN EL DETERIORO DEL RECAMBIO DEL CARTILAGO (TALES COMO ENFERMEDADES QUE  INVOLUCRAN LA ESTIMULACION  ANABOLICA DE LOS CONDROCITOS), MALFORMACIONES CONGENITAS DEL CARTILAGO, ENFERMEDADES ASOCIADAS CON LA HIPERSECRECION DE IL6 Y EL RECHAZO DE TRASPLANTES ( TALES COMO RECHAZO DEL TRASPLANTES DE ORGANOS).<br /> USO DE DICHO COMPUESTO PARA EL TRATAMIENTO DE LAS ENFERMEDADES PROLIFERATIVAS.<br />  
CL2009001637A 2008-07-25 2009-07-23 N-(5-(4-((6-cianopiridin-3-il)metoxi)fenil)-[1,2,4]triazolo[1,5-a]piridin-2-il)ciclopropancarboxamida, inhibidor de jak, composicion farmaceutica; y su uso en el tratamiento y prevencion de enfermedades proliferativas e inflamatorias, tales como osteoartritis, enfermedad de crohn, artritis reumatoide, psoriasis, entre otras. CL2009001637A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13592008P 2008-07-25 2008-07-25
US22068509P 2009-06-26 2009-06-26

Publications (1)

Publication Number Publication Date
CL2009001637A1 true CL2009001637A1 (es) 2010-02-19

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Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009001637A CL2009001637A1 (es) 2008-07-25 2009-07-23 N-(5-(4-((6-cianopiridin-3-il)metoxi)fenil)-[1,2,4]triazolo[1,5-a]piridin-2-il)ciclopropancarboxamida, inhibidor de jak, composicion farmaceutica; y su uso en el tratamiento y prevencion de enfermedades proliferativas e inflamatorias, tales como osteoartritis, enfermedad de crohn, artritis reumatoide, psoriasis, entre otras.

Country Status (35)

Country Link
US (5) US8242274B2 (es)
EP (2) EP2346864B1 (es)
JP (2) JP5480261B2 (es)
KR (2) KR101676391B1 (es)
CN (2) CN102105471B (es)
AR (1) AR072875A1 (es)
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