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EA200500679A1 - Человеческие моноклональные антитела против cd20 - Google Patents

Человеческие моноклональные антитела против cd20

Info

Publication number
EA200500679A1
EA200500679A1 EA200500679A EA200500679A EA200500679A1 EA 200500679 A1 EA200500679 A1 EA 200500679A1 EA 200500679 A EA200500679 A EA 200500679A EA 200500679 A EA200500679 A EA 200500679A EA 200500679 A1 EA200500679 A1 EA 200500679A1
Authority
EA
Eurasian Patent Office
Prior art keywords
human
antibodies
monoclonal antibodies
human monoclonal
antibodies against
Prior art date
Application number
EA200500679A
Other languages
English (en)
Other versions
EA021644B1 (ru
Inventor
Джесика Телинг
Зигрид Руулс
Мартин Гленни
Ян Г.Й. Ван Де Винкель
Пауль Паррен
Йорген Петерсен
Оле Д. М. Ск. Бодсгорд
Хайчан Хуанг
Original Assignee
Генмаб А/С
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Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32110219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200500679(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Генмаб А/С filed Critical Генмаб А/С
Publication of EA200500679A1 publication Critical patent/EA200500679A1/ru
Publication of EA021644B1 publication Critical patent/EA021644B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

Охватываются человеческие моноклональные антитела, которые связываются с человеческим CD20 и ингибируют его, и родственные композиции и молекулы на основе антител. Человеческие антитела можно продуцировать при использовании трансфектомы или в организме отличного от человека трансгенного животного, например в трансгенной мыши, способной продуцировать многие изотипы человеческих моноклональных антител при использовании V-D-J рекомбинации и переключения изотипа. Также охватываются фармацевтические композиции, содержащие человеческие антитела, отличные от человека трансгенные животные и гибридомы, которые продуцируют человеческие антитела и диагностические методы для применения человеческих антител.Отчет о международном поиске был опубликован 2004.08.12.
EA200500679A 2002-10-17 2003-10-17 Человеческое моноклональное антитело против cd20 и его применение EA021644B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41916302P 2002-10-17 2002-10-17
US46002803P 2003-04-02 2003-04-02
PCT/US2003/033057 WO2004035607A2 (en) 2002-10-17 2003-10-17 Human monoclonal antibodies against cd20

Publications (2)

Publication Number Publication Date
EA200500679A1 true EA200500679A1 (ru) 2006-02-24
EA021644B1 EA021644B1 (ru) 2015-08-31

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Family Applications (2)

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EA201492217A EA201492217A1 (ru) 2002-10-17 2003-10-17 Человеческие моноклональные антитела против cd20
EA200500679A EA021644B1 (ru) 2002-10-17 2003-10-17 Человеческое моноклональное антитело против cd20 и его применение

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EA201492217A EA201492217A1 (ru) 2002-10-17 2003-10-17 Человеческие моноклональные антитела против cd20

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US (3) US8529902B2 (ru)
EP (4) EP1558648B1 (ru)
JP (3) JP4662473B2 (ru)
KR (7) KR100944575B1 (ru)
CN (3) CN103709250B (ru)
AT (1) ATE540978T1 (ru)
AU (1) AU2003301445A1 (ru)
BR (1) BRPI0315295C1 (ru)
CA (2) CA2502552C (ru)
CY (2) CY1112750T1 (ru)
DK (2) DK1558648T3 (ru)
EA (2) EA201492217A1 (ru)
ES (3) ES2524694T3 (ru)
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