EA199800538A1 - Производные хинолин-4-карбоксамида, их получение и их применение в качестве антагонистов рецептора нейрокинина-3 (-к-3) и нейрокинина-2 (-к-2) - Google Patents
Производные хинолин-4-карбоксамида, их получение и их применение в качестве антагонистов рецептора нейрокинина-3 (-к-3) и нейрокинина-2 (-к-2)Info
- Publication number
- EA199800538A1 EA199800538A1 EA199800538A EA199800538A EA199800538A1 EA 199800538 A1 EA199800538 A1 EA 199800538A1 EA 199800538 A EA199800538 A EA 199800538A EA 199800538 A EA199800538 A EA 199800538A EA 199800538 A1 EA199800538 A1 EA 199800538A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- group
- optionally substituted
- mono
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
В настоящем изобретении предложено соединение формулы (I)или его соль, или его сольват, где Ar является необязательно замещенной арильной или C-циклоалкдиенильной группой или необязательно замещенной ароматической гетероциклической группой, содержащей одиночное или конденсированное кольцо; R является C-алкилом, C-циклоалкилом, C-циклоалкилалкилом, необязательно замещенным фенилом или фенил-C-алкилом, необязательно замещенным пятичленным гетероароматическим кольцом, содержащим до четырех гетероатомов, выбранных из O и N, гидрокси-C-алкилом, амино-C-алкилом, C-алкиламиноалкилом, ди-C-алкиламиноалкилом, C-ациламиноалкилом, C-алкоксилалкилом, C-алкилкарбонилом, карбокси, C-алкоксикарбонилом, C-алкоксикарбонил-C-алкилом, аминокарбонилом, C-алкиламинокарбонилом, ди-C-алкиламинокарбонилом, галоген-C-алкилом; или R является группой -(CH)-, где p равно 2 или 3, причем эта группа образует кольцо с атомом углерода Ar; Rпредставляет собой водород или до четырех необязательных заместителей, выбранных из списка, состоящего из C-алкила, C-алкенила, арила, C-алкокси, гидрокси, галогена, нитро, циано, карбокси, карбоксамидо, сульфонамидо, C-алкоксикарбонила, трифторметила, ацилокси, фталимидо, амино или моно- и ди-C-алкиламино; Rпредставляет собой водород, C-алкил, гидрокси, галоген, циано, амино, моно- или ди-C-алкиламино, алкилсульфониламино, моно- или ди-C-алканоиламино, где алкильная группа является необязательно замещенной аминогруппой или моно- или диалкиламиногруппой; или Rявляется группой -X-(CH)-Y, где X является связью или -O- и n представляет собой целое число в диапазоне от 1 до 5, при условии, что, когда X является -O-, тогда n представляет собой только целое число от 2 до 5, и Y представляет собой группу NYY, где Yи
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI952462 IT1276171B1 (it) | 1995-11-24 | 1995-11-24 | Derivati chinolinici |
| ITMI961688 IT1307330B1 (it) | 1996-08-02 | 1996-08-02 | Derivati chinolinici |
| PCT/EP1996/005207 WO1997019926A1 (en) | 1995-11-24 | 1996-11-22 | Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (nk-3)- and neurokinin 2 (nk-2) receptor antagonists. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA199800538A1 true EA199800538A1 (ru) | 1998-12-24 |
| EA001771B1 EA001771B1 (ru) | 2001-08-27 |
Family
ID=26331327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199800538A EA001771B1 (ru) | 1995-11-24 | 1996-11-22 | Производные хинолин-4-карбоксамида, их получение и их применение в качестве антагонистов рецептора нейрокинина-3 (-к-3) и нейрокинина-2 (-к-2) |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20020068827A1 (ru) |
| EP (1) | EP1019377A1 (ru) |
| JP (1) | JP2000513325A (ru) |
| KR (1) | KR19990071598A (ru) |
| CN (1) | CN1207729A (ru) |
| AP (1) | AP9801238A0 (ru) |
| AR (1) | AR004735A1 (ru) |
| AU (1) | AU1031897A (ru) |
| BG (1) | BG102557A (ru) |
| BR (1) | BR9611757A (ru) |
| CA (1) | CA2238328A1 (ru) |
| CZ (1) | CZ158098A3 (ru) |
| DZ (1) | DZ2128A1 (ru) |
| EA (1) | EA001771B1 (ru) |
| HU (1) | HUP9901016A3 (ru) |
| IL (1) | IL124418A0 (ru) |
| MA (1) | MA24011A1 (ru) |
| MX (1) | MX9804108A (ru) |
| NO (1) | NO311213B1 (ru) |
| OA (1) | OA11011A (ru) |
| PL (1) | PL326928A1 (ru) |
| SK (1) | SK66898A3 (ru) |
| TR (1) | TR199800883T2 (ru) |
| TW (1) | TW409123B (ru) |
| UY (2) | UY24375A1 (ru) |
| WO (1) | WO1997019926A1 (ru) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2222576T3 (es) * | 1997-03-14 | 2005-02-01 | Smithkline Beecham Corporation | Nueva quinolina- y naftalenocarboxamidas, composiciones farmaceuticas y procedimientos que inhiben el calpain. |
| DE69816290T2 (de) * | 1997-05-23 | 2004-05-27 | Glaxosmithkline S.P.A. | Chinolin-4-carboxamidderivate als nk-2 und nk-3 rezeptor antagonisten |
| US6339089B2 (en) * | 1997-08-13 | 2002-01-15 | Fujirebio Inc. | Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same |
| US6262070B1 (en) | 1998-11-04 | 2001-07-17 | Darwin Discovery Ltd. | Heterocyclic compounds and their therapeutic use |
| TR200101412T2 (tr) * | 1998-11-20 | 2001-10-22 | Smithkline Beecham S.P.A. | Yeni bileşikler. |
| GB9825554D0 (en) | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
| US6780875B2 (en) * | 1998-11-20 | 2004-08-24 | Smithkline Beecham S.P.A. | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists |
| SI1035115T1 (en) * | 1999-02-24 | 2005-02-28 | F. Hoffmann-La Roche Ag | 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists |
| ATE245156T1 (de) * | 1999-03-11 | 2003-08-15 | Neurogen Corp | Aryl-annellierte disubstituierte pyridine : nk3 rezeptor-liganden |
| US7037922B1 (en) | 2000-03-10 | 2006-05-02 | Neurogen Corporation | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands |
| CA2368455A1 (en) | 1999-03-29 | 2000-10-05 | Neurogen Corporation | 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands |
| WO2000064877A1 (en) | 1999-04-26 | 2000-11-02 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
| TWI259180B (en) * | 2000-08-08 | 2006-08-01 | Hoffmann La Roche | 4-Phenyl-pyridine derivatives |
| WO2002013825A1 (en) * | 2000-08-11 | 2002-02-21 | Smithkline Beecham P.L.C. | Novel pharmaceutical use of quinnoline derivatives |
| AU2002220702A1 (en) * | 2000-11-13 | 2002-05-21 | Glaxosmithkline S.P.A. | Quinoline derivatives as nk-3 and nk-2 antagonists |
| GB0028964D0 (en) * | 2000-11-28 | 2001-01-10 | Smithkline Beecham Spa | Novel compounds |
| US6540733B2 (en) | 2000-12-29 | 2003-04-01 | Corazon Technologies, Inc. | Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion |
| JP2004525184A (ja) * | 2001-04-11 | 2004-08-19 | グラクソスミスクライン・ソシエタ・ペル・アチオニ | Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしての３−置換キノリン−４−カルボキサミド誘導体 |
| GB0109122D0 (en) * | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
| MY134211A (en) * | 2001-05-18 | 2007-11-30 | Smithkline Beecham Corp | Novel use |
| AU2003244080A1 (en) * | 2002-06-26 | 2004-01-19 | Kyowa Hakko Kogyo Co., Ltd. | Phosphodiesterase inhibitor |
| GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| EP1635834A4 (en) * | 2003-06-25 | 2009-12-02 | Smithkline Beecham Corp | NEW COMPOUNDS |
| TWI280239B (en) | 2003-07-15 | 2007-05-01 | Hoffmann La Roche | Process for preparation of pyridine derivatives |
| SE0302139D0 (sv) * | 2003-07-28 | 2003-07-28 | Astrazeneca Ab | Novel compounds |
| GB0318727D0 (en) * | 2003-08-08 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| GB0425077D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
| WO2006130080A2 (en) * | 2005-06-03 | 2006-12-07 | Astrazeneca Ab | Quinoline derivatives as nk3 anatgonists |
| JP2008546767A (ja) * | 2005-06-23 | 2008-12-25 | アストラゼネカ・アクチエボラーグ | Ｎｋ３受容体のモジュレーターとしてのキノリン３−スルホン酸エステル |
| GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
| US20080200504A1 (en) * | 2005-08-11 | 2008-08-21 | Astrazeneca Ab | Amide Alkyl Pyridiyl Quinolines as Nk3 Receptor Modulators |
| EP1915361A1 (en) * | 2005-08-11 | 2008-04-30 | AstraZeneca AB | Alkylpyridyl quinolines as nk3 receptor modulators |
| WO2007018469A1 (en) * | 2005-08-11 | 2007-02-15 | Astrazeneca Ab | Oxopyridyl quinoline amides as nk3 receptor modulators |
| AR058051A1 (es) * | 2005-09-21 | 2008-01-23 | Astrazeneca Ab | Quinolinas de alquilnitrilo.proceso de obtencion y composiciones farmaceuticas. |
| AR057130A1 (es) | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
| TW201018662A (en) | 2005-12-12 | 2010-05-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
| ES2388454T3 (es) | 2007-03-22 | 2012-10-15 | Astrazeneca Ab | Derivados de quinolina para el tratamiento de enfermedades inflamatorias |
| PE20091036A1 (es) | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
| CN102924375B (zh) * | 2012-06-21 | 2015-02-18 | 江苏恩华药业股份有限公司 | Talnetant中间体及其制备方法和应用 |
| BR112015026519A2 (pt) | 2013-04-19 | 2017-07-25 | Astrazeneca Ab | composto antagonista do receptor nk3 (nk3ra) para uso em um método destinado ao tratamento de síndrome do ovário policístico (sop) |
| CN107074773A (zh) | 2014-09-09 | 2017-08-18 | 拜耳制药股份公司 | 取代的n,2‑二芳基喹啉‑4‑甲酰胺及其用途 |
| JP2018512404A (ja) | 2015-03-18 | 2018-05-17 | バイエル ファーマ アクチエンゲゼルシャフト | 置換ｎ−ビシクロ−２−アリール−キノリン−４−カルボキサミドおよびその使用 |
| WO2017072629A1 (en) | 2015-10-29 | 2017-05-04 | Cadila Healthcare Limited | Pharmaceutical combination of nk3 receptor antagonist and biguanides |
| WO2017153234A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-2-arylchinolin-4-carboxamide und ihre verwendung |
| WO2017153231A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-2-arylisochinolinon-4-carboxamide und ihre verwendung |
| WO2017153235A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung |
| TWI770157B (zh) * | 2017-04-10 | 2022-07-11 | 德商拜耳廠股份有限公司 | 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途 |
| MX2019012153A (es) * | 2017-04-10 | 2019-11-21 | Bayer Ag | N-ariletil-2-arilquinolina -4-carboxamidas sustituidas y su uso. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2538388B1 (fr) * | 1982-12-24 | 1985-06-21 | Pharmuka Lab | Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments |
| DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
| EP0585913B1 (en) * | 1992-09-04 | 1997-12-29 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
| RO114445B1 (ro) * | 1994-05-27 | 1999-04-30 | Smithkline Beecham S.P.A. | Derivaţi de chinolină antagonişti ai receptorului nk3 tachichinină,procedeu de preparare,compoziţii farmaceutice pe baza acestora şi metodă de tratament |
| IT1270615B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
-
1996
- 1996-11-21 AR ARP960105282A patent/AR004735A1/es unknown
- 1996-11-22 AU AU10318/97A patent/AU1031897A/en not_active Abandoned
- 1996-11-22 HU HU9901016A patent/HUP9901016A3/hu unknown
- 1996-11-22 PL PL96326928A patent/PL326928A1/xx unknown
- 1996-11-22 EA EA199800538A patent/EA001771B1/ru not_active IP Right Cessation
- 1996-11-22 UY UY24375A patent/UY24375A1/es not_active IP Right Cessation
- 1996-11-22 CN CN96199747A patent/CN1207729A/zh active Pending
- 1996-11-22 CZ CZ981580A patent/CZ158098A3/cs unknown
- 1996-11-22 AP APAP/P/1998/001238A patent/AP9801238A0/en unknown
- 1996-11-22 JP JP09520158A patent/JP2000513325A/ja active Pending
- 1996-11-22 EP EP96941025A patent/EP1019377A1/en not_active Withdrawn
- 1996-11-22 MA MA24399A patent/MA24011A1/fr unknown
- 1996-11-22 IL IL12441896A patent/IL124418A0/xx unknown
- 1996-11-22 KR KR1019980703874A patent/KR19990071598A/ko not_active Application Discontinuation
- 1996-11-22 WO PCT/EP1996/005207 patent/WO1997019926A1/en not_active Application Discontinuation
- 1996-11-22 TR TR1998/00883T patent/TR199800883T2/xx unknown
- 1996-11-22 BR BR9611757A patent/BR9611757A/pt unknown
- 1996-11-22 SK SK668-98A patent/SK66898A3/sk unknown
- 1996-11-22 CA CA002238328A patent/CA2238328A1/en not_active Abandoned
- 1996-11-23 DZ DZ960173A patent/DZ2128A1/fr active
- 1996-11-23 TW TW085114501A patent/TW409123B/zh not_active IP Right Cessation
-
1997
- 1997-05-16 UY UY24555A patent/UY24555A1/es not_active Application Discontinuation
-
1998
- 1998-05-22 NO NO19982333A patent/NO311213B1/no not_active IP Right Cessation
- 1998-05-22 OA OA9800062A patent/OA11011A/en unknown
- 1998-05-22 MX MX9804108A patent/MX9804108A/es unknown
- 1998-06-18 BG BG102557A patent/BG102557A/bg unknown
-
2001
- 2001-11-26 US US09/994,402 patent/US20020068827A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000513325A (ja) | 2000-10-10 |
| NO982333L (no) | 1998-07-22 |
| SK66898A3 (en) | 1998-12-02 |
| BR9611757A (pt) | 1999-04-06 |
| PL326928A1 (en) | 1998-11-09 |
| MX9804108A (es) | 1998-09-30 |
| NO982333D0 (no) | 1998-05-22 |
| AR004735A1 (es) | 1999-03-10 |
| AU1031897A (en) | 1997-06-19 |
| CN1207729A (zh) | 1999-02-10 |
| CZ158098A3 (cs) | 1998-10-14 |
| EP1019377A1 (en) | 2000-07-19 |
| DZ2128A1 (fr) | 2002-10-26 |
| IL124418A0 (en) | 1998-12-06 |
| MA24011A1 (fr) | 1997-07-01 |
| AP9801238A0 (en) | 1998-06-30 |
| EA001771B1 (ru) | 2001-08-27 |
| NO311213B1 (no) | 2001-10-29 |
| TW409123B (en) | 2000-10-21 |
| KR19990071598A (ko) | 1999-09-27 |
| US20020068827A1 (en) | 2002-06-06 |
| BG102557A (bg) | 1999-03-31 |
| HUP9901016A3 (en) | 2002-01-28 |
| UY24375A1 (es) | 1997-05-22 |
| TR199800883T2 (xx) | 2000-12-21 |
| CA2238328A1 (en) | 1997-06-05 |
| WO1997019926A1 (en) | 1997-06-05 |
| OA11011A (en) | 2003-03-06 |
| HUP9901016A2 (hu) | 2000-03-28 |
| UY24555A1 (es) | 2001-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA199800538A1 (ru) | Производные хинолин-4-карбоксамида, их получение и их применение в качестве антагонистов рецептора нейрокинина-3 (-к-3) и нейрокинина-2 (-к-2) | |
| EA199901062A1 (ru) | Производные хинолин-4-карбоксамида как антагонисты рецепторов нк-2 и нк-3 | |
| YU68896A (sh) | Jedinjenja hinolina i nihazolina od koristi u terapiji | |
| EA199800908A1 (ru) | Производные индола, полезные в качестве антагонистов рецептора эндотелина | |
| NL980041I1 (nl) | 1H-imidazoc4,5-c!chinoline en 1H-imidazoc4,5-c!chinoline-4-aminen. | |
| EA199800702A1 (ru) | Хиноксалиндионы | |
| EA200000400A1 (ru) | Галогензамещенные тетрациклические производные тетрагидрофурана | |
| NO863961L (no) | Fremgangsmaate for fremstilling av 3-vinyl- og 3-ethynyl-beta-carbolinderivater. | |
| DE69014697D1 (de) | Tetrahydrobenz[c,d]indole als Serotonin-Agonisten. | |
| ATE182889T1 (de) | Bicyclische amidinderivate als no-synthetase inhibitoren | |
| EA199800987A1 (ru) | Бензоксазиноновые антагонисты рецептора допамина d4 | |
| EA199801013A1 (ru) | Производные дистамицина, способ их получения и применение в качестве противоопухолевых и противовирусных агентов | |
| DE69319925D1 (de) | Indol-piperazin-derivate als selektive liganden der 5ht1d und 5ht1b receptoren verwendbar als arzneimittel | |
| CA2264065A1 (en) | Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists | |
| ATE550332T1 (de) | 4-imidazolin-2-onverbindungen als p38-map- kinaseinhibitors | |
| EA200200523A1 (ru) | Новые разветвленные замещенные аминопроизводные 3-амино-1-фенил-1h[1,2,4]триазола, способы их получения и содержащие их фармацевтические композиции | |
| WO2000024717A3 (en) | Isoquinoline derivatives | |
| GB0003257D0 (en) | Heterocyclic compounds and their therapeutic use | |
| EA199900043A1 (ru) | ПРОИЗВОДНЫЕ ПИРИДИЛКАРБАМОИЛИНДОЛИНОВ В КАЧЕСТВЕ АНТАГОНИСТОВ 5-НТ2с-РЕЦЕПТОРОВ | |
| ATE151750T1 (de) | 3-(indol-3-yl) propensäurderivate, die als nmda- antagonisten nützlich sind | |
| DE69334353D1 (de) | Benzodiazepin-Derivate, verwendbar als CCK-Rezeptor Antagonisten | |
| CO4750832A1 (es) | Nuevos derivados de quinolina | |
| ATE212356T1 (de) | Carbamoylmethylharnstoffderivate | |
| CO4761068A1 (es) | Nuevos antagonistas nk-2/nk-3 | |
| DE3482109D1 (de) | Derivate des phenylacetanilids. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |