EA014450B1 - Производные трициклических n-гетероарилкарбоксамидов, содержащих группу бензимидазола, их получение и применение в терапии - Google Patents

Производные трициклических n-гетероарилкарбоксамидов, содержащих группу бензимидазола, их получение и применение в терапии Download PDF

Info

Publication number: EA014450B1
Authority: EA; Eurasian Patent Office
Prior art keywords: alkyl; cycloalkyl; alkylene; aryl; general formula
Prior art date: 2006-02-03

Application number

EA200870226A

Other languages

English (en)

Russian (ru)

Other versions

EA200870226A1 (ru

Inventor

Лоран Дюбуа

Янник Эванно

Люк Эвен

Катрин Жилль

Андре Маланда

Давид Машник

Натали Ракотоарисоа

Original Assignee

Санофи-Авентис

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-02-03

Filing date

2007-02-01

Publication date

2010-12-30

2007-02-01 Application filed by Санофи-Авентис filed Critical Санофи-Авентис

2009-02-27 Publication of EA200870226A1 publication Critical patent/EA200870226A1/ru

2010-12-30 Publication of EA014450B1 publication Critical patent/EA014450B1/ru

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Virology (AREA)
Hematology (AREA)
Pulmonology (AREA)
Gynecology & Obstetrics (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Pregnancy & Childbirth (AREA)
Rheumatology (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EA200870226A 2006-02-03 2007-02-01 Производные трициклических n-гетероарилкарбоксамидов, содержащих группу бензимидазола, их получение и применение в терапии EA014450B1 (ru)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0601007A FR2897061B1 (fr)	2006-02-03	2006-02-03	Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique.
PCT/FR2007/000183 WO2007088277A1 (fr)	2006-02-03	2007-02-01	Dérivés de ν-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur préparation et leur application en thérapeutique

Publications (2)

Publication Number	Publication Date
EA200870226A1 EA200870226A1 (ru)	2009-02-27
EA014450B1 true EA014450B1 (ru)	2010-12-30

Family

ID=36954977

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EA200870226A EA014450B1 (ru)	2006-02-03	2007-02-01	Производные трициклических n-гетероарилкарбоксамидов, содержащих группу бензимидазола, их получение и применение в терапии

Country Status (33)

Country	Link
US (2)	US8143248B2 (es)
EP (1)	EP1987010B1 (es)
JP (1)	JP5136938B2 (es)
KR (1)	KR20080090495A (es)
CN (1)	CN101379041B (es)
AR (1)	AR059279A1 (es)
AT (1)	ATE463484T1 (es)
AU (1)	AU2007211399B2 (es)
BR (1)	BRPI0710480A2 (es)
CA (1)	CA2637333C (es)
CY (1)	CY1110168T1 (es)
DE (1)	DE602007005779D1 (es)
DK (1)	DK1987010T3 (es)
DO (1)	DOP2007000022A (es)
EA (1)	EA014450B1 (es)
ES (1)	ES2344087T3 (es)
FR (1)	FR2897061B1 (es)
HK (1)	HK1129670A1 (es)
HR (1)	HRP20100327T1 (es)
IL (1)	IL192648A (es)
JO (1)	JO2602B1 (es)
MA (1)	MA30229B1 (es)
NO (1)	NO20083520L (es)
NZ (1)	NZ569669A (es)
PE (1)	PE20071325A1 (es)
PL (1)	PL1987010T3 (es)
PT (1)	PT1987010E (es)
RS (1)	RS51366B (es)
SI (1)	SI1987010T1 (es)
TW (1)	TWI401256B (es)
UY (1)	UY30130A1 (es)
WO (1)	WO2007088277A1 (es)
ZA (1)	ZA200806139B (es)

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RU2659779C2 (ru) *	2012-06-18	2018-07-04	Дарт Нейросайенс (Кайман) Лтд	Замещенные соединения тиофен- и фуран-конденсированного азолопиримидин-5-(6н)-она

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FR2888848B1 (fr) *	2005-07-22	2007-09-28	Sanofi Aventis Sa	Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2911605B1 (fr)	2007-01-19	2009-04-17	Sanofi Aventis Sa	Derives de pyrrolopyridine-2-carbowamides, leur preparation et leur application en therapeutique
FR2911604B1 (fr) *	2007-01-19	2009-04-17	Sanofi Aventis Sa	Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2919610B1 (fr) *	2007-08-02	2009-10-16	Sanofi Aventis Sa	Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique
FR2926556B1 (fr) *	2008-01-22	2010-02-19	Sanofi Aventis	Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
FR2926555B1 (fr) *	2008-01-22	2010-02-19	Sanofi Aventis	Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique
FR2926554B1 (fr)	2008-01-22	2010-03-12	Sanofi Aventis	Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique
FR2926553B1 (fr) *	2008-01-23	2010-02-19	Sanofi Aventis	Derives d'indole-2-carboxamides et d'azaindole-2- carboxamides substitues par un groupe silanyle, leur preparation et leur application en therapeutique
WO2009108551A2 (en) *	2008-02-25	2009-09-03	H. Lundbeck A/S	Heteroaryl amide analogues
WO2010005528A2 (en) *	2008-06-30	2010-01-14	Ironwood Pharmaceuticals Incorporated	Pyrrolopyridine carboxylic acid derivatives
AU2009308687A1 (en) *	2008-11-03	2010-05-06	Chemocentryx, Inc.	Compounds for the treatment of osteoporosis and cancers
BRPI1008020A2 (pt)	2009-02-11	2016-03-15	Sunovion Pharmaceuticals Inc	antagonistas e agonistas inversos h3 da histamina e métodos de uso dos mesmos
US20120172350A1 (en) *	2009-09-11	2012-07-05	Sunovion Pharmaceuticals Inc.	Histamine h3 inverse agonists and antagonists and methods of use thereof
CA2797762A1 (en) *	2010-04-27	2011-11-03	Astellas Pharma Inc.	Imidazo[1,2-a]pyridine derivative
AU2013232069B2 (en)	2012-03-16	2017-07-13	Vitae Pharmaceuticals, Inc.	Liver X receptor modulators
EP2825541B1 (en) *	2012-03-16	2016-06-22	Vitae Pharmaceuticals, Inc.	Liver x receptor modulators
CN106573899B (zh)	2014-08-04	2021-04-06	纽韦卢森公司	用于治疗炎性、代谢性、肿瘤性和自身免疫性疾病的任选稠合的、经杂环基取代的嘧啶衍生物
US10513694B2 (en)	2015-06-25	2019-12-24	Promega Corporation	Thienopyrrole compounds and uses thereof
JP7187449B2 (ja) *	2016-09-30	2022-12-12	エピザイム，インコーポレイティド	Ｅｈｍｔ２阻害剤としての置換された融合二環式または三環式複素環化合物
JP7161475B2 (ja)	2016-12-28	2022-10-26	プロメガコーポレイション	官能化ｎａｎｏｌｕｃ阻害剤
US11672800B2 (en)	2017-04-21	2023-06-13	Epizyme, Inc.	Combination therapies with EHMT2 inhibitors
CN109761974B (zh) *	2019-01-21	2021-05-14	河南大学	1,2,3,4-四氢-9H-吡啶并[3,4-b]吲哚类TRPV1拮抗剂及其应用
AU2020405446A1 (en)	2019-12-20	2022-05-26	Nuevolution A/S	Compounds active towards nuclear receptors
AU2021245397A1 (en)	2020-03-31	2022-10-20	Nuevolution A/S	Compounds active towards nuclear receptors
MX2022012259A (es)	2020-03-31	2022-12-08	Nuevolution As	Compuestos activos frente a receptores nucleares.
CN114276354B (zh) *	2022-01-07	2023-06-02	中山大学	1-氨基苯并[4,5]咪唑并[1,2-a]吡嗪-3-甲酰胺类化合物及其制备和应用
CN114539265B (zh) *	2022-03-02	2023-07-21	中山大学	靶向a2a的苯并咪唑并吡嗪-3-甲酰胺及其肿瘤免疫功能

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WO2005028445A2 (en) *	2003-09-19	2005-03-31	Merck Sharp & Dohme Limited	Derivatives of n-(1h-indazolyl)- and n-(1h-indolyl)-urea as well as related compounds as modulators of the vanilloid-1 receptor (vr1) for the treatment of pain
EP1535922A1 (en) *	2002-07-11	2005-06-01	Takeda Pharmaceutical Company Limited	Pyrrolopyridine derivative and use thereof
WO2005105798A1 (en) *	2004-04-30	2005-11-10	Grünenthal GmbH	Substituted imidazo[1,2-a]pyridine compounds and drugs containing substituted imidazo[1,2-a]pyridine compounds

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WO2004069792A2 (en) *	2003-02-03	2004-08-19	Janssen Pharmaceutica N.V.	Quinoline-derived amide modulators of vanilloid vr1 receptor
US7544803B2 (en) *	2004-01-23	2009-06-09	Amgen Inc.	Vanilloid receptor ligands and their use in treatments
EP2314585B1 (en) *	2004-07-15	2012-09-12	Japan Tobacco, Inc.	Condensed benzamide compounds as inhibitors of vanilloid receptor subtype 1 (VR1) activity

2006
- 2006-02-03 FR FR0601007A patent/FR2897061B1/fr not_active Expired - Fee Related
2007
- 2007-01-30 PE PE2007000106A patent/PE20071325A1/es not_active Application Discontinuation
- 2007-01-31 TW TW096103550A patent/TWI401256B/zh not_active IP Right Cessation
- 2007-02-01 JP JP2008552848A patent/JP5136938B2/ja not_active Expired - Fee Related
- 2007-02-01 RS RSP-2010/0301A patent/RS51366B/en unknown
- 2007-02-01 AT AT07730900T patent/ATE463484T1/de active
- 2007-02-01 ES ES07730900T patent/ES2344087T3/es active Active
- 2007-02-01 PT PT07730900T patent/PT1987010E/pt unknown
- 2007-02-01 CA CA2637333A patent/CA2637333C/fr not_active Expired - Fee Related
- 2007-02-01 BR BRPI0710480-4A patent/BRPI0710480A2/pt not_active IP Right Cessation
- 2007-02-01 JO JO200729A patent/JO2602B1/en active
- 2007-02-01 EA EA200870226A patent/EA014450B1/ru not_active IP Right Cessation
- 2007-02-01 WO PCT/FR2007/000183 patent/WO2007088277A1/fr active Application Filing
- 2007-02-01 NZ NZ569669A patent/NZ569669A/en not_active IP Right Cessation
- 2007-02-01 DK DK07730900.3T patent/DK1987010T3/da active
- 2007-02-01 DO DO2007000022A patent/DOP2007000022A/es unknown
- 2007-02-01 SI SI200730254T patent/SI1987010T1/sl unknown
- 2007-02-01 PL PL07730900T patent/PL1987010T3/pl unknown
- 2007-02-01 ZA ZA200806139A patent/ZA200806139B/xx unknown
- 2007-02-01 CN CN2007800042835A patent/CN101379041B/zh not_active Expired - Fee Related
- 2007-02-01 AR ARP070100426A patent/AR059279A1/es not_active Application Discontinuation
- 2007-02-01 EP EP07730900A patent/EP1987010B1/fr active Active
- 2007-02-01 KR KR1020087019041A patent/KR20080090495A/ko not_active Application Discontinuation
- 2007-02-01 AU AU2007211399A patent/AU2007211399B2/en not_active Ceased
- 2007-02-01 DE DE602007005779T patent/DE602007005779D1/de active Active
- 2007-02-02 UY UY30130A patent/UY30130A1/es not_active Application Discontinuation
2008
- 2008-07-06 IL IL192648A patent/IL192648A/en not_active IP Right Cessation
- 2008-08-01 US US12/184,437 patent/US8143248B2/en not_active Expired - Fee Related
- 2008-08-13 NO NO20083520A patent/NO20083520L/no not_active Application Discontinuation
- 2008-08-26 MA MA31193A patent/MA30229B1/fr unknown
2009
- 2009-08-26 HK HK09107854.1A patent/HK1129670A1/xx not_active IP Right Cessation
2010
- 2010-06-07 HR HR20100327T patent/HRP20100327T1/hr unknown
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2012
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Cited By (1)

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RU2659779C2 (ru) *	2012-06-18	2018-07-04	Дарт Нейросайенс (Кайман) Лтд	Замещенные соединения тиофен- и фуран-конденсированного азолопиримидин-5-(6н)-она

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Publication number	Publication date
PE20071325A1 (es)	2008-02-21
CY1110168T1 (el)	2015-01-14
DE602007005779D1 (de)	2010-05-20
AU2007211399A1 (en)	2007-08-09
ATE463484T1 (de)	2010-04-15
PT1987010E (pt)	2010-06-25
JP5136938B2 (ja)	2013-02-06
NZ569669A (en)	2011-05-27
BRPI0710480A2 (pt)	2012-08-14
NO20083520L (no)	2008-09-11
ES2344087T3 (es)	2010-08-17
MA30229B1 (fr)	2009-02-02
UY30130A1 (es)	2007-09-28
RS51366B (en)	2011-02-28
FR2897061A1 (fr)	2007-08-10
ZA200806139B (en)	2010-05-26
CN101379041B (zh)	2012-08-29
KR20080090495A (ko)	2008-10-08
HRP20100327T1 (hr)	2010-08-31
PL1987010T3 (pl)	2010-09-30
US20090042873A1 (en)	2009-02-12
AR059279A1 (es)	2008-03-19
IL192648A0 (en)	2009-02-11
DK1987010T3 (da)	2010-08-02
TW200738726A (en)	2007-10-16
EA200870226A1 (ru)	2009-02-27
AU2007211399B2 (en)	2012-09-20
WO2007088277A1 (fr)	2007-08-09
US8288376B2 (en)	2012-10-16
EP1987010A1 (fr)	2008-11-05
JP2009525313A (ja)	2009-07-09
DOP2007000022A (es)	2007-09-15
HK1129670A1 (en)	2009-12-04
CA2637333A1 (fr)	2007-08-09
JO2602B1 (en)	2011-11-01
US8143248B2 (en)	2012-03-27
TWI401256B (zh)	2013-07-11
CN101379041A (zh)	2009-03-04
IL192648A (en)	2012-06-28
CA2637333C (fr)	2015-12-29
US20120122852A1 (en)	2012-05-17
EP1987010B1 (fr)	2010-04-07
FR2897061B1 (fr)	2010-09-03
SI1987010T1 (sl)	2010-07-30

Publication	Publication Date	Title
EA014450B1 (ru)	2010-12-30	Производные трициклических n-гетероарилкарбоксамидов, содержащих группу бензимидазола, их получение и применение в терапии
AU2009224533B2 (en)	2013-12-05	Azabicyclic carboxamide derivatives, preparation thereof and therapeutic use thereof
JP5264773B2 (ja)	2013-08-14	Ｎ−（ヘテロアリール）−１−ヘテロアリール−１ｈ−インドール−２−カルボキサミドの誘導体、これらの調製およびこれらの治療用途
AU2007279166C1 (en)	2013-03-14	N-(aminoheteroaryl)-1H-indole-2-carboxamide derivatives, preparation thereof and therapeutic use thereof
WO2008093024A2 (fr)	2008-08-07	Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2-carboxamides, leur préparation et leur application en therapeutique
AU2006271518B2 (en)	2012-03-01	N(arylalkyl)-1h-pyrrolopyridine-2-carboxamide derivatives, preparation and therapeutic use thereof
NZ587014A (en)	2012-06-29	Azabicyclic carboxamide derivatives, preparation thereof and therapeutic use thereof
WO2009112677A2 (fr)	2009-09-17	Dérivés bicycliques de carboxamides azabicycliques, leur préparation et leur application en thérapeutique.
US8420817B2 (en)	2013-04-16	Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof
MX2008009926A (es)	2008-10-03	Derivados de n-heteroaril-carboxamidas triciclicas que contienen un resto bencimidazol, su preparacion y su aplicacion en terapeutica

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2011-12-30	MM4A	Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)	Designated state(s): AM AZ KZ KG MD TJ TM
2014-11-28	MM4A	Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)	Designated state(s): BY RU

EA014450B1 - Производные трициклических n-гетероарилкарбоксамидов, содержащих группу бензимидазола, их получение и применение в терапии - Google Patents

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