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DK3207043T6 - Dihydropyrrolopyridin-inhibitorer af ror-gamma - Google Patents

Dihydropyrrolopyridin-inhibitorer af ror-gamma Download PDF

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Publication number
DK3207043T6
DK3207043T6 DK15785013.2T DK15785013T DK3207043T6 DK 3207043 T6 DK3207043 T6 DK 3207043T6 DK 15785013 T DK15785013 T DK 15785013T DK 3207043 T6 DK3207043 T6 DK 3207043T6
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DK
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Prior art keywords
ror gamma
dihydropyrrolopyridine
inhibitors
dihydropyrrolopyridine inhibitors
ror
Prior art date
Application number
DK15785013.2T
Other languages
English (en)
Other versions
DK3207043T3 (da
Inventor
David A Claremon
Lawrence Wayne Dillard
Chengguo Dong
Yi Fan
Lanqi Jia
Stephen D Lotesta
Andrew Marcus
Suresh B Singh
Colin M Tice
Jing Yuan
Wei Zhao
Yajun Zheng
Linghang Zhuang
Original Assignee
Vitae Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitae Pharmaceuticals Llc filed Critical Vitae Pharmaceuticals Llc
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Publication of DK3207043T3 publication Critical patent/DK3207043T3/da
Publication of DK3207043T6 publication Critical patent/DK3207043T6/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
DK15785013.2T 2014-10-14 2015-10-14 Dihydropyrrolopyridin-inhibitorer af ror-gamma DK3207043T6 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US201462074406P 2014-11-03 2014-11-03
PCT/US2015/055420 WO2016061160A1 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (2)

Publication Number Publication Date
DK3207043T3 DK3207043T3 (da) 2019-04-01
DK3207043T6 true DK3207043T6 (da) 2020-01-20

Family

ID=54352515

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15785013.2T DK3207043T6 (da) 2014-10-14 2015-10-14 Dihydropyrrolopyridin-inhibitorer af ror-gamma

Country Status (28)

Country Link
US (3) US9796710B2 (da)
EP (1) EP3207043B3 (da)
JP (1) JP6564029B2 (da)
KR (1) KR20170066628A (da)
CN (1) CN107074852B (da)
AU (1) AU2015333610B2 (da)
BR (1) BR112017007460A2 (da)
CA (1) CA2963140A1 (da)
CL (1) CL2017000902A1 (da)
CO (1) CO2017004525A2 (da)
CY (1) CY1121413T1 (da)
DK (1) DK3207043T6 (da)
EA (1) EA031967B1 (da)
EC (1) ECSP17029371A (da)
ES (1) ES2715458T7 (da)
HU (1) HUE042335T2 (da)
IL (1) IL251584B (da)
MX (1) MX371304B (da)
MY (1) MY182454A (da)
PH (1) PH12017500583A1 (da)
PL (1) PL3207043T6 (da)
PT (1) PT3207043T (da)
SG (1) SG11201702362SA (da)
SI (1) SI3207043T1 (da)
TW (1) TWI675032B (da)
UA (1) UA118989C2 (da)
WO (1) WO2016061160A1 (da)
ZA (1) ZA201702237B (da)

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MY187449A (en) 2013-11-26 2021-09-22 Hoffmann La Roche New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl
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CN107074852B (zh) 2014-10-14 2019-08-16 生命医药有限责任公司 ROR-γ的二氢吡咯并吡啶抑制剂
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
HUE054009T2 (hu) 2015-05-15 2021-08-30 Aurigene Discovery Tech Ltd Szubsztituált tetrahidrokinolinon vegyületek ROR gamma modulátorként
TW202128619A (zh) 2015-06-09 2021-08-01 美商艾伯維有限公司 核受體調節劑
DK3331876T3 (da) 2015-08-05 2021-01-11 Vitae Pharmaceuticals Llc Modulators of ror-gamma
EP3344619B1 (en) 2015-09-04 2020-10-28 H. Hoffnabb-La Roche Ag Phenoxymethyl derivatives
MX2018002217A (es) 2015-09-24 2018-03-23 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores de autotaxina (atx).
MX2018001430A (es) 2015-09-24 2018-04-20 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
CA2984585A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
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CN108463458B (zh) 2015-11-20 2022-02-01 生命医药有限责任公司 ROR-γ的调节剂
TWI728017B (zh) 2015-12-15 2021-05-21 瑞典商阿斯特捷利康公司 異吲哚化合物、包含其之醫藥組成物及其用途
TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
CA3053329A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag Heterocyclic compounds useful as dual atx/ca inhibitors
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
US11034654B2 (en) 2017-06-14 2021-06-15 Astrazeneca Ab 2,3-dihydroisoindole-1-carboxamides useful as ROR-gamma modulators
JP2020142989A (ja) * 2017-06-21 2020-09-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
WO2019007382A1 (zh) 2017-07-06 2019-01-10 江苏恒瑞医药股份有限公司 吲哚甲酰胺类衍生物、其制备方法及其在医药上的应用
WO2019018975A1 (en) * 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
UA126583C2 (uk) 2017-07-24 2022-11-02 Вітае Фармасьютікалс, Ллс ІНГІБІТОРИ ROR<font face="Symbol">g</font>
CN110945002B (zh) 2017-08-01 2021-12-24 正大天晴药业集团股份有限公司 作为RORγ抑制剂的双环化合物
CN109384711A (zh) * 2017-08-07 2019-02-26 南京柯菲平盛辉制药有限公司 一类茚满-5-甲酰胺RORγ调节剂及其用途
WO2019063015A1 (zh) 2017-09-30 2019-04-04 正大天晴药业集团股份有限公司 作为RORγ抑制剂的磺酰基取代的双环化合物
EP3927329A4 (en) * 2019-02-20 2022-11-23 The Regents of the University of California TREATMENT OF CANCERS DEPENDENT ON THE ORPHAN RECEPTOR BOUND ON THE RETINOIC ACID y (RORy) RECEPTOR
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