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DK3481826T3 - Tyrosinkinaseinhibitorer - Google Patents

Tyrosinkinaseinhibitorer Download PDF

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Publication number
DK3481826T3
DK3481826T3 DK17742601.2T DK17742601T DK3481826T3 DK 3481826 T3 DK3481826 T3 DK 3481826T3 DK 17742601 T DK17742601 T DK 17742601T DK 3481826 T3 DK3481826 T3 DK 3481826T3
Authority
DK
Denmark
Prior art keywords
tyrosinkinase
inhibitors
tyrosinkinase inhibitors
Prior art date
Application number
DK17742601.2T
Other languages
English (en)
Inventor
Sacha Holland
Rajinder Singh
Somasekhar Bhamidipati
Pingyu Ding
Rao Kolluri
Ihab Darwish
Esteban Masuda
Jiaxin Yu
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3481826T3 publication Critical patent/DK3481826T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK17742601.2T 2016-07-08 2017-07-10 Tyrosinkinaseinhibitorer DK3481826T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662360297P 2016-07-08 2016-07-08
PCT/US2017/041396 WO2018009938A1 (en) 2016-07-08 2017-07-10 Tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
DK3481826T3 true DK3481826T3 (da) 2022-01-10

Family

ID=59383641

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17742601.2T DK3481826T3 (da) 2016-07-08 2017-07-10 Tyrosinkinaseinhibitorer

Country Status (7)

Country Link
US (4) US10130623B2 (da)
EP (1) EP3481826B1 (da)
JP (2) JP7061993B2 (da)
CA (1) CA3030283A1 (da)
DK (1) DK3481826T3 (da)
ES (1) ES2903526T3 (da)
WO (1) WO2018009938A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3481826B1 (en) 2016-07-08 2021-11-03 Rigel Pharmaceuticals, Inc. Tyrosine kinase inhibitors
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
JP7294734B2 (ja) * 2021-10-27 2023-06-20 シャンハイ ジムン バイオファーマ,インコーポレーテッド カリウムチャネル調節剤としての化合物ならびにその調製および応用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003137866A (ja) * 2001-11-01 2003-05-14 Sankyo Co Ltd フェニレンジアミン誘導体
EP2251341A1 (en) 2005-07-14 2010-11-17 Astellas Pharma Inc. Heterocyclic Janus kinase 3 inhibitors
KR101474228B1 (ko) 2006-12-27 2014-12-18 사노피 사이클로알킬아민 치환된 이소퀴놀론 유도체
WO2012135800A1 (en) * 2011-04-01 2012-10-04 University Of Utah Research Foundation Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase
US9012466B2 (en) * 2013-03-12 2015-04-21 Arqule Inc. Substituted tricyclic pyrazolo-pyrimidine compounds
MX2017002544A (es) * 2014-09-02 2017-07-19 Pf Medicament Derivados de isoquinolinona utiles en el tratamiento contra el cancer.
WO2016183071A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Hetero-tricyclic compounds and their use for the treatment of cancer
EP3481826B1 (en) 2016-07-08 2021-11-03 Rigel Pharmaceuticals, Inc. Tyrosine kinase inhibitors

Also Published As

Publication number Publication date
CA3030283A1 (en) 2018-01-11
JP7061993B2 (ja) 2022-05-02
US10130623B2 (en) 2018-11-20
JP2021185203A (ja) 2021-12-09
EP3481826A1 (en) 2019-05-15
US20180008589A1 (en) 2018-01-11
US20230012676A1 (en) 2023-01-19
US20190099411A1 (en) 2019-04-04
US11672791B2 (en) 2023-06-13
WO2018009938A1 (en) 2018-01-11
US10434096B2 (en) 2019-10-08
US11110082B2 (en) 2021-09-07
US20200078348A1 (en) 2020-03-12
JP2019520397A (ja) 2019-07-18
ES2903526T3 (es) 2022-04-04
EP3481826B1 (en) 2021-11-03

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