DK2330132T3 - Antistoffer mod MMP2 eller MMP9 og farmaceutiske sammensætninger deraf til hæmning af deres metalloproteinaktivitet - Google Patents
Antistoffer mod MMP2 eller MMP9 og farmaceutiske sammensætninger deraf til hæmning af deres metalloproteinaktivitetInfo
- Publication number
- DK2330132T3 DK2330132T3 DK10013205.9T DK10013205T DK2330132T3 DK 2330132 T3 DK2330132 T3 DK 2330132T3 DK 10013205 T DK10013205 T DK 10013205T DK 2330132 T3 DK2330132 T3 DK 2330132T3
- Authority
- DK
- Denmark
- Prior art keywords
- mmp2
- mmp9
- antibodies
- inhibit
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46000503P | 2003-04-04 | 2003-04-04 | |
EP04725641A EP1610678B1 (en) | 2003-04-04 | 2004-04-04 | Antibodies for inhibiting the activity of mmp-2 and mmp-9 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2330132T3 true DK2330132T3 (da) | 2013-11-04 |
Family
ID=33131910
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10013205.9T DK2330132T3 (da) | 2003-04-04 | 2004-04-04 | Antistoffer mod MMP2 eller MMP9 og farmaceutiske sammensætninger deraf til hæmning af deres metalloproteinaktivitet |
DK04725641.7T DK1610678T3 (da) | 2003-04-04 | 2004-04-04 | Antistoffer til inhibering af aktiviteten af MMP-2 og MMP-9 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04725641.7T DK1610678T3 (da) | 2003-04-04 | 2004-04-04 | Antistoffer til inhibering af aktiviteten af MMP-2 og MMP-9 |
Country Status (6)
Country | Link |
---|---|
US (4) | US7524938B2 (da) |
EP (2) | EP2330132B1 (da) |
AT (1) | ATE517926T1 (da) |
DK (2) | DK2330132T3 (da) |
ES (2) | ES2369498T3 (da) |
WO (1) | WO2004087042A2 (da) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7524938B2 (en) * | 2003-04-04 | 2009-04-28 | Yeda Research And Development Co., Ltd. | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
CA2595395A1 (en) * | 2005-02-09 | 2006-08-17 | Genentech, Inc. | Inhibiting her2 shedding with matrix metalloprotease antagonists |
JP2009522302A (ja) | 2005-12-30 | 2009-06-11 | ダイアックス コーポレーション | マトリックスメタロプロテイナーゼ結合タンパク質 |
CA2678304A1 (en) * | 2007-02-23 | 2008-08-28 | Yeda Research And Development Co. Ltd. | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
US8536313B2 (en) | 2007-07-10 | 2013-09-17 | Shionogi & Co., Ltd. | Monoclonal antibody having neutralizing activity against MMP13 |
KR20100071972A (ko) * | 2007-08-15 | 2010-06-29 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | Mmp-9의 조절인자 및 그의 용도 |
CA2707637A1 (en) | 2007-12-17 | 2009-06-25 | Dyax Corp. | Compositions and methods for treating osteolytic disorders comprising mmp-14 binding proteins |
US8183008B2 (en) * | 2007-12-17 | 2012-05-22 | Dyax Corp. | Evaluating MMP expression in patient stratification and other therapeutic, diagnostic and prognostic methods for cancer |
EP2262529A4 (en) | 2008-03-03 | 2013-05-08 | Dyax Corp | METALLOPROTEINASE BINDING PROTEINS 9 |
US8013125B2 (en) * | 2008-03-03 | 2011-09-06 | Dyax Corp. | Metalloproteinase 9 and metalloproteinase 2 binding proteins |
US20110236395A1 (en) * | 2008-09-09 | 2011-09-29 | University Of East Anglia | Treatment of fibrotic eye disorders using an mmp2 inhibitor |
CN101559076B (zh) * | 2009-05-27 | 2012-08-29 | 西北大学 | 抗肿瘤基质金属蛋白酶抑制剂 |
US8697078B2 (en) | 2010-01-27 | 2014-04-15 | Yeda Research And Development Co. Ltd. | Antibodies that inhibit metalloproteins |
PT2608809T (pt) * | 2010-08-27 | 2019-08-26 | Gilead Biologics Inc | Anticorpos para a metaloproteinase 9 da matriz |
ES2688457T3 (es) | 2010-10-28 | 2018-11-02 | Yeda Research And Development Co. Ltd. | Métodos de generación de anticuerpos contra metaloenzimas |
US10314909B2 (en) | 2011-10-21 | 2019-06-11 | Dyax Corp. | Combination therapy comprising an MMP-14 binding protein |
DK2809350T3 (da) | 2012-01-30 | 2019-01-28 | Arecor Ltd | Stabiliserede vandige antistofpræparater |
JP6144286B2 (ja) * | 2012-02-29 | 2017-06-07 | ギリアード バイオロジックス, インコーポレイテッド | マトリックスメタロプロテイナーゼ9に対する抗体 |
JP7109440B2 (ja) | 2017-07-18 | 2022-07-29 | 第一三共株式会社 | 活性型mmp-9結合ペプチド |
IL264768A (en) | 2019-02-10 | 2020-08-31 | Sagi Irit | ANTI-MATRIX METALLOPROTEINASE 7 (MMP-7) inhibitory antibody and its use |
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NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
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NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
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US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
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GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
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US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
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WO2003006006A1 (en) * | 2001-07-09 | 2003-01-23 | The Regents Of The University Of California | Use of matrix metalloproteinase inhibitors to mitigate nerve damage |
WO2003044058A2 (en) * | 2001-11-23 | 2003-05-30 | Universite Catholique De Louvain | Medical use of antibodies directed against human matrix metalloproteinases or related tissue proteinases for the treatment of abnormal uterine bleeding and endometriosis |
US7524938B2 (en) * | 2003-04-04 | 2009-04-28 | Yeda Research And Development Co., Ltd. | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
-
2004
- 2004-04-04 US US10/551,715 patent/US7524938B2/en not_active Expired - Lifetime
- 2004-04-04 DK DK10013205.9T patent/DK2330132T3/da active
- 2004-04-04 ES ES04725641T patent/ES2369498T3/es not_active Expired - Lifetime
- 2004-04-04 AT AT04725641T patent/ATE517926T1/de not_active IP Right Cessation
- 2004-04-04 EP EP10013205.9A patent/EP2330132B1/en not_active Expired - Lifetime
- 2004-04-04 WO PCT/IL2004/000308 patent/WO2004087042A2/en active Application Filing
- 2004-04-04 ES ES10013205T patent/ES2433440T3/es not_active Expired - Lifetime
- 2004-04-04 DK DK04725641.7T patent/DK1610678T3/da active
- 2004-04-04 EP EP04725641A patent/EP1610678B1/en not_active Expired - Lifetime
-
2009
- 2009-03-11 US US12/382,248 patent/US20090208510A1/en not_active Abandoned
-
2011
- 2011-07-05 US US13/175,978 patent/US8841108B2/en not_active Expired - Fee Related
-
2014
- 2014-09-01 US US14/474,203 patent/US20140370031A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1610678A4 (en) | 2008-04-09 |
ES2369498T3 (es) | 2011-12-01 |
US20070172482A1 (en) | 2007-07-26 |
WO2004087042A2 (en) | 2004-10-14 |
EP1610678B1 (en) | 2011-07-27 |
EP2330132B1 (en) | 2013-08-14 |
US20140370031A1 (en) | 2014-12-18 |
EP2330132A1 (en) | 2011-06-08 |
US8841108B2 (en) | 2014-09-23 |
US20090208510A1 (en) | 2009-08-20 |
EP1610678A2 (en) | 2006-01-04 |
US20120003236A1 (en) | 2012-01-05 |
US7524938B2 (en) | 2009-04-28 |
WO2004087042A3 (en) | 2005-07-14 |
DK1610678T3 (da) | 2011-10-24 |
ES2433440T3 (es) | 2013-12-11 |
ATE517926T1 (de) | 2011-08-15 |
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