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DK1981863T3 - Fremgangsmåde til fremstilling af aminocrotonylaminosubtituerede quinazolinderivater - Google Patents

Fremgangsmåde til fremstilling af aminocrotonylaminosubtituerede quinazolinderivater

Info

Publication number
DK1981863T3
DK1981863T3 DK07704145.7T DK07704145T DK1981863T3 DK 1981863 T3 DK1981863 T3 DK 1981863T3 DK 07704145 T DK07704145 T DK 07704145T DK 1981863 T3 DK1981863 T3 DK 1981863T3
Authority
DK
Denmark
Prior art keywords
aminocrotonylaminosubstituted
preparation
quinazoline derivatives
quinazoline
derivatives
Prior art date
Application number
DK07704145.7T
Other languages
English (en)
Inventor
Juergen Schroeder
Georg Dziewas
Thomas Fachinger
Burkhard Jaeger
Carsten Reichel
Svenja Renner
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of DK1981863T3 publication Critical patent/DK1981863T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/02—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms not condensed with other rings
    • C07D293/04—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK07704145.7T 2006-01-26 2007-01-25 Fremgangsmåde til fremstilling af aminocrotonylaminosubtituerede quinazolinderivater DK1981863T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06100914 2006-01-26
PCT/EP2007/050752 WO2007085638A1 (en) 2006-01-26 2007-01-25 Process for preparing aminocrotonylamino-substituted quinazoline derivatives

Publications (1)

Publication Number Publication Date
DK1981863T3 true DK1981863T3 (da) 2013-01-02

Family

ID=38180518

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07704145.7T DK1981863T3 (da) 2006-01-26 2007-01-25 Fremgangsmåde til fremstilling af aminocrotonylaminosubtituerede quinazolinderivater

Country Status (11)

Country Link
US (3) US7960546B2 (da)
EP (1) EP1981863B1 (da)
JP (1) JP5241513B2 (da)
CA (1) CA2639936C (da)
CY (1) CY1113778T1 (da)
DK (1) DK1981863T3 (da)
ES (1) ES2397181T3 (da)
PL (1) PL1981863T3 (da)
PT (1) PT1981863E (da)
SI (1) SI1981863T1 (da)
WO (1) WO2007085638A1 (da)

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US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
US7197160B2 (en) 2001-03-05 2007-03-27 Digimarc Corporation Geographic information systems using digital watermarks
DE10221018A1 (de) 2002-05-11 2003-11-27 Boehringer Ingelheim Pharma Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie
US20050043233A1 (en) * 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
DE10349113A1 (de) 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
SI1948180T1 (sl) * 2005-11-11 2013-06-28 Boehringer Ingelheim International Gmbh Kombinacijsko zdravljenje raka, ki obsega EGFR/HER2 inhibitorje
JP5688877B2 (ja) 2005-11-11 2015-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌疾患の治療用キナゾリン誘導体
US7960546B2 (en) 2006-01-26 2011-06-14 Boehringer Ingelheim International Gmbh Process for preparing aminocrotonylamino-substituted quinazoline derivatives
ATE552835T1 (de) 2006-09-18 2012-04-15 Boehringer Ingelheim Int Verfahren zur behandlung von tumoren mit egfr- mutationen
UY31867A (es) * 2008-06-06 2010-01-29 Boehringer Ingelheim Int Nuevas formulaciones farmacéuticas sólidas que comprenden bibw 2992
SG177451A1 (en) 2009-07-02 2012-02-28 Newgen Therapeutics Inc Phosphorus containing quinazoline compounds and methods of use
DK2451445T3 (da) 2009-07-06 2019-06-24 Boehringer Ingelheim Int Fremgangsmåde til at tørre bibw2992, dets salte og faste farmaceutiske formuleringer omfattende denne aktive ingrediens
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WO2014180271A1 (zh) * 2013-05-10 2014-11-13 苏州明锐医药科技有限公司 阿法替尼及其中间体的制备方法
CN103254156B (zh) * 2013-05-10 2015-08-26 苏州明锐医药科技有限公司 阿法替尼中间体的制备方法
CN103254183B (zh) * 2013-05-10 2015-11-11 苏州明锐医药科技有限公司 阿法替尼的制备方法
CN103288808B (zh) * 2013-05-16 2015-11-11 苏州明锐医药科技有限公司 一种阿法替尼的制备方法
CN104710413B (zh) * 2013-12-16 2019-05-03 江苏豪森药业集团有限公司 二马来酸阿法替尼的制备方法
US9242965B2 (en) * 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN107141261B (zh) * 2014-07-15 2020-05-05 杭州华东医药集团新药研究院有限公司 喹唑啉类化合物及其制备方法和在制备酪氨酸激酶抑制剂中的应用
CN105315263B (zh) * 2014-07-30 2018-11-27 正大天晴药业集团股份有限公司 阿法替尼中间体的合成方法
CN105439879B (zh) * 2014-08-07 2018-08-10 天津法莫西医药科技有限公司 一种反式-4-二甲胺基巴豆酸盐酸盐的制备方法
CN105330652B (zh) * 2014-08-07 2019-04-05 天津法莫西医药科技有限公司 一种阿法替尼的制备方法
CN104447713B (zh) * 2014-11-18 2019-03-29 江苏奥赛康药业股份有限公司 阿法替尼化合物的制备方法
EP3023421A1 (en) 2014-11-21 2016-05-25 Sandoz Ag Crystalline forms of afatinib dimaleate
CN105777655B (zh) * 2014-12-25 2018-02-02 深圳海王医药科技研究院有限公司 萘普替尼对甲苯磺酸盐的α晶型及制备方法和含有其的药物组合物
CN104592212B (zh) * 2014-12-31 2017-11-10 广东东阳光药业有限公司 一种阿法替尼中间体的制备方法
CN105175400B (zh) * 2015-09-29 2018-04-10 河北神威药业有限公司 一种阿法替尼中间体的制备方法
US20190112317A1 (en) 2015-10-05 2019-04-18 The Trustees Of Columbia University In The City Of New York Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies
CN107216317B (zh) * 2016-03-21 2020-04-07 上海医药工业研究院 一种阿法替尼中间体的制备方法
CN105669658B (zh) * 2016-04-05 2018-06-29 北京民康百草医药科技有限公司 一种阿法替尼的精制方法
CN106045983A (zh) * 2016-06-02 2016-10-26 苏州富士莱医药股份有限公司 阿法替尼的制备方法
CN107488171B (zh) * 2016-06-10 2020-08-28 山东新时代药业有限公司 一种阿法替尼制备方法
CN105968103B (zh) * 2016-07-18 2018-11-27 山东罗欣药业集团恒欣药业有限公司 抗肿瘤药物阿法替尼的合成方法
CN106243092B (zh) * 2016-07-28 2019-02-15 南京臣功制药股份有限公司 一种高选择性制备马来酸阿法替尼的方法
CN106565692A (zh) * 2016-11-03 2017-04-19 常茂生物化学工程股份有限公司 一种阿法替尼合成工艺的改进方法
CN106908531B (zh) * 2017-02-22 2019-08-06 深圳海王医药科技研究院有限公司 一种高效液相色谱梯度法同时测定萘普替尼光降解产物及其它有关物质的方法
CN110693846B (zh) * 2018-07-10 2021-07-27 杭州华东医药集团新药研究院有限公司 迈华替尼药物组合物及其制备方法
CN110590754A (zh) * 2019-09-21 2019-12-20 广东安诺药业股份有限公司 一种马来酸阿法替尼中间体的制备方法
CN112770759A (zh) 2020-07-09 2021-05-07 德尔塔菲制药股份有限公司 用于治疗伴脑转移的晚期非小细胞肺癌患者的组合药物
WO2023028056A1 (en) 2021-08-24 2023-03-02 Genentech, Inc. 3-amino piperidyl sodium channel inhibitors
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MXPA01012899A (es) * 1999-06-21 2002-07-30 Boehringer Ingelheim Pharma Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion.
DE10063435A1 (de) * 2000-12-20 2002-07-04 Boehringer Ingelheim Pharma Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US7019012B2 (en) * 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
DE10221018A1 (de) 2002-05-11 2003-11-27 Boehringer Ingelheim Pharma Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie
US20030225079A1 (en) * 2002-05-11 2003-12-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of inhibitors of the EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH)/prostatic hypertrophy
US7223749B2 (en) * 2003-02-20 2007-05-29 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
DE10307165A1 (de) 2003-02-20 2004-09-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
DE10349113A1 (de) * 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
US20060058311A1 (en) * 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
JP5688877B2 (ja) * 2005-11-11 2015-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌疾患の治療用キナゾリン誘導体
SI1948180T1 (sl) 2005-11-11 2013-06-28 Boehringer Ingelheim International Gmbh Kombinacijsko zdravljenje raka, ki obsega EGFR/HER2 inhibitorje
US7960546B2 (en) 2006-01-26 2011-06-14 Boehringer Ingelheim International Gmbh Process for preparing aminocrotonylamino-substituted quinazoline derivatives
ATE552835T1 (de) * 2006-09-18 2012-04-15 Boehringer Ingelheim Int Verfahren zur behandlung von tumoren mit egfr- mutationen
UY31867A (es) 2008-06-06 2010-01-29 Boehringer Ingelheim Int Nuevas formulaciones farmacéuticas sólidas que comprenden bibw 2992
WO2010081817A1 (en) 2009-01-14 2010-07-22 Boehringer Ingelheim International Gmbh Method for treating colorectal cancer
DK2451445T3 (da) 2009-07-06 2019-06-24 Boehringer Ingelheim Int Fremgangsmåde til at tørre bibw2992, dets salte og faste farmaceutiske formuleringer omfattende denne aktive ingrediens

Also Published As

Publication number Publication date
US7960546B2 (en) 2011-06-14
CA2639936A1 (en) 2008-08-02
JP5241513B2 (ja) 2013-07-17
ES2397181T3 (es) 2013-03-05
EP1981863B1 (en) 2012-10-10
PT1981863E (pt) 2012-12-07
CY1113778T1 (el) 2016-07-27
WO2007085638A1 (en) 2007-08-02
CA2639936C (en) 2014-06-17
US20110207929A1 (en) 2011-08-25
EP1981863A1 (en) 2008-10-22
US20110207932A1 (en) 2011-08-25
US20090306378A1 (en) 2009-12-10
PL1981863T3 (pl) 2013-03-29
JP2009528981A (ja) 2009-08-13
US8188274B2 (en) 2012-05-29
US8067593B2 (en) 2011-11-29
SI1981863T1 (sl) 2013-01-31

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