DK3214083T3 - Fremgangsmåde til fremstilling af quinolonforbindelser - Google Patents

Fremgangsmåde til fremstilling af quinolonforbindelser Download PDF

Info

Publication number: DK3214083T3
Authority: DK; Denmark
Prior art keywords: quinolon; compounds; making; quinolon compounds; making quinolon
Prior art date: 2008-09-24

Application number

DK17163383.7T

Other languages

English (en)

Inventor

Roger Hanselmann

Maxwell M Reeve

Graham Johnson

Original Assignee

Melinta Subsidiary Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-09-24

Filing date

2009-09-23

Publication date

2020-12-07

2009-09-23 Application filed by Melinta Subsidiary Corp filed Critical Melinta Subsidiary Corp

2020-12-07 Application granted granted Critical

2020-12-07 Publication of DK3214083T3 publication Critical patent/DK3214083T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/02—Gearboxes; Mounting gearing therein
- F16H57/027—Gearboxes; Mounting gearing therein characterised by means for venting gearboxes, e.g. air breathers
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/02—Gearboxes; Mounting gearing therein
- F16H57/037—Gearboxes for accommodating differential gearings
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H48/00—Differential gearings
- F16H48/06—Differential gearings with gears having orbital motion
- F16H48/08—Differential gearings with gears having orbital motion comprising bevel gears
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/04—Features relating to lubrication or cooling or heating
- F16H57/0457—Splash lubrication
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H57/00—General details of gearing
- F16H57/04—Features relating to lubrication or cooling or heating
- F16H57/048—Type of gearings to be lubricated, cooled or heated
- F16H57/0482—Gearings with gears having orbital motion
- F16H57/0483—Axle or inter-axle differentials
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T74/00—Machine element or mechanism
- Y10T74/19—Gearing
- Y10T74/19642—Directly cooperating gears
- Y10T74/19688—Bevel
- Y10T74/19693—Motor vehicle drive
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T74/00—Machine element or mechanism
- Y10T74/21—Elements
- Y10T74/2186—Gear casings
- Y10T74/2188—Axle and torque tubes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Mechanical Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)

DK17163383.7T 2008-09-24 2009-09-23 Fremgangsmåde til fremstilling af quinolonforbindelser DK3214083T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19408308P	2008-09-24	2008-09-24
EP09816565.7A EP2346855B1 (en)	2008-09-24	2009-09-23	Process for making quinolone compounds

Publications (1)

Publication Number	Publication Date
DK3214083T3 true DK3214083T3 (da)	2020-12-07

Family

ID=42060333

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK09816565.7T DK2346855T3 (da)	2008-09-24	2009-09-23	Fremgangsmåde til fremstilling af quinolonsammensætninger
DK17163383.7T DK3214083T3 (da)	2008-09-24	2009-09-23	Fremgangsmåde til fremstilling af quinolonforbindelser

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK09816565.7T DK2346855T3 (da)	2008-09-24	2009-09-23	Fremgangsmåde til fremstilling af quinolonsammensætninger

Country Status (27)

Country	Link
US (3)	USRE46617E1 (da)
EP (3)	EP2346855B1 (da)
JP (2)	JP6013734B2 (da)
KR (3)	KR20170039758A (da)
CN (2)	CN102164912B (da)
AU (1)	AU2009297085B2 (da)
BR (1)	BRPI0919241B8 (da)
CA (1)	CA2738236C (da)
CY (2)	CY1123658T1 (da)
DK (2)	DK2346855T3 (da)
ES (3)	ES2826273T3 (da)
FI (1)	FI3766876T3 (da)
HK (2)	HK1214243A1 (da)
HR (1)	HRP20201879T1 (da)
HU (2)	HUE052219T2 (da)
IL (1)	IL211845A (da)
LT (3)	LT3766876T (da)
MX (2)	MX2011003122A (da)
NL (1)	NL301091I2 (da)
NO (1)	NO2021006I1 (da)
PL (2)	PL3214083T3 (da)
PT (1)	PT3214083T (da)
RS (1)	RS61194B1 (da)
RU (1)	RU2546667C2 (da)
SG (1)	SG10201605492YA (da)
SI (1)	SI3214083T1 (da)
WO (1)	WO2010036329A2 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7576216B2 (en) *	2004-07-30	2009-08-18	Abbott Laboratories	Preparation of pyridonecarboxylic acid antibacterials
EP2346855B1 (en)	2008-09-24	2017-04-05	Melinta Therapeutics, Inc.	Process for making quinolone compounds
TW201444558A (zh) *	2013-03-15	2014-12-01	Melinta Therapeutics Inc	使用喹諾酮類抗生素治療淋病感染的方法
CN104098548B (zh) *	2013-04-11	2017-07-18	上海医药工业研究院	一种Delafloxacin的精制方法
CN103709100A (zh) *	2013-12-31	2014-04-09	南京工业大学	一种8-氯代喹诺酮衍生物的制备方法
TW201605447A (zh) *	2014-06-20	2016-02-16	美林塔治療學有限公司	處理感染的方法
CN106256824B (zh) *	2015-06-18	2020-10-27	重庆医药工业研究院有限责任公司	一种高纯度德拉沙星葡甲胺盐的制备方法
CN105017224A (zh) *	2015-07-10	2015-11-04	扬子江药业集团有限公司	一种德拉沙星葡甲胺晶型的制备方法
CN107778293B (zh) *	2016-08-29	2023-06-16	鲁南制药集团股份有限公司	一种改进的德拉沙星的制备方法
RU2019130519A (ru)	2017-03-31	2021-04-30	Фуджифилм Корпорэйшн	4-пиридоновое соединение или его соль, фармацевтическая композиция и содержащий их состав
WO2022240897A1 (en)	2021-05-10	2022-11-17	Sepelo Therapeutics, Llc	Pharmaceutical composition comprising delafloxacin for administration into the lung
CN113527262B (zh) *	2021-06-22	2022-07-15	安徽普利药业有限公司	一种德拉沙星及其葡甲胺盐的精制方法
CN114031607B (zh) *	2021-11-16	2023-01-10	海南普利制药股份有限公司	一种德拉沙星及其中间体的精制方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4522811A (en)	1982-07-08	1985-06-11	Syntex (U.S.A.) Inc.	Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
DE69623358T2 (de)	1995-09-22	2003-05-08	Wakunaga Pharma Co Ltd	Pyridoncarbonsäurederivate als antibakterielle Wirkstoffe
NZ516201A (en) *	1999-07-01	2003-06-30	Wakunaga Pharamaceutical Co	Quinolinecarboxylic acid derivative or salts thereof that have antimicrobial effect
JP2005097116A (ja)	1999-11-11	2005-04-14	Wakunaga Pharmaceut Co Ltd	キノリンカルボン酸誘導体アルカリ金属塩及びこれを用いたキノリンカルボン酸誘導体の精製法
CA2575148C (en) *	2004-07-30	2012-07-17	Abbott Laboratories	Preparation of pyridonecarboxylic acid antibacterials
ES2901955T3 (es)	2004-10-08	2022-03-24	Abbvie Inc	Sal meglumínica y formas cristalinas de la misma de un farmaco (delafloxacina)
US20060228411A1 (en)	2005-04-11	2006-10-12	Huailiang Wu	Pharmaceutical compositions having improved dissolution profiles for poorly soluble drugs
EP2346855B1 (en)	2008-09-24	2017-04-05	Melinta Therapeutics, Inc.	Process for making quinolone compounds

2009
- 2009-09-23 EP EP09816565.7A patent/EP2346855B1/en active Active
- 2009-09-23 SI SI200932102T patent/SI3214083T1/sl unknown
- 2009-09-23 US US14/743,365 patent/USRE46617E1/en active Active
- 2009-09-23 MX MX2011003122A patent/MX2011003122A/es active IP Right Grant
- 2009-09-23 RS RS20201519A patent/RS61194B1/sr unknown
- 2009-09-23 SG SG10201605492YA patent/SG10201605492YA/en unknown
- 2009-09-23 FI FIEP20191961.0T patent/FI3766876T3/fi active
- 2009-09-23 LT LTEP20191961.0T patent/LT3766876T/lt unknown
- 2009-09-23 LT LTEP17163383.7T patent/LT3214083T/lt unknown
- 2009-09-23 BR BRPI0919241A patent/BRPI0919241B8/pt active IP Right Grant
- 2009-09-23 US US13/120,278 patent/US8497378B2/en not_active Ceased
- 2009-09-23 HU HUE17163383A patent/HUE052219T2/hu unknown
- 2009-09-23 DK DK09816565.7T patent/DK2346855T3/da active
- 2009-09-23 CN CN200980138280.XA patent/CN102164912B/zh active Active
- 2009-09-23 DK DK17163383.7T patent/DK3214083T3/da active
- 2009-09-23 ES ES17163383T patent/ES2826273T3/es active Active
- 2009-09-23 EP EP17163383.7A patent/EP3214083B1/en active Active
- 2009-09-23 KR KR1020177008707A patent/KR20170039758A/ko not_active Application Discontinuation
- 2009-09-23 JP JP2011529013A patent/JP6013734B2/ja active Active
- 2009-09-23 ES ES20191961T patent/ES2966093T3/es active Active
- 2009-09-23 AU AU2009297085A patent/AU2009297085B2/en active Active
- 2009-09-23 PL PL17163383T patent/PL3214083T3/pl unknown
- 2009-09-23 ES ES09816565.7T patent/ES2629466T3/es active Active
- 2009-09-23 PL PL20191961.0T patent/PL3766876T3/pl unknown
- 2009-09-23 KR KR1020167026280A patent/KR101775304B1/ko active IP Right Grant
- 2009-09-23 PT PT171633837T patent/PT3214083T/pt unknown
- 2009-09-23 WO PCT/US2009/005276 patent/WO2010036329A2/en active Application Filing
- 2009-09-23 CN CN201510401546.2A patent/CN105001207A/zh active Pending
- 2009-09-23 EP EP20191961.0A patent/EP3766876B8/en active Active
- 2009-09-23 RU RU2011116052/04A patent/RU2546667C2/ru active
- 2009-09-23 KR KR1020117009326A patent/KR20110091504A/ko active Application Filing
- 2009-09-23 CA CA2738236A patent/CA2738236C/en active Active
2011
- 2011-03-22 IL IL211845A patent/IL211845A/en active IP Right Grant
- 2011-03-23 MX MX2020009790A patent/MX2020009790A/es unknown
2013
- 2013-07-09 US US13/937,488 patent/US8871938B2/en active Active
2015
- 2015-05-19 JP JP2015101828A patent/JP2015178515A/ja active Pending
2016
- 2016-02-23 HK HK16101979.5A patent/HK1214243A1/zh unknown
2018
- 2018-03-05 HK HK18103144.9A patent/HK1244481A1/zh unknown
2020
- 2020-11-25 HR HRP20201879TT patent/HRP20201879T1/hr unknown
- 2020-12-09 CY CY20201101168T patent/CY1123658T1/el unknown
2021
- 2021-02-04 NL NL301091C patent/NL301091I2/nl unknown
- 2021-02-10 CY CY2021004C patent/CY2021004I2/el unknown
- 2021-02-10 HU HUS2100004C patent/HUS2100004I1/hu unknown
- 2021-02-15 NO NO2021006C patent/NO2021006I1/no unknown
- 2021-02-17 LT LTPA2021002C patent/LTC3214083I2/lt unknown

Also Published As

Publication number	Publication date
NL301091I1 (nl)	2021-02-10
CY1123658T1 (el)	2021-05-05
RS61194B1 (sr)	2021-01-29
RU2546667C2 (ru)	2015-04-10
AU2009297085B2 (en)	2015-07-09
HUE052219T2 (hu)	2021-04-28
JP6013734B2 (ja)	2016-10-25
US8871938B2 (en)	2014-10-28
EP3214083A1 (en)	2017-09-06
EP2346855A4 (en)	2012-07-04
MX2020009790A (es)	2020-10-12
LTC3214083I2 (lt)	2022-06-27
LTPA2021002I1 (lt)	2021-03-10
CY2021004I1 (el)	2021-05-05
KR20160116020A (ko)	2016-10-06
CY2021004I2 (el)	2021-05-05
KR20110091504A (ko)	2011-08-11
AU2009297085A1 (en)	2010-04-01
EP3766876B1 (en)	2023-09-13
ES2966093T3 (es)	2024-04-18
EP2346855B1 (en)	2017-04-05
LT3766876T (lt)	2023-12-11
MX2011003122A (es)	2011-07-20
CA2738236C (en)	2016-11-15
WO2010036329A2 (en)	2010-04-01
BRPI0919241A8 (pt)	2017-10-17
LT3214083T (lt)	2021-01-25
BRPI0919241B1 (pt)	2020-05-12
KR101775304B1 (ko)	2017-09-05
PT3214083T (pt)	2020-12-04
ES2826273T3 (es)	2021-05-17
BRPI0919241B8 (pt)	2021-05-25
WO2010036329A3 (en)	2010-07-01
EP3214083B1 (en)	2020-09-16
US20120041208A1 (en)	2012-02-16
CN102164912A (zh)	2011-08-24
USRE46617E1 (en)	2017-11-28
HRP20201879T1 (hr)	2021-01-22
SG10201605492YA (en)	2016-09-29
HUS2100004I1 (hu)	2021-03-01
DK2346855T3 (da)	2017-07-24
NO2021006I1 (no)	2021-02-15
BRPI0919241A2 (pt)	2016-06-21
JP2012508161A (ja)	2012-04-05
US20140171648A1 (en)	2014-06-19
HK1214243A1 (zh)	2016-07-22
IL211845A0 (en)	2011-06-30
CN105001207A (zh)	2015-10-28
EP3766876B8 (en)	2023-10-18
ES2629466T3 (es)	2017-08-09
RU2011116052A (ru)	2012-10-27
EP3766876A1 (en)	2021-01-20
EP2346855A2 (en)	2011-07-27
NL301091I2 (nl)	2021-08-03
PL3214083T3 (pl)	2021-04-06
FI3766876T3 (fi)	2023-12-05
KR20170039758A (ko)	2017-04-11
HK1244481A1 (zh)	2018-08-10
SI3214083T1 (sl)	2021-02-26
IL211845A (en)	2017-03-30
CA2738236A1 (en)	2010-04-01
CN102164912B (zh)	2015-08-19
PL3766876T3 (pl)	2024-04-02
JP2015178515A (ja)	2015-10-08
US8497378B2 (en)	2013-07-30

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DK3214083T3 (da)	2020-12-07	Fremgangsmåde til fremstilling af quinolonforbindelser
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