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DK1957106T3 - Antagonist-antistoffer, der er rettet mod calcitonin-genrelateret peptid og fremgangsmåder til anvendelse af disse - Google Patents

Antagonist-antistoffer, der er rettet mod calcitonin-genrelateret peptid og fremgangsmåder til anvendelse af disse

Info

Publication number
DK1957106T3
DK1957106T3 DK06809207.1T DK06809207T DK1957106T3 DK 1957106 T3 DK1957106 T3 DK 1957106T3 DK 06809207 T DK06809207 T DK 06809207T DK 1957106 T3 DK1957106 T3 DK 1957106T3
Authority
DK
Denmark
Prior art keywords
methods
directed against
antibodies directed
related peptide
antagonist antibodies
Prior art date
Application number
DK06809207.1T
Other languages
English (en)
Other versions
DK1957106T4 (da
Inventor
Joerg Zeller
Jaume Pons
Arnon Rosenthal
Kristian Todd Poulsen
Yasmina Noubia Abdiche
Sierra Jones Collier
Original Assignee
Labrys Biolog Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37909474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1957106(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Labrys Biolog Inc filed Critical Labrys Biolog Inc
Publication of DK1957106T3 publication Critical patent/DK1957106T3/da
Application granted granted Critical
Publication of DK1957106T4 publication Critical patent/DK1957106T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK06809207T 2005-11-14 2006-11-02 Antagonist-antistoffer, der er rettet mod calcitonin-gen-relateret peptid og fremgangsmåder til anvendelse af disse DK1957106T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73662305P 2005-11-14 2005-11-14
PCT/IB2006/003181 WO2007054809A2 (en) 2005-11-14 2006-11-02 Antagonist antibodies directed against calcitonin gene-related peptide and methods using same

Publications (2)

Publication Number Publication Date
DK1957106T3 true DK1957106T3 (da) 2013-11-04
DK1957106T4 DK1957106T4 (da) 2019-10-28

Family

ID=37909474

Family Applications (3)

Application Number Title Priority Date Filing Date
DK16154418.4T DK3045182T3 (da) 2005-11-14 2006-11-02 Antagonistantistoffer rettet mod calcitonin gen-relateret peptid til behandling af klynge-hovedpine
DK11166787.9T DK2380592T3 (da) 2005-11-14 2006-11-02 Antagonistantistof rettet mod calcitonin gen-relateret peptid
DK06809207T DK1957106T4 (da) 2005-11-14 2006-11-02 Antagonist-antistoffer, der er rettet mod calcitonin-gen-relateret peptid og fremgangsmåder til anvendelse af disse

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK16154418.4T DK3045182T3 (da) 2005-11-14 2006-11-02 Antagonistantistoffer rettet mod calcitonin gen-relateret peptid til behandling af klynge-hovedpine
DK11166787.9T DK2380592T3 (da) 2005-11-14 2006-11-02 Antagonistantistof rettet mod calcitonin gen-relateret peptid

Country Status (38)

Country Link
US (20) US8007794B2 (da)
EP (6) EP1957106B2 (da)
JP (1) JP5123197B2 (da)
KR (2) KR20080068062A (da)
CN (2) CN103421114B (da)
AP (1) AP2008004467A0 (da)
AU (1) AU2006313434B2 (da)
BR (1) BRPI0618705B8 (da)
CA (1) CA2626120C (da)
CR (1) CR9975A (da)
CU (1) CU23872B1 (da)
CY (3) CY1120249T1 (da)
DK (3) DK3045182T3 (da)
EA (1) EA015526B1 (da)
EC (1) ECSP088451A (da)
ES (3) ES2664421T3 (da)
GE (1) GEP20115333B (da)
HK (2) HK1125837A1 (da)
HR (2) HRP20180753T1 (da)
HU (3) HUE036940T2 (da)
IL (3) IL190876A (da)
LT (3) LT2380592T (da)
LU (2) LUC00119I2 (da)
MA (1) MA30136B1 (da)
ME (1) ME00419B (da)
MY (1) MY153249A (da)
NL (1) NL300997I2 (da)
NO (3) NO344099B1 (da)
NZ (1) NZ568237A (da)
PL (3) PL3045182T3 (da)
PT (3) PT2380592T (da)
RS (3) RS57192B1 (da)
SI (3) SI3045182T1 (da)
SV (1) SV2008002905A (da)
TN (1) TNSN08213A1 (da)
UA (1) UA94244C2 (da)
WO (1) WO2007054809A2 (da)
ZA (1) ZA200803484B (da)

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CN103421114B (zh) 2017-09-22
MA30136B1 (fr) 2009-01-02
US8007794B2 (en) 2011-08-30
US20150050267A1 (en) 2015-02-19
US9266951B2 (en) 2016-02-23
IL190876A0 (en) 2008-11-03
US8586045B2 (en) 2013-11-19
EP1957106A2 (en) 2008-08-20
NO344605B1 (no) 2020-02-10
EP2380592A3 (en) 2012-06-06
EP1957106B2 (en) 2019-07-24
US10329343B2 (en) 2019-06-25
US20120009192A1 (en) 2012-01-12
CA2626120C (en) 2012-12-04
UA94244C2 (ru) 2011-04-26
US20170240622A1 (en) 2017-08-24
NL300997I2 (nl) 2019-11-28
US20190092841A1 (en) 2019-03-28
AU2006313434B2 (en) 2011-10-27
CN101309704A (zh) 2008-11-19
US9365648B1 (en) 2016-06-14
IL190876A (en) 2012-06-28
US9890211B2 (en) 2018-02-13
US20150291690A1 (en) 2015-10-15
EP3069731A1 (en) 2016-09-21
EP3045182B1 (en) 2018-03-07
DK1957106T4 (da) 2019-10-28
RS57194B1 (sr) 2018-07-31
CY2019019I1 (el) 2019-11-27
US20170240623A1 (en) 2017-08-24
NL300997I1 (nl) 2019-07-03
US20130216535A1 (en) 2013-08-22
US8597649B2 (en) 2013-12-03
PT3045182T (pt) 2018-06-05
ZA200803484B (en) 2009-03-25
ME00419B (me) 2011-10-10
US9890210B2 (en) 2018-02-13
CY1120267T1 (el) 2019-07-10
KR101250049B1 (ko) 2013-04-04
SV2008002905A (es) 2011-07-05
BRPI0618705B8 (pt) 2021-05-25
PL3045182T3 (pl) 2018-07-31
PT2380592T (pt) 2018-06-06
HK1125837A1 (en) 2009-08-21
ES2433251T5 (es) 2020-03-13
RS57192B1 (sr) 2018-07-31
LUC00126I1 (da) 2019-07-09
EP3178493A1 (en) 2017-06-14
PL2380592T3 (pl) 2018-07-31
HRP20180753T1 (hr) 2018-08-24
LUC00126I2 (da) 2019-12-27
WO2007054809A3 (en) 2007-08-09
EP3842458A1 (en) 2021-06-30
IL248025A0 (en) 2016-11-30
NO2019043I1 (no) 2019-12-09
DK2380592T3 (da) 2018-03-19
HUE036944T2 (hu) 2018-08-28
US20170240624A1 (en) 2017-08-24
AU2006313434A1 (en) 2007-05-18
US20200247878A1 (en) 2020-08-06
TNSN08213A1 (fr) 2009-10-30
US20140147438A1 (en) 2014-05-29
NO344099B1 (no) 2019-09-02
LUC00119I2 (da) 2020-07-10
EA200801094A1 (ru) 2008-10-30
ES2664421T3 (es) 2018-04-19
US20170240625A1 (en) 2017-08-24
US20180162931A1 (en) 2018-06-14
LT2380592T (lt) 2018-05-10
EP2380592A2 (en) 2011-10-26
CU23872B1 (es) 2013-03-27
PT1957106E (pt) 2013-12-26
CN101309704B (zh) 2012-10-10
AP2008004467A0 (en) 2008-06-30
CR9975A (es) 2008-06-02
US20170081395A1 (en) 2017-03-23
JP5123197B2 (ja) 2013-01-16
BRPI0618705B1 (pt) 2018-02-06
DK3045182T3 (da) 2018-03-19
PL1957106T3 (pl) 2014-03-31
US9346881B2 (en) 2016-05-24
HRP20180752T1 (hr) 2018-06-15
US20160168244A1 (en) 2016-06-16
CY1120249T1 (el) 2019-07-10
US20090220489A1 (en) 2009-09-03
SI1957106T2 (sl) 2019-09-30
US9115194B2 (en) 2015-08-25
US9340614B2 (en) 2016-05-17
US8734802B1 (en) 2014-05-27
KR20080068062A (ko) 2008-07-22
HK1225627B (zh) 2017-09-15
US20150361172A1 (en) 2015-12-17
ECSP088451A (es) 2008-07-30
CY2019019I2 (el) 2019-11-27
RS20080200A (en) 2009-07-15
US20150361171A1 (en) 2015-12-17
CU20080088A7 (es) 2012-06-21
NO20081854L (no) 2008-05-19
GEP20115333B (en) 2011-11-25
IL219503A0 (en) 2012-06-28
JP2009515942A (ja) 2009-04-16
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ES2664854T3 (es) 2018-04-23
LT3045182T (lt) 2018-05-10

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