DK1578731T3 - Fremgangsmåde til fremstilling af pyrimidinforbindelser - Google Patents

Fremgangsmåde til fremstilling af pyrimidinforbindelser

Info

Publication number: DK1578731T3
Authority: DK; Denmark
Prior art keywords: preparation; pyrimidine compounds; pyrimidine; compounds
Prior art date: 2002-12-16

Application number

DK03780362.4T

Other languages

English (en)

Inventor

Lee Newton

Mark Bailey

Original Assignee

Astrazeneca Uk Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-16

Filing date

2003-12-09

Publication date

2010-02-15

2002-12-16 Priority claimed from GB0229243A external-priority patent/GB0229243D0/en

2003-02-17 Priority claimed from GB0303589A external-priority patent/GB0303589D0/en

2003-08-07 Priority claimed from GB0318515A external-priority patent/GB0318515D0/en

2003-12-09 Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd

2010-02-15 Application granted granted Critical

2010-02-15 Publication of DK1578731T3 publication Critical patent/DK1578731T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK03780362.4T 2002-12-16 2003-12-09 Fremgangsmåde til fremstilling af pyrimidinforbindelser DK1578731T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB0229243A GB0229243D0 (en)	2002-12-16	2002-12-16	Compounds and process
GB0303589A GB0303589D0 (en)	2003-02-17	2003-02-17	Compounds and process
GB0318515A GB0318515D0 (en)	2003-08-07	2003-08-07	Compounds and process
PCT/GB2003/005359 WO2004054986A2 (en)	2002-12-16	2003-12-09	Process for the preparation of pyrimidine compounds

Publications (1)

Publication Number	Publication Date
DK1578731T3 true DK1578731T3 (da)	2010-02-15

Family

ID=32600665

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03780362.4T DK1578731T3 (da)	2002-12-16	2003-12-09	Fremgangsmåde til fremstilling af pyrimidinforbindelser

Country Status (23)

Country	Link
US (2)	US7524955B2 (da)
EP (2)	EP1578731B1 (da)
JP (2)	JP4579821B2 (da)
KR (1)	KR101060215B1 (da)
AR (1)	AR042355A1 (da)
AT (1)	ATE448209T1 (da)
AU (1)	AU2003288443B2 (da)
BR (1)	BR0317313A (da)
CA (1)	CA2509344C (da)
CY (1)	CY1110605T1 (da)
DE (1)	DE60330050D1 (da)
DK (1)	DK1578731T3 (da)
ES (1)	ES2335279T3 (da)
HK (1)	HK1080477A1 (da)
IL (1)	IL168884A (da)
MX (1)	MXPA05006425A (da)
MY (1)	MY138051A (da)
NO (2)	NO330983B1 (da)
NZ (1)	NZ540722A (da)
PT (1)	PT1578731E (da)
SI (1)	SI1578731T1 (da)
TW (1)	TWI322145B (da)
WO (1)	WO2004054986A2 (da)

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GB0011120D0 (en)	2000-05-09	2000-06-28	Avecia Ltd	Process
NL1015744C2 (nl) *	2000-07-19	2002-01-22	Dsm Nv	Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
CN1301977C (zh)	2001-07-13	2007-02-28	阿斯特拉曾尼卡英国有限公司	氨基嘧啶化合物的制备方法
EP1323717A1 (en)	2001-12-27	2003-07-02	Dsm N.V.	Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
KR20030092446A (ko) *	2002-05-29	2003-12-06	주식회사 한국토종약초연구소	씨형 간염 활성 억제를 갖는 조릿대 추출물을 포함하는조성물
EP1375493A1 (en)	2002-06-17	2004-01-02	Dsm N.V.	Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en)	2002-08-13	2002-09-18	Astrazeneca Ab	Chemical process
MXPA05006425A (es)	2002-12-16	2005-08-19	Astrazeneka Uk Ltd	Procedimiento para la preparacion de compuestos de pirimidina.
GB0312896D0 (en)	2003-06-05	2003-07-09	Astrazeneca Ab	Chemical process
UY28501A1 (es)	2003-09-10	2005-04-29	Astrazeneca Uk Ltd	Compuestos químicos
GB0324791D0 (en)	2003-10-24	2003-11-26	Astrazeneca Ab	Chemical process
GB0428328D0 (en) *	2004-12-24	2005-02-02	Astrazeneca Uk Ltd	Chemical process
GB0514078D0 (en) *	2005-07-08	2005-08-17	Astrazeneca Uk Ltd	Chemical process
US8153791B2 (en)	2005-12-21	2012-04-10	Janssen Pharmaceutica N.V.	Substituted pyrimidinyl oxime kinase inhibitors
US8013153B2 (en) *	2006-03-23	2011-09-06	Janssen Pharmaceutica, N.V.	Substituted pyrimidine kinase inhibitors
TW200831469A (en) *	2006-12-01	2008-08-01	Astrazeneca Uk Ltd	Chemical process
CN103004028B (zh)	2010-05-21	2016-04-06	库柏技术公司	用于套管闭锁的适配件

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CN1164577C (zh)	1999-07-13	2004-09-01	隆萨股份公司	2-氨基-4-(4-氟苯基)-6-烷基嘧啶-5-羧酸酯的制备方法
GB0003305D0 (en)	2000-02-15	2000-04-05	Zeneca Ltd	Pyrimidine derivatives
AU2000254249A1 (en)	2000-03-28	2001-10-08	Biocon India Limited	Synthesis of (r-(r,r))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-
GB0011120D0 (en)	2000-05-09	2000-06-28	Avecia Ltd	Process
GB0011163D0 (en)	2000-05-10	2000-06-28	Astrazeneca Ab	Chemical compound
NL1015744C2 (nl)	2000-07-19	2002-01-22	Dsm Nv	Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
CN1301977C (zh) *	2001-07-13	2007-02-28	阿斯特拉曾尼卡英国有限公司	氨基嘧啶化合物的制备方法
EP1323717A1 (en)	2001-12-27	2003-07-02	Dsm N.V.	Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
KR100511533B1 (ko)	2002-04-09	2005-08-31	임광민	키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법
EP1375493A1 (en)	2002-06-17	2004-01-02	Dsm N.V.	Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en)	2002-08-13	2002-09-18	Astrazeneca Ab	Chemical process
MXPA05006425A (es)	2002-12-16	2005-08-19	Astrazeneka Uk Ltd	Procedimiento para la preparacion de compuestos de pirimidina.
WO2004103977A2 (en)	2003-05-21	2004-12-02	Ciba Specialty Chemicals Holding Inc.	Process for the preparation of pyrimidine derivatives
GB0312896D0 (en)	2003-06-05	2003-07-09	Astrazeneca Ab	Chemical process
UY28501A1 (es)	2003-09-10	2005-04-29	Astrazeneca Uk Ltd	Compuestos químicos
GB0321827D0 (en)	2003-09-18	2003-10-15	Astrazeneca Uk Ltd	Chemical compounds
GB0324791D0 (en)	2003-10-24	2003-11-26	Astrazeneca Ab	Chemical process
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GB0428328D0 (en)	2004-12-24	2005-02-02	Astrazeneca Uk Ltd	Chemical process

2003
- 2003-12-09 MX MXPA05006425A patent/MXPA05006425A/es active IP Right Grant
- 2003-12-09 AU AU2003288443A patent/AU2003288443B2/en not_active Ceased
- 2003-12-09 EP EP03780362A patent/EP1578731B1/en not_active Expired - Lifetime
- 2003-12-09 ES ES03780362T patent/ES2335279T3/es not_active Expired - Lifetime
- 2003-12-09 CA CA2509344A patent/CA2509344C/en not_active Expired - Fee Related
- 2003-12-09 US US10/537,723 patent/US7524955B2/en not_active Expired - Fee Related
- 2003-12-09 JP JP2005502458A patent/JP4579821B2/ja not_active Expired - Fee Related
- 2003-12-09 NZ NZ540722A patent/NZ540722A/en not_active IP Right Cessation
- 2003-12-09 KR KR1020057010964A patent/KR101060215B1/ko not_active IP Right Cessation
- 2003-12-09 EP EP09159247A patent/EP2088142A3/en not_active Ceased
- 2003-12-09 DK DK03780362.4T patent/DK1578731T3/da active
- 2003-12-09 SI SI200331722T patent/SI1578731T1/sl unknown
- 2003-12-09 BR BR0317313-5A patent/BR0317313A/pt not_active IP Right Cessation
- 2003-12-09 PT PT03780362T patent/PT1578731E/pt unknown
- 2003-12-09 WO PCT/GB2003/005359 patent/WO2004054986A2/en active Application Filing
- 2003-12-09 AT AT03780362T patent/ATE448209T1/de active
- 2003-12-09 DE DE60330050T patent/DE60330050D1/de not_active Expired - Lifetime
- 2003-12-10 AR ARP030104541A patent/AR042355A1/es unknown
- 2003-12-12 MY MYPI20034768A patent/MY138051A/en unknown
- 2003-12-16 TW TW092135557A patent/TWI322145B/zh not_active IP Right Cessation
2005
- 2005-05-30 IL IL168884A patent/IL168884A/en not_active IP Right Cessation
- 2005-06-08 NO NO20052781A patent/NO330983B1/no not_active IP Right Cessation
2006
- 2006-01-12 HK HK06100506.1A patent/HK1080477A1/xx not_active IP Right Cessation
2009
- 2009-03-16 US US12/404,575 patent/US8273878B2/en not_active Expired - Fee Related
2010
- 2010-01-11 CY CY20101100025T patent/CY1110605T1/el unknown
- 2010-06-23 JP JP2010142779A patent/JP5318037B2/ja not_active Expired - Fee Related
2011
- 2011-03-10 NO NO20110366A patent/NO20110366L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2003288443A1 (en)	2004-07-09
JP2006515600A (ja)	2006-06-01
JP5318037B2 (ja)	2013-10-16
PT1578731E (pt)	2010-01-12
EP2088142A2 (en)	2009-08-12
MXPA05006425A (es)	2005-08-19
WO2004054986A8 (en)	2005-07-21
NO20052781L (no)	2005-07-07
EP1578731B1 (en)	2009-11-11
HK1080477A1 (en)	2006-04-28
US20060052604A1 (en)	2006-03-09
CA2509344C (en)	2011-10-04
MY138051A (en)	2009-04-30
NO20110366L (no)	2005-07-07
AU2003288443B2 (en)	2007-10-25
WO2004054986A3 (en)	2004-12-02
JP2010248222A (ja)	2010-11-04
KR20050085674A (ko)	2005-08-29
WO2004054986A2 (en)	2004-07-01
BR0317313A (pt)	2005-11-08
ATE448209T1 (de)	2009-11-15
TW200418809A (en)	2004-10-01
US20090264654A1 (en)	2009-10-22
US7524955B2 (en)	2009-04-28
NO330983B1 (no)	2011-08-29
IL168884A (en)	2011-01-31
TWI322145B (en)	2010-03-21
SI1578731T1 (sl)	2010-02-26
US8273878B2 (en)	2012-09-25
NZ540722A (en)	2008-03-28
JP4579821B2 (ja)	2010-11-10
EP1578731A2 (en)	2005-09-28
DE60330050D1 (de)	2009-12-24
AR042355A1 (es)	2005-06-15
KR101060215B1 (ko)	2011-08-29
EP2088142A3 (en)	2010-04-21
CA2509344A1 (en)	2004-07-01
ES2335279T3 (es)	2010-03-24
CY1110605T1 (el)	2015-04-29

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