[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DK141749B - Analogifremgangsmåde til fremstilling af pyridincarboxamidoethylbenzensulfonylurinstof-forbindelser. - Google Patents

Analogifremgangsmåde til fremstilling af pyridincarboxamidoethylbenzensulfonylurinstof-forbindelser. Download PDF

Info

Publication number
DK141749B
DK141749B DK210074AA DK210074A DK141749B DK 141749 B DK141749 B DK 141749B DK 210074A A DK210074A A DK 210074AA DK 210074 A DK210074 A DK 210074A DK 141749 B DK141749 B DK 141749B
Authority
DK
Denmark
Prior art keywords
compounds
prod
mol
urea
methoxynicotinamido
Prior art date
Application number
DK210074AA
Other languages
Danish (da)
English (en)
Other versions
DK141749C (fr
Inventor
Donald Ernest Kuhla
Reinhard Sarges
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK141749B publication Critical patent/DK141749B/da
Application granted granted Critical
Publication of DK141749C publication Critical patent/DK141749C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK210074AA 1973-05-04 1974-04-17 Analogifremgangsmåde til fremstilling af pyridincarboxamidoethylbenzensulfonylurinstof-forbindelser. DK141749B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35746673 1973-05-04
US357466A US3879403A (en) 1973-05-04 1973-05-04 Benzenesulfonylurea derivatives

Publications (2)

Publication Number Publication Date
DK141749B true DK141749B (da) 1980-06-09
DK141749C DK141749C (fr) 1980-10-27

Family

ID=23405725

Family Applications (1)

Application Number Title Priority Date Filing Date
DK210074AA DK141749B (da) 1973-05-04 1974-04-17 Analogifremgangsmåde til fremstilling af pyridincarboxamidoethylbenzensulfonylurinstof-forbindelser.

Country Status (27)

Country Link
US (1) US3879403A (fr)
JP (1) JPS5839829B2 (fr)
AR (1) AR202815A1 (fr)
AT (1) AT342615B (fr)
AU (1) AU460423B2 (fr)
BE (1) BE813807A (fr)
BG (1) BG25080A3 (fr)
CA (1) CA1010042A (fr)
CH (1) CH582675A5 (fr)
CS (1) CS191232B2 (fr)
DD (1) DD111679A5 (fr)
DE (1) DE2419198C3 (fr)
DK (1) DK141749B (fr)
ES (1) ES425343A1 (fr)
FI (1) FI55498C (fr)
FR (1) FR2227865B1 (fr)
GB (1) GB1450801A (fr)
HU (1) HU166760B (fr)
IE (1) IE39116B1 (fr)
IL (1) IL44570A (fr)
LU (1) LU69889A1 (fr)
NL (1) NL171053C (fr)
PL (1) PL96708B1 (fr)
RO (2) RO69254A (fr)
SE (1) SE389866B (fr)
SU (1) SU632300A3 (fr)
YU (1) YU106174A (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2706977A1 (de) * 1977-02-18 1978-08-24 Hoechst Ag Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung
DE2720926C2 (de) * 1977-05-10 1983-02-17 Hoechst Ag, 6000 Frankfurt Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DK455480A (da) * 1979-11-30 1981-05-31 Du Pont Fremgangsmaade til fremstilling af herbicide n- (substituerede heterocycliske aminocarbonyl)-aromatiske sulfonamider
US4716231A (en) * 1987-04-27 1987-12-29 Pfizer Inc. Chlorination of 2-methoxynicotinic acid
JPH042618U (fr) * 1990-04-25 1992-01-10
BRPI0608383B1 (pt) * 2005-04-21 2015-12-29 Ishihara Sangyo Kaisha método para produzir um derivado de ácido nicotínico ou um seu sal
JP5148836B2 (ja) * 2005-04-21 2013-02-20 石原産業株式会社 ニコチン酸誘導体又はその塩の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031088A (en) * 1964-04-16 1966-05-25 Hoechst Ag Benzenesulphonyl-ureas and process for their manufacture

Also Published As

Publication number Publication date
CH582675A5 (fr) 1976-12-15
BE813807A (fr) 1974-10-17
FI55498C (fi) 1979-08-10
NL171053C (nl) 1983-02-01
DK141749C (fr) 1980-10-27
AT342615B (de) 1978-04-10
DE2419198B2 (de) 1980-04-10
YU106174A (en) 1982-02-28
SU632300A3 (ru) 1978-11-05
AU460423B2 (en) 1975-04-07
SE389866B (sv) 1976-11-22
JPS5839829B2 (ja) 1983-09-01
AU6759874A (en)
FR2227865B1 (fr) 1977-08-19
FI55498B (fi) 1979-04-30
ES425343A1 (es) 1976-06-01
AR202815A1 (es) 1975-07-24
PL96708B1 (pl) 1978-01-31
LU69889A1 (fr) 1974-11-21
NL7405187A (fr) 1974-11-06
NL171053B (nl) 1982-09-01
IE39116L (en) 1974-11-04
HU166760B (fr) 1975-05-28
DD111679A5 (fr) 1975-03-05
DE2419198A1 (de) 1974-11-14
IL44570A0 (en) 1974-06-30
GB1450801A (en) 1976-09-29
RO64480A (fr) 1979-05-15
JPS5013379A (fr) 1975-02-12
FR2227865A1 (fr) 1974-11-29
IE39116B1 (en) 1978-08-02
RO69254A (fr) 1982-09-09
BG25080A3 (en) 1978-07-12
ATA316874A (de) 1977-08-15
US3879403A (en) 1975-04-22
DE2419198C3 (de) 1980-12-11
CS191232B2 (en) 1979-06-29
IL44570A (en) 1977-01-31
CA1010042A (en) 1977-05-10

Similar Documents

Publication Publication Date Title
US4379785A (en) Heterocyclic substituted sulfonyl ureas, and their use
RU2074179C1 (ru) Производные индола, способы их получения и фармацевтическая композиция
HU218788B (hu) 3,4,5-Szubsztituált benzoil-guanidin-származékok, az ezeket tartalmazó gyógyászati készítmények és eljárás előállításukra
NO170883B (no) Fremgangsmaate for fremstilling av 2-amino-5-hydroksy-4-metylpyrimidin-derivater
EP0288973B1 (fr) Dérivés de benzothiazolinone, leur préparation et composition pharmaceutique
JP4323803B2 (ja) 置換２−アニリノーベンゾイミダゾール及びｎｈｅ阻害剤としてのその使用
US3998828A (en) 4-[2-(1,3-Dialkyl-1,2,3,4-tetra-hydropyrimidine-2,4-dione-5-carboxamido)ethyl]-1-piperidine sulfonamide
DK141749B (da) Analogifremgangsmåde til fremstilling af pyridincarboxamidoethylbenzensulfonylurinstof-forbindelser.
DE1518874A1 (de) Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
KR100352899B1 (ko) 새로운3-페닐설포닐-3,7-디아자바이사이클로[3,3,1]노난-화합물을함유하는약제
US3829434A (en) Piperidinesulfonylurea derivatives
EP0073507B1 (fr) Sulfonylurées, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur application
US3961065A (en) Benzenesulfonylurea derivatives
CZ43596A3 (en) Substituted benzenesulfonyl ureas and benzenesulfonylthioureas, process of their preparation and use of pharmaceutical preparations based on said compounds, as well as medicaments containing thereof
US4539402A (en) Quinazolinone derivatives
US3944524A (en) 4-Substituted-1-piperidinesulfonamides
US3987172A (en) Piperidinesulfonylurea derivatives
US4379153A (en) Benzenesulfonyl ureas, and pharmaceutical preparations
US3914426A (en) Piperidinesulfonylurea derivatives for lowering blood sugar levels
EP0006587B1 (fr) Sulfonyl-urées, procédés pour leur préparation et compositions pharmaceutiques à base de ces composés
US3936455A (en) Piperidinesulfonylurea derivatives
DK146064B (da) Analogifremgangsmaade til fremstilling af 2,3-polymethylen-5-sulfamoylbenzoesyrer eller basesalte eller estere deraf
EP0016635B1 (fr) Méthyl-3 oxo-4-pipéridinothiazolidine-5N-ylidène-2 acétates d'alcoyle, leur préparation et produits pharmaceutiques les contenant
DK152361B (da) Analogifremgangsmaade til fremstilling af n-(4-pyrazolidinyl)-benzamider
NO140820B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive sulfonylurinstoffderivater

Legal Events

Date Code Title Description
PBP Patent lapsed