DK1023050T3 - Nye formuleringer af farmakologiske midler, fremgangsmåder til fremstillingen deraf og fremgangsmåder til anvendelsen deraf - Google Patents
Nye formuleringer af farmakologiske midler, fremgangsmåder til fremstillingen deraf og fremgangsmåder til anvendelsen derafInfo
- Publication number
- DK1023050T3 DK1023050T3 DK98932874.5T DK98932874T DK1023050T3 DK 1023050 T3 DK1023050 T3 DK 1023050T3 DK 98932874 T DK98932874 T DK 98932874T DK 1023050 T3 DK1023050 T3 DK 1023050T3
- Authority
- DK
- Denmark
- Prior art keywords
- procedures
- production
- pharmacological agents
- new formulations
- formulations
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5102197P | 1997-06-27 | 1997-06-27 | |
US08/926,155 US6096331A (en) | 1993-02-22 | 1997-09-09 | Methods and compositions useful for administration of chemotherapeutic agents |
PCT/US1998/013272 WO1999000113A1 (en) | 1997-06-27 | 1998-06-26 | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1023050T3 true DK1023050T3 (da) | 2013-10-14 |
Family
ID=26728969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98932874.5T DK1023050T3 (da) | 1997-06-27 | 1998-06-26 | Nye formuleringer af farmakologiske midler, fremgangsmåder til fremstillingen deraf og fremgangsmåder til anvendelsen deraf |
Country Status (19)
Country | Link |
---|---|
US (2) | US20080161382A1 (da) |
EP (1) | EP1023050B1 (da) |
JP (2) | JP4865937B2 (da) |
KR (3) | KR100789008B1 (da) |
CN (2) | CN100462066C (da) |
AU (1) | AU8266298A (da) |
BR (1) | BRPI9810945B8 (da) |
CA (1) | CA2294981C (da) |
DK (1) | DK1023050T3 (da) |
ES (1) | ES2435944T3 (da) |
HK (1) | HK1030543A1 (da) |
HU (1) | HU230338B1 (da) |
IL (2) | IL133672A0 (da) |
MX (1) | MX337149B (da) |
NO (2) | NO332166B1 (da) |
NZ (2) | NZ525580A (da) |
PT (1) | PT1023050E (da) |
SG (1) | SG113402A1 (da) |
WO (1) | WO1999000113A1 (da) |
Families Citing this family (143)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
US20070117863A1 (en) * | 1993-02-22 | 2007-05-24 | Desai Neil P | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US6537579B1 (en) * | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
US20070092563A1 (en) * | 1996-10-01 | 2007-04-26 | Abraxis Bioscience, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
HU230338B1 (hu) * | 1997-06-27 | 2016-02-29 | Abraxis Bioscience Llc | Gyógyászati hatóanyagokat tartalmazó új készítmények, eljárás ilyen készítmények előállítására és alkalmazására |
US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
US7314637B1 (en) | 1999-06-29 | 2008-01-01 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
US6040330A (en) * | 1999-01-08 | 2000-03-21 | Bionumerik Pharmaceuticals, Inc. | Pharmaceutical formulations of taxanes |
EP1178786A4 (en) * | 1999-05-21 | 2006-03-01 | American Bioscience Inc | PHARMACOLOGICALLY ACTIVE PROTEIN STABILIZING AGENTS; METHODS OF MANUFACTURE AND METHODS OF USE |
GB9920548D0 (en) * | 1999-08-31 | 1999-11-03 | Rhone Poulenc Rorer Sa | Treatment of hepatocellular carcinoma |
EP1267946A4 (en) | 2000-02-28 | 2008-07-02 | Genesegues Inc | SYSTEM AND METHOD FOR ENCAPSULATING NANOCAPSULES |
ITMI20001107A1 (it) * | 2000-05-18 | 2001-11-18 | Acs Dobfar Spa | Metodo per il trattamento di tumori solici mediante microparticelle di albumina incorporanti paclitaxel |
MXPA03005655A (es) | 2000-12-21 | 2004-12-03 | Nektar Therapeutics | Liberacion pulmonar de agentes antifungicos de polieno. |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
KR100426636B1 (ko) * | 2001-05-18 | 2004-04-08 | 한국과학기술연구원 | 주사 가능한 젤 상의 조성물 및 그의 제조방법 |
BR0212833A (pt) | 2001-09-26 | 2004-10-13 | Baxter Int | Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
US20030087837A1 (en) | 2001-10-15 | 2003-05-08 | Jonas Jeffrey M. | Compositions and methods for delivery of poorly water soluble drugs and methods of treatment |
ITMI20020681A1 (it) * | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina |
ITMI20020680A1 (it) * | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | Composizione antitumorale migliorata a base di paclitaxel e metodo per il suo ottenimento |
US20030207907A1 (en) | 2002-05-03 | 2003-11-06 | Iversen Patrick L. | Delivery of microparticle-conjugated drugs for inhibition of stenosis |
ITMI20021392A1 (it) * | 2002-06-25 | 2003-12-29 | Nicox Sa | Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita' |
ATE424187T1 (de) | 2002-07-15 | 2009-03-15 | Alcon Inc | Bioerodierbare folie zur abgabe eines ophthalmischen arzneimittels |
GB0216700D0 (en) | 2002-07-18 | 2002-08-28 | Astrazeneca Ab | Process |
IL150906A0 (en) * | 2002-07-25 | 2003-02-12 | Yissum Res Dev Co | Diagnostic microspheres |
DE10234784A1 (de) * | 2002-07-30 | 2004-02-19 | Günenthal GmbH | Intravenös applizierbare, pharmazeutische Darreichungsform |
US7838034B2 (en) | 2002-07-30 | 2010-11-23 | Grunenthal Gmbh | Intravenous pharmaceutical form of administration |
KR100871529B1 (ko) * | 2002-12-09 | 2008-12-05 | 치아-시앙 수 | 정맥내 주사용으로 적합한 피브리노겐 입자의 제조방법 |
TR200502189T1 (tr) * | 2002-12-09 | 2007-01-22 | American Bioscience, Inc. | Kompozisyonlar ve farmakolojik etken maddelerin aktarımı için yöntemler. |
CN1700906A (zh) | 2003-02-03 | 2005-11-23 | 新药物公司 | 稳定的无菌过滤性脂质体包封的紫杉烷和其他抗肿瘤药物 |
GB0302673D0 (en) | 2003-02-06 | 2003-03-12 | Astrazeneca Ab | Pharmaceutical formulations |
CN1303994C (zh) * | 2003-03-03 | 2007-03-14 | 浙江海正药业股份有限公司 | 紫杉醇囊泡注射剂及其制备方法 |
US8476010B2 (en) | 2003-07-10 | 2013-07-02 | App Pharmaceuticals Llc | Propofol formulations with non-reactive container closures |
ATE493116T1 (de) | 2004-01-21 | 2011-01-15 | Univ London Pharmacy | Verfahren zur herstellung von mikroteilchen |
KR100578382B1 (ko) | 2004-07-16 | 2006-05-11 | 나재운 | 항암제의 전달체용 수용성 키토산 나노입자 및 그 제조방법 |
US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
JP5769358B2 (ja) | 2005-02-18 | 2015-08-26 | アブラクシス バイオサイエンス, エルエルシー | 治療薬の組み合わせおよび投与の様式ならびに併用療法 |
WO2007000842A1 (ja) * | 2005-06-29 | 2007-01-04 | Mitsubishi Chemical Corporation | 粒状物分散組成物及びその製造方法、並びに、粒状物及び医薬品 |
HUE042678T2 (hu) | 2005-08-31 | 2019-07-29 | Abraxis Bioscience Llc | Vízben rosszul oldódó gyógyszerhatóanyagok és antimikrobiális szerek |
BRPI0615292A8 (pt) * | 2005-08-31 | 2018-03-06 | Abraxis Bioscience Llc | composições e métodos para preparação de fármacos de má solubilidade em água com estabilidade aumentada |
JP2009509675A (ja) * | 2005-09-30 | 2009-03-12 | Tti・エルビュー株式会社 | 新規薬学的ビヒクルを用いる経皮薬剤送達システム、装置、及び方法 |
BRPI0617663A2 (pt) * | 2005-10-21 | 2011-08-02 | Panacea Biotec Ltd | composições aperfeiçoadas para terapia de cáncer |
EP2029640A4 (en) * | 2006-06-08 | 2010-04-28 | 3M Innovative Properties Co | POLYMER BALLS AND METHODS OF MAKING POLYMER BALLS |
CA2664641A1 (en) | 2006-09-26 | 2008-04-10 | Astellas Pharma, Inc. | Controlled release dosage form of tacrolimus |
CN101605535A (zh) | 2006-12-14 | 2009-12-16 | 阿布拉科斯生物科学有限公司 | 用包含紫杉烷的纳米颗粒基于激素受体状态治疗乳腺癌 |
CA2674039A1 (en) | 2006-12-28 | 2008-07-17 | Astellas Pharma Inc. | Sustained release formulation for tacrolimus |
JP2010520289A (ja) | 2007-03-07 | 2010-06-10 | アブラクシス バイオサイエンス, エルエルシー | 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子 |
US20100166869A1 (en) | 2007-05-03 | 2010-07-01 | Desai Neil P | Methods and compositions for treating pulmonary hypertension |
PL2155188T3 (pl) | 2007-06-01 | 2014-03-31 | Abraxis Bioscience Llc | Sposoby i kompozycje do leczenia nawrotowego raka |
CA2713813C (en) * | 2008-01-30 | 2017-12-05 | University Of Kansas | Intralymphatic chemotherapy drug carriers |
EP2259798B1 (en) | 2008-03-05 | 2013-12-11 | Baxter International Inc. | Surface-modified particles and methods for targeted drug delivery |
KR20150136137A (ko) * | 2008-04-10 | 2015-12-04 | 아브락시스 바이오사이언스, 엘엘씨 | 소수성 탁산 유도체의 조성물 및 그의 용도 |
WO2009126401A1 (en) * | 2008-04-10 | 2009-10-15 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
EP3266453A1 (en) | 2008-07-03 | 2018-01-10 | Mayo Foundation for Medical Education and Research | Treating cancer |
KR101043407B1 (ko) * | 2009-02-19 | 2011-06-22 | 한국과학기술연구원 | 암 표적성이 우수한 단백질 복합체 및 이의 제조방법 |
KR101066197B1 (ko) | 2009-04-06 | 2011-09-20 | 한국생명공학연구원 | 코엔자임 q10 나노입자, 그 제조방법 및 상기 나노입자를 포함하는 조성물 |
MX2011010673A (es) * | 2009-04-10 | 2012-02-21 | Abraxis Bioscience Llc | Formulaciones de nanoparticulas y usos de las mismas. |
WO2010121000A1 (en) * | 2009-04-15 | 2010-10-21 | Abraxis Bioscience, Llc | Prion-free nanoparticle compositions and methods |
WO2011025838A1 (en) * | 2009-08-25 | 2011-03-03 | Abraxis Bioscience, Llc | Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors |
JP4856752B2 (ja) * | 2009-11-30 | 2012-01-18 | ホソカワミクロン株式会社 | 薬物含有ナノ粒子の製造方法 |
BR112012014962A2 (pt) * | 2009-12-18 | 2016-04-05 | Exodos Life Sciences Ltd Partnership | métodos e composições para formulações líquidas e estáveis de fármacos |
CA2788663C (en) * | 2010-02-03 | 2018-05-01 | Oncbiomune, L.L.C. | Taxane- and taxoid-protein compositions |
EP2552438B1 (en) | 2010-03-26 | 2016-05-11 | Abraxis BioScience, LLC | Methods of treatment of hepatocellular carcinoma |
NZ602635A (en) | 2010-03-29 | 2014-12-24 | Abraxis Bioscience Llc | Methods of enhancing drug delivery and effectiveness of therapeutic agents |
SG184160A1 (en) | 2010-03-29 | 2012-10-30 | Abraxis Bioscience Llc | Methods of treating cancer |
AU2011248449B2 (en) | 2010-05-03 | 2016-09-15 | Teikoku Pharma Usa, Inc. | Non-aqueous taxane pro-emulsion formulations and methods of making and using the same |
SG186112A1 (en) | 2010-06-04 | 2013-01-30 | Abraxis Bioscience Llc | Methods of treatment of pancreatic cancer |
MY166014A (en) * | 2010-06-07 | 2018-05-21 | Abraxis Bioscience Llc | Combination therapy methods for treating proliferative diseases |
KR101007948B1 (ko) | 2010-08-13 | 2011-01-14 | 김지훈 | 스팀을 이용한 고무 블록의 성형 방법 |
US9782342B2 (en) | 2010-10-11 | 2017-10-10 | Wichita State University | Composite magnetic nanoparticle drug delivery system |
CN102670518B (zh) * | 2011-03-14 | 2014-08-20 | 齐鲁制药有限公司 | 一种难溶性药物球形颗粒的制备方法 |
EP2694056B1 (en) | 2011-04-01 | 2019-10-16 | AstraZeneca AB | Therapeutic treatment |
WO2012154861A2 (en) | 2011-05-09 | 2012-11-15 | Mayo Foundation For Medical Education And Research | Cancer treatments |
RU2640485C2 (ru) | 2011-11-30 | 2018-01-09 | Астразенека Аб | Комбинированное лечение рака |
KR20140107417A (ko) | 2011-12-14 | 2014-09-04 | 아브락시스 바이오사이언스, 엘엘씨 | 입자의 동결건조 또는 동결을 위한 중합체 부형제의 용도 |
WO2013115559A1 (ko) * | 2012-01-30 | 2013-08-08 | 성균관대학교 산학협력단 | 수난용성 약물을 내부에 포함하는 알부민 나노입자 제조방법 |
CA2869460C (en) | 2012-04-04 | 2018-05-15 | Halozyme, Inc. | Combination therapy with an anti-hyaluronan agent and a tumor-targeted taxane |
AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
EP3967306A1 (en) | 2012-10-01 | 2022-03-16 | Mayo Foundation for Medical Education and Research | Cancer treatments |
JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
US20150352050A1 (en) * | 2012-11-15 | 2015-12-10 | Utah-Inha Dds & Advanced Therapeutics Research Center | Biodegradable microbeads with improved anticancer drug adsorptivity, containing albumin and dextran sulfate, and preparation method therefor |
CN104994841B (zh) | 2012-11-27 | 2018-11-16 | 犹他-仁荷Dds及新医疗技术开发共同研究所 | 包含阴离子性高分子的抗癌药吸附能力得到提高的生物降解性微珠及其的制备方法 |
CN103908432B (zh) * | 2013-01-02 | 2018-09-21 | 博瑞生物医药(苏州)股份有限公司 | 一种伊沙匹隆白蛋白的冻干组合物及其制备方法 |
US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
MX362905B (es) | 2013-03-04 | 2019-02-25 | Astrazeneca Ab | Tratamiento de combinacion. |
CN105228612A (zh) * | 2013-03-12 | 2016-01-06 | 阿布拉科斯生物科学有限公司 | 治疗肺癌的方法 |
US9962373B2 (en) | 2013-03-14 | 2018-05-08 | Abraxis Bioscience, Llc | Methods of treating bladder cancer |
KR101329646B1 (ko) * | 2013-05-02 | 2013-11-14 | 주식회사 지니스 | 표적지향증폭형 항암나노입자 및 이의 제조방법 |
IL228528A (en) | 2013-09-17 | 2015-01-29 | Technion Res & Dev Foundation | Potato-based nanoparticles |
WO2015051349A1 (en) * | 2013-10-04 | 2015-04-09 | Sorrento Therapeutics, Inc. | Treating metastatic cancer with micellular paclitaxel |
CN104758942A (zh) * | 2014-01-02 | 2015-07-08 | 国家纳米科学中心 | 基于蛋白质的药理活性物质组合物及其制备方法和应用 |
WO2015152433A1 (en) * | 2014-03-31 | 2015-10-08 | Hanmi Pharm. Co., Ltd. | Amorphous solid dispersion comprising paclitaxel, tablet comprising the same, and method for preparing the same |
WO2015187194A1 (en) * | 2014-06-01 | 2015-12-10 | Crititech, Inc. | Use of paclitaxel particles |
US20150352176A1 (en) * | 2014-06-06 | 2015-12-10 | Newport Research, Inc. | Oil-free and fat-free aqueous suspensions of cyclosporin |
EA201692502A1 (ru) | 2014-06-16 | 2017-09-29 | Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Рисерч | Лечение миелом |
US10987308B2 (en) | 2014-09-03 | 2021-04-27 | Genesegues, Inc. | Therapeutic nanoparticles and related compositions, methods and systems |
US9446148B2 (en) | 2014-10-06 | 2016-09-20 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
US20200237859A1 (en) | 2019-01-25 | 2020-07-30 | Newport Research, Inc. | Aqueous suspensions of cyclosporin |
US11324800B2 (en) | 2015-01-15 | 2022-05-10 | Wellspring Ophthalmics, Inc. | Aqueous suspensions of cyclosporin |
US10527604B1 (en) | 2015-03-05 | 2020-01-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel |
US10705070B1 (en) | 2015-03-05 | 2020-07-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug |
JP6892394B2 (ja) | 2015-06-04 | 2021-06-23 | クリティテック・インコーポレイテッド | ノズルアセンブリおよび使用法 |
DK3313401T3 (da) | 2015-06-29 | 2021-11-15 | Abraxis Bioscience Llc | Nanopartikler omfattende sirolimus og albumin til anvendelse i behandling af epithelioide celletumorer |
TW201707725A (zh) | 2015-08-18 | 2017-03-01 | 美國馬友醫藥教育研究基金會 | 載體-抗體組合物及其製造及使用方法 |
JP6856631B2 (ja) | 2015-09-16 | 2021-04-07 | ディーエフビー ソリア リミテッド ライアビリティ カンパニー | 薬物ナノ粒子の送達およびその使用法 |
TW201713360A (en) | 2015-10-06 | 2017-04-16 | Mayo Foundation | Methods of treating cancer using compositions of antibodies and carrier proteins |
CN105412024B (zh) * | 2015-12-14 | 2018-03-30 | 广州帝奇医药技术有限公司 | 靶向疏水性抗肿瘤药物纳米制剂及其制备方法 |
WO2017120501A1 (en) | 2016-01-07 | 2017-07-13 | Mayo Foundation For Medical Education And Research | Methods of treating cancer with interferon |
JP6953414B2 (ja) * | 2016-01-20 | 2021-10-27 | フラリー パウダーズ エルエルシーFlurry Powders,Llc | 親油性成分を含む吸入に好適な分散性の噴霧乾燥粉末を製造する方法 |
US11833118B2 (en) | 2016-01-20 | 2023-12-05 | Flurry Powders, Llc | Encapsulation of lipophilic ingredients in dispersible spray dried powders suitable for inhalation |
WO2017139698A1 (en) | 2016-02-12 | 2017-08-17 | Mayo Foundation For Medical Education And Research | Hematologic cancer treatments |
CA3018340A1 (en) | 2016-03-21 | 2017-09-28 | Mayo Foundation For Medical Education And Research | Methods for improving the therapeutic index for a chemotherapeutic drug |
AU2017238119A1 (en) | 2016-03-21 | 2018-10-11 | Mayo Foundation For Medical Education And Research | Methods for reducing toxicity of a chemotherapeutic drug |
KR102490665B1 (ko) | 2016-04-04 | 2023-01-27 | 크리티테크, 인크. | 고형 종양의 치료 방법 |
US10618969B2 (en) | 2016-04-06 | 2020-04-14 | Mayo Foundation For Medical Education And Research | Carrier-binding agent compositions and methods of making and using the same |
CN105944109B (zh) * | 2016-05-03 | 2019-06-11 | 四川大学 | 一种肾小球靶向的蛋白纳米颗粒药物组合物及其用途 |
CN110461311A (zh) * | 2016-08-26 | 2019-11-15 | 奥野哲治 | 微细纳米化药剂及其应用 |
CA3035378A1 (en) | 2016-09-01 | 2018-03-08 | Mayo Foundation For Medical Education And Research | Carrier-pd-l1 binding agent compositions for treating cancers |
KR20190053203A (ko) | 2016-09-01 | 2019-05-17 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | T-세포 암을 표적화하는 방법 및 조성물 |
KR102486055B1 (ko) | 2016-09-06 | 2023-01-09 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 파클리탁셀-알부민-결합제 조성물 및 그의 사용 및 제조 방법 |
EP3509635A1 (en) | 2016-09-06 | 2019-07-17 | Vavotar Life Sciences LLC | Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins |
CN109843924A (zh) | 2016-09-06 | 2019-06-04 | 梅约医学教育与研究基金会 | 治疗表达pd-l1的癌症的方法 |
MA46474A (fr) * | 2016-10-10 | 2019-08-14 | Abraxis Bioscience Llc | Formulations nanoparticulaires et leurs procédés de production et d'utilisation |
CA3056395C (en) | 2017-03-15 | 2022-06-28 | Dfb Soria, Llc | Topical therapy for the treatment of skin malignancies using nanoparticles of taxanes |
AU2018279634A1 (en) | 2017-06-09 | 2019-10-31 | Crititech, Inc. | Treatment of epithelial cysts by intracystic injection of antineoplastic particles |
AU2018284247B2 (en) | 2017-06-14 | 2020-04-30 | Crititech Inc. | Methods for treating lung disorders |
WO2019010316A1 (en) * | 2017-07-07 | 2019-01-10 | Dfb Pharmaceuticals, Llc | TREATMENT OF HYPERPLASIC TISSUE GROWTH COMPRISING BENIGN PROSTATIC HYPERPLASIA (HBP) BY DIRECT INJECTION OF ANTINOPLASTIC AGENT |
CN107510600A (zh) * | 2017-08-07 | 2017-12-26 | 苏州大学 | 一种制备药用固体微粒的设备及方法 |
RU2020110399A (ru) | 2017-10-03 | 2021-11-09 | Крититек, Инк. | Местная доставка противоопухолевых частиц в комбинации с системной доставкой иммунотерапевтических агентов для лечения рака |
EP3755148A4 (en) | 2018-02-23 | 2021-12-15 | RHNanoPharma | SALSALATE NANOSUSPENSIONS AND THEIR PROCESSES FOR USE |
CN112165949A (zh) | 2018-03-16 | 2021-01-01 | Dfb索里亚有限责任公司 | 使用紫杉烷纳米颗粒治疗宫颈上皮内瘤变(cin)和宫颈癌的局部疗法 |
SG11202009145PA (en) | 2018-03-20 | 2020-10-29 | Abraxis Bioscience Llc | Methods of treating central nervous system disorders via administration of nanoparticles of an mtor inhibitor and an albumin |
WO2019207060A1 (en) * | 2018-04-25 | 2019-10-31 | Ethris Gmbh | Lipid-based formulations for the delivery of rna |
WO2019222435A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
WO2020249825A1 (en) * | 2019-06-14 | 2020-12-17 | Folium Biosciences Europe B.V. | Method for micro-encapsulation of natural ingredients by means of contacting with supercritical gas |
CA3158764A1 (en) | 2019-10-28 | 2021-05-06 | Abraxis Bioscience, Llc | Pharmaceutical compositions of albumin and rapamycin |
WO2023063796A1 (ko) * | 2021-10-14 | 2023-04-20 | 주식회사 스카이테라퓨틱스 | 유기물, 무기물 또는 이들의 염으로 이루어진 나노 분자 회합체 및 그의 제조방법 |
WO2023194441A1 (en) | 2022-04-05 | 2023-10-12 | Istituto Nazionale Tumori Irccs - Fondazione G. Pascale | Combination of hdac inhibitors and statins for use in the treatment of pancreatic cancer |
KR102683810B1 (ko) * | 2024-03-26 | 2024-07-11 | 큐어라벨 주식회사 | 글루타치온, 아스코빅애씨드 및 항산화 활성을 가지는 유용성 생리활성물질을 포함하는 나노 입자의 제조방법 및 이를 함유하는 화장료 조성물 |
Family Cites Families (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2660556A (en) * | 1952-09-08 | 1953-11-24 | Donald G Butler | Electric arc production of combustible gases |
US3536074A (en) * | 1968-03-29 | 1970-10-27 | Alfred Aufhauser | Oral administration of a pill,tablet or capsule |
US3959457A (en) * | 1970-06-05 | 1976-05-25 | Temple University | Microparticulate material and method of making such material |
US4073943A (en) * | 1974-09-11 | 1978-02-14 | Apoteksvarucentralen Vitrum Ab | Method of enhancing the administration of pharmalogically active agents |
US4107288A (en) * | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
DK143689C (da) * | 1975-03-20 | 1982-03-15 | J Kreuter | Fremgangsmaade til fremstilling af en adsorberet vaccine |
CA1077842A (en) * | 1975-10-09 | 1980-05-20 | Minnesota Mining And Manufacturing Company | Albumin medicament carrier system |
US4357259A (en) * | 1977-08-01 | 1982-11-02 | Northwestern University | Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres |
US4329332A (en) * | 1978-07-19 | 1982-05-11 | Patrick Couvreur | Biodegradable submicroscopic particles containing a biologically active substance and compositions containing them |
US4344934A (en) * | 1978-11-20 | 1982-08-17 | American Home Products Corporation | Therapeutic compositions with enhanced bioavailability |
DE3013839A1 (de) * | 1979-04-13 | 1980-10-30 | Freunt Ind Co Ltd | Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung |
US4247406A (en) * | 1979-04-23 | 1981-01-27 | Widder Kenneth J | Intravascularly-administrable, magnetically-localizable biodegradable carrier |
DE3119383A1 (de) * | 1981-05-15 | 1982-12-02 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten |
US4572203A (en) * | 1983-01-27 | 1986-02-25 | Feinstein Steven B | Contact agents for ultrasonic imaging |
US4622219A (en) * | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
US4818542A (en) * | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
US4671954A (en) * | 1983-12-13 | 1987-06-09 | University Of Florida | Microspheres for incorporation of therapeutic substances and methods of preparation thereof |
US4963367A (en) * | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
US4914084A (en) * | 1984-05-09 | 1990-04-03 | Synthetic Blood Corporation | Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body |
US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
US4752567A (en) * | 1984-06-21 | 1988-06-21 | Janssen Pharmaceutica N.V. | Method of visualizing individual submicroscopic metal particles |
AU5356986A (en) * | 1984-12-14 | 1986-07-22 | Gergely, Gerhard | Teilchen aus euner hydrophoben oder schwerloslichen substanz und verfahren zur ihrer hydrophilisierung |
GB8601100D0 (en) * | 1986-01-17 | 1986-02-19 | Cosmas Damian Ltd | Drug delivery system |
JPS63502117A (ja) * | 1986-02-10 | 1988-08-18 | リポソ−ム テクノロジ−,インコ−ポレイテッド | 放出を制御されたリポソ−ム供給系 |
US4966773A (en) * | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
CA1338736C (fr) * | 1986-12-05 | 1996-11-26 | Roger Baurain | Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation |
FR2608942B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules |
FR2608988B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
FR2634397B2 (fr) * | 1986-12-31 | 1991-04-19 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules |
US4861579A (en) * | 1988-03-17 | 1989-08-29 | American Cyanamid Company | Suppression of B-lymphocytes in mammals by administration of anti-B-lymphocyte antibodies |
US4929446A (en) * | 1988-04-19 | 1990-05-29 | American Cyanamid Company | Unit dosage form |
US5041292A (en) * | 1988-08-31 | 1991-08-20 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
US4957656A (en) * | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
US5114703A (en) * | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
JP2642486B2 (ja) * | 1989-08-04 | 1997-08-20 | 田辺製薬株式会社 | 難溶性薬物の超微粒子化法 |
US5079018A (en) * | 1989-08-14 | 1992-01-07 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
US5188837A (en) * | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
CA2013485C (en) * | 1990-03-06 | 1997-04-22 | John Michael Gardlik | Solid consumer product compositions containing small particle cyclodextrin complexes |
US5091187A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US5441739A (en) * | 1990-06-22 | 1995-08-15 | The Regents Of The University Of California | Reduced and controlled surface binding of biologically active molecules |
US5059699A (en) * | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
DK0504340T3 (da) * | 1990-10-05 | 1995-08-21 | Bracco Int Bv | Fremgangsmåde til fremstilling af stabile suspensioner af hule gasfyldte mikrokugler egnet til ultralyd-ekkografi |
US20030087985A1 (en) * | 1990-10-15 | 2003-05-08 | Hubbell Jeffrey A. | Gels for encapsulation of biological materials |
DK0495187T3 (da) * | 1991-01-15 | 1997-08-11 | Hemosphere Inc | Protein-nanomatricer og fremstillingsmetode. |
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
US5399363A (en) * | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
AU642066B2 (en) * | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
US5143716A (en) * | 1991-02-01 | 1992-09-01 | Unger Evan C | Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region |
JPH06511481A (ja) * | 1991-07-05 | 1994-12-22 | ユニバーシティ オブ ロチェスター | 気泡を取り込む超微小非凝集多孔質粒子 |
US5250236A (en) * | 1991-08-05 | 1993-10-05 | Gasco Maria R | Method for producing solid lipid microspheres having a narrow size distribution |
US5233995A (en) * | 1991-11-21 | 1993-08-10 | Sterling Winthrop Inc. | Encapsulated particles useful as contrast agents in ultrasound and x-ray imaging compositions and methods |
DK0706373T3 (da) * | 1992-03-23 | 2000-09-18 | Univ Georgetown | Liposomindkapslet taxol og en fremgangsmåde til anvendelse heraf |
US5334640A (en) * | 1992-04-08 | 1994-08-02 | Clover Consolidated, Ltd. | Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods |
WO1993024476A1 (en) * | 1992-06-04 | 1993-12-09 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
FR2692168B1 (fr) * | 1992-06-16 | 1995-03-24 | Centre Nat Rech Scient | Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères. |
DE4220624A1 (de) * | 1992-06-24 | 1994-01-05 | Zahnradfabrik Friedrichshafen | Drehschieberventil, insbesondere für Hilfskraftlenkungen |
ZA935111B (en) * | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
CA2086874E (en) * | 1992-08-03 | 2000-01-04 | Renzo Mauro Canetta | Methods for administration of taxol |
US20070117863A1 (en) * | 1993-02-22 | 2007-05-24 | Desai Neil P | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US5665382A (en) * | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of pharmaceutically active agents for in vivo delivery |
ES2219646T5 (es) * | 1993-02-22 | 2008-11-01 | Abraxis Bioscience, Inc. | Metodos para la administracion in vivo de compuestos biologicos y composiciones utiles para los mismos. |
US5916596A (en) * | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
US5362478A (en) * | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
US5650156A (en) * | 1993-02-22 | 1997-07-22 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of nutriceuticals and compositions useful therefor |
US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
US5665383A (en) * | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of immunostimulating agents for in vivo delivery |
US5554730A (en) * | 1993-03-09 | 1996-09-10 | Middlesex Sciences, Inc. | Method and kit for making a polysaccharide-protein conjugate |
DE69435120D1 (de) * | 1993-05-13 | 2008-09-04 | Poniard Pharmaceuticals Inc | Ein Inhibitor für glatte Gefässmuskelzellen für therapeutische Nutzung |
US5886026A (en) * | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
US5543158A (en) * | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
ES2255477T5 (es) * | 1993-07-29 | 2010-04-08 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Uso de paclitaxel y sus derivados en la fabricacion de un medicamento para el tratamiento de reestenosis. |
US5415869A (en) * | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
DE699079T1 (de) * | 1994-03-07 | 1997-09-25 | Dendritech Inc | Bioaktive und/oder gezielte dendrimere-konjugate |
US5565478A (en) * | 1994-03-14 | 1996-10-15 | The United States Of America As Represented By The Department Of Health & Human Services | Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs |
FR2718963B1 (fr) * | 1994-04-25 | 1996-05-24 | Rhone Poulenc Rorer Sa | Nouvelle composition pharmaceutique à base de taxoïdes. |
ES2078190B1 (es) * | 1994-05-20 | 1996-08-01 | Cusi Lab | Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico. |
US5616330A (en) * | 1994-07-19 | 1997-04-01 | Hemagen/Pfc | Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same |
US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
US5534270A (en) * | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
US5510118A (en) * | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
US5565188A (en) * | 1995-02-24 | 1996-10-15 | Nanosystems L.L.C. | Polyalkylene block copolymers as surface modifiers for nanoparticles |
US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
AU6104896A (en) * | 1995-06-07 | 1996-12-30 | Regents Of The University Of California, The | Therapeutic microdevices and methods of making and using sam e |
KR0180334B1 (ko) * | 1995-09-21 | 1999-03-20 | 김윤 | 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 |
US5637625A (en) * | 1996-03-19 | 1997-06-10 | Research Triangle Pharmaceuticals Ltd. | Propofol microdroplet formulations |
CN1148957A (zh) * | 1996-09-02 | 1997-05-07 | 张海茹 | 紫杉醇水溶性粉针剂及其制备方法 |
US20070092563A1 (en) * | 1996-10-01 | 2007-04-26 | Abraxis Bioscience, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
HU230338B1 (hu) * | 1997-06-27 | 2016-02-29 | Abraxis Bioscience Llc | Gyógyászati hatóanyagokat tartalmazó új készítmények, eljárás ilyen készítmények előállítására és alkalmazására |
US8853260B2 (en) * | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
CA2369740A1 (en) * | 1999-04-22 | 2000-11-02 | American Biosciences, Inc. | Long term administration of pharmacologically active agents |
ITMI20020681A1 (it) * | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina |
ITMI20020680A1 (it) * | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | Composizione antitumorale migliorata a base di paclitaxel e metodo per il suo ottenimento |
TR200502189T1 (tr) * | 2002-12-09 | 2007-01-22 | American Bioscience, Inc. | Kompozisyonlar ve farmakolojik etken maddelerin aktarımı için yöntemler. |
US8420603B2 (en) * | 2004-05-14 | 2013-04-16 | Abraxis Bioscience, Llc | SPARC and methods of use thereof |
US20070166388A1 (en) * | 2005-02-18 | 2007-07-19 | Desai Neil P | Combinations and modes of administration of therapeutic agents and combination therapy |
JP5769358B2 (ja) * | 2005-02-18 | 2015-08-26 | アブラクシス バイオサイエンス, エルエルシー | 治療薬の組み合わせおよび投与の様式ならびに併用療法 |
BRPI0615292A8 (pt) * | 2005-08-31 | 2018-03-06 | Abraxis Bioscience Llc | composições e métodos para preparação de fármacos de má solubilidade em água com estabilidade aumentada |
HUE042678T2 (hu) * | 2005-08-31 | 2019-07-29 | Abraxis Bioscience Llc | Vízben rosszul oldódó gyógyszerhatóanyagok és antimikrobiális szerek |
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1998
- 1998-06-26 HU HU0003972A patent/HU230338B1/hu unknown
- 1998-06-26 MX MX2012014591A patent/MX337149B/es unknown
- 1998-06-26 NZ NZ525580A patent/NZ525580A/en not_active IP Right Cessation
- 1998-06-26 KR KR1019997012361A patent/KR100789008B1/ko not_active IP Right Cessation
- 1998-06-26 KR KR1020057006157A patent/KR100904931B1/ko not_active IP Right Cessation
- 1998-06-26 CA CA2294981A patent/CA2294981C/en not_active Expired - Lifetime
- 1998-06-26 CN CNB98808225XA patent/CN100462066C/zh not_active Expired - Lifetime
- 1998-06-26 NZ NZ502500A patent/NZ502500A/en not_active IP Right Cessation
- 1998-06-26 EP EP98932874.5A patent/EP1023050B1/en not_active Expired - Lifetime
- 1998-06-26 IL IL13367298A patent/IL133672A0/xx unknown
- 1998-06-26 JP JP50574999A patent/JP4865937B2/ja not_active Expired - Lifetime
- 1998-06-26 WO PCT/US1998/013272 patent/WO1999000113A1/en active Application Filing
- 1998-06-26 KR KR1020077019451A patent/KR100923172B1/ko not_active IP Right Cessation
- 1998-06-26 PT PT98932874T patent/PT1023050E/pt unknown
- 1998-06-26 AU AU82662/98A patent/AU8266298A/en not_active Abandoned
- 1998-06-26 SG SG200200079A patent/SG113402A1/en unknown
- 1998-06-26 DK DK98932874.5T patent/DK1023050T3/da active
- 1998-06-26 CN CNB200310121217XA patent/CN100525748C/zh not_active Expired - Lifetime
- 1998-06-26 BR BRPI9810945A patent/BRPI9810945B8/pt not_active IP Right Cessation
- 1998-06-26 ES ES98932874T patent/ES2435944T3/es not_active Expired - Lifetime
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1999
- 1999-12-23 NO NO19996433A patent/NO332166B1/no not_active IP Right Cessation
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2001
- 2001-02-02 HK HK01100752.7A patent/HK1030543A1/xx not_active IP Right Cessation
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2007
- 2007-08-03 US US11/890,197 patent/US20080161382A1/en not_active Abandoned
- 2007-08-06 US US11/890,599 patent/US20080160095A1/en not_active Abandoned
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2011
- 2011-06-15 JP JP2011132758A patent/JP5405527B2/ja not_active Expired - Lifetime
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2012
- 2012-03-22 NO NO20120338A patent/NO340319B1/no not_active IP Right Cessation
- 2012-09-20 IL IL222002A patent/IL222002B/en not_active IP Right Cessation
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