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DK0828736T3 - Substituerede sulfonylphenylheterocycler som cyclooxygenase-2- og 5-lipoxygenase-inhibitorer - Google Patents

Substituerede sulfonylphenylheterocycler som cyclooxygenase-2- og 5-lipoxygenase-inhibitorer

Info

Publication number
DK0828736T3
DK0828736T3 DK96917888T DK96917888T DK0828736T3 DK 0828736 T3 DK0828736 T3 DK 0828736T3 DK 96917888 T DK96917888 T DK 96917888T DK 96917888 T DK96917888 T DK 96917888T DK 0828736 T3 DK0828736 T3 DK 0828736T3
Authority
DK
Denmark
Prior art keywords
cyclooxygenase
heterocycles
lipoxygenase inhibitors
sulfonylphenyl
substituted
Prior art date
Application number
DK96917888T
Other languages
English (en)
Inventor
John J Talley
Jeffery S Carter
James A Sikorski
David L Brown
Srinivasan Nagarajan
Matthew J Graneto
Balekudru Devadas
Bryan H Norman
Roland S Rogers
Hwang-Fun Lu
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23828245&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0828736(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0828736T3 publication Critical patent/DK0828736T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK96917888T 1995-06-02 1996-05-31 Substituerede sulfonylphenylheterocycler som cyclooxygenase-2- og 5-lipoxygenase-inhibitorer DK0828736T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/460,324 US5643933A (en) 1995-06-02 1995-06-02 Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
PCT/US1996/008183 WO1996038442A1 (en) 1995-06-02 1996-05-31 Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors

Publications (1)

Publication Number Publication Date
DK0828736T3 true DK0828736T3 (da) 2003-11-24

Family

ID=23828245

Family Applications (2)

Application Number Title Priority Date Filing Date
DK96917888T DK0828736T3 (da) 1995-06-02 1996-05-31 Substituerede sulfonylphenylheterocycler som cyclooxygenase-2- og 5-lipoxygenase-inhibitorer
DK00100201T DK0995747T3 (da) 1995-06-02 1996-05-31 Substituterede sulfonylphenylheterocykler som cyclooxygenase-2- og 5-lipoxygenase-inhibitorer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK00100201T DK0995747T3 (da) 1995-06-02 1996-05-31 Substituterede sulfonylphenylheterocykler som cyclooxygenase-2- og 5-lipoxygenase-inhibitorer

Country Status (10)

Country Link
US (1) US5643933A (da)
EP (2) EP0995747B1 (da)
AT (2) ATE221885T1 (da)
AU (1) AU6027996A (da)
CA (1) CA2223091A1 (da)
DE (2) DE69622894T2 (da)
DK (2) DK0828736T3 (da)
ES (2) ES2205035T3 (da)
PT (2) PT995747E (da)
WO (1) WO1996038442A1 (da)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633272A (en) * 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
US6512121B2 (en) 1998-09-14 2003-01-28 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
WO1996038418A1 (en) 1995-06-02 1996-12-05 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
DK0888127T3 (da) 1996-02-13 2002-04-08 Searle & Co Kombinationer med immunoundertrykkende virkninger indeholdende cyclooxygenase-2-inhibitorer og 5-lipooxygenaseinhibitortorer
US5908858A (en) 1996-04-05 1999-06-01 Sankyo Company, Limited 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
US6677364B2 (en) * 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
EA003754B1 (ru) * 1996-08-14 2003-08-28 Джи. Ди. Сирл Энд Ко. 4-[5-метил-3-фенилизоксазол-4-ил] бензолсульфонамид
FR2753449B1 (fr) * 1996-09-13 1998-12-04 Union Pharma Scient Appl Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique
DK0971714T3 (da) * 1997-04-03 2002-11-04 Searle & Co Metode til anvendelse af cyklooxygenase-2-inhibitorer til behandling og forebyggelse af demens
EA199900837A1 (ru) * 1997-04-18 2000-10-30 Дж.Д.Сирл Энд Ко. Способ применения ингибиторов циклооксигеназы-2 для предупреждения сердечно-сосудистых расстройств
US6127545A (en) * 1997-04-18 2000-10-03 Merck & Co., Inc. Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors
US6130334A (en) * 1998-04-15 2000-10-10 Merck & Co., Inc. Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors
TW492959B (en) * 1997-04-18 2002-07-01 Merck & Co Inc Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors
FR2769311B1 (fr) * 1997-10-07 1999-12-24 Union Pharma Scient Appl Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique
US7041694B1 (en) 1997-12-17 2006-05-09 Cornell Research Foundation, Inc. Cyclooxygenase-2 inhibition
AU4428899A (en) 1998-06-08 1999-12-30 Advanced Medicine, Inc. Multibinding inhibitors of cyclooxygenase-2
TW477789B (en) 1998-09-03 2002-03-01 Japan Tobacco Inc Production method of oxazole compound
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
ES2159479B1 (es) * 1999-10-25 2002-05-01 Menarini Lab Nuevos indazoles como inhibidores de la ciclooxigenasa-ii
CZ20013162A3 (cs) * 1999-12-08 2002-06-12 Pharmacia Corporation Prostředky obsahující inhibitor cyklooxygenasy-2 mající rychlý nástup terapeutického účinku
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
MY137736A (en) 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
US20050101563A1 (en) * 2001-08-14 2005-05-12 Pharmacia Corporation Method and compositions for the treatment and prevention of pain and inflammation
US20030114416A1 (en) * 2001-08-14 2003-06-19 Pharmacia Corporation Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
US20030212138A1 (en) * 2002-01-14 2003-11-13 Pharmacia Corporation Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor
US20030220374A1 (en) * 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
US20040006100A1 (en) * 2002-04-18 2004-01-08 Stephenson Diane T. Monotherapy for the treatment of parkinson's disease with cyclooxygenase-2 (COX 2) inhibitor(S)
BR0309259A (pt) * 2002-04-18 2005-02-09 Pharmacia Corp Terapia combinada para o tratamento de doença de parkinson com inibidores de ciclooxigenase-2 (cox 2)
US7670769B2 (en) 2002-05-09 2010-03-02 The Brigham And Women's Hospital, Inc. IL1RL-1 as a cardiovascular disease marker and therapeutic target
IL165355A0 (en) * 2002-05-24 2006-01-15 Pharmacia Corp Synthesis of diaryl pyrazoles
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
SI1572173T1 (sl) 2002-12-13 2010-08-31 Warner Lambert Co Alfa-2-delta ligand za zdravljenje simptomov spodnjega dela sečil
US20040204411A1 (en) * 2002-12-17 2004-10-14 Pharmacia Corporation Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
US20040235925A1 (en) * 2002-12-17 2004-11-25 Pharmacia Corporation Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
DK1534305T3 (da) * 2003-05-07 2007-02-05 Osteologix As Behandling af brusk-/knoglelidelser med vandoplöselige strontiumsalte
PL2266584T3 (pl) * 2003-05-07 2013-02-28 Osteologix As Kompozycja ze strontem i witaminą D do profilaktyki i/lub leczenia chorób chrząstki i/lub kości
ES2567135T3 (es) 2003-08-29 2016-04-20 The Brigham And Women's Hospital, Inc. Derivados de hidantoína como inhibidores de necrosis celular
US7781219B2 (en) 2003-12-05 2010-08-24 The Cleveland Clinic Foundation Risk markers for cardiovascular disease
EP1708718A1 (en) 2004-01-22 2006-10-11 Pfizer Limited Triazole derivatives which inhibit vasopressin antagonistic activity
DK1809759T3 (da) 2004-10-06 2014-01-06 Brigham & Womens Hospital Relevans af opnåede niveauer af markører for systemisk inflammation efter behandling
US8119358B2 (en) * 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
WO2007056497A1 (en) * 2005-11-07 2007-05-18 Irm Llc Compounds and compositions as ppar modulators
CA2680413C (en) 2006-03-15 2020-06-09 The Brigham And Women's Hospital, Inc. Use of gelsolin to diagnose and treat rheumatoid arthritis
WO2007146229A2 (en) 2006-06-07 2007-12-21 Tethys Bioscience, Inc. Markers associated with arteriovascular events and methods of use thereof
US8128460B2 (en) * 2006-09-14 2012-03-06 The Material Works, Ltd. Method of producing rust inhibitive sheet metal through scale removal with a slurry blasting descaling cell
US20080153888A1 (en) 2006-12-22 2008-06-26 Recordati Ireland Limited Alpha-2-delta ligand/nsaid therapeutic treatment of lower urinary tract disorders
WO2008091530A2 (en) * 2007-01-19 2008-07-31 Mallinckrodt Inc. Diagnostic and therapeutic cyclooxygenase-2 binding ligands
WO2008131224A2 (en) 2007-04-18 2008-10-30 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
US8247423B2 (en) 2007-07-12 2012-08-21 Tragara Pharmaceuticals, Inc. Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
GB2462022B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof
WO2011094730A2 (en) 2010-02-01 2011-08-04 The Hospital For Sick Children Remote ischemic conditioning for treatment and reventon of restenosis
US20110240043A1 (en) 2010-03-31 2011-10-06 The Hospital For Sick Children Use of remote ischemic conditioning to improve outcome after myocardial infarction
DK2705365T3 (da) * 2011-01-14 2016-10-24 Hal Allergy Holding B V Immunoassay til direkte bestemmelse af antigenindhold i produkter indeholdende adjuvans-koblede antigenpartikler
CN107674071B (zh) 2012-05-11 2021-12-31 同步制药公司 作为隐花色素调节剂的含有咔唑的磺酰胺类
CN102839200B (zh) * 2012-05-25 2015-03-18 杭州师范大学 酶催化合成2,4,5-三取代的咪唑环类衍生物的方法
KR20150042269A (ko) 2012-08-16 2015-04-20 얀센 파마슈티카 엔.브이. N형 칼슘 채널 차단제로서의 치환된 피라졸
ES2926662T3 (es) 2012-08-21 2022-10-27 Janssen Pharmaceutica Nv Anticuerpos contra haptenos de risperidona y uso de los mismos
WO2014031630A2 (en) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc Antibodies to paliperidone and use thereof
JP6571532B2 (ja) 2013-02-20 2019-09-04 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ アントラニルアミド化合物、それらの混合物およびそれらの殺有害生物剤としての使用
US9725452B2 (en) 2013-03-15 2017-08-08 Presidents And Fellows Of Harvard College Substituted indoles and pyrroles as RIP kinase inhibitors
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
EP3852732A1 (en) 2018-09-19 2021-07-28 ModernaTX, Inc. Peg lipids and uses thereof
EP3853305B1 (en) 2018-09-19 2024-10-02 ModernaTX, Inc. High-purity peg lipids and uses thereof
CA3209491A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242940A (en) * 1987-05-29 1993-09-07 Ortho Pharmaceutical Corporation Pharmacologically active N-1 and C-5 heterocyclic pyrazoles and method for synthesizing the same
US5234950A (en) * 1988-12-23 1993-08-10 Imperial Chemical Industries Plc Tetrahydrofuran derivatives
GB8927287D0 (en) * 1988-12-23 1990-01-31 Ici Plc Cyclic ether derivatives
US5196419A (en) * 1989-02-28 1993-03-23 Imperial Chemical Industries Plc Heterocyclic cyclic ethers
US5234939A (en) * 1990-03-27 1993-08-10 Warner-Lambert Company 3,5-di-tertiary-butyl-4-hydroxyphenyl imidazolyl methanones and related compounds as antiinflammatory agents
AU637500B2 (en) * 1990-06-21 1993-05-27 Zeneca Limited Bicyclic heterocyclic compounds
DE69117355T2 (de) * 1990-06-21 1996-08-08 Zeneca Ltd Bizyklische Pyran-Derivate und ihre Verwendung als 5-Lipoxygenasehemmer
GB9113137D0 (en) * 1990-07-13 1991-08-07 Ici Plc Thioxo heterocycles
IE913655A1 (en) * 1990-11-06 1992-05-22 Zeneca Ltd Synergistic agents
EP0569493A4 (en) * 1991-01-31 1993-11-24 Warner-Lambert Company Substituted 4,6-di-tertiary-butyl-5-hydroxy-pyrimidines
US5308852A (en) * 1992-06-29 1994-05-03 Merck Frosst Canada, Inc. Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
US5354865A (en) * 1992-09-10 1994-10-11 Abbott Laboratories Phenylmethyl derivatives having lipoxygenase inhibitory activity
US5604260A (en) * 1992-12-11 1997-02-18 Merck Frosst Canada Inc. 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
JP3137648B2 (ja) * 1993-01-15 2001-02-26 ジー．ディー．サール アンド カンパニー 抗炎症剤としての用途を有する３，４−ジアリールチオフェンおよびその類似体
US5409944A (en) * 1993-03-12 1995-04-25 Merck Frosst Canada, Inc. Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
CA2161789A1 (en) * 1993-05-13 1994-11-24 Jacques Yves Gauthier 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5298521A (en) * 1993-08-30 1994-03-29 Ortho Pharmaceutical Corporation 1,5-diphenyl-3-pyrazolylalkyl-N-hydroxydithiocaramates, compositions and use
US5344991A (en) * 1993-10-29 1994-09-06 G.D. Searle & Co. 1,2 diarylcyclopentenyl compounds for the treatment of inflammation
US5401765A (en) * 1993-11-30 1995-03-28 G. D. Searle 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders
US5393790A (en) * 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation
WO1995030669A1 (en) * 1994-05-06 1995-11-16 Zeneca Limited Ether derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE221885T1 (de) 2002-08-15
EP0828736A1 (en) 1998-03-18
WO1996038442A1 (en) 1996-12-05
EP0995747B1 (en) 2002-08-07
EP0828736B1 (en) 2003-07-30
ES2205035T3 (es) 2004-05-01
DE69629290T2 (de) 2004-04-22
DK0995747T3 (da) 2002-11-25
AU6027996A (en) 1996-12-18
HK1027802A1 (en) 2001-01-23
PT995747E (pt) 2002-12-31
DE69622894D1 (de) 2002-09-12
PT828736E (pt) 2003-12-31
US5643933A (en) 1997-07-01
EP0995747A1 (en) 2000-04-26
DE69629290D1 (en) 2003-09-04
DE69622894T2 (de) 2003-04-30
CA2223091A1 (en) 1996-12-05
ES2181614T3 (es) 2003-03-01
ATE246188T1 (de) 2003-08-15

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