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DK0574571T3 - Farmaceutiske sammensætninger indeholdende polymerbundne anthracyclinglycosider og en fremgangsmåde til fremstilling deraf - Google Patents

Farmaceutiske sammensætninger indeholdende polymerbundne anthracyclinglycosider og en fremgangsmåde til fremstilling deraf

Info

Publication number
DK0574571T3
DK0574571T3 DK93902124T DK93902124T DK0574571T3 DK 0574571 T3 DK0574571 T3 DK 0574571T3 DK 93902124 T DK93902124 T DK 93902124T DK 93902124 T DK93902124 T DK 93902124T DK 0574571 T3 DK0574571 T3 DK 0574571T3
Authority
DK
Denmark
Prior art keywords
bound
preparation
pharmaceutical compositions
compositions containing
containing polymer
Prior art date
Application number
DK93902124T
Other languages
Danish (da)
English (en)
Inventor
Marco Adami
Roberto Magrini
Paolo Maranghi
Antonino Suarato
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Application granted granted Critical
Publication of DK0574571T3 publication Critical patent/DK0574571T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK93902124T 1992-01-07 1992-12-21 Farmaceutiske sammensætninger indeholdende polymerbundne anthracyclinglycosider og en fremgangsmåde til fremstilling deraf DK0574571T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929200247A GB9200247D0 (en) 1992-01-07 1992-01-07 Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation
PCT/EP1992/002968 WO1993013804A1 (en) 1992-01-07 1992-12-21 Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation

Publications (1)

Publication Number Publication Date
DK0574571T3 true DK0574571T3 (da) 1999-11-01

Family

ID=10708214

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93902124T DK0574571T3 (da) 1992-01-07 1992-12-21 Farmaceutiske sammensætninger indeholdende polymerbundne anthracyclinglycosider og en fremgangsmåde til fremstilling deraf

Country Status (22)

Country Link
US (1) US6245358B1 (ko)
EP (1) EP0574571B1 (ko)
JP (1) JPH06505755A (ko)
KR (1) KR100290222B1 (ko)
AT (1) ATE179618T1 (ko)
AU (1) AU666513B2 (ko)
CA (1) CA2105466A1 (ko)
DE (1) DE69229109T2 (ko)
DK (1) DK0574571T3 (ko)
ES (1) ES2133380T3 (ko)
FI (1) FI933853A0 (ko)
GB (1) GB9200247D0 (ko)
GR (1) GR3030633T3 (ko)
HU (2) HU217806B (ko)
IL (1) IL104256A (ko)
MX (1) MX9207605A (ko)
NZ (1) NZ246577A (ko)
RU (1) RU2118171C1 (ko)
TW (1) TW218847B (ko)
UA (1) UA32522C2 (ko)
WO (1) WO1993013804A1 (ko)
ZA (1) ZA9210049B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320781D0 (en) * 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
AU7124598A (en) * 1997-04-18 1998-11-13 Access Pharmaceuticals, Inc. Polymer-platinum compounds
US5965118A (en) * 1997-04-18 1999-10-12 Access Pharmaceuticals, Inc. Polymer-platinum compounds
US7314956B2 (en) 2001-08-08 2008-01-01 Vaxim, Inc. Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell
US20030124742A1 (en) * 2001-08-22 2003-07-03 Prakash Ramesh K. Conjugates targeted to target receptors
US20030125268A1 (en) * 2002-08-28 2003-07-03 Rybak Mary Ellen Margaret Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives
JP2006505579A (ja) * 2002-10-25 2006-02-16 ファイザー・プロダクツ・インク 懸濁形態でのアリール複素環活性薬物の蓄積製剤
AU2004206842A1 (en) * 2003-01-14 2004-08-05 Teva Pharmaceutical Industries, Ltd. Parenteral formulations of peptides for the treatment of systemic lupus erythematosus
JP2008513519A (ja) * 2005-05-11 2008-05-01 シコール インコーポレイティド 安定した凍結乾燥されたアントラサイクリングリコシド
US20100160442A1 (en) * 2006-07-18 2010-06-24 Ossovskaya Valeria S Formulations for cancer treatment
RU2481830C2 (ru) * 2007-01-16 2013-05-20 Бипар Сайенсиз, Инк. Лекарственные препараты для лечения рака
EP2316422A1 (en) * 2007-11-12 2011-05-04 Novartis AG Liquid compositions comprising valsartan
WO2009118754A2 (en) * 2008-03-28 2009-10-01 Astron Research Limited A process for preparing a stable lyophilized composition
EP2274017B1 (en) * 2008-04-30 2016-04-13 Ben Gurion University Of The Negev Research And Development Authority E-selectin specific vascular delivery systems
KR102239752B1 (ko) * 2019-12-11 2021-04-13 한국과학기술연구원 종양 특이적 약물복합체와 항pd-l1 항체를 유효성분으로 하는 암 예방 또는 치료를 위한 병용 투여용 약학 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS173846B1 (ko) * 1974-04-23 1977-03-31
US4460560A (en) * 1982-06-18 1984-07-17 University Of Southern California Drug delivery by polymeric carriers
FR2561916B1 (fr) * 1984-03-30 1987-12-11 Lafon Labor Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau
FR2583983B1 (fr) * 1985-06-07 1988-05-27 Centre Nat Rech Scient Nouvelles prodrogues macromoleculaires hydrosolubles, leur preparation et leur utilisation comme medicaments notamment antitumoraux et antiparasitaires
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US4968742A (en) * 1987-11-09 1990-11-06 Miles Inc. Preparation of ligand-polymer conjugate having a controlled number of introduced ligands
US5135736A (en) * 1988-08-15 1992-08-04 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
US5094848A (en) * 1989-06-30 1992-03-10 Neorx Corporation Cleavable diphosphate and amidated diphosphate linkers
US5079018A (en) * 1989-08-14 1992-01-07 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs

Also Published As

Publication number Publication date
IL104256A0 (en) 1993-05-13
IL104256A (en) 1997-02-18
JPH06505755A (ja) 1994-06-30
HU211636A9 (en) 1995-12-28
RU2118171C1 (ru) 1998-08-27
AU3346893A (en) 1993-08-03
EP0574571B1 (en) 1999-05-06
KR100290222B1 (ko) 2001-09-17
ZA9210049B (en) 1993-10-06
WO1993013804A1 (en) 1993-07-22
GB9200247D0 (en) 1992-02-26
MX9207605A (es) 1993-08-01
US6245358B1 (en) 2001-06-12
TW218847B (ko) 1994-01-11
FI933853A (fi) 1993-09-03
DE69229109T2 (de) 1999-08-26
HU217806B (hu) 2000-04-28
CA2105466A1 (en) 1993-07-08
ATE179618T1 (de) 1999-05-15
NZ246577A (en) 1996-03-26
DE69229109D1 (de) 1999-06-10
UA32522C2 (uk) 2001-02-15
HU9302517D0 (en) 1993-12-28
HUT74578A (en) 1997-01-28
EP0574571A1 (en) 1993-12-22
FI933853A0 (fi) 1993-09-03
AU666513B2 (en) 1996-02-15
GR3030633T3 (en) 1999-10-29
ES2133380T3 (es) 1999-09-16

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