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DE69916828D1 - Pyrazoline, ihre herstellung und verwendung als medikamente - Google Patents

Pyrazoline, ihre herstellung und verwendung als medikamente

Info

Publication number
DE69916828D1
DE69916828D1 DE69916828T DE69916828T DE69916828D1 DE 69916828 D1 DE69916828 D1 DE 69916828D1 DE 69916828 T DE69916828 T DE 69916828T DE 69916828 T DE69916828 T DE 69916828T DE 69916828 D1 DE69916828 D1 DE 69916828D1
Authority
DE
Germany
Prior art keywords
pyrazoline
medicine
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69916828T
Other languages
English (en)
Other versions
DE69916828T2 (de
Inventor
Maria Rosa Cuberes-Altisent
Juana Maria Berrocal-Romero
Maria Montser Contijoch-Llobet
Jordi Frigola-Constansa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of DE69916828D1 publication Critical patent/DE69916828D1/de
Application granted granted Critical
Publication of DE69916828T2 publication Critical patent/DE69916828T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69916828T 1998-05-29 1999-05-27 Pyrazoline, ihre herstellung und verwendung als medikamente Expired - Lifetime DE69916828T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES009801129A ES2137138B1 (es) 1998-05-29 1998-05-29 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
ES9801129 1998-05-29
PCT/ES1999/000156 WO1999062884A1 (es) 1998-05-29 1999-05-27 Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos

Publications (2)

Publication Number Publication Date
DE69916828D1 true DE69916828D1 (de) 2004-06-03
DE69916828T2 DE69916828T2 (de) 2005-04-14

Family

ID=8303969

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69916828T Expired - Lifetime DE69916828T2 (de) 1998-05-29 1999-05-27 Pyrazoline, ihre herstellung und verwendung als medikamente

Country Status (32)

Country Link
US (2) US6353117B1 (de)
EP (1) EP1083171B1 (de)
JP (1) JP4633928B2 (de)
KR (1) KR100603666B1 (de)
CN (1) CN1189459C (de)
AR (1) AR018402A1 (de)
AT (1) ATE265437T1 (de)
AU (1) AU752001B2 (de)
BG (1) BG64950B1 (de)
BR (1) BR9910801A (de)
CA (1) CA2333475C (de)
CO (1) CO5031241A1 (de)
CU (1) CU22995A3 (de)
CZ (1) CZ298391B6 (de)
DE (1) DE69916828T2 (de)
DK (1) DK1083171T3 (de)
ES (2) ES2137138B1 (de)
GE (1) GEP20043237B (de)
HU (1) HUP0102102A3 (de)
IS (1) IS2040B (de)
LT (1) LT4879B (de)
LV (1) LV12632B (de)
NO (1) NO316600B1 (de)
NZ (1) NZ508990A (de)
PL (1) PL344412A1 (de)
PT (1) PT1083171E (de)
RU (1) RU2233272C2 (de)
SI (1) SI20580B (de)
SK (1) SK285550B6 (de)
TW (1) TW572898B (de)
WO (1) WO1999062884A1 (de)
ZA (1) ZA200007638B (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2377153A1 (en) * 1999-06-16 2000-12-21 Temple University - Of The Commonwealth System Of Higher Education 1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines as inhibitors of cyclooxygenase-2
ES2174757B1 (es) * 2001-04-06 2003-11-01 Esteve Labor Dr Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares.
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US6878729B2 (en) 2001-05-04 2005-04-12 The Procter & Gamble Company Medicinal uses of dihydropyrazoles
ES2183720B1 (es) 2001-06-18 2004-01-16 Esteve Labor Dr Procedimiento para la preparacion de derivados de 1,5-diaril-3-trifluorometil-delta2-pirazolinas racemicas y enantiomericamente puras.
EP1745791B1 (de) 2003-05-07 2013-06-26 Osteologix A/S Behandlung von Knorpel/Knochen-Erkrankungen mit wasserlöslichen Strontiumsalzen
ES2238923B1 (es) * 2004-02-16 2006-11-01 Laboratorios Del Dr. Esteve, S.A. Nuevos derivados pirazolinicos sustituidos.
US7998996B2 (en) * 2004-02-17 2011-08-16 Laboratorios Del Dr. Esteve S.A. Substituted pyrazoline compounds for reducing triglycerides in blood
ES2257929B1 (es) * 2004-07-16 2007-05-01 Laboratorios Del Dr. Esteve, S.A. Derivados de pirazolina, procedimiento para su obtencion y utilizacion de los mismos como agentes terapeuticos.
ES2278503B1 (es) * 2005-06-27 2008-06-16 Laboratorios Del Dr. Esteve, S.A. Epoxidacion de cetonas alfa, beta - insaturadas.
WO2007009710A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds: methods for their preparation
EP1743636A1 (de) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Kombination eines substituierten Pyrazolins und eines bei Essstörungen verwendeten Mittels
ES2312286B1 (es) * 2005-07-15 2010-01-13 Laboratorios Del Dr. Esteve, S.A Uso de compuestos de pirazolina sustituidos para el tratamiento de los trastornos alimentarios que incluyen obesidad o sindrome metabolico en pacientes con una diabetes desarrollada.
EP1743892A1 (de) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Substituierte Pyrazolin Verbindungen, deren Herstellung und Verwendung als Medikament
EP1743643A1 (de) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Neue Darreichungsformen substituierter Pyrazolinverbindungen
WO2007009699A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases
EP1749526A1 (de) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Verwendung substituierter Pyrazolinderivate zur Behandlung von Nahrungsmittel bedingten Störungen, wie Obesitas oder des metabolischen Syndroms in Patienten mit fortgeschrittener Diabetis
EP1743642A1 (de) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Verwendung substituierter Pyrazolinverbindungen und ihrer Derivate zur Behandlung von Cannabinoidsystem-assoziierten Erkrankungen.
WO2007009704A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
WO2007009693A1 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr.Esteve, S.A Combination of a substituted pyrazoline compound and a drug used in food-related disorders
EP1757587A1 (de) * 2005-07-15 2007-02-28 Laboratorios Del Dr. Esteve, S.A. Substituierte Pyrazolinderivate, ihre Herstellung und Verwendung als Arzneimittel
ES2334967B1 (es) * 2005-07-15 2010-10-21 Laboratorios Del Dr. Esteve, S.A. Compuestos de pirazolina sustituidos, con una estereoquimica predeterminada, para la reduccion de trigliceridos en sangre.
EP1760078A1 (de) * 2005-07-15 2007-03-07 Laboratorios Del Dr. Esteve, S.A. Substituierte Pyrazoline und Verfahren zu ihrer Herstellung
EP1849784A1 (de) * 2006-04-26 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Indolin-substituierte Pyrazolinderivate, ihre Herstellung und Anwendung als Arzneimittel
ES2330993B1 (es) * 2005-07-15 2010-07-06 Laboratorios Del Dr. Esteve, S.A. Combinacion de antagonista del receptor de cannabinoides de tipo pirazolina y estatina.
WO2007009683A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr.Esteve, S.A. Pharmaceutical formulations of substituted pyrazoline compounds
EP1745781A1 (de) * 2005-07-15 2007-01-24 Laboratorios Del Dr. Esteve, S.A. Kombination von Cannabinoid Rezeptor Antagonist des Pyrazolin-Typs und Statin
ES2326724B1 (es) * 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Nuevas formulaciones de compuestos de pirazolina sustituidos.
ES2336883B1 (es) * 2005-07-15 2011-03-22 Laboratorios Del Dr. Esteve, S.A. Compuestos de pirazolina sustituidos, con una estereoquimica predeterminada, para la reduccion de trigliceridos en sangre.
EP1743638A1 (de) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Pharmazeutische Formulierungen von substituierten Pyrazolinderivaten
AR061623A1 (es) * 2006-06-26 2008-09-10 Novartis Ag Derivados de acido fenilacetico
CN101626787A (zh) * 2007-01-19 2010-01-13 马林克罗特公司 诊断的和治疗的环氧合酶-2结合配体
EP3009137A1 (de) * 2014-10-16 2016-04-20 Ecuphar N.V. Pyrazolinabgeleitete Verbindung und deren Verwendung in einem wöchentlichen Dosierungsschema gegen Entzündungen und Schmerzen aufgrund von degenerativen Gelenkerkrankungen bei Säugetieren
EP4029502A1 (de) 2021-01-15 2022-07-20 Ecuphar N.V. Pyrazolinabgeleitete verbindung (enflicoxib) zur verwendung bei der vorbeugung und/oder behandlung von schmerzen und entzündungen im zusammenhang mit chirurgie bei säugetieren
CA3209491A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2060660B (en) * 1979-10-18 1983-11-23 Bostik Ltd Adhesives containing pyrazoline activators
JPS5818363A (ja) * 1981-07-13 1983-02-02 アメリカン・サイアナミド・カンパニ− 複素環式置換アミノピラゾリン類およびその薬としての用途
AU598633B2 (en) * 1987-01-05 1990-06-28 E.I. Du Pont De Nemours And Company 1-sub-phenyl-3-sub-phenylamino(thio) carbonyl-pyrazolines as insecticides
NZ308875A (en) * 1995-05-25 1999-08-30 Searle & Co Method of preparing 3-haloalkyl-1h-pyrazoles
GB9520584D0 (en) * 1995-10-09 1995-12-13 Fujisawa Pharmaceutical Co Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
TW572898B (en) 2004-01-21
LV12632B (en) 2001-07-20
CU22995A3 (es) 2004-10-12
AR018402A1 (es) 2001-11-14
USRE38963E1 (en) 2006-01-31
NO20006029L (no) 2001-01-26
ES2137138A1 (es) 1999-12-01
CA2333475A1 (en) 1999-12-09
PT1083171E (pt) 2004-09-30
US6353117B1 (en) 2002-03-05
SI20580A (sl) 2001-12-31
CZ20004418A3 (en) 2001-06-13
SK18072000A3 (sk) 2001-07-10
ZA200007638B (en) 2001-11-13
IS2040B (is) 2005-08-15
WO1999062884A1 (es) 1999-12-09
BG64950B1 (bg) 2006-10-31
SK285550B6 (sk) 2007-03-01
EP1083171A1 (de) 2001-03-14
LV12632A (lv) 2001-03-20
CN1189459C (zh) 2005-02-16
KR100603666B1 (ko) 2006-07-24
IS5736A (is) 2000-11-28
CA2333475C (en) 2009-12-08
EP1083171B1 (de) 2004-04-28
DE69916828T2 (de) 2005-04-14
AU752001B2 (en) 2002-09-05
LT4879B (lt) 2002-01-25
NZ508990A (en) 2002-12-20
LT2000108A (en) 2001-09-25
ES2137138B1 (es) 2000-09-16
BR9910801A (pt) 2001-11-27
BG105005A (en) 2001-08-31
NO316600B1 (no) 2004-03-01
PL344412A1 (en) 2001-11-05
CO5031241A1 (es) 2001-04-27
HUP0102102A3 (en) 2002-06-28
HUP0102102A2 (hu) 2002-03-28
JP2002516908A (ja) 2002-06-11
NO20006029D0 (no) 2000-11-28
JP4633928B2 (ja) 2011-02-16
DK1083171T3 (da) 2004-08-09
CN1307566A (zh) 2001-08-08
CZ298391B6 (cs) 2007-09-19
KR20010052437A (ko) 2001-06-25
SI20580B (sl) 2007-10-31
GEP20043237B (en) 2004-05-25
RU2233272C2 (ru) 2004-07-27
ATE265437T1 (de) 2004-05-15
ES2221382T3 (es) 2004-12-16
AU3932999A (en) 1999-12-20

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