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DE69822814D1 - Zusammensetzung enthalten Cyclsoporin in einem hydrophilen Träger - Google Patents

Zusammensetzung enthalten Cyclsoporin in einem hydrophilen Träger

Info

Publication number
DE69822814D1
DE69822814D1 DE69822814T DE69822814T DE69822814D1 DE 69822814 D1 DE69822814 D1 DE 69822814D1 DE 69822814 T DE69822814 T DE 69822814T DE 69822814 T DE69822814 T DE 69822814T DE 69822814 D1 DE69822814 D1 DE 69822814D1
Authority
DE
Germany
Prior art keywords
propylene glycol
hydrophilic carrier
cyclsoporin
cyclosporin
composition contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69822814T
Other languages
English (en)
Other versions
DE69822814T2 (de
Inventor
Amarjit Singh
Rajesh Jain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panacea Biotec Ltd
Original Assignee
Panacea Biotec Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacea Biotec Ltd filed Critical Panacea Biotec Ltd
Publication of DE69822814D1 publication Critical patent/DE69822814D1/de
Application granted granted Critical
Publication of DE69822814T2 publication Critical patent/DE69822814T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69822814T 1998-08-18 1998-08-18 Zusammensetzung enthaltend Cyclosporin in einem hydrophilen Träger Expired - Lifetime DE69822814T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
RU98115892/14A RU2178293C2 (ru) 1998-08-18 1998-08-18 Фармацевтическая композиция, содержащая циклоспорин, способ получения мягких желатиновых капсул
EP98306607A EP0982035B1 (de) 1998-08-18 1998-08-18 Zusammensetzung enthalten Cyclsoporin in einem hydrophilen Träger
CNB981185851A CN1199642C (zh) 1998-08-18 1998-09-04 含环孢菌素的新型药物组合物
CA002249675A CA2249675A1 (en) 1998-08-18 1998-10-06 A novel composition containing cyclosporin

Publications (2)

Publication Number Publication Date
DE69822814D1 true DE69822814D1 (de) 2004-05-06
DE69822814T2 DE69822814T2 (de) 2005-01-27

Family

ID=31999277

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69822814T Expired - Lifetime DE69822814T2 (de) 1998-08-18 1998-08-18 Zusammensetzung enthaltend Cyclosporin in einem hydrophilen Träger
DE69921409T Expired - Lifetime DE69921409T2 (de) 1998-08-18 1999-08-16 Cyclosporin enthaltende Zusammensetzungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69921409T Expired - Lifetime DE69921409T2 (de) 1998-08-18 1999-08-16 Cyclosporin enthaltende Zusammensetzungen

Country Status (9)

Country Link
EP (2) EP0982035B1 (de)
CN (1) CN1199642C (de)
AT (1) ATE262916T1 (de)
CA (1) CA2249675A1 (de)
DE (2) DE69822814T2 (de)
DK (1) DK0982035T3 (de)
ES (1) ES2215277T3 (de)
PT (1) PT982035E (de)
RU (1) RU2178293C2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002531515A (ja) * 1998-12-11 2002-09-24 ファーマソリューションズ・インコーポレイテッド 水に難溶性の薬剤のための自己乳化組成物
DE60020727T2 (de) 1999-10-27 2006-05-04 Robert London Zhong Zusammensetzung zur vorbeugung und behandlung von transplantatabstossung
GB2362573A (en) * 2000-05-25 2001-11-28 Cipla Ltd Cyclosporin formulation
DE60018715T2 (de) * 2000-05-04 2006-04-27 Panacea Biotec Ltd. Pharmazeutische Zusammensetzung enthaltend Cyclosprin als aktiven Bestandteil
PT1333851E (pt) 2000-09-18 2007-11-26 Rpg Life Sciences Ltd Formulação auto-emulsionável que tem actividades de bioabsorção e de imunossupressão aumentadas
WO2002026245A2 (en) 2000-09-29 2002-04-04 Zhong Z Robert Use of serp-1 in combination with an immunosuppressant for influencing inflammatory and immune reactions
US7842791B2 (en) 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US7285530B2 (en) 2004-10-21 2007-10-23 Viron Therapeutics, Inc. Use of SERP-1 as an antiplatelet agent
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
WO2013168172A1 (en) * 2012-05-10 2013-11-14 Painreform Ltd. Depot formulations of a local anesthetic and methods for preparation thereof
CN103301068B (zh) * 2013-07-08 2014-09-10 广东彼迪药业有限公司 一种头孢克肟干混悬剂剂及其制备方法
CN103462914B (zh) * 2013-09-04 2015-12-09 南京正宽医药科技有限公司 一种头孢克肟片剂及其制备方法
CN111789943B (zh) * 2019-04-08 2024-01-19 洛阳赛威生物科技有限公司 一种水包油佐剂组合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
DE69435104D1 (de) * 1993-09-28 2008-07-31 Scherer Gmbh R P Herstellung von Weichgelatinekapseln
IT1277338B1 (it) * 1995-07-25 1997-11-10 Poli Ind Chimicia S P A Composizioni farmaceutiche di ciclosporina o altre sostanze peptidiche
GB2355195B (en) * 1997-01-30 2001-09-12 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A

Also Published As

Publication number Publication date
DE69921409D1 (de) 2004-12-02
ATE262916T1 (de) 2004-04-15
ES2215277T3 (es) 2004-10-01
EP0985412A3 (de) 2001-05-02
RU2178293C2 (ru) 2002-01-20
EP0985412B1 (de) 2004-10-27
CA2249675A1 (en) 2000-04-06
EP0982035A1 (de) 2000-03-01
CN1199642C (zh) 2005-05-04
EP0982035B1 (de) 2004-03-31
PT982035E (pt) 2004-08-31
EP0985412A2 (de) 2000-03-15
DK0982035T3 (da) 2004-06-28
CN1247060A (zh) 2000-03-15
DE69921409T2 (de) 2006-03-09
DE69822814T2 (de) 2005-01-27

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