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DE69430485D1 - Immobilisierte fehlpaarung - bildendes protein zur detektion oder reinigung von mutationen oder polymorphismen - Google Patents

Immobilisierte fehlpaarung - bildendes protein zur detektion oder reinigung von mutationen oder polymorphismen

Info

Publication number
DE69430485D1
DE69430485D1 DE69430485T DE69430485T DE69430485D1 DE 69430485 D1 DE69430485 D1 DE 69430485D1 DE 69430485 T DE69430485 T DE 69430485T DE 69430485 T DE69430485 T DE 69430485T DE 69430485 D1 DE69430485 D1 DE 69430485D1
Authority
DE
Germany
Prior art keywords
detecting
mutations
immobilized
base
misparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69430485T
Other languages
English (en)
Other versions
DE69430485T2 (de
Inventor
Robert E Wagner Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valigen US Inc
Original Assignee
Valigen US Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valigen US Inc filed Critical Valigen US Inc
Application granted granted Critical
Publication of DE69430485D1 publication Critical patent/DE69430485D1/de
Publication of DE69430485T2 publication Critical patent/DE69430485T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE69430485T 1993-11-04 1994-11-04 Immobilisierte fehlpaarung - bildendes protein zur detektion oder reinigung von mutationen oder polymorphismen Expired - Fee Related DE69430485T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/147,785 US6027877A (en) 1993-11-04 1993-11-04 Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, purification of amplified DNA samples and allele identification
PCT/US1994/012768 WO1995012689A1 (en) 1993-11-04 1994-11-04 Immobilized mismatch binding protein for detection or purification of mutations or polymorphisms

Publications (2)

Publication Number Publication Date
DE69430485D1 true DE69430485D1 (de) 2002-05-29
DE69430485T2 DE69430485T2 (de) 2002-12-19

Family

ID=22522893

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430485T Expired - Fee Related DE69430485T2 (de) 1993-11-04 1994-11-04 Immobilisierte fehlpaarung - bildendes protein zur detektion oder reinigung von mutationen oder polymorphismen

Country Status (8)

Country Link
US (2) US6027877A (de)
EP (1) EP0733126B1 (de)
JP (1) JPH09504699A (de)
AT (1) ATE216727T1 (de)
AU (1) AU700959B2 (de)
CA (1) CA2175222A1 (de)
DE (1) DE69430485T2 (de)
WO (1) WO1995012689A1 (de)

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US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5877280A (en) * 1995-06-06 1999-03-02 The Mount Sinai School Of Medicine Of The City University Of New York Thermostable muts proteins
ATE236270T1 (de) * 1995-12-15 2003-04-15 Univ Duke Verfahren zum nachweis und zur entfernung von mutantsequenzen, die während enzymatischer amplifikation entstehen
SE9602062D0 (sv) * 1996-05-29 1996-05-29 Pharmacia Biotech Ab Method for detection of mutations
DE19708758A1 (de) * 1997-03-04 1998-09-17 Christoph Prof Dr Wagener Verfahren zum Nachweis von mutierten Allelen
US6599704B2 (en) 1997-03-04 2003-07-29 Christoph Wagener Method for detecting mutated alleles
JP3318579B2 (ja) 1997-07-07 2002-08-26 理化学研究所 Ｄｎａの塩基配列決定方法
GB9724480D0 (en) * 1997-11-19 1998-01-14 Hexagen Technology Limited Screening process
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US6214552B1 (en) * 1998-09-17 2001-04-10 Igen International, Inc. Assays for measuring nucleic acid damaging activities
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
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US7122339B2 (en) 1998-10-09 2006-10-17 Medical Research Council Method for generating diversity
WO2000024939A1 (en) * 1998-10-27 2000-05-04 Affymetrix, Inc. Complexity management and analysis of genomic dna
US7166432B2 (en) 1999-03-12 2007-01-23 Integragen Compositions and methods for genetic analysis
DE19911130A1 (de) 1999-03-12 2000-09-21 Hager Joerg Verfahren zur Identifikation chromosomaler Regionen und Gene
EP1169473B1 (de) * 1999-04-14 2006-11-22 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Hochsensitiver nachweis von biomolekülen mittels "phage display"
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US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
WO2001062968A2 (en) * 2000-02-25 2001-08-30 General Atomics Mutant nucleic binding enzymes and use thereof in diagnostic, detection and purification methods
US6365355B1 (en) * 2000-03-28 2002-04-02 The Regents Of The University Of California Chimeric proteins for detection and quantitation of DNA mutations, DNA sequence variations, DNA damage and DNA mismatches
US6340566B1 (en) * 2000-03-28 2002-01-22 The Regents Of The University Of California Detection and quantitation of single nucleotide polymorphisms, DNA sequence variations, DNA mutations, DNA damage and DNA mismatches
ATE418733T1 (de) * 2000-05-04 2009-01-15 Blood Res Center Kolloidzusammensetzungen für festphasen- biomolekulare analytische systeme
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AU2003213696B2 (en) * 2002-02-28 2008-01-24 Wisconsin Alumni Research Foundation Method of error reduction in nucleic acid populations
US7998699B2 (en) 2002-08-15 2011-08-16 University Of South Florida Early detection of pathogens in blood
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
US7879580B2 (en) * 2002-12-10 2011-02-01 Massachusetts Institute Of Technology Methods for high fidelity production of long nucleic acid molecules
US7452699B2 (en) * 2003-01-15 2008-11-18 Dana-Farber Cancer Institute, Inc. Amplification of DNA in a hairpin structure, and applications
ATE430812T1 (de) * 2003-08-15 2009-05-15 Univ South Florida Materialien und verfahren zum einfangen von krankheitserregern und zur abtrennung von aurintricarbonsäure aus einer probe
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TW200525026A (en) 2003-12-25 2005-08-01 Riken Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same
EP1623996A1 (de) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verbessertes Verfahren zur Auswahl eines Proteins von einer Bibliothek
CA2578564C (en) * 2004-08-27 2013-05-28 Wisconsin Alumni Research Foundation Method of error reduction in nucleic acid populations
US20070269870A1 (en) * 2004-10-18 2007-11-22 George Church Methods for assembly of high fidelity synthetic polynucleotides
US20070122817A1 (en) * 2005-02-28 2007-05-31 George Church Methods for assembly of high fidelity synthetic polynucleotides
KR100681945B1 (ko) 2005-08-18 2007-02-12 학교법인 포항공과대학교 ＭｕｔＳ 돌연변이체-형광물질 결합체의 형광발광 변화를이용한 잘못 짝지어진 ＤＮＡ의 검출방법
US20070196834A1 (en) * 2005-09-09 2007-08-23 Francesco Cerrina Method and system for the generation of large double stranded DNA fragments
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US20070231805A1 (en) * 2006-03-31 2007-10-04 Baynes Brian M Nucleic acid assembly optimization using clamped mismatch binding proteins
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US5556750A (en) * 1989-05-12 1996-09-17 Duke University Methods and kits for fractionating a population of DNA molecules based on the presence or absence of a base-pair mismatch utilizing mismatch repair systems
ATE151114T1 (de) * 1991-07-19 1997-04-15 Upstate Biotech Inc Verfahren zum nachweis von mutationen
WO1993020233A1 (en) * 1992-03-27 1993-10-14 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
WO1993022457A1 (en) * 1992-04-24 1993-11-11 Massachusetts Institute Of Technology Screening for genetic variation

Also Published As

Publication number Publication date
AU1050895A (en) 1995-05-23
ATE216727T1 (de) 2002-05-15
EP0733126A4 (de) 1999-03-03
DE69430485T2 (de) 2002-12-19
CA2175222A1 (en) 1995-05-11
US6027877A (en) 2000-02-22
WO1995012689A1 (en) 1995-05-11
EP0733126B1 (de) 2002-04-24
JPH09504699A (ja) 1997-05-13
AU700959B2 (en) 1999-01-14
EP0733126A1 (de) 1996-09-25
US6114115A (en) 2000-09-05

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