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DE68918402D1 - 1,2,3,4-Tetrahydro-1,9-Acridindiamine, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. - Google Patents

1,2,3,4-Tetrahydro-1,9-Acridindiamine, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.

Info

Publication number
DE68918402D1
DE68918402D1 DE68918402T DE68918402T DE68918402D1 DE 68918402 D1 DE68918402 D1 DE 68918402D1 DE 68918402 T DE68918402 T DE 68918402T DE 68918402 T DE68918402 T DE 68918402T DE 68918402 D1 DE68918402 D1 DE 68918402D1
Authority
DE
Germany
Prior art keywords
arylloweralkyl
loweralkyl
preparation
chem
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68918402T
Other languages
English (en)
Other versions
DE68918402T2 (de
Inventor
Gregory Michael Shutske
Kevin James Kapples
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of DE68918402D1 publication Critical patent/DE68918402D1/de
Application granted granted Critical
Publication of DE68918402T2 publication Critical patent/DE68918402T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
DE68918402T 1988-11-09 1989-11-06 1,2,3,4-Tetrahydro-1,9-Acridindiamine, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. Expired - Fee Related DE68918402T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/269,038 US4868177A (en) 1988-11-09 1988-11-09 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use

Publications (2)

Publication Number Publication Date
DE68918402D1 true DE68918402D1 (de) 1994-10-27
DE68918402T2 DE68918402T2 (de) 1995-03-09

Family

ID=23025549

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918402T Expired - Fee Related DE68918402T2 (de) 1988-11-09 1989-11-06 1,2,3,4-Tetrahydro-1,9-Acridindiamine, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.

Country Status (18)

Country Link
US (1) US4868177A (de)
EP (1) EP0368188B1 (de)
JP (1) JPH03153667A (de)
KR (1) KR900007808A (de)
AT (1) ATE111899T1 (de)
AU (1) AU623701B2 (de)
CA (1) CA2002531A1 (de)
DE (1) DE68918402T2 (de)
DK (1) DK166620B1 (de)
ES (1) ES2059677T3 (de)
FI (1) FI895288A0 (de)
HU (1) HU208530B (de)
IE (1) IE64499B1 (de)
IL (1) IL92233A0 (de)
NO (1) NO894445L (de)
NZ (1) NZ231293A (de)
PT (1) PT92234B (de)
ZA (1) ZA898498B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85741A (en) * 1987-03-17 1996-05-14 Hoechst Roussel Pharma Transformed Tetra-Hydroacridines Process for their preparation and pharmaceutical preparations containing A-amino-Tetra-Transformed Hydroacridines
US6075144A (en) * 1987-04-20 2000-06-13 Hoechst Marion Roussel, Inc. 9-hydroxyamino tetrahydroacridine and related compounds
US4970316A (en) * 1987-05-07 1990-11-13 American Home Products Corporation Pyrano-, thiopyrano- and cyclohexylquinolines as inhibitors of interleukin 1
US5053513A (en) * 1990-03-29 1991-10-01 Hoechst-Roussel Pharmaceuticals Incorporated Method of reducing a carbonyl containing acridine
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5929093A (en) * 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
CN1768745A (zh) 1998-09-30 2006-05-10 武田药品工业株式会社 改善膀胱排泄能力的药物
AR047759A1 (es) 2003-09-26 2006-02-22 Vertex Pharma Derivados de fenil - piperazina como moduladores de receptores muscarnicos
WO2005072713A2 (en) 2004-01-27 2005-08-11 The Feinstein Institute For Medical Research Cholinesterase inhibitors for treating inflammation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
EP0268871A1 (de) * 1986-10-31 1988-06-01 Sumitomo Pharmaceuticals Company, Limited Chinolinderivate
IL85741A (en) * 1987-03-17 1996-05-14 Hoechst Roussel Pharma Transformed Tetra-Hydroacridines Process for their preparation and pharmaceutical preparations containing A-amino-Tetra-Transformed Hydroacridines
US5013741A (en) * 1987-09-08 1991-05-07 Hoechst-Roussel Pharmaceuticals Incorporated N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives

Also Published As

Publication number Publication date
ATE111899T1 (de) 1994-10-15
DK557189D0 (da) 1989-11-08
AU623701B2 (en) 1992-05-21
HU208530B (en) 1993-11-29
IE64499B1 (en) 1995-08-09
EP0368188A1 (de) 1990-05-16
DK166620B1 (da) 1993-06-21
FI895288A0 (fi) 1989-11-07
ZA898498B (en) 1990-08-29
NZ231293A (en) 1991-09-25
IL92233A0 (en) 1990-07-26
NO894445D0 (no) 1989-11-08
ES2059677T3 (es) 1994-11-16
HU895830D0 (en) 1990-01-28
IE893592L (en) 1990-05-09
CA2002531A1 (en) 1990-05-09
NO894445L (no) 1990-05-10
PT92234B (pt) 1995-07-06
PT92234A (pt) 1990-05-31
US4868177A (en) 1989-09-19
JPH03153667A (ja) 1991-07-01
DK557189A (da) 1990-05-30
EP0368188B1 (de) 1994-09-21
KR900007808A (ko) 1990-06-02
DE68918402T2 (de) 1995-03-09
AU4442389A (en) 1990-05-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee