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DE60302139D1 - Verfahren zur herstellung von aripiprazole - Google Patents

Verfahren zur herstellung von aripiprazole

Info

Publication number
DE60302139D1
DE60302139D1 DE60302139T DE60302139T DE60302139D1 DE 60302139 D1 DE60302139 D1 DE 60302139D1 DE 60302139 T DE60302139 T DE 60302139T DE 60302139 T DE60302139 T DE 60302139T DE 60302139 D1 DE60302139 D1 DE 60302139D1
Authority
DE
Germany
Prior art keywords
preparing aripiprazole
aripiprazole
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60302139T
Other languages
English (en)
Other versions
DE60302139T2 (de
DE60302139T3 (de
Inventor
Hisayuki Tsujimori
Tatsuya Yamaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32652780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60302139(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of DE60302139D1 publication Critical patent/DE60302139D1/de
Publication of DE60302139T2 publication Critical patent/DE60302139T2/de
Application granted granted Critical
Publication of DE60302139T3 publication Critical patent/DE60302139T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
DE60302139T 2003-01-09 2003-12-18 Verfahren zur herstellung von aripiprazole Expired - Lifetime DE60302139T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003002996 2003-01-09
JP2003002996 2003-01-09
PCT/JP2003/016256 WO2004063162A1 (en) 2003-01-09 2003-12-18 Process for preparing aripiprazole

Publications (3)

Publication Number Publication Date
DE60302139D1 true DE60302139D1 (de) 2005-12-08
DE60302139T2 DE60302139T2 (de) 2006-07-20
DE60302139T3 DE60302139T3 (de) 2011-02-24

Family

ID=32652780

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60302139T Expired - Lifetime DE60302139T3 (de) 2003-01-09 2003-12-18 Verfahren zur herstellung von aripiprazole

Country Status (20)

Country Link
US (1) US6995264B2 (de)
EP (1) EP1480953B2 (de)
JP (2) JP5797090B2 (de)
KR (1) KR100583667B1 (de)
CN (1) CN1263742C (de)
AR (1) AR042702A1 (de)
AT (1) ATE308524T1 (de)
AU (1) AU2003288755C1 (de)
BR (2) BR0305500A (de)
CA (2) CA2458929C (de)
DE (1) DE60302139T3 (de)
DK (1) DK1480953T4 (de)
EG (1) EG23557A (de)
ES (1) ES2250919T5 (de)
HK (1) HK1073110A1 (de)
MX (1) MXPA04002519A (de)
MY (1) MY129831A (de)
SI (1) SI1480953T2 (de)
TW (1) TWI258470B (de)
WO (1) WO2004063162A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7714129B2 (en) * 2003-12-16 2010-05-11 Teva Pharmaceutical Industries Ltd. Methods of preparing anhydrous aripiprazole form II
CA2550726A1 (en) * 2003-12-16 2005-06-30 Teva Pharmaceutical Industries Ltd. Methods of preparing aripiprazole crystalline forms
MXPA06008828A (es) * 2004-02-05 2007-04-25 Teva Pharma Proceso para preparar aripiprazol.
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
WO2006038220A1 (en) * 2004-10-08 2006-04-13 Suven Life Sciences Limited Novel intermediates useful for the preparation of aripiprazole and methods for the preparation of the novel intermediates and aripiprazole
US20060079689A1 (en) * 2004-10-12 2006-04-13 Vladimir Naddaka Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
CN101111481A (zh) * 2004-11-18 2008-01-23 斯索恩有限公司 制备结晶阿立哌唑的方法
CN1303068C (zh) * 2005-01-11 2007-03-07 中国人民解放军第二军医大学 一种阿立哌唑的制备方法
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
EP1933814A2 (de) 2005-09-15 2008-06-25 Elan Pharma International Limited Nanoteilchenförmige aripiprazol-formulierungen
WO2007075871A2 (en) * 2005-12-22 2007-07-05 Teva Pharmaceutical Industries Ltd. Processes for reducing particle size of aripiprazole
US20070149782A1 (en) * 2005-12-23 2007-06-28 Michael Brand Methods of preparing a crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1h)-quinolinone and the use thereof in the synthesis of Aripiprazole
DE602007001620D1 (de) * 2006-04-10 2009-09-03 Ranbaxy Lab Ltd Verbesserter Herstellungsprozess für Aripipirazol
MX2009012506A (es) 2007-05-21 2009-12-09 Reviva Pharmaceuticals Inc Composiciones, sintesis, y metodos para utilizar agentes antipsicoticos atipicos basados en quinolinona.
EP2299814A4 (de) 2008-05-27 2011-06-15 Reviva Pharmaceuticals Inc Zusammensetzungen, synthese und verfahren zur verwendung von antipsychotika auf piperazinbasis
CN101781246B (zh) * 2009-01-15 2012-02-29 成都康弘药业集团股份有限公司 一种合成阿立哌唑的改进方法
MX2011008885A (es) 2009-02-26 2011-09-29 Reviva Pharmaceuticals Inc Composiciones, sintesis y metodos para usar derivados de arilpiperazina.
JOP20200109A1 (ar) 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
US20180155290A1 (en) * 2015-05-08 2018-06-07 Davuluri Ramamohan Rao Improved Process for the Preparation of Aripiprazole with Reduced Particle Size

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE3034237A1 (de) 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JP2608788B2 (ja) * 1988-10-31 1997-05-14 大塚製薬 株式会社 精神分裂病治療剤
JP4060523B2 (ja) 1999-11-24 2008-03-12 大塚製薬株式会社 カルボスチリル誘導体の製造法
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma

Also Published As

Publication number Publication date
HK1073110A1 (en) 2005-09-23
SI1480953T1 (sl) 2006-04-30
KR20040093655A (ko) 2004-11-06
CA2676216A1 (en) 2004-07-09
EP1480953A1 (de) 2004-12-01
WO2004063162A1 (en) 2004-07-29
BR0305500A (pt) 2004-11-03
AU2003288755C1 (en) 2015-02-19
AU2003288755B2 (en) 2005-08-25
SI1480953T2 (sl) 2010-12-31
ATE308524T1 (de) 2005-11-15
DE60302139T2 (de) 2006-07-20
DE60302139T3 (de) 2011-02-24
AU2003288755A1 (en) 2004-08-10
KR100583667B1 (ko) 2006-05-26
CA2458929C (en) 2009-09-08
TW200418840A (en) 2004-10-01
CN1590377A (zh) 2005-03-09
US6995264B2 (en) 2006-02-07
JP5797090B2 (ja) 2015-10-21
CA2458929A1 (en) 2004-07-09
US20040192915A1 (en) 2004-09-30
AR042702A1 (es) 2005-06-29
ES2250919T3 (es) 2006-04-16
EP1480953B2 (de) 2010-08-18
MY129831A (en) 2007-05-31
EP1480953B1 (de) 2005-11-02
TWI258470B (en) 2006-07-21
EG23557A (en) 2006-06-05
DK1480953T4 (da) 2010-11-15
MXPA04002519A (es) 2005-04-04
ES2250919T5 (es) 2010-12-03
JP2012031203A (ja) 2012-02-16
BRPI0305500B1 (pt) 2018-01-23
CN1263742C (zh) 2006-07-12
DK1480953T3 (da) 2005-12-19
JP2014148511A (ja) 2014-08-21

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings