DE60302139D1 - Verfahren zur herstellung von aripiprazole - Google Patents
Verfahren zur herstellung von aripiprazoleInfo
- Publication number
- DE60302139D1 DE60302139D1 DE60302139T DE60302139T DE60302139D1 DE 60302139 D1 DE60302139 D1 DE 60302139D1 DE 60302139 T DE60302139 T DE 60302139T DE 60302139 T DE60302139 T DE 60302139T DE 60302139 D1 DE60302139 D1 DE 60302139D1
- Authority
- DE
- Germany
- Prior art keywords
- preparing aripiprazole
- aripiprazole
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 title 1
- 229960004372 aripiprazole Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003002996 | 2003-01-09 | ||
JP2003002996 | 2003-01-09 | ||
PCT/JP2003/016256 WO2004063162A1 (en) | 2003-01-09 | 2003-12-18 | Process for preparing aripiprazole |
Publications (3)
Publication Number | Publication Date |
---|---|
DE60302139D1 true DE60302139D1 (de) | 2005-12-08 |
DE60302139T2 DE60302139T2 (de) | 2006-07-20 |
DE60302139T3 DE60302139T3 (de) | 2011-02-24 |
Family
ID=32652780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60302139T Expired - Lifetime DE60302139T3 (de) | 2003-01-09 | 2003-12-18 | Verfahren zur herstellung von aripiprazole |
Country Status (20)
Country | Link |
---|---|
US (1) | US6995264B2 (de) |
EP (1) | EP1480953B2 (de) |
JP (2) | JP5797090B2 (de) |
KR (1) | KR100583667B1 (de) |
CN (1) | CN1263742C (de) |
AR (1) | AR042702A1 (de) |
AT (1) | ATE308524T1 (de) |
AU (1) | AU2003288755C1 (de) |
BR (2) | BR0305500A (de) |
CA (2) | CA2458929C (de) |
DE (1) | DE60302139T3 (de) |
DK (1) | DK1480953T4 (de) |
EG (1) | EG23557A (de) |
ES (1) | ES2250919T5 (de) |
HK (1) | HK1073110A1 (de) |
MX (1) | MXPA04002519A (de) |
MY (1) | MY129831A (de) |
SI (1) | SI1480953T2 (de) |
TW (1) | TWI258470B (de) |
WO (1) | WO2004063162A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7714129B2 (en) * | 2003-12-16 | 2010-05-11 | Teva Pharmaceutical Industries Ltd. | Methods of preparing anhydrous aripiprazole form II |
CA2550726A1 (en) * | 2003-12-16 | 2005-06-30 | Teva Pharmaceutical Industries Ltd. | Methods of preparing aripiprazole crystalline forms |
MXPA06008828A (es) * | 2004-02-05 | 2007-04-25 | Teva Pharma | Proceso para preparar aripiprazol. |
US7507823B2 (en) | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
WO2006038220A1 (en) * | 2004-10-08 | 2006-04-13 | Suven Life Sciences Limited | Novel intermediates useful for the preparation of aripiprazole and methods for the preparation of the novel intermediates and aripiprazole |
US20060079689A1 (en) * | 2004-10-12 | 2006-04-13 | Vladimir Naddaka | Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones |
CN101111481A (zh) * | 2004-11-18 | 2008-01-23 | 斯索恩有限公司 | 制备结晶阿立哌唑的方法 |
CN1303068C (zh) * | 2005-01-11 | 2007-03-07 | 中国人民解放军第二军医大学 | 一种阿立哌唑的制备方法 |
TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
EP1933814A2 (de) | 2005-09-15 | 2008-06-25 | Elan Pharma International Limited | Nanoteilchenförmige aripiprazol-formulierungen |
WO2007075871A2 (en) * | 2005-12-22 | 2007-07-05 | Teva Pharmaceutical Industries Ltd. | Processes for reducing particle size of aripiprazole |
US20070149782A1 (en) * | 2005-12-23 | 2007-06-28 | Michael Brand | Methods of preparing a crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1h)-quinolinone and the use thereof in the synthesis of Aripiprazole |
DE602007001620D1 (de) * | 2006-04-10 | 2009-09-03 | Ranbaxy Lab Ltd | Verbesserter Herstellungsprozess für Aripipirazol |
MX2009012506A (es) | 2007-05-21 | 2009-12-09 | Reviva Pharmaceuticals Inc | Composiciones, sintesis, y metodos para utilizar agentes antipsicoticos atipicos basados en quinolinona. |
EP2299814A4 (de) | 2008-05-27 | 2011-06-15 | Reviva Pharmaceuticals Inc | Zusammensetzungen, synthese und verfahren zur verwendung von antipsychotika auf piperazinbasis |
CN101781246B (zh) * | 2009-01-15 | 2012-02-29 | 成都康弘药业集团股份有限公司 | 一种合成阿立哌唑的改进方法 |
MX2011008885A (es) | 2009-02-26 | 2011-09-29 | Reviva Pharmaceuticals Inc | Composiciones, sintesis y metodos para usar derivados de arilpiperazina. |
JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
US20180155290A1 (en) * | 2015-05-08 | 2018-06-07 | Davuluri Ramamohan Rao | Improved Process for the Preparation of Aripiprazole with Reduced Particle Size |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54130587A (en) * | 1978-03-30 | 1979-10-09 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
DE3034237A1 (de) † | 1979-09-18 | 1981-04-16 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel |
US5006528A (en) * | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
JP2608788B2 (ja) * | 1988-10-31 | 1997-05-14 | 大塚製薬 株式会社 | 精神分裂病治療剤 |
JP4060523B2 (ja) † | 1999-11-24 | 2008-03-12 | 大塚製薬株式会社 | カルボスチリル誘導体の製造法 |
AR033485A1 (es) † | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
-
2003
- 2003-12-18 CA CA002458929A patent/CA2458929C/en not_active Expired - Fee Related
- 2003-12-18 AT AT03780889T patent/ATE308524T1/de active
- 2003-12-18 BR BR0305500-0A patent/BR0305500A/pt not_active IP Right Cessation
- 2003-12-18 DK DK03780889.6T patent/DK1480953T4/da active
- 2003-12-18 CA CA002676216A patent/CA2676216A1/en not_active Abandoned
- 2003-12-18 DE DE60302139T patent/DE60302139T3/de not_active Expired - Lifetime
- 2003-12-18 ES ES03780889T patent/ES2250919T5/es not_active Expired - Lifetime
- 2003-12-18 KR KR1020047003990A patent/KR100583667B1/ko active IP Right Grant
- 2003-12-18 SI SI200330153T patent/SI1480953T2/sl unknown
- 2003-12-18 MX MXPA04002519A patent/MXPA04002519A/es active IP Right Grant
- 2003-12-18 WO PCT/JP2003/016256 patent/WO2004063162A1/en active IP Right Grant
- 2003-12-18 BR BRPI0305500-0A patent/BRPI0305500B1/pt unknown
- 2003-12-18 TW TW092135997A patent/TWI258470B/zh not_active IP Right Cessation
- 2003-12-18 EP EP03780889A patent/EP1480953B2/de not_active Expired - Lifetime
- 2003-12-18 AU AU2003288755A patent/AU2003288755C1/en not_active Ceased
-
2004
- 2004-01-05 AR ARP040100006A patent/AR042702A1/es not_active Application Discontinuation
- 2004-01-05 EG EG2004010004A patent/EG23557A/xx active
- 2004-01-08 US US10/752,490 patent/US6995264B2/en not_active Expired - Lifetime
- 2004-01-08 MY MYPI20040043A patent/MY129831A/en unknown
- 2004-01-09 CN CNB2004100020641A patent/CN1263742C/zh not_active Expired - Lifetime
-
2005
- 2005-07-11 HK HK05105804A patent/HK1073110A1/xx not_active IP Right Cessation
-
2011
- 2011-11-04 JP JP2011241871A patent/JP5797090B2/ja not_active Expired - Lifetime
-
2014
- 2014-03-06 JP JP2014043786A patent/JP2014148511A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8366 | Restricted maintained after opposition proceedings |