[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DE602006005902D1 - Pyy-agonisten und anwendungen davon - Google Patents

Pyy-agonisten und anwendungen davon

Info

Publication number
DE602006005902D1
DE602006005902D1 DE602006005902T DE602006005902T DE602006005902D1 DE 602006005902 D1 DE602006005902 D1 DE 602006005902D1 DE 602006005902 T DE602006005902 T DE 602006005902T DE 602006005902 T DE602006005902 T DE 602006005902T DE 602006005902 D1 DE602006005902 D1 DE 602006005902D1
Authority
DE
Germany
Prior art keywords
applications
pyy agonists
pyy
agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006005902T
Other languages
English (en)
Inventor
Rory Francis Finn
Ned Roger Siegel
Neena Lynne Summers
Nancy Ann Nardone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of DE602006005902D1 publication Critical patent/DE602006005902D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE602006005902T 2005-02-04 2006-01-30 Pyy-agonisten und anwendungen davon Active DE602006005902D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65036605P 2005-02-04 2005-02-04
US73365605P 2005-11-04 2005-11-04
PCT/IB2006/000270 WO2006082517A1 (en) 2005-02-04 2006-01-30 Pyy agonists and uses thereof

Publications (1)

Publication Number Publication Date
DE602006005902D1 true DE602006005902D1 (de) 2009-05-07

Family

ID=36175074

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006005902T Active DE602006005902D1 (de) 2005-02-04 2006-01-30 Pyy-agonisten und anwendungen davon

Country Status (33)

Country Link
US (3) US20060178501A1 (de)
EP (2) EP2078729A1 (de)
JP (1) JP4314304B2 (de)
KR (1) KR100892545B1 (de)
AP (1) AP2007004069A0 (de)
AR (1) AR052108A1 (de)
AT (1) ATE426614T1 (de)
AU (1) AU2006211039A1 (de)
BR (1) BRPI0606142A2 (de)
CA (1) CA2596977C (de)
CY (1) CY1109054T1 (de)
DE (1) DE602006005902D1 (de)
DK (1) DK1846445T3 (de)
DO (1) DOP2006000025A (de)
EA (1) EA011882B1 (de)
ES (1) ES2322293T3 (de)
GT (1) GT200600038A (de)
HR (1) HRP20090245T1 (de)
IL (1) IL184324A0 (de)
MA (1) MA29243B1 (de)
MX (1) MX2007009389A (de)
NL (2) NL1031067C2 (de)
NO (1) NO20074498L (de)
PA (1) PA8660701A1 (de)
PE (1) PE20061412A1 (de)
PL (1) PL1846445T3 (de)
PT (1) PT1846445E (de)
RS (1) RS50966B (de)
SI (1) SI1846445T1 (de)
TN (1) TNSN07305A1 (de)
TW (1) TWI310038B (de)
UY (1) UY29357A1 (de)
WO (1) WO2006082517A1 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100350968C (zh) 2001-09-24 2007-11-28 皇家创新有限公司 饮食行为的改进
AU2004236174B2 (en) 2001-10-10 2011-06-02 Novo Nordisk A/S Glycopegylation methods and proteins/peptides produced by the methods
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US20080146782A1 (en) 2006-10-04 2008-06-19 Neose Technologies, Inc. Glycerol linked pegylated sugars and glycopeptides
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
JP5743368B2 (ja) 2004-01-08 2015-07-01 ラショファーム ゲーエムベーハー ペプチドのｏ結合型グリコシル化
US20050215710A1 (en) * 2004-03-23 2005-09-29 Gegg Colin V Jr Chemically modified protein compositions and methods
EP1771066A2 (de) 2004-07-13 2007-04-11 Neose Technologies, Inc. Remodellierung von verzweigtem peg und klykolysierung von glucagonähnlichem peptide-1 glp-1
JP5948627B2 (ja) 2004-10-29 2016-07-20 レイショファーム ゲーエムベーハー 線維芽細胞成長因子（ｆｇｆ）のリモデリングと糖質ペグ化
WO2006074467A2 (en) 2005-01-10 2006-07-13 Neose Technologies, Inc. Glycopegylated granulocyte colony stimulating factor
EP1871795A4 (de) 2005-04-08 2010-03-31 Biogenerix Ag Zusammensetzungen und verfahren zur herstellung von glycosylierungsmutanten eines proteaseresistenten menschlichen wachstumshormons
EP1893240A2 (de) * 2005-06-13 2008-03-05 Nastech Pharmaceutical Company Inc. Transmukosale abgabe von peptid-derivaten
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090158449A1 (en) * 2005-08-31 2009-06-18 Kaneka Corporation Transgenic avian which has foreign gene containing sequence encoding feline-derived protein and method for production thereof
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
WO2007085887A1 (en) * 2006-01-27 2007-08-02 Pfizer Products Inc. Pyy agonists and uses thereof
US20080280818A1 (en) 2006-07-21 2008-11-13 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
JP2008069073A (ja) * 2006-09-12 2008-03-27 Yokohama Tlo Co Ltd ラクトフェリン複合体及びその製造方法
EP2054521A4 (de) 2006-10-03 2012-12-19 Novo Nordisk As Verfahren zur reinigung von polypeptid-konjugate
TWI428346B (zh) 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
JP2010523582A (ja) 2007-04-03 2010-07-15 バイオジェネリクス アクチェンゲゼルシャフト グリコｐｅｇ化ｇ−ｃｓｆを用いた治療方法
WO2008154639A2 (en) 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
WO2009108806A1 (en) 2008-02-27 2009-09-03 Novo Nordisk A/S Conjugated factor viii molecules
WO2010016936A1 (en) * 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Pharmaceutical compositions of analogues of glucose-dependent insulinotropic polypeptide
MX2011004718A (es) * 2008-11-04 2011-07-28 Janssen Pharmaceutica Nv Péptidos agonistas de crhr2 y usos de éstos.
WO2010067233A1 (en) 2008-12-08 2010-06-17 Pfizer Inc. 1,2,4 triazolo [4, 3 -a] [1,5] benzodiazepin-5 (6h) -ones as agonists of the cholecystokinin-1 receptor (cck-ir)
WO2010084428A1 (en) 2009-01-20 2010-07-29 Pfizer Inc. Substituted pyrazinone amides
TW201038580A (en) 2009-02-02 2010-11-01 Pfizer 4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl derivatives
WO2010089685A1 (en) 2009-02-03 2010-08-12 Pfizer Inc. 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives
WO2010089686A1 (en) 2009-02-04 2010-08-12 Pfizer Inc. 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives
EP2406230A1 (de) 2009-03-11 2012-01-18 Pfizer Inc. Substituierte indazolamide und ihre verwendung als glucokinaseaktivatoren
RS52903B (en) 2009-03-11 2014-02-28 Pfizer Inc BENZOFURANIL DERIVATIVES FOR USE AS GLUCOKINASE INHIBITORS
JP2012520868A (ja) 2009-03-20 2012-09-10 ファイザー・インク ３−オキサ−７−アザビシクロ［３．３．１］ノナン
GEP20135907B (en) 2009-06-05 2013-08-12 Pfizer L-(piperidin-4-yl)-pyrazole derivatives as gpr 119 modulators
EP2480551A1 (de) 2009-09-23 2012-08-01 Pfizer Inc. Gpr-119-modulatoren
DK2496583T3 (en) 2009-11-02 2015-02-02 Pfizer Dioxa-bicyclo [3.2.1] octane-2,3,4-triol DERIVATIVES
EP2499140A1 (de) 2009-11-10 2012-09-19 Pfizer Inc. N2-pyrazolospiroketon-acetyl-coa-carboxylasehemmer
CN102695708B (zh) 2009-11-10 2014-10-15 辉瑞大药厂 N1-吡唑并螺酮乙酰辅酶a羧化酶抑制剂
JP2013511571A (ja) 2009-11-23 2013-04-04 ファイザー・インク Ｇｐｒ１１９阻害剤としてのイミダゾ−ピラゾール
DK2547679T3 (en) 2010-03-19 2016-01-11 Pfizer 2,3 dihydro-1H-inden-1-yl-2,7-diazaspiro [3.6] nonane derivatives and their use as antagonists or inverse agonists of ghrelin receptor
WO2011158149A1 (en) 2010-06-18 2011-12-22 Pfizer Inc. 2-(3,5-disubstitutedphenyl)pyrimidin-4(3h)-one derivatives
LT2621493T (lt) 2010-09-30 2016-10-25 Pfizer Inc. N1-pirazolo-spiro-ketono acetil-coa-karboksilazės inhibitoriai
WO2012056372A1 (en) 2010-10-29 2012-05-03 Pfizer Inc. N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS
AU2011346670B2 (en) 2010-12-23 2015-05-07 Pfizer Inc. Glucagon receptor modulators
ME02502B (de) 2011-02-08 2017-02-20 Pfizer Glucagonrezeptormodulator
RS54526B1 (en) 2011-04-22 2016-06-30 Pfizer Inc. USE OF PIRAZOLOSPIROKETONE DERIVATIVES AS ACETYL-COA CARBOXYLASE INHIBITORS
JP2014520879A (ja) 2011-07-15 2014-08-25 ファイザー・インク Ｇｐｒ１１９調節因子
RU2013157388A (ru) 2011-07-22 2015-08-27 Пфайзер Инк. Хинолинильные модуляторы глюкагонового рецептора
WO2013030713A1 (en) 2011-08-31 2013-03-07 Pfizer Inc. Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds
MX353608B (es) 2012-02-24 2018-01-19 Alteogen Inc Anticuerpo modificado en el que el tema que comprende residuos de cisteina esta ligado, conjugado de farmaco de anticuerpo modificado que comprende el anticuerpo modificado y metodo de produccion para el mismo.
MX2014011373A (es) 2012-04-06 2014-10-14 Pfizer Inhibidores de diacilglicerol aciltransferasa 2.
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2872154C (en) 2012-05-04 2016-08-23 Pfizer Inc. Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of app, bace1 and bace2
EP2897964A1 (de) 2012-09-20 2015-07-29 Pfizer Inc. Alkylsubstituierte hexahydro[3,4-d][1,3]thiazin-2-amin-verbindungen
CA2893256A1 (en) 2012-12-11 2014-06-19 Pfizer Inc. Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
WO2014097038A1 (en) 2012-12-19 2014-06-26 Pfizer Inc. CARBOCYCLIC- AND HETEROCYCLIC-SUBSTITUTED HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS
CA2897678A1 (en) 2013-02-13 2014-08-21 Pfizer Inc. Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
WO2014178018A1 (en) 2013-05-02 2014-11-06 Glaxosmithkline Intellectual Property Development Limited Therapeutic peptides
JP6348582B2 (ja) 2013-10-09 2018-06-27 ファイザー・インク プロスタグランジンｅｐ３受容体の拮抗薬
BR112016012325A2 (pt) * 2013-12-20 2017-09-26 Hoffmann La Roche métodos para amidação c-terminal in vivo de um polipeptídeo e para a produção recombinante de um polipeptídeo e uso de uma peptidilglicina
PL3119757T3 (pl) 2014-03-17 2018-09-28 Pfizer Inc. Inhibitory diacyloglicerolo acylotransferazy 2 do stosowania w leczeniu zaburzeń metabolicznych i związanych
EP3129388A1 (de) 2014-04-10 2017-02-15 Pfizer Inc. 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl-1,3-thiazol-4-yl-amide
WO2016092413A1 (en) 2014-12-10 2016-06-16 Pfizer Inc. Indole and indazole compounds that activate ampk
EP3237401B1 (de) 2014-12-22 2019-03-06 Pfizer Inc Antagonisten des prostaglandin-ep3-rezeptors
WO2016124687A1 (en) * 2015-02-04 2016-08-11 Novo Nordisk A/S Selective pyy compounds and uses thereof
HUE051898T2 (hu) 2015-06-17 2021-03-29 Pfizer Triciklusos vegyületek és alkalmazásuk foszfodiészteráz inhibitorokként
JP2018534251A (ja) 2015-09-24 2018-11-22 ファイザー・インク Ｂａｃｅ阻害剤として有用なｎ−［２−（３−アミノ−２，５−ジメチル−１，１−ジオキシド−５，６−ジヒドロ−２ｈ−１，２，４−チアジアジン−５−イル）−１，３−チアゾール−４−イル］アミド
BR112018003489A2 (pt) 2015-09-24 2018-09-25 Pfizer n-[2-(2-amino-6,6-dissubstituído-4,4a,5,6-tetra-hidropirano[3,4-d][1,3]tiazin-8a(8h)-il)-1,3-tiazol-4-il]amidas
EP3353182A1 (de) 2015-09-24 2018-08-01 Pfizer Inc Tetrahydropyrano[3,4-d][1,3]oxazin-derivate und deren verwendung als bace-inhibitoren
US9809579B2 (en) 2015-12-29 2017-11-07 Pfizer Inc. Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
US20210171598A1 (en) 2017-12-01 2021-06-10 University Of Copenhagen Peptide hormone with one or more o-glycans
CA3098304A1 (en) * 2018-04-26 2019-10-31 Colorado State University Research Foundation Methods and compositions for tracking vegetation
CA3110601C (en) 2018-08-31 2023-09-05 Pfizer Inc. Combinations for treatment of nash/nafld and related diseases
CA3140972C (en) 2019-05-20 2024-06-18 Pfizer Inc. Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
EP4366755A1 (de) * 2021-07-08 2024-05-15 Gila Therapeutics, Inc. Zusammensetzungen und verfahren zur aktivierung eines neuronalen rezeptors
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
WO2024118524A1 (en) 2022-11-28 2024-06-06 Cerevel Therapeutics, Llc Azaindole compounds and their use as phosphodiesterase inhibitors

Family Cites Families (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US141985A (en) * 1873-08-19 Improvement in sewing-machine tables
US176643A (en) * 1876-04-25 Improvement in ironing-tables
US244041A (en) * 1881-07-12 Machine for blocking and shaping hats
US176630A (en) * 1876-04-25 Improvement in wagon-locks
US2919901A (en) * 1957-01-25 1960-01-05 Thor Power Tool Co Drill system with suction
US4908713A (en) * 1981-12-14 1990-03-13 Levine Michael R VCR Programmer
US5508815A (en) * 1981-12-14 1996-04-16 Smart Vcr Limited Partnership Schedule display system for video recorder programming
US4586158A (en) * 1983-02-22 1986-04-29 International Business Machines Corp. Screen management system
US4708934A (en) 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
US6319685B1 (en) 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
DE3590766T (de) 1985-03-30 1987-04-23
US4821097A (en) * 1987-03-05 1989-04-11 General Instrument Corporation Apparatus and method for providing digital audio on the sound carrier of a standard television signal
US5789234A (en) 1987-08-14 1998-08-04 Unigene Laboratories, Inc. Expression systems for amidating enzyme
US4930158A (en) * 1987-09-02 1990-05-29 Vogel Peter S Selective video playing system
US4984152A (en) * 1987-10-06 1991-01-08 Bell Communications Research, Inc. System for controlling computer processing utilizing a multifunctional cursor with decoupling of pointer and image functionalities in space and time
US4827250A (en) * 1987-10-26 1989-05-02 Tektronix, Inc. Graphics display system having data transform circuit
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US4991011A (en) * 1988-12-23 1991-02-05 Scientific-Atlanta, Inc. Interactive television terminal with programmable background audio or video
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP2877509B2 (ja) 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
US5727060A (en) * 1989-10-30 1998-03-10 Starsight Telecast, Inc. Television schedule system
DK0463151T3 (da) 1990-01-12 1996-07-01 Cell Genesys Inc Frembringelse af xenogene antistoffer
DK0814159T3 (da) 1990-08-29 2005-10-24 Genpharm Int Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US5293357A (en) * 1990-09-10 1994-03-08 The Superguide Corporation Method and apparatus for controlling a television program recording device
US5247347A (en) * 1991-09-27 1993-09-21 Bell Atlantic Network Services, Inc. Pstn architecture for video-on-demand services
JP2654283B2 (ja) * 1991-09-30 1997-09-17 株式会社東芝 アイコン表示方法
US5317391A (en) * 1991-11-29 1994-05-31 Scientific-Atlanta, Inc. Method and apparatus for providing message information to subscribers in a cable television system
US5291554A (en) * 1992-05-28 1994-03-01 Tv Answer, Inc. Shared-price custom video rentals via interactive TV
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
ES2301158T3 (es) 1992-07-24 2008-06-16 Amgen Fremont Inc. Produccion de anticuerpos xenogenicos.
JPH06139671A (ja) * 1992-10-27 1994-05-20 Sony Corp 記録再生システム
KR100246247B1 (ko) * 1992-10-30 2000-05-01 야마오카 다께오 자동포장 및 밀봉장치내의 절단유닛
US5592551A (en) * 1992-12-01 1997-01-07 Scientific-Atlanta, Inc. Method and apparatus for providing interactive electronic programming guide
US5715515A (en) * 1992-12-02 1998-02-03 Scientific-Atlanta, Inc. Method and apparatus for downloading on-screen graphics and captions to a television terminal
US5410326A (en) * 1992-12-04 1995-04-25 Goldstein; Steven W. Programmable remote control device for interacting with a plurality of remotely controlled devices
ES2145119T3 (es) * 1992-12-09 2000-07-01 Discovery Communicat Inc Terminal reprogramable para sugerir programas ofrecidos en un sistema de distribucion de programas de television.
US5600364A (en) * 1992-12-09 1997-02-04 Discovery Communications, Inc. Network controller for cable television delivery systems
US5483277A (en) * 1992-12-15 1996-01-09 Alcatel Network Systems Simplified set-top converter for broadband switched network
US5598524A (en) * 1993-03-03 1997-01-28 Apple Computer, Inc. Method and apparatus for improved manipulation of data between an application program and the files system on a computer-controlled display system
PL310897A1 (en) * 1993-03-29 1996-01-08 Univ Cincinnati Analogues of yy peptide and their application
US5594509A (en) * 1993-06-22 1997-01-14 Apple Computer, Inc. Method and apparatus for audio-visual interface for the display of multiple levels of information on a display
US5621456A (en) * 1993-06-22 1997-04-15 Apple Computer, Inc. Methods and apparatus for audio-visual interface for the display of multiple program categories
US5414455A (en) * 1993-07-07 1995-05-09 Digital Equipment Corporation Segmented video on demand system
US5410344A (en) * 1993-09-22 1995-04-25 Arrowsmith Technologies, Inc. Apparatus and method of selecting video programs based on viewers' preferences
US5398071A (en) * 1993-11-02 1995-03-14 Texas Instruments Incorporated Film-to-video format detection for digital television
US5481542A (en) * 1993-11-10 1996-01-02 Scientific-Atlanta, Inc. Interactive information services control system
US5422674A (en) * 1993-12-22 1995-06-06 Digital Equipment Corporation Remote display of an image by transmitting compressed video frames representing background and overlay portions thereof
US5516653A (en) * 1993-12-28 1996-05-14 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
JPH07244781A (ja) * 1994-03-07 1995-09-19 C S K Sogo Kenkyusho:Kk ソフトウェアレンタル方法および装置ならびに流通媒体
US5629732A (en) * 1994-03-29 1997-05-13 The Trustees Of Columbia University In The City Of New York Viewer controllable on-demand multimedia service
US5512958A (en) * 1994-04-29 1996-04-30 Matsushita Electric Corporation Of America System for controlling the effects of noise in television receivers
US5521631A (en) * 1994-05-25 1996-05-28 Spectravision, Inc. Interactive digital video services system with store and forward capabilities
JP3575063B2 (ja) * 1994-07-04 2004-10-06 ソニー株式会社 再生装置、再生方法
US5596106A (en) 1994-07-15 1997-01-21 Eli Lilly And Company Cannabinoid receptor antagonists
EP0699000B1 (de) * 1994-08-24 2001-06-20 Hyundai Electronics America Videoserver und diesen verwendendes System
US5682325A (en) * 1994-09-12 1997-10-28 Bell Atlantic Network Services, Inc. Level 1 gateway for video tone networks
US5619249A (en) * 1994-09-14 1997-04-08 Time Warner Entertainment Company, L.P. Telecasting service for providing video programs on demand with an interactive interface for facilitating viewer selection of video programs
DE4435477A1 (de) 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
US5614940A (en) * 1994-10-21 1997-03-25 Intel Corporation Method and apparatus for providing broadcast information with indexing
RO118715B1 (ro) 1994-10-27 2003-09-30 Janssen Pharmaceutica Nv Inhibitori ai sintezei apolipoproteinei-b
US5521186A (en) 1994-10-27 1996-05-28 Janssen Pharmaceutica N.V. Apolipoprotein-β synthesis inhibitors
US5724521A (en) * 1994-11-03 1998-03-03 Intel Corporation Method and apparatus for providing electronic advertisements to end users in a consumer best-fit pricing manner
US5623613A (en) * 1994-11-29 1997-04-22 Microsoft Corporation System for displaying programming information
US5912227A (en) * 1995-01-27 1999-06-15 North Carolina State University Method of enhancing nutrient uptake
US5619247A (en) * 1995-02-24 1997-04-08 Smart Vcr Limited Partnership Stored program pay-per-play
US5632681A (en) * 1995-03-07 1997-05-27 International Business Machines Corporation Universal electronic video game renting/distributing system
US5651010A (en) * 1995-03-16 1997-07-22 Bell Atlantic Network Services, Inc. Simultaneous overlapping broadcasting of digital programs
CA2761116A1 (en) 1995-04-27 1996-10-31 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
US5721829A (en) * 1995-05-05 1998-02-24 Microsoft Corporation System for automatic pause/resume of content delivered on a channel in response to switching to and from that channel and resuming so that a portion of the content is repeated
US6558708B1 (en) * 1995-05-17 2003-05-06 Cedars-Sinai Medical Center Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
US5740549A (en) * 1995-06-12 1998-04-14 Pointcast, Inc. Information and advertising distribution system and method
US5751282A (en) * 1995-06-13 1998-05-12 Microsoft Corporation System and method for calling video on demand using an electronic programming guide
US5724106A (en) * 1995-07-17 1998-03-03 Gateway 2000, Inc. Hand held remote control device with trigger button
US5745837A (en) * 1995-08-25 1998-04-28 Terayon Corporation Apparatus and method for digital data transmission over a CATV system using an ATM transport protocol and SCDMA
US5737028A (en) * 1995-11-01 1998-04-07 International Business Machines Corporation Previous channel listing with cursor controlled user interface for television video displays
US5919901A (en) * 1996-04-08 1999-07-06 Bayer Corporation Neuropeptide Y receptor Y5 and nucleic acid sequences
US5721897A (en) * 1996-04-09 1998-02-24 Rubinstein; Seymour I. Browse by prompted keyword phrases with an improved user interface
US5721827A (en) * 1996-10-02 1998-02-24 James Logan System for electrically distributing personalized information
EP2699012A3 (de) * 1996-12-10 2014-04-02 United Video Properties, Inc. Internet-fernsehprogrammleitsystem
US6654933B1 (en) * 1999-09-21 2003-11-25 Kasenna, Inc. System and method for media stream indexing
ATE484572T1 (de) 1997-04-16 2010-10-15 Unigene Lab Inc Direkte expression von peptiden ins kulturmedium
IL121230A (en) * 1997-07-03 2004-05-12 Nds Ltd Intelligent electronic program guide
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
EP1017803B1 (de) 1997-09-26 2010-06-16 ABT Holding Company Expression von endogenen genen durch homologe rekombination eines vektorkonstruktes mit zellulärer dna
US6046167A (en) * 1998-03-25 2000-04-04 University Of Cincinnati Peptide YY analogs
US6505348B1 (en) * 1998-07-29 2003-01-07 Starsight Telecast, Inc. Multiple interactive electronic program guide system and methods
US6360053B1 (en) * 1998-08-07 2002-03-19 Replaytv, Inc. Method and apparatus for fast forwarding and rewinding in a video recording device
KR100652994B1 (ko) 1998-09-11 2006-11-30 아방티 파르마 소시에테 아노님 아제티딘 유도체, 이의 제조방법 및 이를 함유하는 약제
US20020026638A1 (en) * 2000-08-31 2002-02-28 Eldering Charles A. Internet-based electronic program guide advertisement insertion method and apparatus
FR2789079B3 (fr) 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
JP2003518914A (ja) * 1999-02-10 2003-06-17 キュリス インコーポレイテッド グルコース代謝障害を治療する方法および試薬
US7086077B2 (en) * 1999-04-01 2006-08-01 Sedna Patent Services, Llc Service rate change method and apparatus
US6986156B1 (en) * 1999-06-11 2006-01-10 Scientific Atlanta, Inc Systems and methods for adaptive scheduling and dynamic bandwidth resource allocation management in a digital broadband delivery system
US6832386B1 (en) * 1999-06-11 2004-12-14 Scientific-Atlanta, Inc. System and method for allowing a user to quickly navigate within a program guide to an established reference point
US7010801B1 (en) * 1999-06-11 2006-03-07 Scientific-Atlanta, Inc. Video on demand system with parameter-controlled bandwidth deallocation
US7150031B1 (en) * 2000-06-09 2006-12-12 Scientific-Atlanta, Inc. System and method for reminders of upcoming rentable media offerings
US7228556B2 (en) * 1999-12-21 2007-06-05 Tivo Inc. Distributed, interactive television program guide; system and method
US20030030679A1 (en) * 2000-01-06 2003-02-13 Anuj Kumar Jain User-definable images in bookmarks
CA2403240C (en) * 2000-03-31 2013-12-03 United Video Properties, Inc. Interactive media system and method for presenting pause-time content
WO2001075736A1 (en) * 2000-03-31 2001-10-11 Liquid Engines, Inc. Electronic matching engine for matching desired characteristics with item attributes
US20020007485A1 (en) * 2000-04-03 2002-01-17 Rodriguez Arturo A. Television service enhancements
GB0008691D0 (en) * 2000-04-07 2000-05-31 Post Impressions Systems Ltd Input and output systems for data processing
US7934232B1 (en) * 2000-05-04 2011-04-26 Jerding Dean F Navigation paradigm for access to television services
US8069259B2 (en) * 2000-06-09 2011-11-29 Rodriguez Arturo A Managing removal of media titles from a list
US7685520B2 (en) * 2000-06-22 2010-03-23 Intel Corporation Electronic programming guide with selectable categories
US7962370B2 (en) * 2000-06-29 2011-06-14 Rodriguez Arturo A Methods in a media service system for transaction processing
JP4356226B2 (ja) * 2000-09-12 2009-11-04 ソニー株式会社 サーバ装置、配信システム、配信方法、及び端末装置
US8302127B2 (en) * 2000-09-25 2012-10-30 Thomson Licensing System and method for personalized TV
AR030870A1 (es) * 2000-10-11 2003-09-03 United Video Properties Inc Disposicion y metodo para construir listas de medios de usuario
US20020049978A1 (en) * 2000-10-20 2002-04-25 Rodriguez Arturo A. System and method for access and placement of media content information items on a screen display with a remote control device
US6924291B2 (en) 2001-01-23 2005-08-02 Merck & Co., Inc. Process for making spiro isobenzofuranone compounds
DE60202270T2 (de) 2001-03-22 2005-05-19 Solvay Pharmaceuticals B.V. 4,5-dihydro-1h-pyrazolderivate mit cb1-antagonistischer wirkung
EP1456360B1 (de) 2001-04-19 2015-06-03 The Scripps Research Institute Verfahren und zusammensetzungen zur herstellung von orthoganalen trna/aminoacyl-trna-synthetase-paaren
CN1522246B (zh) 2001-06-28 2010-04-21 辉瑞产品公司 三酰胺取代的吲哚、苯并呋喃及苯并噻吩
US8006262B2 (en) * 2001-06-29 2011-08-23 Rodriguez Arturo A Graphic user interfaces for purchasable and recordable media (PRM) downloads
CN100350968C (zh) 2001-09-24 2007-11-28 皇家创新有限公司 饮食行为的改进
US7142590B2 (en) * 2001-10-11 2006-11-28 Utstarcom Inc. Method and system for oversubscribing a DSL modem
US20030074257A1 (en) * 2001-10-12 2003-04-17 Michael Saveliev Method and apparatus for advertising adjacent to a beverage dispenser to facilitate advertising income device placement in high traffic venues
US7334251B2 (en) * 2002-02-11 2008-02-19 Scientific-Atlanta, Inc. Management of television advertising
WO2003075660A1 (en) 2002-03-06 2003-09-18 Merck & Co., Inc. Method of treatment or prevention of obesity
WO2003082190A2 (en) 2002-03-26 2003-10-09 Merck & Co., Inc. Spirocyclic amides as cannabinoid receptor modulators
CN100486973C (zh) 2002-07-29 2009-05-13 霍夫曼-拉罗奇有限公司 新苯并间二氧杂环戊烯类
CA2494091C (en) 2002-08-02 2011-02-01 Richard B. Toupence Substituted furo [2,3-b| pyridine derivatives
US7129239B2 (en) 2002-10-28 2006-10-31 Pfizer Inc. Purine compounds and uses thereof
MY134457A (en) 2002-11-22 2007-12-31 Merck & Co Inc Substituted amides
WO2004056314A2 (en) 2002-12-17 2004-07-08 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity
US7186692B2 (en) 2002-12-17 2007-03-06 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity
US7865595B2 (en) * 2002-12-18 2011-01-04 International Business Machines Corporation Processing call requests with respect to objects
US7329658B2 (en) 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
WO2004089279A2 (en) * 2003-04-08 2004-10-21 Yeda Research And Development Co. Ltd. Long-acting derivatives of pyy agonists
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US7141669B2 (en) 2003-04-23 2006-11-28 Pfizer Inc. Cannabiniod receptor ligands and uses thereof
BRPI0411165A (pt) 2003-05-14 2006-07-11 Emisphere Tech Inc composição farmacêutica, forma de unidade de dosagem e métodos para preparar seu uso
US8008255B2 (en) 2003-05-30 2011-08-30 Amylin Pharmaceuticals, Inc. Methods and compositions for enhanced transmucosal delivery of peptides and proteins
US7274740B2 (en) * 2003-06-25 2007-09-25 Sharp Laboratories Of America, Inc. Wireless video transmission system
US20050091693A1 (en) * 2003-10-22 2005-04-28 Rochelle Communications, Inc. Dual mode set-top box that optimizes the delivery and user selection of audio or video programming over data networks
US7151097B2 (en) 2003-11-07 2006-12-19 Pfizer Inc. Bicyclic pyrazolyl and imidazolyl compounds and uses thereof
KR100799802B1 (ko) 2004-02-04 2008-01-31 화이자 프로덕츠 인크. 치환된 퀴놀린 화합물
EP2335716A3 (de) * 2004-02-11 2011-10-19 Amylin Pharmaceuticals Inc. Pankreas-polypeptidfamilienmotive und diese enthaltende polypeptide
EP1718671A2 (de) * 2004-02-23 2006-11-08 Rheoscience A/S Peptid-yy-analoga
US7954129B2 (en) * 2004-09-24 2011-05-31 Smartvue Corporation Wireless video surveillance system and method with remote viewing
US20060088105A1 (en) * 2004-10-27 2006-04-27 Bo Shen Method and system for generating multiple transcoded outputs based on a single input
US7620065B2 (en) * 2005-07-22 2009-11-17 Trellia Networks, Inc. Mobile connectivity solution
US8189472B2 (en) * 2005-09-07 2012-05-29 Mcdonald James F Optimizing bandwidth utilization to a subscriber premises

Also Published As

Publication number Publication date
US20090170778A1 (en) 2009-07-02
NO20074498L (no) 2007-11-02
NL1031067A1 (nl) 2006-08-07
EP1846445B1 (de) 2009-03-25
DOP2006000025A (es) 2006-09-15
ES2322293T3 (es) 2009-06-18
PT1846445E (pt) 2009-05-14
EA011882B1 (ru) 2009-06-30
AU2006211039A1 (en) 2006-08-10
AP2007004069A0 (en) 2007-08-31
EP1846445A1 (de) 2007-10-24
TNSN07305A1 (fr) 2008-12-31
RS50966B (sr) 2010-10-31
US20060178501A1 (en) 2006-08-10
EA200701439A1 (ru) 2008-02-28
KR100892545B1 (ko) 2009-04-09
KR20070094829A (ko) 2007-09-21
MX2007009389A (es) 2008-02-12
JP4314304B2 (ja) 2009-08-12
ATE426614T1 (de) 2009-04-15
CA2596977C (en) 2010-11-02
SI1846445T1 (sl) 2009-06-30
WO2006082517A1 (en) 2006-08-10
TW200639180A (en) 2006-11-16
NL1033469A1 (nl) 2007-06-06
PL1846445T3 (pl) 2009-07-31
US20090171071A1 (en) 2009-07-02
CA2596977A1 (en) 2006-08-10
NL1031067C2 (nl) 2007-03-13
MA29243B1 (fr) 2008-02-01
IL184324A0 (en) 2007-10-31
AR052108A1 (es) 2007-02-28
UY29357A1 (es) 2006-10-02
EP2078729A1 (de) 2009-07-15
PE20061412A1 (es) 2007-03-08
DK1846445T3 (da) 2009-05-04
NL1033469C2 (nl) 2007-10-23
GT200600038A (es) 2006-09-13
PA8660701A1 (es) 2006-09-22
JP2008528050A (ja) 2008-07-31
TWI310038B (en) 2009-05-21
CY1109054T1 (el) 2014-07-02
BRPI0606142A2 (pt) 2009-06-02
HRP20090245T1 (en) 2009-07-31

Similar Documents

Publication Publication Date Title
DE602006005902D1 (de) Pyy-agonisten und anwendungen davon
ATE442368T1 (de) 3-amino-2-arylpropylazaindole und anwendungen davon
DK1717469T3 (da) Lejeelement
ATE521638T1 (de) Gegen angiopoietin-2 gerichtete antikörper und anwendungen davon
DE602006007563D1 (de) Agonisten
DE602006020061D1 (de) Mucin-glycoprotein und anwendung davon
DK2079485T3 (da) Phenylpropionamidforbindelser og anvendelsen deraf
DE602006011600D1 (de) Audiocodierungseinrichtung und audiocodierungsverfahren
ITPD20060384A1 (it) Dispositivo di manipolazione
DE602006014957D1 (de) Audiocodierungseinrichtung und audiocodierungsverfahren
DE602008003575D1 (de) Piperidinverbindungen und anwendungen davon
DE602006015540D1 (de) Durchführung und buchse
DE602006001781D1 (de) Verbinder und Verbinderanordnung
DE602006016225D1 (de) Verbinder und Verbinderanordnung
DE602005019098D1 (de) Tetralin- und indanderivate und deren anwendungen
DE602006017825D1 (de) N konstruktion
DE502006001206D1 (de) Objektiv und Mikroskop
DE602006002451D1 (de) Adapterhülse und entsprechende Zusammenbau und Montageverfahren
DE602006003075D1 (de) Uracilen und 3-sulfonylisoxazolinen
DE112006002272T8 (de) Katheter und Katheter-Kit
DE602005016976D1 (de) Informationssendevorrichtung und informationssendeverfahren
DE602006004152D1 (de) Verbinder und Verbinderanordnung
DE602006017883D1 (de) Pipd-papier und daraus hergestellte komponenten
DE602007006966D1 (de) Pyrazoloä1,5-aüpyrimidine, verfahren, anwendungen und zusammensetzungen
DE602007011466D1 (de) Arylpiperazinderivate und anwendungen davon

Legal Events

Date Code Title Description
8364 No opposition during term of opposition