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DE602004027811D1 - Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon - Google Patents

Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon

Info

Publication number
DE602004027811D1
DE602004027811D1 DE602004027811T DE602004027811T DE602004027811D1 DE 602004027811 D1 DE602004027811 D1 DE 602004027811D1 DE 602004027811 T DE602004027811 T DE 602004027811T DE 602004027811 T DE602004027811 T DE 602004027811T DE 602004027811 D1 DE602004027811 D1 DE 602004027811D1
Authority
DE
Germany
Prior art keywords
oxazolidinonantibiotics
derivatives
group substituted
cyclopropyl group
cyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004027811T
Other languages
English (en)
Inventor
Yasumichi Fukuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Merck Sharp and Dohme LLC
Original Assignee
Kyorin Pharmaceutical Co Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd, Merck Sharp and Dohme LLC filed Critical Kyorin Pharmaceutical Co Ltd
Publication of DE602004027811D1 publication Critical patent/DE602004027811D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE602004027811T 2003-07-02 2004-06-29 Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon Expired - Lifetime DE602004027811D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48390403P 2003-07-02 2003-07-02
US54698404P 2004-02-24 2004-02-24
PCT/US2004/020734 WO2005005398A2 (en) 2003-07-02 2004-06-29 Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof

Publications (1)

Publication Number Publication Date
DE602004027811D1 true DE602004027811D1 (de) 2010-08-05

Family

ID=34068173

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004027811T Expired - Lifetime DE602004027811D1 (de) 2003-07-02 2004-06-29 Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon

Country Status (23)

Country Link
US (2) US7462633B2 (de)
EP (1) EP1646629B1 (de)
JP (1) JP4607107B2 (de)
KR (1) KR20060113625A (de)
AR (1) AR044990A1 (de)
AT (1) ATE471937T1 (de)
AU (1) AU2004256083B2 (de)
BR (1) BRPI0411688A (de)
CA (1) CA2530140C (de)
CL (1) CL2004001678A1 (de)
DE (1) DE602004027811D1 (de)
EC (1) ECSP056257A (de)
IL (1) IL172785A0 (de)
IS (1) IS8178A (de)
MA (1) MA27938A1 (de)
MX (1) MXPA06000228A (de)
MY (1) MY140137A (de)
NO (1) NO20060558L (de)
NZ (1) NZ544237A (de)
PE (1) PE20050732A1 (de)
RU (1) RU2348628C2 (de)
TW (1) TW200510421A (de)
WO (1) WO2005005398A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003027083A1 (en) * 2001-04-17 2003-04-03 Merck & Co., Inc. Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
JP5043428B2 (ja) * 2003-06-03 2012-10-10 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリール複素環式化合物ならびにその製造および使用方法
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
ATE471937T1 (de) 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
AU2004256086B2 (en) * 2003-07-02 2007-12-06 Kyorin Pharmaceutical Co., Ltd. Oxazolidinone antibiotics and derivatives thereof
JP2007514782A (ja) * 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
EP1799677A1 (de) * 2004-10-08 2007-06-27 Ranbaxy Laboratories Limited Oxazolidinon-derivate mit antimikrobieller funktion
KR101394307B1 (ko) 2005-06-08 2014-05-13 멜린타 테라퓨틱스, 인크. 트리아졸의 합성 방법
WO2007023507A2 (en) * 2005-06-20 2007-03-01 Wockhardt Limited Oxazolidinones bearing antimicrobial activity composition and methods of preparation
US7838526B2 (en) * 2005-08-05 2010-11-23 Esther Baldinger Method of treating neurological disorders
AR054608A1 (es) * 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
WO2008150364A1 (en) * 2007-05-23 2008-12-11 Merck & Co., Inc. Cyclopropyl pyrrolidine orexin receptor antagonists
WO2010042887A2 (en) 2008-10-10 2010-04-15 Trius Therapeutics Methods for preparing oxazolidinones and compositions containing them
CU24089B1 (es) 2009-02-03 2015-04-29 Trius Therapeutics Forma cristalina del fosfato de dihidrógeno r)-3-(4-(2-(2-metiltretazol-5-il)-3-fluorofenil)-5-hidroximetil oxazolidin-2-ona
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
CA2765692A1 (en) 2009-06-26 2010-12-29 Panacea Biotec Ltd. Novel azabicyclohexanes
WO2012042539A2 (en) 2010-09-28 2012-04-05 Panacea Biotec Ltd Novel bicyclic compounds
WO2017066964A1 (en) * 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
WO2020021468A1 (en) 2018-07-25 2020-01-30 Cadila Healthcare Limited Substituted oxazolidinones for the treatment of mammalian infections

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053593A (en) 1975-11-26 1977-10-11 Lew Frumoff Medical product combining antimicrobial, antiporasitic and vitamin complex
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
DE69216251T2 (de) 1991-11-01 1997-05-15 Pharmacia & Upjohn Co., Kalamazoo, Mich. Substituierte aryl- und heteroaryl-phenyloxazolidinone
NZ257031A (en) 1992-12-08 1996-07-26 Upjohn Co Tropone substituted phenyloxazolidinone derivatives and anti-bacterial medicaments thereof
TW286317B (de) 1993-12-13 1996-09-21 Hoffmann La Roche
DE4425612A1 (de) 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
HRP960159A2 (en) 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
MX9708627A (es) 1995-05-11 1998-02-28 Upjohn Co Oxazolidinonas de diazinilo y carbazinilo espirociclicas y biciclicas.
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
DE60035330T2 (de) 1999-05-14 2008-03-06 Kabushiki Kaisha Toshiba, Kawasaki Oberflächenwellenfilter
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
WO2001058885A1 (en) 2000-02-10 2001-08-16 Pharmacia & Upjohn Company Oxazolidinone thioamides with piperazine amide substituents
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
CA2411859A1 (en) * 2000-06-05 2001-12-13 Jae-Gul Lee Novel oxazolidinone derivatives and a process for the preparation thereof
WO2002006278A1 (en) 2000-07-17 2002-01-24 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
AU2001293163A1 (en) * 2000-09-27 2002-04-08 Lynx Therapeutics, Inc. Method for determining relative abundance of nucleic acid sequences
CA2424402A1 (en) 2000-12-21 2002-08-01 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
YU52403A (sh) 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
WO2003027083A1 (en) 2001-04-17 2003-04-03 Merck & Co., Inc. Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
US6686363B2 (en) 2001-11-29 2004-02-03 Kyorin Pharmaceutical Co., Ltd. Cyclopropyl containing oxazolidinone antibiotics and derivatives thereof
CN1155585C (zh) 2001-12-19 2004-06-30 中国医学科学院医药生物技术研究所 3,5－取代噁唑烷酮衍生物及其制备方法和应用
TW200302095A (en) 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
IL163688A0 (en) 2002-02-28 2005-12-18 Astrazeneca Ab 3-Cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and theiruse as antibacterial agents
CN1662240A (zh) 2002-05-15 2005-08-31 兰贝克赛实验室有限公司 苯基噁唑烷酮衍生物
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
WO2004048350A2 (en) 2002-11-28 2004-06-10 Astrazeneca Ab Oxazolidinones as antibacterial agents
TW200500360A (en) 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
CA2521685A1 (en) 2003-04-09 2004-10-21 Pharmacia & Upjohn Company Llc Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues
AU2003223034A1 (en) 2003-05-06 2004-11-26 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
AU2004256084B2 (en) * 2003-07-02 2007-10-18 Kyorin Pharmaceutical Co., Ltd. Oxazolidinone antibiotics and derivatives thereof
ATE471937T1 (de) * 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
AU2004256086B2 (en) 2003-07-02 2007-12-06 Kyorin Pharmaceutical Co., Ltd. Oxazolidinone antibiotics and derivatives thereof
AU2004256085B2 (en) 2003-07-02 2007-12-06 Kyorin, Pharmaceutical Co., Ltd. Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof

Also Published As

Publication number Publication date
PE20050732A1 (es) 2005-11-02
US7582659B2 (en) 2009-09-01
US7462633B2 (en) 2008-12-09
ATE471937T1 (de) 2010-07-15
AU2004256083A1 (en) 2005-01-20
MA27938A1 (fr) 2006-06-01
KR20060113625A (ko) 2006-11-02
IS8178A (is) 2005-12-13
EP1646629B1 (de) 2010-06-23
JP2007521281A (ja) 2007-08-02
BRPI0411688A (pt) 2006-12-26
NZ544237A (en) 2008-09-26
IL172785A0 (en) 2006-06-11
RU2348628C2 (ru) 2009-03-10
NO20060558L (no) 2006-02-02
JP4607107B2 (ja) 2011-01-05
CL2004001678A1 (es) 2005-05-20
TW200510421A (en) 2005-03-16
US20070203187A1 (en) 2007-08-30
WO2005005398A3 (en) 2005-04-28
MY140137A (en) 2009-11-30
WO2005005398A2 (en) 2005-01-20
AU2004256083B2 (en) 2007-10-11
US20050038092A1 (en) 2005-02-17
ECSP056257A (es) 2006-04-19
EP1646629A2 (de) 2006-04-19
CA2530140C (en) 2010-11-09
CA2530140A1 (en) 2005-01-20
RU2005140379A (ru) 2007-08-10
MXPA06000228A (es) 2006-06-27
AR044990A1 (es) 2005-10-12

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