DK1606277T3 - Imidazol-4-yl-ethynyl-pyridinderivater - Google Patents

Imidazol-4-yl-ethynyl-pyridinderivater

Info

Publication number: DK1606277T3
Authority: DK; Denmark
Prior art keywords: imidazol; ethynyl; pyridine derivatives; pyridine; derivatives
Prior art date: 2003-03-10

Application number

DK04717578T

Other languages

English (en)

Inventor

Bernd Buettelmann

Simona Maria Ceccarelli

Georg Jaeschke

Sabine Kolczewski

Richard Hugh Phillip Porter

Eric Vieira

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-10

Filing date

2004-03-05

Publication date

2008-08-18

2004-03-05 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-08-18 Application granted granted Critical

2008-08-18 Publication of DK1606277T3 publication Critical patent/DK1606277T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK04717578T 2003-03-10 2004-03-05 Imidazol-4-yl-ethynyl-pyridinderivater DK1606277T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03004952		2003-03-10
PCT/EP2004/002276 WO2004080998A1 (en)	2003-03-10	2004-03-05	Imidazol-4-yl-ethynyl-pyridine derivatives

Publications (1)

Publication Number	Publication Date
DK1606277T3 true DK1606277T3 (da)	2008-08-18

Family

ID=32981724

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04717578T DK1606277T3 (da)	2003-03-10	2004-03-05	Imidazol-4-yl-ethynyl-pyridinderivater

Country Status (31)

Country	Link
US (1)	US7153874B2 (da)
EP (1)	EP1606277B8 (da)
JP (1)	JP4404896B2 (da)
KR (1)	KR100742019B1 (da)
CN (1)	CN100358889C (da)
AR (1)	AR043501A1 (da)
AT (1)	ATE395345T1 (da)
AU (1)	AU2004220382B2 (da)
BR (1)	BRPI0408093A (da)
CA (1)	CA2516682C (da)
CL (1)	CL2004000449A1 (da)
CO (1)	CO5601027A2 (da)
DE (1)	DE602004013746D1 (da)
DK (1)	DK1606277T3 (da)
ES (1)	ES2305739T3 (da)
HK (1)	HK1089443A1 (da)
HR (1)	HRP20050774A2 (da)
IL (1)	IL170129A (da)
MX (1)	MXPA05009524A (da)
MY (1)	MY135491A (da)
NO (1)	NO20054136L (da)
NZ (1)	NZ541643A (da)
PA (1)	PA8597301A1 (da)
PE (1)	PE20041061A1 (da)
PL (1)	PL1606277T3 (da)
PT (1)	PT1606277E (da)
RU (1)	RU2342383C2 (da)
SI (1)	SI1606277T1 (da)
TW (1)	TWI292318B (da)
WO (1)	WO2004080998A1 (da)
ZA (1)	ZA200506834B (da)

Families Citing this family (28)

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UA80888C2 (en) *	2003-06-05	2007-11-12	Hoffmann La Roche	Imidazole derivatives as glutmate receptor antagonists
US7452909B2 (en) *	2003-09-04	2008-11-18	Hoffman-La Roche Inc.	Imidazole derivatives
JP4690395B2 (ja) *	2004-06-01	2011-06-01	エフ．ホフマン−ラロシュアーゲー	ｍＧｌｕ５レセプターアンタゴニストとしてのピリジン−４−エチニル−イミダゾール及びピラゾール
CA2568725C (en) *	2004-06-01	2012-11-27	F. Hoffmann-La Roche Ag	Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists
WO2007025177A2 (en)	2005-08-26	2007-03-01	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
US7985756B2 (en)	2005-10-21	2011-07-26	Braincells Inc.	Modulation of neurogenesis by PDE inhibition
JP2009513672A (ja)	2005-10-31	2009-04-02	ブレインセルス，インコーポレイティド	神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
DE102006011574A1 (de)	2006-03-10	2007-10-31	Grünenthal GmbH	Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
JP2009536667A (ja)	2006-05-09	2009-10-15	ブレインセルス，インコーポレイティド	５ｈｔ受容体介在性の神経新生
EP2377531A2 (en)	2006-05-09	2011-10-19	Braincells, Inc.	Neurogenesis by modulating angiotensin
MX2009002496A (es) *	2006-09-08	2009-07-10	Braincells Inc	Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
DK2125779T3 (da)	2006-12-21	2016-07-04	Hoffmann La Roche	Polymorfer af en mglur5 receptor antagonist
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
US8334287B2 (en) *	2009-07-17	2012-12-18	Hoffmann-La Roche Inc.	Imidazoles
US8586581B2 (en) *	2009-12-17	2013-11-19	Hoffmann-La Roche Inc	Ethynyl compounds useful for treatment of CNS disorders
MX337443B (es)	2011-04-26	2016-03-07	Hoffmann La Roche	Derivados de etinilo como moduladores alostericos positivos del receptor de glutamato metabotropico del subtipo 5 (mglur5).
UA116023C2 (uk)	2013-07-08	2018-01-25	Ф. Хоффманн-Ля Рош Аг	Етинільні похідні як антагоністи метаботропного глутаматного рецептора
EP3400220B1 (en) *	2016-01-05	2021-03-24	Hua Medicine (Shanghai) Ltd.	Pyrazole derivatives
JP7098630B2 (ja)	2017-01-10	2022-07-11	バイエル・アクチエンゲゼルシヤフト	有害生物防除剤としてのヘテロサイクレン誘導体
US11058115B2 (en)	2017-01-10	2021-07-13	Bayer Aktiengesellschaft	Heterocycle derivatives as pesticides
JP2023504177A (ja) *	2019-12-02	2023-02-01	エフ．ホフマン－ラロシュアーゲー	アルキニル－（ヘテロアリール）－カルボキサミドｈｃｎ１阻害剤
CN111416154B (zh) *	2020-05-22	2021-08-06	松山湖材料实验室	高电压锂离子电池电解液硅基吡啶添加剂、电解液及其电池
WO2022207479A1 (en)	2021-03-27	2022-10-06	Syngenta Crop Protection Ag	Microbiocidal isonicotinic amide derivatives
EP4433460A2 (en)	2021-11-19	2024-09-25	Syngenta Crop Protection AG	Microbiocidal isonicotinic amide derivatives
WO2024132901A1 (en)	2022-12-19	2024-06-27	Syngenta Crop Protection Ag	Microbiocidal pyridazine dihydrooxadiazine derivatives

Family Cites Families (12)

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Publication number	Priority date	Publication date	Assignee	Title
US3303199A (en)	1963-07-15	1967-02-07	Geigy Chem Corp	Certain imidazolone derivatives and process for making same
US3341548A (en)	1964-04-29	1967-09-12	Hoffmann La Roche	Nitroimidazoles and their preparation
DE2035905A1 (de)	1970-07-20	1972-02-03	Chemische Fabrik Stockhausen & Cie.,4150Krefeld	Imidazolverbindungen und deren Herstellungsverfahren
CA1174673A (en)	1981-02-27	1984-09-18	Walter Hunkeler	Imidazodiazepines
US4711962A (en)	1984-10-18	1987-12-08	Stauffer Chemical Company	Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles
US4882343A (en) *	1987-08-28	1989-11-21	G. D. Searle & Co.	Biarylalkylimidazole derivatives as anti-depressants
HU217958B (hu)	1989-06-30	2000-05-28	E. I. Du Pont De Nemours And Co.	Helyettesített imidazolszármazékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
TW544448B (en)	1997-07-11	2003-08-01	Novartis Ag	Pyridine derivatives
ES2216305T3 (es)	1997-08-14	2004-10-16	F. Hoffmann-La Roche Ag	Vinileteres heterociclicos contra trastornos neurologicos.
WO2001016121A1 (en)	1999-08-31	2001-03-08	Merck & Co., Inc.	Heterocyclic compounds and methods of use thereof
RS43903A (en)	2000-12-04	2006-12-15	F.Hoffmann-La Roche Ag.	Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists
CA2470612A1 (en) *	2001-12-19	2003-07-03	Merck & Co., Inc.	Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5

2004
- 2004-03-04 TW TW093105737A patent/TWI292318B/zh not_active IP Right Cessation
- 2004-03-05 JP JP2006504558A patent/JP4404896B2/ja not_active Expired - Fee Related
- 2004-03-05 PA PA20048597301A patent/PA8597301A1/es unknown
- 2004-03-05 AU AU2004220382A patent/AU2004220382B2/en not_active Ceased
- 2004-03-05 RU RU2005131165/04A patent/RU2342383C2/ru not_active IP Right Cessation
- 2004-03-05 EP EP04717578A patent/EP1606277B8/en not_active Expired - Lifetime
- 2004-03-05 KR KR1020057016753A patent/KR100742019B1/ko not_active IP Right Cessation
- 2004-03-05 ES ES04717578T patent/ES2305739T3/es not_active Expired - Lifetime
- 2004-03-05 BR BRPI0408093-9A patent/BRPI0408093A/pt not_active IP Right Cessation
- 2004-03-05 AT AT04717578T patent/ATE395345T1/de active
- 2004-03-05 DK DK04717578T patent/DK1606277T3/da active
- 2004-03-05 PL PL04717578T patent/PL1606277T3/pl unknown
- 2004-03-05 DE DE602004013746T patent/DE602004013746D1/de not_active Expired - Lifetime
- 2004-03-05 PT PT04717578T patent/PT1606277E/pt unknown
- 2004-03-05 MX MXPA05009524A patent/MXPA05009524A/es active IP Right Grant
- 2004-03-05 CA CA002516682A patent/CA2516682C/en not_active Expired - Fee Related
- 2004-03-05 WO PCT/EP2004/002276 patent/WO2004080998A1/en active IP Right Grant
- 2004-03-05 SI SI200430735T patent/SI1606277T1/sl unknown
- 2004-03-05 CN CNB2004800065725A patent/CN100358889C/zh not_active Expired - Fee Related
- 2004-03-05 NZ NZ541643A patent/NZ541643A/en unknown
- 2004-03-08 AR ARP040100722A patent/AR043501A1/es not_active Application Discontinuation
- 2004-03-08 CL CL200400449A patent/CL2004000449A1/es unknown
- 2004-03-08 PE PE2004000252A patent/PE20041061A1/es not_active Application Discontinuation
- 2004-03-08 US US10/795,619 patent/US7153874B2/en not_active Expired - Fee Related
- 2004-03-09 MY MYPI20040806A patent/MY135491A/en unknown
2005
- 2005-08-04 IL IL170129A patent/IL170129A/en not_active IP Right Cessation
- 2005-08-25 ZA ZA200506834A patent/ZA200506834B/en unknown
- 2005-08-25 CO CO05085015A patent/CO5601027A2/es active IP Right Grant
- 2005-09-05 HR HR20050774A patent/HRP20050774A2/xx not_active Application Discontinuation
- 2005-09-06 NO NO20054136A patent/NO20054136L/no not_active Application Discontinuation
2006
- 2006-09-06 HK HK06109889A patent/HK1089443A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
BRPI0408093A (pt)	2006-02-14
RU2342383C2 (ru)	2008-12-27
PL1606277T3 (pl)	2008-10-31
MY135491A (en)	2008-04-30
ATE395345T1 (de)	2008-05-15
MXPA05009524A (es)	2005-10-18
EP1606277B8 (en)	2008-10-15
HRP20050774A2 (en)	2006-09-30
RU2005131165A (ru)	2007-04-20
NZ541643A (en)	2008-03-28
JP2006519802A (ja)	2006-08-31
AU2004220382B2 (en)	2007-08-02
PA8597301A1 (es)	2004-09-16
KR20050109074A (ko)	2005-11-17
EP1606277B1 (en)	2008-05-14
CO5601027A2 (es)	2006-01-31
US20040229917A1 (en)	2004-11-18
AU2004220382A1 (en)	2004-09-23
ES2305739T3 (es)	2008-11-01
AR043501A1 (es)	2005-08-03
CL2004000449A1 (es)	2005-01-07
NO20054136D0 (no)	2005-09-06
TW200423935A (en)	2004-11-16
US7153874B2 (en)	2006-12-26
CA2516682A1 (en)	2004-09-23
DE602004013746D1 (de)	2008-06-26
ZA200506834B (en)	2006-05-31
CN100358889C (zh)	2008-01-02
PT1606277E (pt)	2008-07-08
NO20054136L (no)	2005-09-26
HK1089443A1 (en)	2006-12-01
WO2004080998A1 (en)	2004-09-23
CN1759111A (zh)	2006-04-12
CA2516682C (en)	2010-02-02
IL170129A (en)	2013-02-28
JP4404896B2 (ja)	2010-01-27
PE20041061A1 (es)	2005-01-22
TWI292318B (en)	2008-01-11
SI1606277T1 (sl)	2008-08-31
KR100742019B1 (ko)	2007-07-23
EP1606277A1 (en)	2005-12-21

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ATE450506T1 (de)	2009-12-15	Indol-3-schwefelderivate
ATE467631T1 (de)	2010-05-15	Chinuclidinamidderivate
IS7720A (is)	2005-03-01	Píperidín-N-oxíð-afleiður
ATE438644T1 (de)	2009-08-15	Chinazolinderivate
DK1474408T3 (da)	2012-06-25	N-Phenyl-2-pyrimidinaminderivater
ATE363383T1 (de)	2007-06-15	Schlingenware
DE602004009521D1 (de)	2007-11-29	Flüssigkeitsbehalter
DK1606277T3 (da)	2008-08-18	Imidazol-4-yl-ethynyl-pyridinderivater
IS8364A (is)	2006-03-20	N-þíasól-2-ýl-bensamíð afleiður
DE602004029114D1 (de)	2010-10-28	Trennanalysator
IS8180A (is)	2005-12-14	Nýjar besímídasólafleiður
DE502004009566D1 (de)	2009-07-16	Raftfahrzeug
DE60319796D1 (de)	2008-04-30	tsdetektion
ATE335729T1 (de)	2006-09-15	3h-chinazoline -4-on derivaten
ATE423771T1 (de)	2009-03-15	Tetrahydrochinolinderivate
ATE449064T1 (de)	2009-12-15	Amidoacetonitrilderivate
ATA662003A (de)	2005-11-15	Trink-mundstück
IS8045A (is)	2005-09-26	Púrín-6-ón-afleiður
DE50306277D1 (de)	2007-02-22	4-alkyl-/4-alkenyl-/4-alkinylmethyl/-1-arylcyclohexylamin-derivate
DE502004006563D1 (de)	2008-04-30	Brieftaubenkonstatiersystem