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DE60020869D1 - Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil - Google Patents

Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil

Info

Publication number
DE60020869D1
DE60020869D1 DE60020869T DE60020869T DE60020869D1 DE 60020869 D1 DE60020869 D1 DE 60020869D1 DE 60020869 T DE60020869 T DE 60020869T DE 60020869 T DE60020869 T DE 60020869T DE 60020869 D1 DE60020869 D1 DE 60020869D1
Authority
DE
Germany
Prior art keywords
purity
production
proxetil
cefpodoxim
cefpodoxim proxetil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60020869T
Other languages
English (en)
Other versions
DE60020869T2 (de
Inventor
Gwan Sun Lee
Young Kil Chang
Jae Heon Lee
Chul Hyun Park
Gha Seung Park
Keum Shin Jung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanmi Pharmaceutical Co Ltd
Original Assignee
Hanmi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharmaceutical Co Ltd filed Critical Hanmi Pharmaceutical Co Ltd
Publication of DE60020869D1 publication Critical patent/DE60020869D1/de
Application granted granted Critical
Publication of DE60020869T2 publication Critical patent/DE60020869T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60020869T 1999-11-08 2000-11-07 Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil Expired - Lifetime DE60020869T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1019990049174A KR100342944B1 (ko) 1999-11-08 1999-11-08 고순도 세프포독심 프록세틸의 제조방법
KR9949174 1999-11-08
PCT/KR2000/001272 WO2001034611A1 (en) 1999-11-08 2000-11-07 Method of preparing highly pure cefpodoxime proxetil

Publications (2)

Publication Number Publication Date
DE60020869D1 true DE60020869D1 (de) 2005-07-21
DE60020869T2 DE60020869T2 (de) 2005-11-03

Family

ID=19618994

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60020869T Expired - Lifetime DE60020869T2 (de) 1999-11-08 2000-11-07 Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil

Country Status (14)

Country Link
US (1) US6639068B1 (de)
EP (1) EP1228074B1 (de)
JP (1) JP3751880B2 (de)
KR (1) KR100342944B1 (de)
CN (1) CN1160361C (de)
AT (1) ATE297933T1 (de)
AU (1) AU755284B2 (de)
BR (1) BR0015411A (de)
CA (1) CA2389039A1 (de)
DE (1) DE60020869T2 (de)
ES (1) ES2240200T3 (de)
RU (1) RU2217434C1 (de)
TR (1) TR200201243T2 (de)
WO (1) WO2001034611A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT408226B (de) * 1999-05-05 2001-09-25 Biochemie Gmbh Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2
WO2002068429A1 (en) * 2001-02-27 2002-09-06 Ranbaxy Laboratories Limited Process for the preparation of cefpodoxime proxetil
WO2004048387A1 (en) * 2002-11-22 2004-06-10 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefpodoxime proxetil
ES2291547T3 (es) * 2002-12-20 2008-03-01 Lupin Limited Un procedimiento para la preparacion de cefpodoxima proxetil.
US20060149055A1 (en) * 2003-01-06 2006-07-06 Gharpure Milind M Process for the manufacture of cefpodoxime proxetil
CN1305876C (zh) * 2004-01-08 2007-03-21 上海三维制药有限公司 制备高纯度头孢泊肟酯的方法
US20090269400A1 (en) * 2005-05-16 2009-10-29 Elan Pharma International Limited Nanoparticulate and Controlled Release Compositions Comprising a Cephalosporin
WO2010097675A1 (en) 2009-02-27 2010-09-02 Dhanuka Laboratories Ltd. An improved preparation process for cefpodoxime proxetil
EP2520578A1 (de) 2011-05-06 2012-11-07 Lupin Limited Verfahren zur Reinigung von Cephalosporinen
CN109232609B (zh) * 2018-09-27 2021-07-02 浙江普洛得邦制药有限公司 一种制备高纯度头孢泊肟酯的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1598568A (en) 1977-04-19 1981-09-23 Glaxo Lab Ltd Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
US4486425A (en) * 1980-09-30 1984-12-04 Sankyo Company Limited 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
DK0620225T3 (da) * 1993-04-16 2003-03-17 Basilea Pharmaceutica Ag Cephalosporinderivater
TW293010B (en) * 1994-04-20 1996-12-11 Hui-Po Wang Method for preparing cephalosporin derivatives
US5705689A (en) * 1995-06-19 1998-01-06 Associated Universities, Inc. Aza compounds as anion receptors

Also Published As

Publication number Publication date
TR200201243T2 (tr) 2002-09-23
ES2240200T3 (es) 2005-10-16
CA2389039A1 (en) 2001-05-17
JP3751880B2 (ja) 2006-03-01
ATE297933T1 (de) 2005-07-15
BR0015411A (pt) 2002-06-25
US6639068B1 (en) 2003-10-28
KR100342944B1 (ko) 2002-07-02
WO2001034611A1 (en) 2001-05-17
RU2217434C1 (ru) 2003-11-27
EP1228074A4 (de) 2003-02-26
KR20010045748A (ko) 2001-06-05
AU1420201A (en) 2001-06-06
EP1228074B1 (de) 2005-06-15
CN1160361C (zh) 2004-08-04
JP2003513983A (ja) 2003-04-15
EP1228074A1 (de) 2002-08-07
CN1387533A (zh) 2002-12-25
AU755284B2 (en) 2002-12-05
DE60020869T2 (de) 2005-11-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition