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DE3850535D1 - Topisch aktive Doppelstrang-RNS-Zusammensetzungen. - Google Patents

Topisch aktive Doppelstrang-RNS-Zusammensetzungen.

Info

Publication number
DE3850535D1
DE3850535D1 DE3850535T DE3850535T DE3850535D1 DE 3850535 D1 DE3850535 D1 DE 3850535D1 DE 3850535 T DE3850535 T DE 3850535T DE 3850535 T DE3850535 T DE 3850535T DE 3850535 D1 DE3850535 D1 DE 3850535D1
Authority
DE
Germany
Prior art keywords
double strand
strand rna
topically active
active double
rna compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3850535T
Other languages
English (en)
Other versions
DE3850535T2 (de
Inventor
William Carter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HEM PHARMACEUTICALS CORP ROCKVILLE MD US
HEM Pharmaceuticals Corp
Original Assignee
HEM PHARMACEUTICALS CORP ROCKVILLE MD US
HEM Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HEM PHARMACEUTICALS CORP ROCKVILLE MD US, HEM Pharmaceuticals Corp filed Critical HEM PHARMACEUTICALS CORP ROCKVILLE MD US
Publication of DE3850535D1 publication Critical patent/DE3850535D1/de
Application granted granted Critical
Publication of DE3850535T2 publication Critical patent/DE3850535T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Details Or Accessories Of Spraying Plant Or Apparatus (AREA)
  • Credit Cards Or The Like (AREA)
  • Holo Graphy (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
DE3850535T 1987-08-12 1988-08-12 Topisch aktive Doppelstrang-RNS-Zusammensetzungen. Expired - Fee Related DE3850535T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8422687A 1987-08-12 1987-08-12

Publications (2)

Publication Number Publication Date
DE3850535D1 true DE3850535D1 (de) 1994-08-11
DE3850535T2 DE3850535T2 (de) 1995-01-12

Family

ID=22183613

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3850535T Expired - Fee Related DE3850535T2 (de) 1987-08-12 1988-08-12 Topisch aktive Doppelstrang-RNS-Zusammensetzungen.

Country Status (20)

Country Link
EP (1) EP0303516B1 (de)
JP (1) JP2714021B2 (de)
KR (1) KR970007904B1 (de)
CN (1) CN1031325A (de)
AT (1) ATE108066T1 (de)
AU (3) AU2053688A (de)
CA (1) CA1327001C (de)
DE (1) DE3850535T2 (de)
DK (1) DK449988A (de)
FI (1) FI883734A (de)
HU (1) HU209749B (de)
IE (1) IE66830B1 (de)
IL (1) IL87415A (de)
MX (1) MX12643A (de)
NO (1) NO883564L (de)
NZ (1) NZ225755A (de)
PH (1) PH31174A (de)
PT (1) PT88248B (de)
RU (1) RU2061470C1 (de)
ZA (1) ZA885874B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963532A (en) * 1987-11-25 1990-10-16 Hem Research, Inc. dsRNA-based prevention of viral escape
EP0473576A4 (en) * 1989-05-19 1993-03-10 Hem Research, Inc. Short therapeutic dsrna of defined structure
WO1994024983A2 (en) * 1993-04-28 1994-11-10 Ribozyme Pharmaceuticals, Inc. Ocular delivery of nucleic acid
JP2690276B2 (ja) * 1995-01-10 1997-12-10 科学技術振興事業団 静電結合型高分子ミセル薬物担体とその薬剤
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
ES2374534T3 (es) 1998-03-20 2012-02-17 Commonwealth Scientific And Industrial Research Organisation Control de la expresión de genes.
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
AU776150B2 (en) 1999-01-28 2004-08-26 Medical College Of Georgia Research Institute, Inc. Composition and method for (in vivo) and (in vitro) attenuation of gene expression using double stranded RNA
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
IL151928A0 (en) 2000-03-30 2003-04-10 Whitehead Biomedical Inst Rna sequence-specific mediators of rna interference
SI1407044T2 (en) 2000-12-01 2018-03-30 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Rna interference mediating small rna molecules
EP1229134A3 (de) 2001-01-31 2004-01-28 Nucleonics, Inc Verwendung von post-transkriptioneller Genabschaltung zur Identifizierung von Nukleinsäuresequenzen die die Funktion einer Zelle beeinflussen
JP2005324511A (ja) * 2004-05-17 2005-11-24 Kawamura Sangyo Kk 積層体及びその製造方法
UA93354C2 (ru) * 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат
EP2351577A1 (de) * 2004-12-29 2011-08-03 Mannkind Corporation Verfahren zum Auslösen, Beibehalten und Manipulieren von Immunantworten durch gezielte Verabreichung von Modifikationsmitteln der biologischen Reaktion in lymphatische Organe
FR2885808B1 (fr) * 2005-05-19 2007-07-06 Oreal Vectorisation de dsrna par des particules cationiques et utilisation topique.
US9139850B2 (en) 2005-05-19 2015-09-22 L'oreal Vectorization of dsRNA by cationic particles and topical use
KR20080106219A (ko) * 2006-03-06 2008-12-04 나노캬리아 가부시키가이샤 소수성 화합물의 안정화제
US9603919B2 (en) * 2009-03-31 2017-03-28 Japan As Represented By The Director-General Of National Institute Of Infectious Diseases Method for prophylaxis of influenza using vaccine for intranasal administration
CN105434341B (zh) * 2015-12-22 2018-07-10 肇庆大华农生物药品有限公司 一种兽用聚腺尿苷酸注射液及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3582468A (en) * 1968-09-27 1971-06-01 Merck & Co Inc Recovery of double-stranded ribonucleic acid
BE793157A (fr) * 1971-12-21 1973-06-21 Beecham Group Ltd Substance antivirale
US4024222A (en) * 1973-10-30 1977-05-17 The Johns Hopkins University Nucleic acid complexes
US4415548A (en) * 1980-02-12 1983-11-15 Schmid Laboratories, Inc. Spermicidally lubricated prophylactics and method for making same
JPS57209050A (en) * 1981-06-19 1982-12-22 Jekusu Kk Condome
US4507281A (en) * 1981-10-13 1985-03-26 Exovir, Inc. Interferon-containing compositions
JPS59124514U (ja) * 1983-02-10 1984-08-22 不二ラテックス株式会社 避妊効果を確実に向上させたコンド−ム
FR2556727B1 (fr) * 1983-12-19 1990-01-19 Biostabilex Labo Pharma Nouvelles compositions therapeutiques a base d'adn a haut poids moleculaire et leur procede de preparation
CA1326450C (en) * 1985-08-26 1994-01-25 William A. Carter Modulation of aids virus-related events by double stranded rnas (dsrnas)

Also Published As

Publication number Publication date
IE66830B1 (en) 1996-02-07
HUT47855A (en) 1989-04-28
FI883734A (fi) 1989-02-13
AU1736592A (en) 1992-07-30
RU2061470C1 (ru) 1996-06-10
NZ225755A (en) 1990-03-27
JP2714021B2 (ja) 1998-02-16
IE882398L (en) 1989-02-12
PT88248B (pt) 1995-03-01
IL87415A0 (en) 1989-01-31
NO883564D0 (no) 1988-08-11
CN1031325A (zh) 1989-03-01
KR970007904B1 (ko) 1997-05-17
EP0303516A2 (de) 1989-02-15
EP0303516B1 (de) 1994-07-06
ZA885874B (en) 1989-04-26
HU209749B (en) 1994-10-28
AU1001395A (en) 1995-03-09
DE3850535T2 (de) 1995-01-12
JPH01139531A (ja) 1989-06-01
PH31174A (en) 1998-03-20
NO883564L (no) 1989-02-13
EP0303516A3 (en) 1989-12-06
AU2053688A (en) 1989-04-20
ATE108066T1 (de) 1994-07-15
MX12643A (es) 1993-09-01
PT88248A (pt) 1989-06-30
FI883734A0 (fi) 1988-08-11
KR890003387A (ko) 1989-04-14
DK449988A (da) 1989-02-13
DK449988D0 (da) 1988-08-11
CA1327001C (en) 1994-02-15
IL87415A (en) 1993-05-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee