DE3779374D1 - Xanthinderivate. - Google Patents

Xanthinderivate.

Info

Publication number: DE3779374D1
Authority: DE; Germany
Prior art keywords: xanthinderivate
Prior art date: 1986-08-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE8787810481T

Other languages

English (en)

Inventor

Zoltan L Kis

John Morley

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Sandoz Patent GmbH

Original Assignee

Sandoz AG

Sandoz Patent GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-28

Filing date

1987-08-25

Publication date

1992-07-02

1986-08-28 Priority claimed from GB868620825A external-priority patent/GB8620825D0/en

1987-01-30 Priority claimed from GB878702129A external-priority patent/GB8702129D0/en

1987-02-13 Priority claimed from GB878703435A external-priority patent/GB8703435D0/en

1987-08-25 Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG

1992-07-02 Application granted granted Critical

1992-07-02 Publication of DE3779374D1 publication Critical patent/DE3779374D1/de

2007-08-26 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE8787810481T 1986-08-28 1987-08-25 Xanthinderivate. Expired - Lifetime DE3779374D1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB868620825A GB8620825D0 (en)	1986-08-28	1986-08-28	Organic compounds
GB878702129A GB8702129D0 (en)	1987-01-30	1987-01-30	Organic compounds
GB878703435A GB8703435D0 (en)	1987-02-13	1987-02-13	Organic compounds

Publications (1)

Publication Number	Publication Date
DE3779374D1 true DE3779374D1 (en)	1992-07-02

Family

ID=27263135

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE8787810481T Expired - Lifetime DE3779374D1 (en)	1986-08-28	1987-08-25	Xanthinderivate.

Country Status (17)

Country	Link
EP (1)	EP0258191B1 (de)
JP (1)	JPH0631236B2 (de)
KR (1)	KR880002870A (de)
AU (1)	AU600021B2 (de)
CA (1)	CA1289954C (de)
DE (1)	DE3779374D1 (de)
DK (1)	DK169337B1 (de)
ES (1)	ES2033922T3 (de)
FI (1)	FI87356C (de)
GR (1)	GR3004747T3 (de)
HU (1)	HU199840B (de)
IE (1)	IE60512B1 (de)
IL (1)	IL83659A (de)
MY (1)	MY101830A (de)
NZ (1)	NZ221571A (de)
PH (1)	PH24761A (de)
PT (1)	PT85594B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9020921D0 (en) *	1990-09-26	1990-11-07	Beecham Group Plc	Novel compounds
DE4129603A1 (de) *	1991-09-06	1993-03-11	Thomae Gmbh Dr K	Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB9210839D0 (en) *	1992-05-21	1992-07-08	Smithkline Beecham Plc	Novel compounds
GB9312853D0 (en)	1993-06-22	1993-08-04	Euro Celtique Sa	Chemical compounds
US5591776A (en)	1994-06-24	1997-01-07	Euro-Celtique, S.A.	Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en)	1994-06-24	1999-07-13	Euro-Celtique, S.A.	Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
ATE247116T1 (de)	1994-12-13	2003-08-15	Euro Celtique Sa	Arylthioxanthine
EP0799040B1 (de)	1994-12-13	2003-08-20	Euroceltique S.A.	Dreifachsubstituierte thioxanthine
US6166041A (en)	1995-10-11	2000-12-26	Euro-Celtique, S.A.	2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en)	1996-04-10	2000-06-13	Euro-Celtique S.A.	6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en)	1996-06-06	1999-01-26	Euro-Celtique, S.A.	Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US6821978B2 (en)	2000-09-19	2004-11-23	Schering Corporation	Xanthine phosphodiesterase V inhibitors
AR036674A1 (es)	2001-08-28	2004-09-29	Schering Corp	Inhibidores de fosfodiesterasa v de guanina de policiclicos, composicion farmaceutica, y el uso de dichos compuestos para la preparacion de medicamentos para tratar desordenes fisiologicos
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en)	2007-06-04	2011-02-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20100120694A1 (en)	2008-06-04	2010-05-13	Synergy Pharmaceuticals, Inc.	Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es)	2011-03-01	2018-06-27	Synergy Pharmaceuticals Inc Star	Proceso de preparacion de agonistas c de guanilato ciclasa.
US9545446B2 (en)	2013-02-25	2017-01-17	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
CA2905438A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
EP3004138B1 (de)	2013-06-05	2024-03-13	Bausch Health Ireland Limited	Ultrareine agonisten von guanylatcyclase c, verfahren zur herstellung und verwendung davon
JP6694385B2 (ja)	2013-08-09	2020-05-13	アーデリクス，インコーポレーテッド	リン酸塩輸送阻害のための化合物及び方法
US20200368223A1 (en)	2019-05-21	2020-11-26	Ardelyx, Inc.	Methods for inhibiting phosphate transport

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1024968B (de) *	1956-03-31	1958-02-27	Asal Fabrik Biolog Und Pharmaz	Verfahren zur Herstellung von 7-Ketonyl-8-amino-theophyllinen
AT212847B (de) *	1959-08-13	1961-01-10	Hans Dr Med Voigt	Verfahren zur Herstellung des neuen Coffeino-(8)-(β-Phenyl-isopropyl)-amin
FR2157727A1 (en) *	1971-10-29	1973-06-08	Brun Lab Sa Le	!,#dimethyl-8-aminopurines - with analgesicantitussive and other theophylline-like activities
US4558051A (en) *	1983-10-11	1985-12-10	Richardson-Vicks, Inc.	Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
DE3400951A1 (de) *	1984-01-13	1985-07-18	Robert Bosch Gmbh, 7000 Stuttgart	Verfahren und vorrichtung zur drehzahlregelung bei einer brennkraftmaschine
HU197746B (en) *	1985-09-05	1989-05-29	Sandoz Ag	Process for producing xantin derivatives and pharmaceutical compositions containing them

1987
- 1987-08-25 EP EP87810481A patent/EP0258191B1/de not_active Expired - Lifetime
- 1987-08-25 ES ES198787810481T patent/ES2033922T3/es not_active Expired - Lifetime
- 1987-08-25 DE DE8787810481T patent/DE3779374D1/de not_active Expired - Lifetime
- 1987-08-26 NZ NZ221571A patent/NZ221571A/en unknown
- 1987-08-26 FI FI873704A patent/FI87356C/fi not_active IP Right Cessation
- 1987-08-26 CA CA000545408A patent/CA1289954C/en not_active Expired - Lifetime
- 1987-08-26 PT PT85594A patent/PT85594B/pt not_active IP Right Cessation
- 1987-08-26 IL IL83659A patent/IL83659A/xx not_active IP Right Cessation
- 1987-08-26 AU AU77445/87A patent/AU600021B2/en not_active Ceased
- 1987-08-27 MY MYPI87001462A patent/MY101830A/en unknown
- 1987-08-27 DK DK448787A patent/DK169337B1/da not_active IP Right Cessation
- 1987-08-27 JP JP62214119A patent/JPH0631236B2/ja not_active Expired - Lifetime
- 1987-08-27 IE IE229687A patent/IE60512B1/en not_active IP Right Cessation
- 1987-08-27 KR KR870009453A patent/KR880002870A/ko not_active Application Discontinuation
- 1987-08-27 PH PH35741A patent/PH24761A/en unknown
- 1987-08-27 HU HU873781A patent/HU199840B/hu not_active IP Right Cessation
1992
- 1992-05-28 GR GR920401069T patent/GR3004747T3/el unknown

Also Published As

Publication number	Publication date
CA1289954C (en)	1991-10-01
EP0258191B1 (de)	1992-05-27
AU600021B2 (en)	1990-08-02
HUT47111A (en)	1989-01-30
FI873704A0 (fi)	1987-08-26
GR3004747T3 (de)	1993-04-28
FI873704A (fi)	1988-02-29
IE60512B1 (en)	1994-07-27
PH24761A (en)	1990-10-01
DK169337B1 (da)	1994-10-10
PT85594B (pt)	1990-05-31
PT85594A (en)	1987-09-01
HU199840B (en)	1990-03-28
FI87356B (fi)	1992-09-15
DK448787A (da)	1988-02-29
DK448787D0 (da)	1987-08-27
IL83659A (en)	1991-06-10
EP0258191A1 (de)	1988-03-02
IE872296L (en)	1988-02-28
MY101830A (en)	1992-01-31
ES2033922T3 (es)	1993-04-01
JPH0631236B2 (ja)	1994-04-27
JPS6363679A (ja)	1988-03-22
KR880002870A (ko)	1988-05-12
IL83659A0 (en)	1988-01-31
FI87356C (fi)	1992-12-28
NZ221571A (en)	1990-11-27
AU7744587A (en)	1988-03-03

Publication	Publication Date	Title
DE3765969D1 (en)	1990-12-13	Thiazepinverbindungen.
DE3768161D1 (en)	1991-04-04	Acylanilidabkoemmlinge.
DE3762303D1 (en)	1990-05-23	Suessstoff.
DE3769236D1 (en)	1991-05-16	Differential-planetengetriebe.
DE3776060D1 (en)	1992-02-27	Polyphenylenaetherzusammensetzung.
DE3772064D1 (en)	1991-09-19	Porphyrinderivate.
DE3776328D1 (en)	1992-03-05	Halographisches abtastsystem.
DE3766605D1 (en)	1991-01-17	Eishockey-puck.
DE3762520D1 (en)	1990-06-07	Thienothiophenfarbstoffe.
DE3776359D1 (en)	1992-03-12	Duennschichtmagnetkopf.
DE3776726D1 (en)	1992-03-26	Digitalrechner-differentialrelais.
DE3779374D1 (en)	1992-07-02	Xanthinderivate.
DE3761369D1 (en)	1990-02-15	Foerderer.
DE3768919D1 (en)	1991-05-02	Fluessige photoinitiatorgemische.
DE3775342D1 (en)	1992-01-30	Fluegelzellenverdichter.
DE3768001D1 (en)	1991-03-14	Temperaturkompensierter thermodrucker.
DE3768767D1 (en)	1991-04-25	Duennschichtmonitor.
DE3768095D1 (en)	1991-04-04	Brueckenverstaerker.
DE3767080D1 (en)	1991-02-07	Waermesensible polyurethan-dispersionen.
DE3771692D1 (en)	1991-08-29	Arbiterschaltung.
DE3771117D1 (en)	1991-08-08	Oehlkuehler.
DE3768140D1 (en)	1991-04-04	Fluegelzellenpumpe.
DE3765225D1 (en)	1990-10-31	Roentgenstrahlroehre.
DE3773255D1 (en)	1991-10-31	Thermosensitiver widerstand.
DE3766931D1 (en)	1991-02-07	Fluegelzellenpumpe.

Legal Events

Date	Code	Title	Description
1993-06-24	8364	No opposition during term of opposition
1999-10-07	8339	Ceased/non-payment of the annual fee