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DE3486043D1 - Chinolinzwischenprodukte fuer die synthese von 1h-imidazo(4,5-c)chinolinen und 1h-imidazo(4,5-c)chinolin-4-aminen. - Google Patents

Chinolinzwischenprodukte fuer die synthese von 1h-imidazo(4,5-c)chinolinen und 1h-imidazo(4,5-c)chinolin-4-aminen.

Info

Publication number
DE3486043D1
DE3486043D1 DE8888116137T DE3486043T DE3486043D1 DE 3486043 D1 DE3486043 D1 DE 3486043D1 DE 8888116137 T DE8888116137 T DE 8888116137T DE 3486043 T DE3486043 T DE 3486043T DE 3486043 D1 DE3486043 D1 DE 3486043D1
Authority
DE
Germany
Prior art keywords
imidazo
synthesis
carbon atoms
chinoline
quinolines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888116137T
Other languages
English (en)
Other versions
DE3486043T2 (de
Inventor
John F Gerster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Application granted granted Critical
Publication of DE3486043D1 publication Critical patent/DE3486043D1/de
Publication of DE3486043T2 publication Critical patent/DE3486043T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Water Treatments (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Alarm Systems (AREA)
  • Quinoline Compounds (AREA)
  • Lubricants (AREA)
  • Luminescent Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE8888116137T 1983-11-18 1984-11-16 Chinolinzwischenprodukte fuer die synthese von 1h-imidazo(4,5-c)chinolinen und 1h-imidazo(4,5-c)chinolin-4-aminen. Expired - Lifetime DE3486043T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55315783A 1983-11-18 1983-11-18
US55315883A 1983-11-18 1983-11-18

Publications (2)

Publication Number Publication Date
DE3486043D1 true DE3486043D1 (de) 1993-02-25
DE3486043T2 DE3486043T2 (de) 1993-06-03

Family

ID=27070262

Family Applications (3)

Application Number Title Priority Date Filing Date
DE8484307974T Expired - Lifetime DE3481124D1 (de) 1983-11-18 1984-11-16 1h-imidazo(4,5c)chinoline und 1h-imidazo(4,5-c)chinolin-4-amine.
DE8888116137T Expired - Lifetime DE3486043T2 (de) 1983-11-18 1984-11-16 Chinolinzwischenprodukte fuer die synthese von 1h-imidazo(4,5-c)chinolinen und 1h-imidazo(4,5-c)chinolin-4-aminen.
DE1999175027 Active DE19975027I2 (de) 1983-11-18 1984-11-16 1H-imidazo(4,5c)chinoline und 1H-Imidazo(4,5-c)chinolin-4-amine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8484307974T Expired - Lifetime DE3481124D1 (de) 1983-11-18 1984-11-16 1h-imidazo(4,5c)chinoline und 1h-imidazo(4,5-c)chinolin-4-amine.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1999175027 Active DE19975027I2 (de) 1983-11-18 1984-11-16 1H-imidazo(4,5c)chinoline und 1H-Imidazo(4,5-c)chinolin-4-amine

Country Status (15)

Country Link
EP (2) EP0310950B1 (de)
JP (1) JPS60123488A (de)
KR (1) KR900005657B1 (de)
AT (2) ATE84525T1 (de)
AU (2) AU581190B2 (de)
CA (1) CA1271477A (de)
DE (3) DE3481124D1 (de)
DK (6) DK164280C (de)
ES (1) ES537677A0 (de)
IE (1) IE57874B1 (de)
IL (2) IL84537A (de)
NL (2) NL980043I1 (de)
NO (7) NO163819C (de)
NZ (1) NZ210228A (de)
PH (1) PH22338A (de)

Families Citing this family (72)

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CA1306260C (en) * 1985-10-18 1992-08-11 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
US4942168A (en) * 1987-07-13 1990-07-17 Hoechst-Roussel Pharmaceuticals Inc. Hydroxyquinoline amines, and method of enhancing memory in mammals
CA1335996C (en) * 1988-02-16 1995-06-20 Susumu Takada 2-substituted carbonylimidazo¬4,5-c|quinolines
EP0361489A3 (de) * 1988-09-30 1991-06-12 Chugai Seiyaku Kabushiki Kaisha 3,4-Diaminochinolin- und Pyridinverbindungen
EP0385630B1 (de) * 1989-02-27 1996-11-27 Riker Laboratories, Inc. 4-Amino-1H-Imidazo(4,5-c)chinoline als antivirale Mittel
CA2011504C (en) * 1989-03-07 1998-06-02 Kenji Ohmori Imidazoquinolone derivatives
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
JP2988692B2 (ja) * 1989-07-18 1999-12-13 協和醗酵工業株式会社 イミダゾキノロン誘導体
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
FR2654021B1 (fr) * 1989-11-07 1992-02-28 Simond Jacques Procede de vitrification de cendres volantes et dispositif pour sa mise en óoeuvre.
GB8928281D0 (en) * 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
JP3016905B2 (ja) * 1990-06-01 2000-03-06 協和醗酵工業株式会社 イミダゾナフチリジン誘導体
ES2131070T3 (es) * 1991-03-01 1999-07-16 Minnesota Mining & Mfg 1h-imidazo(4,5-c)quinolin-4-aminas sustituidas en posicion 1 y sustituidas en posicion 2.
US5266575A (en) * 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) * 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5395937A (en) * 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
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JPH10298181A (ja) * 1997-04-25 1998-11-10 Sumitomo Pharmaceut Co Ltd タイプ２ヘルパーｔ細胞選択的免疫応答抑制剤
JP2000119271A (ja) 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd １ｈ―イミダゾピリジン誘導体
EP1438295B1 (de) * 2001-10-23 2012-08-15 Merck Serono SA Azolderivate und sie enthaltende pharmazeutische zusammensetzungen
GB0211649D0 (en) * 2002-05-21 2002-07-03 Novartis Ag Organic compounds
PT1543002E (pt) 2002-07-23 2006-11-30 Teva Gyogyszergyar Zartkoeruen Preparação de intermediários 1h-imidazo ( 4,5-c )quinolin-4-aminas via 1h- imidazo (4,5-c ) quinolina-4-ftalimida
IL166307A0 (en) 2002-07-26 2006-01-15 Preparation of 1h-imidazoÄ4,5-cÜquinolin-4-amines via novel 1h-imidazoÄ4,5-cÜquinolin-4-cyano and 1h-imidazo Ä4,5-cÜquinolin-4-cyano and 1h-imidazoÄ4,5-cÜquinolin-4-carboxamide intermediates
AR045260A1 (es) 2003-08-12 2005-10-19 3M Innovative Properties Co Compuestos que contienen imidazo-oxima sustituidos
JP5128815B2 (ja) * 2003-08-27 2013-01-23 スリーエム イノベイティブ プロパティズ カンパニー アリールオキシ置換およびアリールアルキレンオキシ置換イミダゾキノリン
EP1660026A4 (de) 2003-09-05 2008-07-16 3M Innovative Properties Co Behandlung von cd5+ b-zell-lyphom
CA2536530A1 (en) 2003-10-01 2005-04-14 Taro Pharmaceuticals U.S.A., Inc. Method of preparing 4-amino-1h-imidazo(4,5-c)quinolines and acid addition salts thereof
EP1673087B1 (de) 2003-10-03 2015-05-13 3M Innovative Properties Company Alkoxy-substituierte imidazochinoline
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
ITMI20032121A1 (it) * 2003-11-04 2005-05-05 Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm Procedimento per la preparazione di imiquimod e suoi intermedi
US8598192B2 (en) 2003-11-14 2013-12-03 3M Innovative Properties Company Hydroxylamine substituted imidazoquinolines
CA2545774A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
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WO2005066169A2 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
AU2005228150A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
CA2594674C (en) 2004-12-30 2016-05-17 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
US9248127B2 (en) 2005-02-04 2016-02-02 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
AU2006213746A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods
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IL68495A0 (en) * 1982-05-03 1983-07-31 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines

Also Published As

Publication number Publication date
NO890823D0 (no) 1989-02-27
NO1999015I1 (no) 1999-07-08
ES8603477A1 (es) 1985-12-16
NO890823L (no) 1985-05-20
NO165146C (no) 1991-01-02
NO165147C (no) 1991-01-02
NO890825D0 (no) 1989-02-27
NO890825L (no) 1985-05-20
EP0145340A2 (de) 1985-06-19
EP0145340B1 (de) 1990-01-24
DK135791D0 (da) 1991-07-16
AU581190B2 (en) 1989-02-16
DK164280B (da) 1992-06-01
NO169437C (no) 1992-06-24
AU2991189A (en) 1989-06-15
KR850003890A (ko) 1985-06-29
DK136191A (da) 1991-07-16
NO890826L (no) 1985-05-20
NL980041I1 (nl) 1999-02-01
NO165145B (no) 1990-09-24
NO890824L (no) 1985-05-20
IE842952L (en) 1985-05-18
DK542684A (da) 1985-05-19
NO168705B (no) 1991-12-16
JPS60123488A (ja) 1985-07-02
AU611997B2 (en) 1991-06-27
NO890822L (no) 1985-05-20
ATE84525T1 (de) 1993-01-15
DK542684D0 (da) 1984-11-15
DK165921B (da) 1993-02-08
NO163819C (no) 1990-08-01
NL980043I1 (nl) 1999-02-01
DE3481124D1 (de) 1990-03-01
DK164455C (da) 1992-11-16
DK164280C (da) 1992-11-30
NO890826D0 (no) 1989-02-27
DE3486043T2 (de) 1993-06-03
CA1271477A (en) 1990-07-10
NO169437B (no) 1992-03-16
DK164451B (da) 1992-06-29
DK164451C (da) 1992-11-09
IL84537A (en) 1990-12-23
DK164455B (da) 1992-06-29
NO165146B (no) 1990-09-24
AU3540284A (en) 1985-05-23
DK135891A (da) 1991-07-16
ES537677A0 (es) 1985-12-16
DE19975027I2 (de) 2000-09-21
NO165145C (no) 1991-01-02
NO163819B (no) 1990-04-17
DK135991A (da) 1991-07-16
DK169179B1 (da) 1994-09-05
NL980041I2 (nl) 1999-07-01
DK164452B (da) 1992-06-29
DK135991D0 (da) 1991-07-16
NO890822D0 (no) 1989-02-27
DK135891D0 (da) 1991-07-16
EP0310950B1 (de) 1993-01-13
PH22338A (en) 1988-08-12
DK136191D0 (da) 1991-07-16
NO890824D0 (no) 1989-02-27
NO844565L (no) 1985-05-20
ATE49763T1 (de) 1990-02-15
EP0310950A1 (de) 1989-04-12
DK135791A (da) 1991-07-16
DK136091A (da) 1991-07-16
DK165921C (da) 1993-06-28
KR900005657B1 (ko) 1990-08-03
IL84537A0 (en) 1988-04-29
JPH0586391B2 (de) 1993-12-10
NZ210228A (en) 1989-01-27
NO165147B (no) 1990-09-24
DK136091D0 (da) 1991-07-16
EP0145340A3 (en) 1986-06-11
IE57874B1 (en) 1993-05-05
DK164452C (da) 1992-11-09
NO168705C (no) 1992-03-25

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Publication Publication Date Title
DE3486043D1 (de) Chinolinzwischenprodukte fuer die synthese von 1h-imidazo(4,5-c)chinolinen und 1h-imidazo(4,5-c)chinolin-4-aminen.

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