CY1124316T1 - Κρυσταλλικο τοσυλικο αλας ενος ρι3κ δελτα εκλεκτικου αναστολεα για χρηση σε φαρμακευτικα σκευασματα - Google Patents
Κρυσταλλικο τοσυλικο αλας ενος ρι3κ δελτα εκλεκτικου αναστολεα για χρηση σε φαρμακευτικα σκευασματαInfo
- Publication number
- CY1124316T1 CY1124316T1 CY20211100652T CY211100652T CY1124316T1 CY 1124316 T1 CY1124316 T1 CY 1124316T1 CY 20211100652 T CY20211100652 T CY 20211100652T CY 211100652 T CY211100652 T CY 211100652T CY 1124316 T1 CY1124316 T1 CY 1124316T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pharmaceutical preparations
- pi3k delta
- selective inhibitor
- tosylate salt
- crystalline tosylate
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση αφορά μορφές στερεάς κατάστασης ενός άλατος p-τολουολοσουλφονικού οξέος (PTSA) του εκλεκτικού ΡΙ3Κ δέλτα αναστολέα (S)-2-(1-(4-αμινο-3-(3-φθορο-4-ισοπροποξυφαινυλ)-1Η-πυραζολο[3,4-d]πυριμιδιν-1-υλ)αιθυλ)-3-(3-φθορο-φαινυλ)-4Η-χρωμεν-4-όνη (TGR-1202). Η παρούσα εφεύρεση αφορά επίσης μεθόδους παρασκευής αυτών, φαρμακευτικές συνθέσεις που περιέχουν αυτές και μεθόδους θεραπείας μιας νόσου ή διαταραχής που διαμεσολαβείται από ΡΙ3Κ κινάση, όπως ο καρκίνος, δια της χορήγησης αυτών.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2597CH2014 | 2014-05-27 | ||
| IN2596CH2014 | 2014-05-27 | ||
| PCT/IB2015/053940 WO2015181728A1 (en) | 2014-05-27 | 2015-05-26 | Improved forms of a pi3k delta selective inhibitor for use in pharmaceutical formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124316T1 true CY1124316T1 (el) | 2022-07-22 |
Family
ID=53499042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100652T CY1124316T1 (el) | 2014-05-27 | 2021-07-21 | Κρυσταλλικο τοσυλικο αλας ενος ρι3κ δελτα εκλεκτικου αναστολεα για χρηση σε φαρμακευτικα σκευασματα |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9969740B2 (el) |
| EP (2) | EP3971188A1 (el) |
| JP (3) | JP6987501B2 (el) |
| KR (1) | KR20170007480A (el) |
| CN (2) | CN106661030B (el) |
| AU (1) | AU2015265542B2 (el) |
| BR (1) | BR112016027674A2 (el) |
| CA (1) | CA2949932C (el) |
| CY (1) | CY1124316T1 (el) |
| DK (1) | DK3149000T3 (el) |
| EA (1) | EA032506B1 (el) |
| ES (1) | ES2880999T3 (el) |
| HR (1) | HRP20211151T1 (el) |
| HU (1) | HUE054916T2 (el) |
| IL (1) | IL249058B2 (el) |
| LT (1) | LT3149000T (el) |
| PL (1) | PL3149000T3 (el) |
| PT (1) | PT3149000T (el) |
| RS (1) | RS62136B1 (el) |
| SI (1) | SI3149000T1 (el) |
| WO (1) | WO2015181728A1 (el) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA032506B1 (ru) * | 2014-05-27 | 2019-06-28 | Ризен Фармасьютикалз Са | Улучшенные формы селективного ингибитора pi3k-дельта для применения в фармацевтических препаратах |
| EP3463318A4 (en) | 2016-05-27 | 2020-01-01 | TG Therapeutics Inc. | COMBINATION OF AN ANTI-CD20 ANTIBODY, A SELECTIVE P13 KINASE-DELTA INHIBITOR AND A BTK INHIBITOR FOR TREATING B LYMPHOCYTE PROLIFERATIVE DISORDERS |
| WO2018049263A1 (en) | 2016-09-09 | 2018-03-15 | Tg Therapeutics, Inc. | Combination of an anti-cd20 antibody, pi3 kinase-delta inhibitor, and anti-pd-1 or anti-pd-l1 antibody for treating hematological cancers |
| JP2022540466A (ja) | 2019-07-15 | 2022-09-15 | ジョンソン、マッセイ、パブリック、リミテッド、カンパニー | 非晶質ウムブラリシブモノトシレート |
| US20220143026A1 (en) | 2020-11-12 | 2022-05-12 | Tg Therapeutics, Inc. | Triple combination to treat b-cell malignancies |
| US11814439B1 (en) | 2022-06-01 | 2023-11-14 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11807689B1 (en) | 2022-06-01 | 2023-11-07 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11884740B1 (en) | 2022-06-01 | 2024-01-30 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11965032B1 (en) | 2022-06-01 | 2024-04-23 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ522076A (en) * | 2000-04-25 | 2005-08-26 | Icos Corp | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
| PT1572744E (pt) | 2002-12-16 | 2010-09-07 | Genentech Inc | Variantes de imunoglobulina e utilizações destas |
| WO2005016348A1 (en) | 2003-08-14 | 2005-02-24 | Icos Corporation | Method of inhibiting immune responses stimulated by an endogenous factor |
| NZ611764A (en) | 2008-11-13 | 2015-01-30 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| EP2411391A1 (en) | 2009-03-24 | 2012-02-01 | Gilead Calistoga LLC | Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| EA201101507A1 (ru) | 2009-04-20 | 2012-05-30 | Гилеад Калистога Ллс. | Способы лечения солидных опухолей |
| PL2870157T3 (pl) * | 2012-07-04 | 2018-01-31 | Rhizen Pharmaceuticals S A | Selektywne inhibitory pi3k delta |
| EA032506B1 (ru) * | 2014-05-27 | 2019-06-28 | Ризен Фармасьютикалз Са | Улучшенные формы селективного ингибитора pi3k-дельта для применения в фармацевтических препаратах |
-
2015
- 2015-05-26 EA EA201692255A patent/EA032506B1/ru unknown
- 2015-05-26 KR KR1020167036318A patent/KR20170007480A/ko not_active Application Discontinuation
- 2015-05-26 CA CA2949932A patent/CA2949932C/en active Active
- 2015-05-26 LT LTEPPCT/IB2015/053940T patent/LT3149000T/lt unknown
- 2015-05-26 PL PL15733532T patent/PL3149000T3/pl unknown
- 2015-05-26 JP JP2016569636A patent/JP6987501B2/ja active Active
- 2015-05-26 DK DK15733532.4T patent/DK3149000T3/da active
- 2015-05-26 CN CN201580034288.7A patent/CN106661030B/zh active Active
- 2015-05-26 EP EP21182208.5A patent/EP3971188A1/en not_active Withdrawn
- 2015-05-26 RS RS20210920A patent/RS62136B1/sr unknown
- 2015-05-26 AU AU2015265542A patent/AU2015265542B2/en active Active
- 2015-05-26 PT PT157335324T patent/PT3149000T/pt unknown
- 2015-05-26 BR BR112016027674A patent/BR112016027674A2/pt not_active Application Discontinuation
- 2015-05-26 CN CN202010471226.5A patent/CN111635406A/zh active Pending
- 2015-05-26 ES ES15733532T patent/ES2880999T3/es active Active
- 2015-05-26 SI SI201531656T patent/SI3149000T1/sl unknown
- 2015-05-26 EP EP15733532.4A patent/EP3149000B1/en active Active
- 2015-05-26 WO PCT/IB2015/053940 patent/WO2015181728A1/en active Application Filing
- 2015-05-26 HU HUE15733532A patent/HUE054916T2/hu unknown
- 2015-05-26 US US15/313,454 patent/US9969740B2/en active Active
-
2016
- 2016-11-20 IL IL249058A patent/IL249058B2/en unknown
-
2018
- 2018-04-11 US US15/950,606 patent/US10414773B2/en active Active
-
2019
- 2019-08-30 US US16/557,091 patent/US10947244B2/en active Active
-
2020
- 2020-05-20 JP JP2020088147A patent/JP2020122022A/ja active Pending
- 2020-12-23 US US17/247,806 patent/US20210269446A1/en not_active Abandoned
-
2021
- 2021-07-19 HR HRP20211151TT patent/HRP20211151T1/hr unknown
- 2021-07-21 CY CY20211100652T patent/CY1124316T1/el unknown
-
2022
- 2022-04-05 JP JP2022062937A patent/JP2022082680A/ja active Pending
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