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CY1121783T1 - Συζευγμα αντισωματος-igf-1r-φαρμακου και η χρηση αυτου για την αγωγη του καρκινου - Google Patents

Συζευγμα αντισωματος-igf-1r-φαρμακου και η χρηση αυτου για την αγωγη του καρκινου

Info

Publication number
CY1121783T1
CY1121783T1 CY20191100523T CY191100523T CY1121783T1 CY 1121783 T1 CY1121783 T1 CY 1121783T1 CY 20191100523 T CY20191100523 T CY 20191100523T CY 191100523 T CY191100523 T CY 191100523T CY 1121783 T1 CY1121783 T1 CY 1121783T1
Authority
CY
Cyprus
Prior art keywords
antibody
drug conjugate
treatment
igf
cancer
Prior art date
Application number
CY20191100523T
Other languages
English (en)
Inventor
Ian RILATT
Michel Perez
Liliane Goetsch
Matthieu BROUSSAS
Charlotte Beau-Larvor
Jean-François HAEUW
Thierry Champion
Alain Robert
Original Assignee
Pierre Fabre Médicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Médicament filed Critical Pierre Fabre Médicament
Publication of CY1121783T1 publication Critical patent/CY1121783T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με ένα σύζευγμα αντισώματος-φαρμάκου δυνάμενο δέσμευσης IGF-1R. Από μια άποψη του θέματος, η εφεύρεση σχετίζεται με ένα σύζευγμα αντισώματος-φαρμάκου περιλαμβάνοντας ένα αντίσωμα δυνάμενο δέσμευσης σε IGF-1R, με το εν λόγω αντίσωμα να συζεύγεται σε τουλάχιστον ένα φάρμακο που επιλέγεται από παράγωγα δολαστατίνης 10 και αουριστατινών. Η εφεύρεση περιλαμβάνει επίσης μέθοδο αγωγής και τη χρήση του εν λόγω συζεύγματος αντισώματος-φαρμάκου για την αγωγή του καρκίνου.
CY20191100523T 2014-04-25 2019-05-15 Συζευγμα αντισωματος-igf-1r-φαρμακου και η χρηση αυτου για την αγωγη του καρκινου CY1121783T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14305620 2014-04-25
PCT/EP2015/059045 WO2015162291A1 (en) 2014-04-25 2015-04-27 Igf-1r antibody-drug-conjugate and its use for the treatment of cancer

Publications (1)

Publication Number Publication Date
CY1121783T1 true CY1121783T1 (el) 2020-07-31

Family

ID=50630736

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100523T CY1121783T1 (el) 2014-04-25 2019-05-15 Συζευγμα αντισωματος-igf-1r-φαρμακου και η χρηση αυτου για την αγωγη του καρκινου

Country Status (27)

Country Link
US (2) US10633448B2 (el)
EP (2) EP3498301A1 (el)
JP (1) JP6258523B2 (el)
KR (1) KR101795984B1 (el)
CN (1) CN106456800B (el)
AU (1) AU2015250759B2 (el)
BR (1) BR112016024619A2 (el)
CA (1) CA2946469C (el)
CY (1) CY1121783T1 (el)
DK (1) DK3134124T3 (el)
ES (1) ES2727103T3 (el)
HR (1) HRP20190888T8 (el)
HU (1) HUE044862T2 (el)
IL (1) IL248455B (el)
LT (1) LT3134124T (el)
MA (2) MA39909B1 (el)
MX (1) MX2016013704A (el)
MY (1) MY186711A (el)
PL (1) PL3134124T3 (el)
PT (1) PT3134124T (el)
RS (1) RS58742B1 (el)
RU (1) RU2692563C2 (el)
SA (1) SA516380120B1 (el)
SI (1) SI3134124T1 (el)
TN (1) TN2016000472A1 (el)
UA (1) UA120364C2 (el)
WO (1) WO2015162291A1 (el)

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Also Published As

Publication number Publication date
CN106456800B (zh) 2018-05-01
AU2015250759A1 (en) 2016-11-10
EP3498301A1 (en) 2019-06-19
MX2016013704A (es) 2017-03-31
EP3134124B1 (en) 2019-02-20
SI3134124T1 (sl) 2019-06-28
JP2017513900A (ja) 2017-06-01
ES2727103T8 (es) 2020-03-02
AU2015250759B2 (en) 2017-11-30
MY186711A (en) 2021-08-12
KR101795984B1 (ko) 2017-11-10
BR112016024619A2 (pt) 2017-10-10
HRP20190888T8 (hr) 2019-10-04
SA516380120B1 (ar) 2019-02-27
IL248455B (en) 2020-01-30
ES2727103T3 (es) 2019-10-14
WO2015162291A1 (en) 2015-10-29
US20170043031A1 (en) 2017-02-16
CA2946469A1 (en) 2015-10-29
RU2016145444A (ru) 2018-05-28
CA2946469C (en) 2019-10-29
PT3134124T (pt) 2019-06-03
UA120364C2 (uk) 2019-11-25
MA39909B1 (fr) 2019-05-31
US20200270352A1 (en) 2020-08-27
HUE044862T2 (hu) 2019-11-28
RU2016145444A3 (el) 2018-11-22
LT3134124T (lt) 2019-05-27
RU2692563C2 (ru) 2019-06-25
RS58742B1 (sr) 2019-06-28
PL3134124T3 (pl) 2019-09-30
KR20160146817A (ko) 2016-12-21
US11661457B2 (en) 2023-05-30
DK3134124T3 (da) 2019-05-06
MA47811A (fr) 2019-06-19
HRP20190888T1 (hr) 2019-07-12
CN106456800A (zh) 2017-02-22
EP3134124A1 (en) 2017-03-01
JP6258523B2 (ja) 2018-01-10
MA39909A (fr) 2017-03-01
US10633448B2 (en) 2020-04-28
IL248455A0 (en) 2016-11-30
TN2016000472A1 (en) 2018-04-04

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