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BR112018075651A2 - anticorpos anti-cd98 e conjugados anticorpo fármaco - Google Patents

anticorpos anti-cd98 e conjugados anticorpo fármaco

Info

Publication number
BR112018075651A2
BR112018075651A2 BR112018075651-2A BR112018075651A BR112018075651A2 BR 112018075651 A2 BR112018075651 A2 BR 112018075651A2 BR 112018075651 A BR112018075651 A BR 112018075651A BR 112018075651 A2 BR112018075651 A2 BR 112018075651A2
Authority
BR
Brazil
Prior art keywords
antibodies
antibody conjugates
drug antibody
cafs
drug
Prior art date
Application number
BR112018075651-2A
Other languages
English (en)
Inventor
Benatuil Lorenzo
Bruncko Milan
S. Judd Andrew
Li Yingchun
Mccluskey Andrew
C. Phillips Andrew
C. Phillips Darren
Seagal Jane
J. Souers Andrew
Original Assignee
Abbvie Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc. filed Critical Abbvie Inc.
Publication of BR112018075651A2 publication Critical patent/BR112018075651A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/52—Purines, e.g. adenine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Animal Behavior & Ethology (AREA)
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Abstract

a invenção se relaciona com anticorpos anti-cd98 e conjugados anticorpo fármaco (cafs), incluindo composições e métodos de uso dos referidos anticorpos e cafs.
BR112018075651-2A 2016-06-08 2017-06-08 anticorpos anti-cd98 e conjugados anticorpo fármaco BR112018075651A2 (pt)

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CA3027047A1 (en) 2017-12-14
CN109562170B (zh) 2023-01-13
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WO2017214462A2 (en) 2017-12-14
WO2017214462A4 (en) 2018-04-05
CN116173232A (zh) 2023-05-30
US20230135723A1 (en) 2023-05-04
US20200121803A1 (en) 2020-04-23
CN109562170A (zh) 2019-04-02
AU2017277920A1 (en) 2019-01-03
EP3468596A2 (en) 2019-04-17
JP2019524649A (ja) 2019-09-05

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