[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CY1114869T1 - Παραγωγα 5-αμινο-2-(1-υδροξυ-αιθυλο)-τετραϋδροπυρανιου - Google Patents

Παραγωγα 5-αμινο-2-(1-υδροξυ-αιθυλο)-τετραϋδροπυρανιου

Info

Publication number
CY1114869T1
CY1114869T1 CY20131101136T CY131101136T CY1114869T1 CY 1114869 T1 CY1114869 T1 CY 1114869T1 CY 20131101136 T CY20131101136 T CY 20131101136T CY 131101136 T CY131101136 T CY 131101136T CY 1114869 T1 CY1114869 T1 CY 1114869T1
Authority
CY
Cyprus
Prior art keywords
tethydropyranium
aythyl
hydroxy
amino
production
Prior art date
Application number
CY20131101136T
Other languages
English (en)
Inventor
Christian Hubschwerlen
Georg Rueedi
Jean-Philippe Surivet
Acklin Cornelia Zumbrunn
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of CY1114869T1 publication Critical patent/CY1114869T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/056Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D497/00Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Η εφεύρεση αφορά σε αντιβακτηριακές ενώσεις του τύπου Ι, όπου το R1 παριστάνει αλκοξύ (ειδικά μεθοξύ), το R2 παριστάνει Η ή F, έκαστο από τα R3, R4, R5 και R6 παριστάνει ανεξάρτητα Η ή D, το V παριστάνει CΗ και το W παριστάνει CH ή Ν ή το V παριστάνει Ν και το W παριστάνει CH, το Υ παριστάνει CH ή Ν, το Ζ παριστάνει Ο, S ή CΗ2, και το Α παριστάνει, CΗ2, CH2CH2 ή CD2CD2, και άλατα τέτοιων ενώσεων.
CY20131101136T 2008-12-12 2013-12-18 Παραγωγα 5-αμινο-2-(1-υδροξυ-αιθυλο)-τετραϋδροπυρανιου CY1114869T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2008055261 2008-12-12
EP09796819.2A EP2376497B1 (en) 2008-12-12 2009-12-11 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives

Publications (1)

Publication Number Publication Date
CY1114869T1 true CY1114869T1 (el) 2016-12-14

Family

ID=41723046

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131101136T CY1114869T1 (el) 2008-12-12 2013-12-18 Παραγωγα 5-αμινο-2-(1-υδροξυ-αιθυλο)-τετραϋδροπυρανιου

Country Status (28)

Country Link
US (1) US8211890B2 (el)
EP (1) EP2376497B1 (el)
JP (1) JP4955835B2 (el)
KR (1) KR101297450B1 (el)
CN (1) CN102232078B (el)
AR (1) AR074604A1 (el)
AU (1) AU2009325902B2 (el)
BR (1) BRPI0924081A2 (el)
CA (1) CA2744456C (el)
CL (1) CL2011001413A1 (el)
CY (1) CY1114869T1 (el)
DK (1) DK2376497T3 (el)
ES (1) ES2435596T3 (el)
HK (1) HK1162478A1 (el)
HR (1) HRP20140010T1 (el)
IL (1) IL213432A (el)
MA (1) MA32956B1 (el)
MX (1) MX2011005905A (el)
MY (1) MY159183A (el)
NZ (1) NZ593891A (el)
PL (1) PL2376497T3 (el)
PT (1) PT2376497E (el)
RU (1) RU2525541C2 (el)
SG (1) SG172088A1 (el)
SI (1) SI2376497T1 (el)
TW (1) TWI426076B (el)
WO (1) WO2010067332A1 (el)
ZA (1) ZA201105095B (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
ES2578182T3 (es) 2011-05-31 2016-07-21 Actelion Pharmaceuticals Ltd. Procedimientos de preparación de intermediarios sintéticos que pueden usarse para la fabricación de antibióticos
WO2013003383A1 (en) * 2011-06-27 2013-01-03 Kyorin Pharmaceutical Co., Ltd. Bridged bicyclic compounds for the treatment of bacterial infections
WO2013038374A1 (en) 2011-09-16 2013-03-21 Actelion Pharmaceuticals Ltd Process for manufacturing a synthetic intermediate
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
AR090844A1 (es) 2012-04-27 2014-12-10 Actelion Pharmaceuticals Ltd Proceso para elaborar derivados de naftiridina
TW201722965A (zh) * 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
IL301709A (en) 2017-08-09 2023-05-01 Denali Therapeutics Inc Compounds, preparations and methods
WO2019046779A1 (en) * 2017-09-01 2019-03-07 Denali Therapeutics Inc. COMPOUNDS, COMPOSITIONS AND METHODS
JP2022520236A (ja) 2019-02-13 2022-03-29 デナリ セラピューティクス インコーポレイテッド 化合物、組成物、及び、方法
MA54959A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1095611A1 (ru) * 1982-09-10 2007-06-27 Краснодарский ордена Трудового Красного Знамени политехнический институт Хлорид 5-хлорметил-2-этил-8-метил-4Н-м-диоксино-(4,5-с)-пиридиния, обладающий антимикробной активностью
CA2195129C (en) * 1991-03-28 2002-09-10 Anabella Villalobos Substituted piperidine intermediates for producing heterocyclic-cyclic amine derivatives capable of inhibiting cholinesterase
GB9822450D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
AR038240A1 (es) * 2002-01-29 2005-01-05 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para su preparacion
TW200409637A (en) * 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
DE10316081A1 (de) 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
JP2008505920A (ja) 2004-07-08 2008-02-28 グラクソ グループ リミテッド 抗菌剤
JP4887297B2 (ja) * 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質
JP5314244B2 (ja) 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
AU2006250987A1 (en) * 2005-05-24 2006-11-30 Astrazeneca Ab Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
WO2007016610A2 (en) * 2005-08-02 2007-02-08 Glaxo Group Limited Antibacterial agents
EA200801128A1 (ru) 2005-10-21 2008-10-30 Глэксо Груп Лимитед Пери-конденсированные трициклические соединения, полезные в качестве антибактериальных средств
WO2007071936A1 (en) 2005-12-22 2007-06-28 Glaxo Group Limited Heterocyclic compounds, their preparation and their use as antibacterials
DE102005062889A1 (de) 2005-12-29 2007-07-05 Robert Bosch Gmbh Elektrische Null-Kraft-Steckvorrichtung
ES2376488T3 (es) * 2006-01-26 2012-03-14 Actelion Pharmaceuticals Ltd. Antibióticos de tetrahidropirano.
CA2643962A1 (en) * 2006-03-10 2007-09-20 Actelion Pharmaceuticals Ltd Antibiotic compounds
DE602007009205D1 (de) 2006-04-06 2010-10-28 Glaxo Group Ltd Pyrrolochinoxalinonderivate als antibakterielle mittel
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
BRPI0812942B1 (pt) * 2007-06-15 2018-11-21 Actelion Pharmaceuticals Ltd composto derivado de 3-amino-6 - (1-amino-etil) - tetra-hidropirano, composição farmacêutica e uso de referido composto.
US8354426B2 (en) 2007-11-26 2013-01-15 Toyama Chemical Co., Ltd. Naphthyridine derivative monohydrate and method for producing the same

Also Published As

Publication number Publication date
CN102232078B (zh) 2014-07-16
US20110245259A1 (en) 2011-10-06
CN102232078A (zh) 2011-11-02
BRPI0924081A2 (pt) 2018-03-20
TWI426076B (zh) 2014-02-11
PL2376497T3 (pl) 2014-03-31
PT2376497E (pt) 2013-11-21
SG172088A1 (en) 2011-07-28
DK2376497T3 (da) 2013-11-18
US8211890B2 (en) 2012-07-03
HRP20140010T1 (hr) 2014-02-14
WO2010067332A1 (en) 2010-06-17
NZ593891A (en) 2013-05-31
SI2376497T1 (sl) 2014-01-31
KR101297450B1 (ko) 2013-08-20
CA2744456C (en) 2017-09-26
KR20110086643A (ko) 2011-07-28
CA2744456A1 (en) 2010-06-17
EP2376497B1 (en) 2013-09-18
IL213432A (en) 2013-11-28
JP2012511566A (ja) 2012-05-24
MA32956B1 (fr) 2012-01-02
ZA201105095B (en) 2012-12-27
EP2376497A1 (en) 2011-10-19
CL2011001413A1 (es) 2011-11-11
MY159183A (en) 2016-12-30
ES2435596T3 (es) 2013-12-20
TW201026699A (en) 2010-07-16
AR074604A1 (es) 2011-01-26
RU2011128550A (ru) 2013-01-20
MX2011005905A (es) 2011-06-20
AU2009325902B2 (en) 2015-01-29
IL213432A0 (en) 2011-07-31
JP4955835B2 (ja) 2012-06-20
HK1162478A1 (el) 2012-08-31
AU2009325902A1 (en) 2011-07-21
RU2525541C2 (ru) 2014-08-20

Similar Documents

Publication Publication Date Title
CY1114869T1 (el) Παραγωγα 5-αμινο-2-(1-υδροξυ-αιθυλο)-τετραϋδροπυρανιου
CY1123333T1 (el) Παραγωγα ινδολινονης και διαδικασια για την παραγωγη τους
ECSP099091A (es) Profarmaco de compuesto de cinamida
CY1114452T1 (el) Ενωσεις πυρρολιου
CY1112467T1 (el) Παραγωγα 1-θειο-d-γλυκιτολης
CY1118435T1 (el) Παραγωγο μορφολινο νουκλεϊνικου οξεος
CY1116945T1 (el) Παραγωγα ινδολιζινης, διεργασια για την παρασκευη αυτης και θεραπευτικη χρηση αυτης
EA201170096A1 (ru) Замещенные производные пиримидона
CY1117142T1 (el) Παραγωγο αμινοπυραζολης
ECSP099818A (es) Procesos para la preparacion de pirazoles
CY1119423T1 (el) Παραγωγο κυκλοαλκυλ-υποκατεστημενης ιμιδαζολης
CY1120477T1 (el) Ενεργοποιητης του υποδοχεα που ενεργοποιειται απο πολλαπλασιαστες των υπεροξεισωματων
CY1112780T1 (el) Νεα σουλφονυλοπυρρολια ως αναστολεις της ηdac
CY1110489T1 (el) Παραγωγα ισοκινολινης
CY1112914T1 (el) Υποκατεστημενα παραγωγα ινδολυλ αλκυλ αμινης ως νεοι αναστολεις των αποακετυλασων ιστονης
CR10662A (es) Compuestos de metilpiridopirimidinona
CY1116540T1 (el) Μεθοδος παραγωγης 2'-δεοξυ-5-αζακυτιδινης (δεσιταβινη)
CY1117862T1 (el) Ετεροκυκλικες ενωσεις βενζοδιοξολιου ή βενζοδιοξεπινης ως αναστολεις φωσφοδιεστερασης
UA117151C2 (uk) N-ациліміногетероциклічні сполуки
CY1112520T1 (el) Βενζυλαμινες, μια διαδικασια για την παραγωγη τους και η χρηση τους ως αντι-φλεγμονωδεις παραγοντες
EA200801608A1 (ru) Производные бензимидазолонкарбоновой кислоты
EA200801365A1 (ru) Замещенные 5-фенил-3,6-дигидро-2-оксо-6h-1,3,4-тиадиазины
CY1121626T1 (el) Νεο παραγωγο υδροξαμικου οξεος ή αλας αυτου
CO6341610A2 (es) Compuesto heterociclilo aromatico que contiene nitrogeno.
CY1111748T1 (el) Παραγωγα 7-αλκυνυλο-1.8-ναφθυριδονων, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη