AR042486A1 - Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion . - Google Patents
Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .Info
- Publication number
- AR042486A1 AR042486A1 ARP030104653A ARP030104653A AR042486A1 AR 042486 A1 AR042486 A1 AR 042486A1 AR P030104653 A ARP030104653 A AR P030104653A AR P030104653 A ARP030104653 A AR P030104653A AR 042486 A1 AR042486 A1 AR 042486A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aromatic ring
- hydroxy
- aromatic
- optionally substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuesto de quinolina y nafteridina halosustituido en la posición 3 que tiene la fórmula (1) en la cual Z1 es N o CR1a, R1 y R1a se seleccionan independientemente entre H, nitro, halógeno, alquiltio (C1-3), alquilo (C1-3) y alcoxi (C1-3) opcionalmente sustituidos con alcoxi (C1-3); o R1 y R1a están conjuntamente unidos para formar un grupo etilendioxi, R1b es H o halógeno; con la condición de que cuando Z1 es N entonces R1b es H y cuando Z1 es CR1a entonces R1 no es H; R1c es halógeno; AB es -CHR6-CO o CHR6-CH2; R6 es H, NH2, CH2OH o hidroxi; R3 es hasta dos sustituyentes seleccionados entre H, halógeno, alquilo (C1-3), hidroxi-alquilo (C1-3), -CONH2, -COOH, -CH2CONH2, -CH2COOH, -CONCH3 e hidroxi en la porción 3 opcionalmente sustituidos con alquilo (C1-3); R4 es un grupo -U-R5 en donde R5 es un sistema (A) de anillos carbocíclicos o heterocíclicos, bicíclico, sustituido o sin sustituir (como se muestra en la fórmula (2), que contiene hasta cuatro heteroátomos en cada anillo y en el cual al menos uno de los anillos (a) y (b) es aromático; X1 es C o N cuando es parte de un anillo aromático o CR14 cuando es parte de un anillo no aromático; X2 es N, NR13, O, S(O)x, CO o CR14 cuando es parte de un anillo aromático o no aromático o puede ser además CR14R15 cuando es parte de un anillo no aromático; X3 y X5 son independientemente N o C; Y1 es un grupo conector de 0 a 4 átomos, en el que cada átomo se selecciona independientemente entre N, NR13, O, S(O)x, CO y CR14 cuando es parte de un anillo aromático o no aromático o puede ser adicionalmente CR14R15 cuando es parte de un anillo no aromático; Y2 es un grupo conector de 2 a 6 átomos, en el que cada átomo de Y2 se selecciona independientemente entre N, NR13, O, S(O)x, CO y CR14 cuando es parte de un anillo aromático o no aromático o puede ser adicionalmente CR14R15 cuando es parte de un anillo no aromático; cada uno de R14 y R15 se selecciona independientemente entre H, alquiltio (C1-4), halo, alquilo (C1-4), alquenilo (C2-4), hidroxi, hidroxi-alquilo (C1-4), mercapto-alquilo (C1-4), alcoxi (C1-4), trifluorometoxi, nitro, ciano, carboxi, amino o aminocarbonilo opcionalmente sustituido con alquilo (C1-4); cada R13 es independientemente H, trifluorometilo, alquilo (C1-4) opcionalmente sustituido con hidroxi, carboxi, alcoxi (C1-4), alquiltio (C1-6), halo o trifluorometilo; alquenilo (C2-4), o aminocarbonilo en el que el grupo amino está opcionalmente sustituido con alquilo (C1-4); cada x es independientemente 0, 1 o 2, y U es CO, SO2 o CH2; o una sal farmacéuticamente aceptable del mismo. Se provee también un procedimiento para preparar un compuesto de la fórmula (1). Composición farmacéutica que comprende el compuesto y un vehículo farmacéuticamente aceptable, y su uso para preparar una composición farmacéutica para tratar infecciones bacterianas en mamíferos, particularmente seres humanos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43472902P | 2002-12-18 | 2002-12-18 | |
| US45701303P | 2003-03-24 | 2003-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR042486A1 true AR042486A1 (es) | 2005-06-22 |
Family
ID=32685334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104653A AR042486A1 (es) | 2002-12-18 | 2003-12-16 | Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion . |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060041123A1 (es) |
| EP (1) | EP1578743A4 (es) |
| JP (1) | JP2006511622A (es) |
| AR (1) | AR042486A1 (es) |
| AU (1) | AU2003300965A1 (es) |
| TW (1) | TW200427688A (es) |
| WO (1) | WO2004058144A2 (es) |
Families Citing this family (64)
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| GB0112834D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
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| JP4508650B2 (ja) | 2002-01-29 | 2010-07-21 | グラクソ グループ リミテッド | アミノピペリジン化合物、当該化合物の製法および当該化合物を含有する医薬組成物 |
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| FR2844270B1 (fr) * | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
| FR2844268B1 (fr) * | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| KR20050072432A (ko) * | 2002-10-10 | 2005-07-11 | 모르포켐 악티엥게셀샤프트 퓌르 콤비나토리셰 케미 | 항균 활성을 갖는 신규한 화합물 |
| EP1560488B1 (en) * | 2002-11-05 | 2010-09-01 | Glaxo Group Limited | Antibacterial agents |
| JP4704755B2 (ja) * | 2002-11-05 | 2011-06-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
| ES2312839T3 (es) * | 2002-12-04 | 2009-03-01 | Glaxo Group Limited | Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos. |
| US7232833B2 (en) * | 2003-03-28 | 2007-06-19 | Novexel | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
| DE10316081A1 (de) * | 2003-04-08 | 2004-10-21 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| US7348434B2 (en) * | 2003-08-08 | 2008-03-25 | Antony Bigot | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
-
2003
- 2003-12-16 AR ARP030104653A patent/AR042486A1/es not_active Application Discontinuation
- 2003-12-16 TW TW092135477A patent/TW200427688A/zh unknown
- 2003-12-17 EP EP03814042A patent/EP1578743A4/en not_active Withdrawn
- 2003-12-17 AU AU2003300965A patent/AU2003300965A1/en not_active Abandoned
- 2003-12-17 JP JP2005509974A patent/JP2006511622A/ja active Pending
- 2003-12-17 US US10/538,931 patent/US20060041123A1/en not_active Abandoned
- 2003-12-17 WO PCT/US2003/040032 patent/WO2004058144A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003300965A1 (en) | 2004-07-22 |
| WO2004058144A3 (en) | 2004-10-21 |
| EP1578743A2 (en) | 2005-09-28 |
| EP1578743A4 (en) | 2006-11-29 |
| AU2003300965A8 (en) | 2004-07-22 |
| TW200427688A (en) | 2004-12-16 |
| US20060041123A1 (en) | 2006-02-23 |
| WO2004058144A2 (en) | 2004-07-15 |
| JP2006511622A (ja) | 2006-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |