CS226181B2 - Method of preparing 4-amino-5-alkylsulphonylorthoanisamide derivatives - Google Patents

Method of preparing 4-amino-5-alkylsulphonylorthoanisamide derivatives Download PDF

Info

Publication number: CS226181B2
Authority: CS; Czechoslovakia
Prior art keywords: amino; acid; ethyl; methoxy; methyl
Prior art date: 1978-01-20

Application number

CS79443A

Other languages

Czech (cs)

English (en)

Inventor

Michel Ing Thominet

Jacques Ing Acher

Jean Claude Ing Monier

Original Assignee

Ile De France

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-01-20

Filing date

1979-01-19

Publication date

1984-03-19

1979-01-19 Application filed by Ile De France filed Critical Ile De France

1982-07-26 Priority to CS825654A priority Critical patent/CS226200B2/cs

1984-03-19 Publication of CS226181B2 publication Critical patent/CS226181B2/cs

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)
Hydrogenated Pyridines (AREA)

CS79443A 1978-01-20 1979-01-19 Method of preparing 4-amino-5-alkylsulphonylorthoanisamide derivatives CS226181B2 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CS825654A CS226200B2 (cs)	1979-01-19	1982-07-26	Způsob výroby derivátů 4-amino-5-alkylsulfonylorthoanisamidů

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR7801632A FR2415099A1 (fr)	1978-01-20	1978-01-20	Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes

Publications (1)

Publication Number	Publication Date
CS226181B2 true CS226181B2 (en)	1984-03-19

Family

ID=9203689

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS79443A CS226181B2 (en)	1978-01-20	1979-01-19	Method of preparing 4-amino-5-alkylsulphonylorthoanisamide derivatives

Country Status (42)

Country	Link
US (2)	US4294828A (ro)
JP (1)	JPS6049192B2 (ro)
AR (2)	AR221354A1 (ro)
AT (1)	AT377977B (ro)
AU (1)	AU528561B2 (ro)
BE (1)	BE872585A (ro)
BG (2)	BG31497A3 (ro)
CA (1)	CA1101430A (ro)
CH (1)	CH637927A5 (ro)
CS (1)	CS226181B2 (ro)
CY (1)	CY1201A (ro)
DD (1)	DD141520A5 (ro)
DE (1)	DE2901181C2 (ro)
DK (1)	DK158346C (ro)
EG (1)	EG14045A (ro)
ES (2)	ES476755A1 (ro)
FI (1)	FI71126C (ro)
FR (1)	FR2415099A1 (ro)
GB (2)	GB2083458B (ro)
GR (1)	GR64431B (ro)
HK (1)	HK12184A (ro)
HU (1)	HU179793B (ro)
IE (1)	IE47798B1 (ro)
IL (1)	IL56411A (ro)
IN (1)	IN150226B (ro)
IT (1)	IT1164655B (ro)
LU (1)	LU80786A1 (ro)
MC (1)	MC1232A1 (ro)
MX (2)	MX5793E (ro)
NL (1)	NL191707C (ro)
NO (1)	NO151320C (ro)
NZ (1)	NZ189378A (ro)
OA (1)	OA06156A (ro)
PH (2)	PH15725A (ro)
PL (2)	PL118151B1 (ro)
PT (1)	PT69068A (ro)
RO (2)	RO76393A (ro)
SE (2)	SE448874B (ro)
SU (1)	SU820659A3 (ro)
YU (2)	YU42172B (ro)
ZA (1)	ZA79219B (ro)
ZM (1)	ZM579A1 (ro)

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FR2440946A2 (fr) *	1978-01-20	1980-06-06	Ile De France	Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement
ZA818221B (en) *	1980-12-12	1982-10-27	Beecham Group Plc	Pharmaceutical compounds
FR2550447B1 (fr) *	1983-08-10	1986-01-17	Ile De France	Application du n-(ally-2-pyrrolidinylmethyl) 2-methoxy 4-amino 5-methylsulfamoyl benzamide comme antiagregant plaquettaire
FR2574795B1 (fr) *	1984-12-18	1987-11-20	Ile De France	Nouveau procede industriel de synthese du n-((1'-allyl 2'-pyrrolidinyl) methyl) 2-methoxy 4,5-azimido benzamide
FR2584401B1 (fr) *	1985-07-04	1987-11-20	Ile De France	Nouveau benzamide, son procede de preparation et son application dans le domaine therapeutique
US5227388A (en) *	1989-12-26	1993-07-13	Hoechst-Roussel Pharmaceuticals Incorporated	Thienobenzoxepins and naphthothiophenes
US5260319A (en) *	1989-12-26	1993-11-09	Hoechst-Roussel Pharmaceuticals Incorporated	Thienobenzoxepins and naphthothiophenes
FR2678266A1 (fr) *	1991-06-28	1992-12-31	Delagrange Laboratoires	Nouveaux derives de 2-hydroxy 4-amino 5-ethylsulfonyl benzamide utiles comme anxiolytiques.
FR2699533A1 (fr) *	1992-12-21	1994-06-24	Mouhtaram Mohamed	Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications.
FR2753376B1 (fr) *	1996-09-18	1998-10-16	Synthelabo	Compositions pharmaceutiques comprenant de l'amisulpride et leurs applications therapeutiques
FR2762213B1 (fr) *	1997-04-18	1999-05-14	Synthelabo	Composition pharmaceutique a retention gastrique
US6169094B1 (en)	1998-07-14	2001-01-02	Sanofi-Synthelabo	Compositions of (S) (-)-amisulpride
EP1554572B1 (en)	2001-07-25	2009-10-14	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
WO2004100992A2 (en) *	2003-05-16	2004-11-25	Pfizer Products Inc.	Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines
FR2857263B1 (fr) *	2003-07-09	2005-09-09	Sanofi Synthelabo	Nouvelle composition pharmaceutique solide comprenant de l'amisulpride
CA2565996A1 (en) *	2004-05-11	2005-11-17	Pfizer Products Inc.	Combination of atypical antipsychotics and 5-ht1b receptor antagonists
WO2006116221A2 (en) *	2005-04-22	2006-11-02	Wyeth	Therapeutic combinations for the treatment or prevention of psychotic disorders
CA2608144C (en)	2005-04-28	2012-11-13	Proteus Biomedical, Inc.	Pharma-informatics system
KR20090071598A (ko)	2006-09-18	2009-07-01	랩터 파마슈티컬 인코포레이티드	수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
US7825156B2 (en) *	2007-02-02	2010-11-02	Copharms	Method of treating bipolar depression with a benzamide derivative
JP2011526881A (ja) *	2008-06-25	2011-10-20	ファイザー・インク	ジアリール化合物およびそれらの使用
US20100105755A1 (en) *	2008-09-12	2010-04-29	Auspex Pharmaceuticals, Inc.	Substituted benzamide modulators of dopamine receptor
ES2728225T3 (es)	2009-02-20	2019-10-23	2 Bbb Medicines B V	Sistema de administración de fármacos a base de glutatión
CA2760945A1 (en)	2009-05-06	2010-11-11	Laboratory Skin Care, Inc.	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
CN101898991B (zh) *	2009-05-31	2013-09-25	江苏天士力帝益药业有限公司	一种(s)(-)-氨磺必利d-(-)-酒石酸盐的合成方法
CN101628886B (zh) *	2009-08-25	2012-12-12	北京紫萌同达科技有限公司	一种2-甲氧基-4-氨基-5-乙砜基苯甲酸的合成方法
AU2014202535B2 (en) *	2010-03-11	2016-05-26	Acacia Pharma Limited	The use of amisulpride as an anti-emetic
GB201004020D0 (en)	2010-03-11	2010-04-21	Acacia Pharma Ltd	New therapeutic use
AU2016216578B2 (en) *	2010-03-11	2017-11-23	Acacia Pharma Limited	The use of amisulpride as an anti-emetic
BR112012031959A2 (pt)	2010-06-17	2015-09-22	Lupin Ltd	um processo aperfeiçoado para preparação de amisulpride
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
CN103319384A (zh) *	2013-06-18	2013-09-25	苏州诚和医药化学有限公司	制备2-甲氧基-4-氨基-5-乙砜基苯甲酸的方法
CN103304453A (zh) *	2013-06-18	2013-09-18	苏州诚和医药化学有限公司	两步法合成2-甲氧基-4-氨基-5-乙砜基苯甲酸
CN103450058B (zh) *	2013-09-18	2015-10-14	广安凯特医药化工有限公司	一种氨磺必利酸的制备方法
CN104725292B (zh) *	2015-03-23	2017-07-25	湖北荆江源制药股份有限公司	一种(s)(‑)‑氨磺必利的制备方法
GB201618425D0 (en) *	2016-11-01	2016-12-14	Acacia Pharma Ltd	method
US11377421B2 (en)	2016-11-28	2022-07-05	Lb Pharmaceuticals Inc.	Psychotropic agents and uses thereof
WO2018098497A1 (en)	2016-11-28	2018-05-31	Lb Pharmaceuticals Inc.	Psychotropic agents and uses thereof
CN106995397B (zh) *	2016-12-12	2020-01-14	河北医科大学	R-氨磺必利药用盐、制备方法、晶型及其用途
GB201702250D0 (en)	2017-02-10	2017-03-29	Acacia Pharma Ltd	Method
JP2021505595A (ja)	2017-12-05	2021-02-18	サノビオンファーマシューティカルズインクＳｕｎｏｖｉｏｎＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃ．	結晶形およびその製造方法
SG11202005016SA (en)	2017-12-05	2020-06-29	Sunovion Pharmaceuticals Inc	Nonracemic mixtures and uses thereof
CN110790693A (zh) *	2018-08-02	2020-02-14	北京万全德众医药生物技术有限公司	一种(s)(-)-氨磺必利的制备方法
US11160758B2 (en)	2019-06-04	2021-11-02	Sunovion Pharmaceuticals Inc.	Modified release formulations and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3342826A (en) *	1964-01-13	1967-09-19	Ile De France	Heterocyclic aminoalkyl benzamides
FR2313935A1 (fr) *	1975-06-10	1977-01-07	Ile De France	Nouveaux benzamides substitues, leurs derives et leur procede de preparation
US3862139A (en) *	1972-06-23	1975-01-21	Delmar Chem	Heterocyclic benzamide compounds
FR2244760B1 (ro) *	1973-09-25	1980-06-27	Ile De France
FR2299862B1 (fr) *	1975-02-07	1978-07-21	Ile De France	Nouveau
FR2294698A1 (fr) *	1974-12-18	1976-07-16	Synthelabo	Nouveaux derives des methoxy-2 benzamides substitues, leurs sels, leur preparation et les medicaments qui en renferment
DE2556457C3 (de) *	1974-12-18	1981-02-12	Synthelabo S.A., Paris	N-(Pyrrolidin-2-yl-methyl)-2-methoxybenzamide, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

1978
- 1978-01-20 FR FR7801632A patent/FR2415099A1/fr active Granted
- 1978-12-07 BE BE1009179A patent/BE872585A/xx not_active IP Right Cessation
1979
- 1979-01-10 AR AR275115A patent/AR221354A1/es active
- 1979-01-10 BG BG043588A patent/BG31497A3/xx unknown
- 1979-01-10 BG BG042018A patent/BG31496A3/xx unknown
- 1979-01-11 IN IN21/CAL/79A patent/IN150226B/en unknown
- 1979-01-11 ES ES476755A patent/ES476755A1/es not_active Expired
- 1979-01-11 IL IL56411A patent/IL56411A/xx unknown
- 1979-01-11 YU YU50/79A patent/YU42172B/xx unknown
- 1979-01-12 PT PT69068A patent/PT69068A/pt unknown
- 1979-01-13 DE DE2901181A patent/DE2901181C2/de not_active Expired
- 1979-01-15 GR GR58090A patent/GR64431B/el unknown
- 1979-01-15 NZ NZ189378A patent/NZ189378A/xx unknown
- 1979-01-15 CH CH37379A patent/CH637927A5/fr active Protection Beyond IP Right Term
- 1979-01-15 LU LU80786A patent/LU80786A1/xx unknown
- 1979-01-15 AU AU43373/79A patent/AU528561B2/en not_active Expired
- 1979-01-16 SE SE7900380A patent/SE448874B/sv not_active IP Right Cessation
- 1979-01-16 RO RO7996297A patent/RO76393A/ro unknown
- 1979-01-16 MC MC791357A patent/MC1232A1/xx unknown
- 1979-01-16 RO RO79103170A patent/RO80311A/ro unknown
- 1979-01-17 GB GB8118999A patent/GB2083458B/en not_active Expired
- 1979-01-17 CY CY1201A patent/CY1201A/xx unknown
- 1979-01-17 GB GB791690A patent/GB2012765B/en not_active Expired
- 1979-01-17 EG EG29/79A patent/EG14045A/xx active
- 1979-01-18 US US06/004,397 patent/US4294828A/en not_active Expired - Lifetime
- 1979-01-18 NO NO790180A patent/NO151320C/no unknown
- 1979-01-18 ZM ZM5/79A patent/ZM579A1/xx unknown
- 1979-01-18 DK DK020979A patent/DK158346C/da not_active IP Right Cessation
- 1979-01-18 IT IT47706/79A patent/IT1164655B/it active Protection Beyond IP Right Term
- 1979-01-19 MX MX797669U patent/MX5793E/es unknown
- 1979-01-19 SU SU792714652A patent/SU820659A3/ru active
- 1979-01-19 CA CA319,969A patent/CA1101430A/en not_active Expired
- 1979-01-19 CS CS79443A patent/CS226181B2/cs unknown
- 1979-01-19 MX MX7911208U patent/MX7623E/es unknown
- 1979-01-19 FI FI790182A patent/FI71126C/fi not_active IP Right Cessation
- 1979-01-19 ZA ZA79219A patent/ZA79219B/xx unknown
- 1979-01-19 PL PL1979224894A patent/PL118151B1/pl unknown
- 1979-01-19 HU HU79SO1241A patent/HU179793B/hu unknown
- 1979-01-19 NL NL7900457A patent/NL191707C/xx not_active IP Right Cessation
- 1979-01-19 PL PL1979212899A patent/PL116532B1/pl unknown
- 1979-01-19 AT AT0039879A patent/AT377977B/de not_active IP Right Cessation
- 1979-01-19 OA OA56717A patent/OA06156A/xx unknown
- 1979-01-19 JP JP54005483A patent/JPS6049192B2/ja not_active Expired
- 1979-01-22 DD DD79210583A patent/DD141520A5/de unknown
- 1979-01-30 IE IE92/79A patent/IE47798B1/en active Protection Beyond IP Right Term
- 1979-02-16 ES ES477782A patent/ES477782A1/es not_active Expired
- 1979-08-16 AR AR277738A patent/AR220574A1/es active
- 1979-11-06 PH PH23252A patent/PH15725A/en unknown
1980
- 1980-08-20 PH PH24465A patent/PH22287A/en unknown
1981
- 1981-10-09 US US06/310,336 patent/US4401822A/en not_active Expired - Lifetime
1983
- 1983-02-04 YU YU254/83A patent/YU41278B/xx unknown
1984
- 1984-02-16 HK HK121/84A patent/HK12184A/xx not_active IP Right Cessation
1986
- 1986-09-09 SE SE8603773A patent/SE460968B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE790092L (en)	1979-07-20
SE8603773D0 (sv)	1986-09-09
SE7900380L (sv)	1979-07-21
AR221354A1 (es)	1981-01-30
PL116532B1 (en)	1981-06-30
YU42172B (en)	1988-06-30
IL56411A (en)	1982-09-30
GB2012765A (en)	1979-08-01
EG14045A (en)	1983-09-30
MC1232A1 (fr)	1979-10-26
IE47798B1 (en)	1984-06-27
DE2901181C2 (de)	1984-07-19
JPS6049192B2 (ja)	1985-10-31
NZ189378A (en)	1983-03-15
NL191707C (nl)	1996-04-02
FR2415099A1 (fr)	1979-08-17
DK20979A (da)	1979-07-21
US4294828A (en)	1981-10-13
RO80311A (ro)	1982-12-06
BE872585A (fr)	1979-06-07
CH637927A5 (fr)	1983-08-31
LU80786A1 (fr)	1979-09-07
MX5793E (es)	1984-07-19
GB2083458B (en)	1983-03-09
CY1201A (en)	1983-12-31
OA06156A (fr)	1981-06-30
DE2901181A1 (de)	1979-07-26
PL118151B1 (en)	1981-09-30
IT1164655B (it)	1987-04-15
YU25483A (en)	1983-10-31
CA1101430A (en)	1981-05-19
GR64431B (en)	1980-03-21
ES477782A1 (es)	1979-09-16
BG31496A3 (en)	1982-01-15
GB2012765B (en)	1982-09-08
AU4337379A (en)	1979-07-26
SE460968B (sv)	1989-12-11
DK158346B (da)	1990-05-07
FI71126C (fi)	1986-11-24
PT69068A (fr)	1979-02-01
YU5079A (en)	1983-06-30
ATA39879A (de)	1983-12-15
ZA79219B (en)	1980-01-30
NO151320C (no)	1985-04-17
IN150226B (ro)	1982-08-21
ZM579A1 (en)	1979-12-21
MX7623E (es)	1990-03-27
AT377977B (de)	1985-05-28
BG31497A3 (en)	1982-01-15
HK12184A (en)	1984-02-24
AU528561B2 (en)	1983-05-05
NO151320B (no)	1984-12-10
IT7947706A0 (it)	1979-01-18
PH15725A (en)	1983-03-18
IL56411A0 (en)	1979-03-12
JPS54145658A (en)	1979-11-14
SU820659A3 (ru)	1981-04-07
PH22287A (en)	1988-07-22
SE448874B (sv)	1987-03-23
NL7900457A (nl)	1979-07-24
FI71126B (fi)	1986-08-14
FI790182A (fi)	1979-07-21
DD141520A5 (de)	1980-05-07
SE8603773L (sv)	1986-09-09
HU179793B (en)	1982-12-28
YU41278B (en)	1986-12-31
NL191707B (nl)	1995-12-01
US4401822A (en)	1983-08-30
NO790180L (no)	1979-07-23
DK158346C (da)	1990-10-08
GB2083458A (en)	1982-03-24
FR2415099B1 (ro)	1981-02-20
AR220574A1 (es)	1980-11-14
ES476755A1 (es)	1979-06-01
RO76393A (ro)	1981-03-30
PL212899A1 (ro)	1980-01-14

Publication	Publication Date	Title
CS226181B2 (en)	1984-03-19	Method of preparing 4-amino-5-alkylsulphonylorthoanisamide derivatives
SU1060112A3 (ru)	1983-12-07	Способ получени производных 1,8-нафтиридин-3-карбоновой кислоты или их солей
FI91401B (fi)	1994-03-15	Menetelmä terapeuttisesti aktiivisten substituoitujen 9-aminotetrahydroakriinien ja niille läheisten yhdisteiden valmistamiseksi
EP0208210B1 (en)	1990-10-24	Pyridonecarboxylic acid derivatives and process for their preparation
PL192864B1 (pl)	2006-12-29	Pochodna pirazyny i środek farmaceutyczny
SK280822B6 (sk)	2000-08-14	Imidazopyridíny, spôsob ich prípravy, farmaceutické prostriedky s ich obsahom a ich použitie
CZ285799B6 (cs)	1999-11-17	Indolové deriváty, způsob jejich výroby, jejich použití pro výrobu farmaceutických prostředků a farmaceutické prostředky s jejich obsahem
SK285165B6 (sk)	2006-07-07	Tetrahydropyridoétery, farmaceutický prostriedok s ich obsahom a ich použitie
EP0040401B1 (en)	1984-03-21	Triazoloquinoxalin-4-ones and such oxaline-4-thiones
HU220066B (hu)	2001-10-28	Imidazo[1,2-a]piridinek alkoxi-alkil-karbamátjai, alkalmazásuk, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
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