CS189717B2 - Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes - Google Patents

Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes

Info

Publication number: CS189717B2
Authority: CS; Czechoslovakia
Prior art keywords: benzomorphanes; tetrahydrofurfuryl; disubstituted; beta; producing novel
Prior art date: 1974-08-05

Application number

CS755425A

Other languages

Czech (cs)

English (en)

Inventor

Herbert Merz

Adolf Langbein

Gerhard Walther

Klaus Stockhaus

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-08-05

Filing date

1975-08-04

Publication date

1979-04-30

1975-08-04 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1977-11-09 Priority to CS777330A priority Critical patent/CS189750B2/cs

1977-11-09 Priority to CS777329A priority patent/CS189749B2/cs

1979-04-30 Publication of CS189717B2 publication Critical patent/CS189717B2/cs

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CS755425A 1974-08-05 1975-08-04 Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes CS189717B2 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
CS777330A CS189750B2 (en)	1974-08-05	1977-11-09	Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes
CS777329A CS189749B2 (en)	1974-08-05	1977-11-09	Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2437610A DE2437610A1 (de)	1974-08-05	1974-08-05	Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number	Publication Date
CS189717B2 true CS189717B2 (en)	1979-04-30

Family

ID=5922448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS755425A CS189717B2 (en)	1974-08-05	1975-08-04	Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes

Country Status (27)

Country	Link
US (1)	US3982005A (da)
JP (1)	JPS60358B2 (da)
AT (1)	AT348140B (da)
BE (1)	BE832099R (da)
BG (3)	BG25090A3 (da)
CA (1)	CA1049008A (da)
CH (7)	CH613963A5 (da)
CS (1)	CS189717B2 (da)
DD (1)	DD122685A5 (da)
DE (1)	DE2437610A1 (da)
DK (1)	DK138992C (da)
ES (6)	ES452764A1 (da)
FI (1)	FI63229C (da)
FR (1)	FR2320096A2 (da)
GB (1)	GB1513950A (da)
HU (1)	HU177952B (da)
IE (1)	IE42216B1 (da)
IL (1)	IL47860A (da)
LU (1)	LU73138A1 (da)
NL (1)	NL7509249A (da)
NO (1)	NO143460C (da)
PH (1)	PH13687A (da)
PL (3)	PL99816B1 (da)
RO (3)	RO67390A (da)
SE (1)	SE425392B (da)
SU (3)	SU591147A3 (da)
ZA (1)	ZA754997B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4087532A (en) *	1974-03-09	1978-05-02	Boehringer Ingelheim Gmbh	Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) *	1976-06-21	1980-09-17	Acf Chemiefarma Nv	6,7-benzomorphan derivatives
DE2716687A1 (de) *	1977-04-15	1978-10-19	Boehringer Sohn Ingelheim	2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) *	1978-04-26	1979-10-30	Acf Chemiefarma Nv	Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) *	1978-06-26	1980-01-10	Boehringer Sohn Ingelheim	2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) *	1979-08-31	1981-04-09	Shin Etsu Chem Co Ltd	Production of alkenyloxy group-containing organopolysiloxane
WO2009017671A1 (en)	2007-07-26	2009-02-05	Vitae Pharmaceuticals, Inc.	Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
CL2008003407A1 (es)	2007-11-16	2010-01-11	Boehringer Ingelheim Int	Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1.
EP2229368A1 (en)	2007-12-11	2010-09-22	Vitae Pharmaceuticals, Inc.	Cyclic urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW200934490A (en)	2008-01-07	2009-08-16	Vitae Pharmaceuticals Inc	Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en)	2008-01-24	2009-07-30	Vitae Pharmaceuticals, Inc.	Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5730021B2 (ja)	2008-02-15	2015-06-03	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体
AU2009241727B2 (en)	2008-05-01	2013-05-02	Vitae Pharmaceuticals, Inc	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134392A1 (en)	2008-05-01	2009-11-05	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134387A1 (en)	2008-05-01	2009-11-05	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2288596B1 (en)	2008-05-13	2016-11-30	Boehringer Ingelheim International GmbH	Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
CN104327062A (zh)	2008-07-25	2015-02-04	贝林格尔·英格海姆国际有限公司	11β-羟基类固醇脱氢酶1的环状抑制剂
US8846668B2 (en)	2008-07-25	2014-09-30	Vitae Pharmaceuticals, Inc.	Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en)	2009-04-30	2014-03-25	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2440537A1 (en)	2009-06-11	2012-04-18	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
TWI531571B (zh) *	2009-11-06	2016-05-01	維它藥物公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
JP5860042B2 (ja)	2010-06-16	2016-02-16	ヴァイティーファーマシューティカルズ，インコーポレイテッド	置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en)	2011-08-17	2014-05-27	Boehringer Ingelheim International Gmbh	Indenopyridine derivatives
EP4253494A4 (en)	2020-11-26	2024-11-13	Shinetsu Chemical Co	ROOM TEMPERATURE CURABLE ORGANOPOLYSILOXANE COMPOSITION, ARTICLE, HYDROLYZABLE ORGANOSILANE COMPOUND AND METHOD FOR PRODUCING SAME
JPWO2023032745A1 (da)	2021-09-03	2023-03-09

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE582575A (da) *	1958-09-22
US3700734A (en) *	1969-01-23	1972-10-24	Merck & Co Inc	2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) *	1971-02-08	1979-11-29	Boehringer Sohn Ingelheim	2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166804B2 (da) *	1971-02-08	1976-03-29	Boehringer Sohn Ingelheim
DE2200596A1 (de) *	1972-01-07	1973-07-12	Boehringer Sohn Ingelheim	N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) *	1972-04-12	1981-03-12	C.H. Boehringer Sohn, 6507 Ingelheim	N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) *	1972-06-19	1974-01-31	Boehringer Sohn Ingelheim	2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

1974
- 1974-08-05 DE DE2437610A patent/DE2437610A1/de not_active Ceased
1975
- 1975-07-08 AT AT523775A patent/AT348140B/de not_active IP Right Cessation
- 1975-07-25 SU SU752162235A patent/SU591147A3/ru active
- 1975-07-30 RO RO7583017A patent/RO67390A/ro unknown
- 1975-07-30 JP JP50092995A patent/JPS60358B2/ja not_active Expired
- 1975-07-30 US US05/600,374 patent/US3982005A/en not_active Expired - Lifetime
- 1975-07-31 RO RO7593231A patent/RO72736A/ro unknown
- 1975-07-31 RO RO7593232A patent/RO72735A/ro unknown
- 1975-07-31 CH CH1002475A patent/CH613963A5/xx not_active IP Right Cessation
- 1975-08-01 CA CA75232728A patent/CA1049008A/en not_active Expired
- 1975-08-02 BG BG031843A patent/BG25090A3/xx unknown
- 1975-08-02 BG BG031842A patent/BG25089A3/xx unknown
- 1975-08-02 BG BG030726A patent/BG25088A3/xx unknown
- 1975-08-04 CS CS755425A patent/CS189717B2/cs unknown
- 1975-08-04 NL NL7509249A patent/NL7509249A/xx not_active Application Discontinuation
- 1975-08-04 ZA ZA754997A patent/ZA754997B/xx unknown
- 1975-08-04 DD DD187666A patent/DD122685A5/xx unknown
- 1975-08-04 PL PL1975190659A patent/PL99816B1/pl unknown
- 1975-08-04 SE SE7508789A patent/SE425392B/xx not_active IP Right Cessation
- 1975-08-04 DK DK352875A patent/DK138992C/da active
- 1975-08-04 PL PL1975190658A patent/PL99819B1/pl unknown
- 1975-08-04 LU LU73138A patent/LU73138A1/xx unknown
- 1975-08-04 FI FI752211A patent/FI63229C/fi not_active IP Right Cessation
- 1975-08-04 PH PH17443A patent/PH13687A/en unknown
- 1975-08-04 HU HU75BO1566A patent/HU177952B/hu unknown
- 1975-08-04 PL PL1975182528A patent/PL99838B1/pl unknown
- 1975-08-04 NO NO752731A patent/NO143460C/no unknown
- 1975-08-04 IL IL47860A patent/IL47860A/xx unknown
- 1975-08-04 GB GB32576/75A patent/GB1513950A/en not_active Expired
- 1975-08-04 BE BE158924A patent/BE832099R/xx not_active IP Right Cessation
- 1975-08-05 FR FR7524380A patent/FR2320096A2/fr active Granted
- 1975-08-05 IE IE1738/75A patent/IE42216B1/en unknown
1976
- 1976-04-16 SU SU762346107A patent/SU587858A3/ru active
- 1976-04-16 SU SU762346108A patent/SU587859A3/ru active
- 1976-10-27 ES ES452764A patent/ES452764A1/es not_active Expired
- 1976-10-27 ES ES452768A patent/ES452768A1/es not_active Expired
- 1976-10-27 ES ES452766A patent/ES452766A1/es not_active Expired
- 1976-10-27 ES ES452765A patent/ES452765A1/es not_active Expired
- 1976-10-27 ES ES452767A patent/ES452767A1/es not_active Expired
- 1976-10-27 ES ES452763A patent/ES452763A1/es not_active Expired
1979
- 1979-04-26 CH CH393179A patent/CH615677A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393479A patent/CH615679A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393379A patent/CH616420A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393579A patent/CH616421A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393279A patent/CH615678A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393679A patent/CH615680A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE2437610A1 (de)	1976-02-26
RO72736A (ro)	1982-09-09
NO143460C (no)	1981-02-18
GB1513950A (en)	1978-06-14
CH615678A5 (da)	1980-02-15
FR2320096A2 (fr)	1977-03-04
BG25090A3 (en)	1978-07-12
NO143460B (no)	1980-11-10
NO752731L (da)	1976-02-06
JPS60358B2 (ja)	1985-01-07
ES452767A1 (es)	1977-10-01
SU591147A3 (ru)	1978-01-30
ES452764A1 (es)	1977-10-16
FI63229C (fi)	1983-05-10
DD122685A5 (da)	1976-10-20
AT348140B (de)	1979-01-25
ES452766A1 (es)	1977-10-01
DK138992B (da)	1978-11-27
AU8364675A (en)	1977-02-10
IE42216L (en)	1976-02-05
IL47860A (en)	1979-01-31
LU73138A1 (da)	1977-04-13
BG25088A3 (en)	1978-07-12
CA1049008A (en)	1979-02-20
BG25089A3 (en)	1978-07-12
IE42216B1 (en)	1980-07-02
NL7509249A (nl)	1976-02-09
DK352875A (da)	1976-02-06
IL47860A0 (en)	1975-11-25
ZA754997B (en)	1977-04-27
CH613963A5 (da)	1979-10-31
PH13687A (en)	1980-09-01
RO67390A (ro)	1981-06-30
PL99838B1 (pl)	1978-08-31
PL99816B1 (pl)	1978-08-31
RO72735A (ro)	1982-09-09
SU587858A3 (ru)	1978-01-05
CH616421A5 (da)	1980-03-31
SE425392B (sv)	1982-09-27
CH615679A5 (da)	1980-02-15
DK138992C (da)	1979-04-30
FI752211A (da)	1976-02-06
SU587859A3 (ru)	1978-01-05
CH615680A5 (da)	1980-02-15
CH616420A5 (da)	1980-03-31
JPS5139673A (en)	1976-04-02
ES452765A1 (es)	1977-10-16
HU177952B (en)	1982-02-28
FI63229B (fi)	1983-01-31
US3982005A (en)	1976-09-21
PL99819B1 (pl)	1978-08-31
BE832099R (fr)	1976-02-04
FR2320096B2 (da)	1978-09-01
ES452763A1 (es)	1977-10-01
SE7508789L (sv)	1976-02-10
CH615677A5 (da)	1980-02-15
ES452768A1 (es)	1977-10-01
ATA523775A (de)	1978-06-15

Publication	Publication Date	Title
CS189717B2 (en)	1979-04-30	Method of producing novel 5,9-beta-disubstituted 2-tetrahydrofurfuryl-6,7-benzomorphanes
JPS53101385A (en)	1978-09-04	Method of producing phenyllpyrimidine
CS188985B2 (en)	1979-03-30	Method of producing aryl-1-azolylmethanes
CS191960B2 (en)	1979-07-31	Method of producing novel 2-decarboxy-2-/5-tatrazolyl/-11-deoxy-omega-pentanorprostaglandins
CS188221B2 (en)	1979-02-28	Method of producing new 2-tetrahydrofurfuryl-6,7-benzomorphanes
BG24950A3 (en)	1978-06-15	A method of obtaining 1,3,4-trisubstituted-4-arilpiperidines
CS191264B2 (en)	1979-06-29	Method of producing new pyridobenzodiazepinones
CS182260B2 (en)	1978-04-28	Method of producing 1,3-oxidated 8alfa-estratrienes
CS188938B2 (en)	1979-03-30	Method of producing xanthene-9-spiro-4-piperidines
SU677666A3 (en)	1981-11-30	Method of producing 7l-or extradiols
CS191289B2 (en)	1979-06-29	Method of producing 7-substituted 1,3-dialkyl-xanthines
CS189635B2 (en)	1979-04-30	Method of producing bromderivatives of 4-imido-thioazetidin-2-one
BG27234A3 (en)	1979-09-14	Production method of 2- carbalkoxyamino- 5(6)- phenylsulfonyloxy- benzimidazoles
CS183785B2 (en)	1978-07-31	Method of producing s-triazolo-3,4-benzothiazoles
CS182298B2 (en)	1978-04-28	Method of producing substituted benzendisulphon-amides
CS189777B2 (en)	1979-04-30	Method of producing 2 alpha, 3 alpha, 16 alpha, 17 alpha-diepoxy-17 beta-brom-5 alpha-androstene
CS194733B2 (en)	1979-12-31	Method of producing novel 11-deoxy-omega-pentanorprostaglandins
CS190503B2 (en)	1979-05-31	Method of producing novel derivatives of 5,7-dihydroxy tetrahydreisequinoline
CS181287B2 (en)	1978-03-31	Method of producing n,n-diallyldichloroacetamide
YU39940B (en)	1985-06-30	Process for dehydrohalogenization of 7-halo-or 1,7-dihalo -dihydrocedeinone dialkylketals
GR58594B (en)	1977-11-10	Preparation method of 2-halogenmethyl-1,4,-benzodiazepine
CS188945B2 (en)	1979-03-30	Method of producing 1-aryluracils
CS190498B2 (en)	1979-05-31	Method of producing novel pgf beta-prostaglandins
CS181271B2 (en)	1978-03-31	Method of producing 17 beta-oxalylsteroids
CS191953B2 (en)	1979-07-31	Method of preparing 3,7-dimethyl-3-hydroxy-6-octennitrile