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CR20140537A - Compuesto heterocíclico nitrogenado - Google Patents

Compuesto heterocíclico nitrogenado

Info

Publication number
CR20140537A
CR20140537A CR20140537A CR20140537A CR20140537A CR 20140537 A CR20140537 A CR 20140537A CR 20140537 A CR20140537 A CR 20140537A CR 20140537 A CR20140537 A CR 20140537A CR 20140537 A CR20140537 A CR 20140537A
Authority
CR
Costa Rica
Prior art keywords
heterocyclic compound
nitrogen heterocyclic
compound
pde2a
schizophrenia
Prior art date
Application number
CR20140537A
Other languages
English (en)
Inventor
Satoshi Mikami
Shinji Nakamura
Tomoko Ashizawa
Shigekazu Sasaki
Takahiko Taniguchi
Izumi Nomura
Masanori Kawasaki
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of CR20140537A publication Critical patent/CR20140537A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se provee un compuesto que tiene una acción inhibidora selectiva de la PDE2A, y es útil como agente para la profilaxis o tratamiento de esquizofrenia, la enfermedad de Alzheimer y similar. Un compuesto representado por la fórmula (1): [en donde cada símbolo es como se describe en la descripción] o una sal del mismo
CR20140537A 2012-04-25 2014-11-24 Compuesto heterocíclico nitrogenado CR20140537A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012100374 2012-04-25
JP2012283470 2012-12-26
PCT/JP2013/062140 WO2013161913A1 (ja) 2012-04-25 2013-04-24 含窒素複素環化合物

Publications (1)

Publication Number Publication Date
CR20140537A true CR20140537A (es) 2015-02-03

Family

ID=49483221

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140537A CR20140537A (es) 2012-04-25 2014-11-24 Compuesto heterocíclico nitrogenado

Country Status (25)

Country Link
US (2) US9469637B2 (es)
EP (1) EP2848618B1 (es)
JP (1) JP6157455B2 (es)
KR (1) KR20150005936A (es)
AU (1) AU2013253516B2 (es)
BR (1) BR112014025711A8 (es)
CA (1) CA2869730A1 (es)
CL (1) CL2014002880A1 (es)
CO (1) CO7141410A2 (es)
CR (1) CR20140537A (es)
DO (1) DOP2014000243A (es)
EA (1) EA029892B1 (es)
GE (1) GEP20166554B (es)
HK (1) HK1203500A1 (es)
IL (1) IL235048B (es)
MX (1) MX361539B (es)
MY (1) MY173949A (es)
NZ (1) NZ631258A (es)
PE (1) PE20142258A1 (es)
PH (1) PH12014502396A1 (es)
SG (1) SG11201406552UA (es)
TN (1) TN2014000416A1 (es)
UA (1) UA115057C2 (es)
WO (1) WO2013161913A1 (es)
ZA (1) ZA201408644B (es)

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NZ631258A (en) 2012-04-25 2016-11-25 Takeda Pharmaceuticals Co Nitrogenated heterocyclic compound
WO2014010732A1 (ja) 2012-07-13 2014-01-16 武田薬品工業株式会社 複素環化合物
JP6280912B2 (ja) 2013-03-14 2018-02-14 武田薬品工業株式会社 複素環化合物
JP6427491B2 (ja) 2013-07-03 2018-11-21 武田薬品工業株式会社 複素環化合物
WO2015002230A1 (ja) 2013-07-03 2015-01-08 武田薬品工業株式会社 アミド化合物
WO2015012328A1 (ja) * 2013-07-24 2015-01-29 武田薬品工業株式会社 複素環化合物
US20160264536A1 (en) * 2013-10-23 2016-09-15 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2015096651A1 (en) 2013-12-23 2015-07-02 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as pde2 inhibitors
JP2017114764A (ja) * 2014-04-25 2017-06-29 武田薬品工業株式会社 片頭痛治療剤
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
US10287269B2 (en) 2015-03-26 2019-05-14 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as PDE2 inhibitors
EP3291817B1 (en) 2015-05-05 2019-10-02 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as pde2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
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WO2017000277A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Substituted triazolo bicycliccompounds as pde2 inhibitors
WO2017000276A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
EP3713572A1 (en) 2017-11-23 2020-09-30 Oslo University Hospital HF Treatment of tachycardia
WO2019241315A1 (en) 2018-06-12 2019-12-19 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
CN113214172A (zh) * 2021-04-25 2021-08-06 西南大学 氟康唑中间体还原胺化产物的制备方法

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Also Published As

Publication number Publication date
PH12014502396B1 (en) 2014-12-22
JPWO2013161913A1 (ja) 2015-12-24
MY173949A (en) 2020-02-28
IL235048B (en) 2018-11-29
UA115057C2 (uk) 2017-09-11
GEP20166554B (en) 2016-10-10
US20170129887A1 (en) 2017-05-11
NZ631258A (en) 2016-11-25
AU2013253516A2 (en) 2015-04-02
EA201491936A1 (ru) 2015-03-31
HK1203500A1 (en) 2015-10-30
SG11201406552UA (en) 2014-11-27
US9469637B2 (en) 2016-10-18
ZA201408644B (en) 2016-02-24
PH12014502396A1 (en) 2014-12-22
TN2014000416A1 (en) 2016-03-30
AU2013253516A1 (en) 2014-12-18
CA2869730A1 (en) 2013-10-31
MX2014013011A (es) 2015-01-12
PE20142258A1 (es) 2015-01-15
US20150105373A1 (en) 2015-04-16
WO2013161913A1 (ja) 2013-10-31
EA029892B1 (ru) 2018-05-31
AU2013253516B2 (en) 2017-10-12
JP6157455B2 (ja) 2017-07-05
KR20150005936A (ko) 2015-01-15
EP2848618A4 (en) 2015-11-11
CL2014002880A1 (es) 2015-02-06
US10017508B2 (en) 2018-07-10
EP2848618B1 (en) 2018-03-14
CO7141410A2 (es) 2014-12-12
BR112014025711A8 (pt) 2018-01-16
BR112014025711A2 (pt) 2017-07-04
DOP2014000243A (es) 2014-12-31
EP2848618A1 (en) 2015-03-18
MX361539B (es) 2018-12-10
CN104245698A (zh) 2014-12-24

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