CO6640254A2 - Método para preparar anticuerpos con propiedades mejoradas - Google Patents
Método para preparar anticuerpos con propiedades mejoradasInfo
- Publication number
- CO6640254A2 CO6640254A2 CO12215100A CO12215100A CO6640254A2 CO 6640254 A2 CO6640254 A2 CO 6640254A2 CO 12215100 A CO12215100 A CO 12215100A CO 12215100 A CO12215100 A CO 12215100A CO 6640254 A2 CO6640254 A2 CO 6640254A2
- Authority
- CO
- Colombia
- Prior art keywords
- improved properties
- preparing antibodies
- antibodies
- glycoproteins
- cytotoxicity
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract
La presente invención proporciona métodos de preparación de polipéptidos o proteínas glicosiladas (glicoproteínas) y, específicamente, anticuerpos que son útiles como agentes terapéuticos para seres humanos o animales, que se caracterizan por presentar una región constante del anticuerpo (Fc), con mutaciones en las posiciones 243 y 264, que le confieren propiedades mejoradas relacionadas con la afinidad molecular y la citotoxicidad de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34896810P | 2010-05-27 | 2010-05-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6640254A2 true CO6640254A2 (es) | 2013-03-22 |
Family
ID=45004737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12215100A CO6640254A2 (es) | 2010-05-27 | 2012-11-27 | Método para preparar anticuerpos con propiedades mejoradas |
Country Status (16)
Country | Link |
---|---|
US (4) | US9187552B2 (es) |
EP (1) | EP2576616A4 (es) |
JP (2) | JP5956982B2 (es) |
KR (1) | KR101818274B1 (es) |
CN (1) | CN103080130B (es) |
AR (1) | AR081427A1 (es) |
AU (1) | AU2011258425B2 (es) |
BR (1) | BR112012030179A8 (es) |
CA (1) | CA2799595C (es) |
CO (1) | CO6640254A2 (es) |
IL (1) | IL223018A0 (es) |
MX (1) | MX339809B (es) |
NZ (1) | NZ603883A (es) |
RU (1) | RU2604811C2 (es) |
TW (1) | TW201202266A (es) |
WO (1) | WO2011149999A2 (es) |
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CA2834589A1 (en) * | 2011-05-25 | 2012-11-29 | Merck Sharp & Dohme Corp. | Method for preparing fc-containing polypeptides having improved properties |
WO2013074598A1 (en) | 2011-11-18 | 2013-05-23 | Merck Sharp & Dohme Corp. | Fc CONTAINING POLYPEPTIDES HAVING INCREASED ANTI-INFLAMMATORY PROPERTIES AND INCREASED FcRN BINDING |
KR20150013503A (ko) * | 2012-05-11 | 2015-02-05 | 머크 샤프 앤드 돔 코포레이션 | 표면 앵커링된 경쇄 미끼 항체 디스플레이 시스템 |
AU2014207549B2 (en) | 2013-01-15 | 2018-12-06 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
MX2016002870A (es) * | 2013-09-05 | 2017-02-23 | Amgen Inc | Moleculas que contienen fc que presentan perfiles de glicoforma predecibles, consistentes y reproducibles. |
WO2015054039A1 (en) * | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Fc CONTAINING POLYPEPTIDES HAVING INCREASED BINDING TO FcGammaRIIB |
US20170101466A1 (en) * | 2014-06-03 | 2017-04-13 | Masahisa Handa | Anti-blys antibodies |
WO2020236797A1 (en) * | 2019-05-21 | 2020-11-26 | Novartis Ag | Variant cd58 domains and uses thereof |
JP2023535677A (ja) * | 2020-07-10 | 2023-08-21 | バイオモレキュラー・ホールディングス・エルエルシー | 四面体抗体 |
-
2011
- 2011-05-25 RU RU2012157270/10A patent/RU2604811C2/ru active
- 2011-05-25 WO PCT/US2011/037826 patent/WO2011149999A2/en active Application Filing
- 2011-05-25 CN CN201180033821.XA patent/CN103080130B/zh active Active
- 2011-05-25 CA CA2799595A patent/CA2799595C/en active Active
- 2011-05-25 JP JP2013512181A patent/JP5956982B2/ja active Active
- 2011-05-25 KR KR1020127033769A patent/KR101818274B1/ko active IP Right Grant
- 2011-05-25 NZ NZ603883A patent/NZ603883A/en not_active IP Right Cessation
- 2011-05-25 MX MX2012013771A patent/MX339809B/es active IP Right Grant
- 2011-05-25 US US13/699,213 patent/US9187552B2/en active Active
- 2011-05-25 EP EP11787290.3A patent/EP2576616A4/en active Pending
- 2011-05-25 AU AU2011258425A patent/AU2011258425B2/en active Active
- 2011-05-25 BR BR112012030179A patent/BR112012030179A8/pt active Search and Examination
- 2011-05-27 AR ARP110101823A patent/AR081427A1/es unknown
- 2011-05-27 TW TW100118713A patent/TW201202266A/zh unknown
-
2012
- 2012-11-13 IL IL223018A patent/IL223018A0/en unknown
- 2012-11-27 CO CO12215100A patent/CO6640254A2/es unknown
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2015
- 2015-11-03 US US14/931,354 patent/US20160083765A1/en not_active Abandoned
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2016
- 2016-03-18 JP JP2016054741A patent/JP2016155838A/ja active Pending
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2018
- 2018-06-13 US US16/007,590 patent/US10858686B2/en active Active
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Also Published As
Publication number | Publication date |
---|---|
RU2012157270A (ru) | 2014-07-10 |
CN103080130B (zh) | 2016-08-17 |
US11959118B2 (en) | 2024-04-16 |
CA2799595A1 (en) | 2011-12-01 |
US10858686B2 (en) | 2020-12-08 |
US20160083765A1 (en) | 2016-03-24 |
NZ603883A (en) | 2015-01-30 |
TW201202266A (en) | 2012-01-16 |
BR112012030179A8 (pt) | 2023-03-14 |
AU2011258425B2 (en) | 2015-12-10 |
US9187552B2 (en) | 2015-11-17 |
WO2011149999A2 (en) | 2011-12-01 |
MX2012013771A (es) | 2013-01-24 |
AU2011258425A1 (en) | 2012-12-20 |
JP2016155838A (ja) | 2016-09-01 |
JP2013529908A (ja) | 2013-07-25 |
EP2576616A4 (en) | 2014-05-21 |
CN103080130A (zh) | 2013-05-01 |
US20130071390A1 (en) | 2013-03-21 |
RU2604811C2 (ru) | 2016-12-10 |
WO2011149999A3 (en) | 2012-01-19 |
KR20130109983A (ko) | 2013-10-08 |
US20210047670A1 (en) | 2021-02-18 |
AR081427A1 (es) | 2012-08-29 |
JP5956982B2 (ja) | 2016-07-27 |
EP2576616A2 (en) | 2013-04-10 |
US20180346951A1 (en) | 2018-12-06 |
BR112012030179A2 (pt) | 2016-11-01 |
KR101818274B1 (ko) | 2018-01-12 |
MX339809B (es) | 2016-06-09 |
CA2799595C (en) | 2022-08-16 |
IL223018A0 (en) | 2013-02-03 |
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