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CO5221052A1 - Nuevos derivados del acido aminocarboxilo farmaceuticas - Google Patents

Nuevos derivados del acido aminocarboxilo farmaceuticas

Info

Publication number
CO5221052A1
CO5221052A1 CO00068921A CO00068921A CO5221052A1 CO 5221052 A1 CO5221052 A1 CO 5221052A1 CO 00068921 A CO00068921 A CO 00068921A CO 00068921 A CO00068921 A CO 00068921A CO 5221052 A1 CO5221052 A1 CO 5221052A1
Authority
CO
Colombia
Prior art keywords
carbon atoms
straight
branched chain
alkyl
cycloalkyl
Prior art date
Application number
CO00068921A
Other languages
English (en)
Inventor
Cristina Alonso-Alija
Markus Heil
Flubacher Dietmar
Paul Naab
Josef Pernerstorfe
Peter Stasch Johannes
Frank Wunder
Dembowsky Klaus
Elisabeth Perzborn
Stahl Elke
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CO5221052A1 publication Critical patent/CO5221052A1/es

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
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    • C07C233/00—Carboxylic acid amides
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    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
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    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
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    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de fórmula general (I):<EMI FILE="00068921_1" ID="1" IMF=JPEG > (I)En la que V falta o es =, NR4, NR4 CONR4, NR4 CO, NR4 SO2, COO, CONR4 o S(O)O,En la que R4 es independiente de otro resto R4 eventualmente existente, un alquilo de cadena lineal o ramificada con hasta 8 átomos de carbono, cicloalquilo con 3 a 8 átomos de carbono, arilo con 6 a 10 átomos de carbono arilalquilo con 7 a 18 átomos de carbono, pudiendo estar sustituido el resto arilo a su vez una o varias veces con halógeno, alquilo, alcoxi con hasta 6 átomos de carbono,ó es 0, 1 ó 2,Q falta o es alquilo de cadena lineal o ramificada, alquendiilo de cadena lineal o ramificada o alquindiilo de cadena lineal o ramificada, cada uno con hasta 12 átomos de carbono, pudiendo tener cada uno, uno o varios grupos seleccionados entre O, S(O)p, NR5, CO, NR5 SO2 o CONR5 y pudiendo estar sustituidos una o varias veces con halógeno, hidroxi o alcoxi con hasta 4 átomos de carbono, donde eventualmente dos átomos cualquiera de la cadena anterior pueden estar unidos entre sí formando un anillo de tres a ocho elementos,en la queR5 es hidrógeno, alquilo de cadena lineal o, ramificada con hasta 8 átomos de carbono o cicloalquilo con 3 a 8 átomos de carbono que puede estar sustituido con halógeno o alcoxi con hasta 4 átomos de carbono, - 2 -p es 0, 1 ó 2,Y es hidrógeno, NR8 R9, arilo con 6 a 10 átomos de carbono un heterociclo aromático o saturado con 1 a 9 átomos de carbono y hasta 3 heteroátomos de la serie S, N y/o O o cicloalquilo de cadena lineal o ramificada con 3 a 8 átomos de carbono, que también, pueden estar unidos a través del N, pudiendo estar sustituido cada uno de los restos cíclicos de una a tres veces con alquilo de cadena lineal o ramificada, alquenilo de cadena lineal, alquinilo de cadena lineal o ramificada, alcoxi de cadena lineal o ramificada, halógenoalquilo de cadena lineal o ramificada, halogenoalcoxi de cadena lineal o ramificada, cada uno con hasta 8 átomos de carbono, cicloalquilo de cadena lineal o ramificada con 3 a 8 átomos de carbono, halógeno, hidroxi, CN, SR6, NO2 NR8 R9, NR7 COR7, NR7 CONR7 R10 o CONR11 R12,en la queR6 es hidrógeno, alquilo de cadena lineal o ramificada con hasta 8 átomos de carbono, halógenoalquilo de cadena lineal o ramificada con hasta 8 átomos de carbono o cicloalquilo con 3 a 8 átomos de carbono,R7 es independientemente de otro resto R7 eventualmente existente hidrógeno, alquilo de cadena lineal o ramificada con hasta 8 átomos de carbono o cicloalquilo con 3 a 8 átomos de carbonoR8, R9, R11 y R12 son, independientemente unos de otros hidrógeno, alquilo de cadena lineal o ramificada, alquenilo de cadena lineal o ramificada con hasta 8 átomos de carbono, arilo con 6 a 10 átomos de carbono, un heterociclo aromático con 1 a 9 átomos de carbono y hasta 3 heteroátomos de a serie S, N y/o 0, arilalquilo con 8 a 18 átomos de carbono, cicloalquilo con 3 a 8 átomos de carbono o un resto de fórmula SO2R13, pudiendo estar sustituido el resto de arilo a su vez una o varias veces con halógeno, hidroxi, CN, NO2, NH2, NHCOR7, alquilo, alcoxi, halógenoalquilo o halógenoalcoxi con hasta 6 átomos de carbono, donde eventualmente dos sustituyentes de entre R8 y R9 o R11 y R12 pueden estar unidos entre sí formando un anillo de cinco o seis elementos, que puede contener 0 o N,en la queR13 es alquilo de cadena lineal o ramificada con hasta 4 átomos de carbono o arilo con 6 a 10 átomos de carbono, donde el resto de arilo a su vez puede estar sustituido una o varias veces con halógeno CN, NO2, alquilo, alcoxi, halógenoalquilo con hasta 6 átomos de carbono,R10 es hidrógeno, alquilo de cadena lineal o ramificada con hasta 12 átomos de carbono, alquenilo de cadena lineal o ramificada con hasta 12 átomos de carbono, arilo con 6 a 10 átomos de carbono, un heterociclo aromático con 1 a 9 átomos de carbono y hasta 3 heteroátomos de la serie S, N y/o o cicloalquilo con 3 a 8 átomos de carbono, que a su vez pueden estar sustituidos con halógeno, hidroxi CN, NO2, NH2, NHCOR7, alquilo, alcoxi, halógenoalquilo alcoxi, halógenoalquilo o halógenoalcoxi con hasta 6 átomos de carbono;y/o los restos cíclicos pueden estar sustituidos cada uno de ellos de una a tres veces con arilo con 6 a 10 átomos de carbono, un heterociclo aromático o saturado con 1 a 9 átomos de carbono y hasta 3 heteroátomos de la serie S,N y/o O, que también pueden estar unidos mediante el N, los cuales pueden estar unidos directamente o mediante un grupo seleccionado entre O, S, SO SO2, NR7, SO2 NR7, CONR7, alquileno de cadena lineal o ramificada, alquenilo de cadena lineal o ramificada, alquiloxi de cadena lineal o ramificada, oxialquiloxi de cadena lineal o ramificada, sulfonilalquilo de cadena lineal o ramificada, tioalquilo de cadena lineal o ramificada, cada uno con hasta 8 átomos de carbono, pudiendo estar sustituidos de una a tres veces con alquilo de cadena lineal o ramificada, alcoxi de cadena lineal o alógenoalquilo de cadena lineal o ramificada, alógenoalcoxi de cadena lineal o ramificada, carbonilalquilo o alquenilo de cadena lineal o ramificada, cada uno con hasta 6 átomos de carbono, halógeno, SR6, CN, NO2, NR8 R9, CONR15 R16 o NR14 COR17,en la queR14 es hidrógeno, alquilo de cadena lineal o ramificada con hasta 8 átomos de carbono o cicloalquilo con 3 a 8 átomos de carbono,R15, R16 independientemente uno de otro, son hidrógeno, alquilo de cadena lineal o ramificada con hasta 8 átomos de carbono, cicloalquilo con 3 átomos de carbono, arilo con 6 a 10 átomos de carbono o, arilo con 6 a 10 átomos de carbono o un resto de fórmula SO2 R18, pudiendo estar a su vez el resto arilo una o varias veces sustituido con halógeno, hidroxi, CN, NO2, NH2, NHCOR7 alquilo, - 3 - halógenoalquilo o halógenoalcoxi con hasta 6 átomos de carbono,en la queR18 es alquilo de cadena lineal o ramificada con hasta 4 átomos de carbono o arilo con 6 a 10 átomos de carbono, pudiendo estar a su vez el resto arilo una o varias veces sustituido con halógeno, hidroxi, CN, NO2, NH2, NHCOR7, hasta 6 átomosde carbono,yR17 es hidrógeno, alquilo de cadena lineal o ramificada, con hasta 12 átomos de carbono, alquenilo de cadena lineal o ramificada con hasta 12 átomos de carbono, arilo con 6 a 10 átomos de carbono, un heterocíclo aromático con 1 a 9 átomos de carbono y hasta 3 heteroátomos de la serie S, N, y/o cicloalquilo con 3 a 8 átomos de carbón, los cuales a su vez pueden estar sustituidos con halógeno, hidroxi, CN, NO2 NH2, NHCOR7 alquilo, alcoxi, halogenoalquilo o halogenoalcoxi con hasta 6 átomos de carbono;y/o los restos cíclicos pueden estar condensados con un carbociclo aromático o saturado con 1 a 10 átomos de carbono o un heterociclo aromático o saturado con 1 a 9 átomos de carbono y hasta 3 heteroátomos de la serie S, N y/o O,R3 es hidrógeno, halógeno, alquilo de cadena lineal o ramificada, halógenoalquilo de cadena lineal o ramificada, alcoxi de cadena lineal o ramificada o alcoxicarbonilo, cada uno con hasta 4 átomos de carbono, CN, NO2 o NR19R20,en la queR19 y R20 son independientemente uno de otro, hidrógeno, alquilo de cadena lineal o ramificada con hasta 4 átomos de carbono o cicloalquilo con 3 a 8 átomos de carbono,m es un número entero de 1 a 4,W es alquileno de cadena lineal o ramificada, con hasta 6 átomos de carbono o alquendiilo de cadena lineal o ramificada con hasta 6 átomos de carbono, pudiendo contener cada uno un grupo seleccionado entre 0, S (O)q, NR21, CO o CONR21 o CO, NHCO o OCO,en la queq es 0, 1 ó 2,R21 es hidrógeno, alquilo de cadena lineal o ramificada con hasta 8 átomos de carbono o cicloalquilo con 3 a 8 átomos de carbono,U es un alquilo de cadena lineal o ramificada con hasta 4 átomos de carbono,A es arilo con 6 a 10 átomos de carbono o un heterocicloaromático con 1 a 9 átomos de carbono y hasta 3 heteroátomos de la serie S, N y/o O, los cuales a su vez pueden estar sustituidos una a tres veces con halógeno, alquilo de cadena lineal o ramificada, halógenoalquilo de cadena lineal o ramificada, alcoxi de cadena lineal o ramificada, halógenoalcoxi o alcoxicarbonilo con hasta 4 átomos de carbono, CN, NO2 o NR22 R23,en la queR22 y R23 es cada uno de ellos independientemente hidrógeno, alquilo de cadena lineal o ramificada con hasta 8 átomos de carbono o cicloalquilo con 3 a 8 átomos de carbono, carbonilalquilo o sulfonilalquilo,R22 es tetrazolilo, COOR24 o CONR25R26,en la queR24 es hidrógeno, alquilo con 1 hasta 8 átomos de carbono o cicloalquilo con 3 a 8 átomos de carbono R25 y R26 son independientemente uno de otro hidrógeno, alquilo de cadena lineal o ramificada con hasta 8 átomos de carbono, cicloalquilo con 3 a 8 átomos de carbono o un resto de fórmula SO2 R27,o R25 y R26 forman juntos un anillo de cinco a seis elementos que puede contener N o O,en la queR27 es alquilo de cadena lineal o ramificada con hasta 4 átomos de carbono o arilo con 6 a 10 átomos de carbono, pudiendo estar a su vez el resto arilo una o varias veces sustituido con halógeno, CN, NO2, alquilo, alcoxi, halógenoalquilo o halógenoalcoxi con hasta 6 átomos de carbono, - 4 -X es alquileno de cadena lineal o ramificada con hasta 12 átomos de carbono o alquendiilo de cadena lineal o ramificada con hasta 12 átomos de carbono, pudiendo contener cada uno, de uno a tres grupos seleccionado entre O, S(O)r NR28 CO o CONR29, arilo o ariloxi con 6 a 10 átomos de carbono, pudiendo estar sustituido el resto arilo a su vez una vez o varias veces con alógeno, CN, NO2, alquilo, alcoxi, halógenoalquilo o halógenoalcoxi con hasta 6 átomos de carbono, donde eventualmente dos átomos cualquiera de la cadena anterior están unidos mediante una cadena alquilo formando de uno a tres anillos de ocho elementos,en la quer es 0, 1 ó 2, R28 es hidrógeno, alquilo con 1 a 8 átomos de carbono o cicloalquilo con 3 a 8 átomos de carbono,R29 es hidrógeno, alquilo de cadena lineal o ramificada con hasta 8 átomos de carbono o cicloalquilo con 3 átomos de carbono,n es 1 ó 2;R1 es tetrazolilo, COOR30 o CONR31R32,en la
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