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CO4950561A1 - Derivados de ergolina - Google Patents

Derivados de ergolina

Info

Publication number
CO4950561A1
CO4950561A1 CO98030085A CO98030085A CO4950561A1 CO 4950561 A1 CO4950561 A1 CO 4950561A1 CO 98030085 A CO98030085 A CO 98030085A CO 98030085 A CO98030085 A CO 98030085A CO 4950561 A1 CO4950561 A1 CO 4950561A1
Authority
CO
Colombia
Prior art keywords
carbon atoms
hydrogen
alkyl
formula
chlorine
Prior art date
Application number
CO98030085A
Other languages
English (en)
Inventor
Paul Pfaeffli
Peter Neumann
Robert Swodoba
Peter Stutz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO4950561A1 publication Critical patent/CO4950561A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se relaciona con un compuesto de lafórmula I:en donde: R1 es hidrógeno, alquilo (de 1 a 4 átomos de carbono), o un grupo de la fórmula: en donde n es de 1 a 4, y R7 es flúor, cloro, hidroxi, alquilo (de 1 a 4 átomos de carbono), o alcoxi (de 1 a 4 átomos de carbono), R2 es hidrógeno, cloro bromo, yodo, alquilo (de 1 a 4 átomos de carbono) o tioalquilo (de 1 a 4 átomos de carbono), R3 es hidrógeno o alquilo (de 1 a 4 átomos de carbono), R4 es: (i) un grupo de la fórmula: en donde R8 es flúor, cloro, nitro, o ciano, R9 y R10 , independientemente, son hidrógeno, flúor, cloro, nitro, o ciano, y R11 es alquilo (de 1 a 4 átomos de carbono), o alquenilo (de 2 a 5 átomos de carbono), ó (ii) de la fórmula: en donde los X son independientemente O ó S, y R5 y R6 son cada uno hidrógeno, o forman juntos un enlace adicional entre los dos átomos de carbono sobre los que se localizan, en el entendido de que R8 no es 4-NO2 si R1 , R2 , R9 y R10 son hidrógeno, R3 es metilo, y R5 y R6 forman juntos un enlace adicional entre los dos átomos de carbono sobre los que se localizan, y de que R8 no es cloro si R1 , R2 , R9 y R10 son hidrógeno, y R3 es metilo, en forma de base libre o de sal de adición de ácido.
CO98030085A 1997-05-29 1998-05-28 Derivados de ergolina CO4950561A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9711043.1A GB9711043D0 (en) 1997-05-29 1997-05-29 Organic compounds

Publications (1)

Publication Number Publication Date
CO4950561A1 true CO4950561A1 (es) 2000-09-01

Family

ID=10813201

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98030085A CO4950561A1 (es) 1997-05-29 1998-05-28 Derivados de ergolina

Country Status (24)

Country Link
US (1) US6221870B1 (es)
EP (1) EP0986558A2 (es)
JP (1) JP2001527580A (es)
KR (1) KR20010013103A (es)
CN (1) CN1259946A (es)
AR (1) AR012870A1 (es)
AU (1) AU727841B2 (es)
BR (1) BR9809491A (es)
CA (1) CA2288810A1 (es)
CO (1) CO4950561A1 (es)
CZ (1) CZ289466B6 (es)
GB (1) GB9711043D0 (es)
HU (1) HUP0002311A3 (es)
ID (1) ID22916A (es)
IL (1) IL132571A0 (es)
NO (1) NO995482D0 (es)
NZ (1) NZ500386A (es)
PE (1) PE74899A1 (es)
PL (1) PL336502A1 (es)
RU (1) RU2191776C2 (es)
SK (1) SK160899A3 (es)
TR (1) TR199902848T2 (es)
WO (1) WO1998054183A2 (es)
ZA (1) ZA984560B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070243240A9 (en) * 2000-08-24 2007-10-18 Fred Windt-Hanke Transdermal therapeutic system
DE10053397A1 (de) 2000-10-20 2002-05-02 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
DE10341317B4 (de) * 2003-09-03 2008-10-23 Axxonis Pharma Ag Transdermales therapeutisches System (TTS) zur Verabreichung von Ergolinverbindungen ausgenommen Pergolid
DE10066158B4 (de) * 2000-08-24 2007-08-09 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung des Restless-Legs-Syndroms
KR100620435B1 (ko) * 2001-06-08 2006-09-12 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. 소마토스타틴-도파민 키메라 유사체
FI20031454A0 (fi) 2003-10-06 2003-10-06 Juvantia Pharma Ltd Oy Selektiivisiä somatostatiinireseptori 1 ja/tai 4 -agonisteja ja -antagonisteja
KR101000923B1 (ko) * 2004-01-08 2010-12-13 삼성전자주식회사 원격 제어기의 매크로 설정 장치 및 방법
JP2008540618A (ja) * 2005-05-18 2008-11-20 ブルスター，ジークフリート ソマトスタチン受容体サブタイプ１及び／又は４に選択的なペプチド模倣薬
JP2007067096A (ja) * 2005-08-30 2007-03-15 Fujitsu Ltd 半導体装置
WO2011079313A1 (en) * 2009-12-23 2011-06-30 Map Pharmaceuticals, Inc. Novel ergoline analogs
WO2012177962A1 (en) 2011-06-23 2012-12-27 Map Pharmaceuticals, Inc. Novel fluoroergoline analogs
WO2013095707A1 (en) 2011-12-19 2013-06-27 Map Pharmaceuticals, Inc. Novel iso-ergoline derivatives
WO2013095708A1 (en) 2011-12-21 2013-06-27 Map Pharmaceuticals, Inc. Novel neuromodulatory compounds
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives
WO2014070965A2 (en) 2012-11-01 2014-05-08 Ipsen Pharma S.A.S Somatostatin analogs and dimers thereof
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
US9657020B2 (en) * 2015-01-20 2017-05-23 Xoc Pharmaceuticals, Inc. Ergoline compounds and uses thereof
CA2974113A1 (en) 2015-01-20 2016-07-28 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
CN111132980A (zh) 2017-06-01 2020-05-08 Xoc制药股份有限公司 用于医学的麦角灵衍生物
JP7099717B2 (ja) 2019-09-30 2022-07-12 株式会社理研バイオ ソマトスタチン受容体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH475252A (de) * 1966-02-08 1969-07-15 Sandoz Ag Verfahren zur Herstellung neuer Lysergsäure-Derivate
US3592816A (en) 1966-02-08 1971-07-13 Sandoz Ltd N-substituted piperazides of lysergic acid
GB1188197A (en) 1967-10-11 1970-04-15 Sandoz Ltd Lysergic Acid Derivatives
NL6818658A (es) * 1968-01-18 1969-07-22
GB1580448A (en) * 1976-12-06 1980-12-03 Farmaceutici Italia 8 -acetyl-6-methyl-ergoline i derivatives
GB8501078D0 (en) * 1985-01-16 1985-02-20 Erba Farmitalia Piperazin-1-yl-ergo-line derivatives
TW357143B (en) * 1995-07-07 1999-05-01 Novartis Ag Benzo[g]quinoline derivatives

Also Published As

Publication number Publication date
KR20010013103A (ko) 2001-02-26
US6221870B1 (en) 2001-04-24
HUP0002311A3 (en) 2002-08-28
CN1259946A (zh) 2000-07-12
EP0986558A2 (en) 2000-03-22
ID22916A (id) 1999-12-16
PE74899A1 (es) 1999-09-14
GB9711043D0 (en) 1997-07-23
HUP0002311A2 (hu) 2000-12-28
AR012870A1 (es) 2000-11-22
ZA984560B (en) 1998-11-30
WO1998054183A2 (en) 1998-12-03
SK160899A3 (en) 2000-07-11
WO1998054183A3 (en) 1999-03-04
IL132571A0 (en) 2001-03-19
AU8210898A (en) 1998-12-30
TR199902848T2 (xx) 2000-02-21
AU727841B2 (en) 2001-01-04
NO995482L (no) 1999-11-09
BR9809491A (pt) 2000-10-17
CZ289466B6 (cs) 2002-01-16
NO995482D0 (no) 1999-11-09
CA2288810A1 (en) 1998-12-03
CZ424599A3 (cs) 2000-03-15
NZ500386A (en) 2002-05-31
JP2001527580A (ja) 2001-12-25
PL336502A1 (en) 2000-07-03
RU2191776C2 (ru) 2002-10-27

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