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AR009413A1 - Un compuesto, el cual es un derivado de distamicina benzoheterociclico, su utilizacion, un procedimiento para producirlo y una composicionfarmaceutica que lo comprende - Google Patents

Un compuesto, el cual es un derivado de distamicina benzoheterociclico, su utilizacion, un procedimiento para producirlo y una composicionfarmaceutica que lo comprende

Info

Publication number
AR009413A1
AR009413A1 ARP970105209A ARP970105209A AR009413A1 AR 009413 A1 AR009413 A1 AR 009413A1 AR P970105209 A ARP970105209 A AR P970105209A AR P970105209 A ARP970105209 A AR P970105209A AR 009413 A1 AR009413 A1 AR 009413A1
Authority
AR
Argentina
Prior art keywords
derivative
alkyl
pharmaceutical composition
distamicina
benzoheterociclico
Prior art date
Application number
ARP970105209A
Other languages
English (en)
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of AR009413A1 publication Critical patent/AR009413A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un derivado de distamicina benzoheterocíclico de la formula (I), donde: n es 2, 3 o 4; A es O, S o NR, donde R es hidrogeno o alquilo C1-C4; B es CH oN; R1 es hidrogeno o alquilo C1-C4; T se selecciona entre: (i) de ka formula (II), donde: p escero o 1; R2 y R3 se seleccionan, cada una de maneraindependiente, entre: hidrogeno, alquilo C1-C4 opcionalmente sustituido por uno o más átomos de fluor, y alcoxi C1-C4; R4 es alquilo C1-C4 o haloalquiloC1-C3; X1 es un átomo de halogeno; y (ii) de la formula (III), donde X2 es un átomo de halogeno; y las sales farmacéuticamente aceptables de los mismos,su utilizacion, un procedimiento para producir dicho derivado y una composicion farmacéutica que lo comprende. Los compuestos son utiles como agentesantineoplásicos y antivirales.
ARP970105209A 1996-11-11 1997-11-10 Un compuesto, el cual es un derivado de distamicina benzoheterociclico, su utilizacion, un procedimiento para producirlo y una composicionfarmaceutica que lo comprende AR009413A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9623522.1A GB9623522D0 (en) 1996-11-11 1996-11-11 Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents

Publications (1)

Publication Number Publication Date
AR009413A1 true AR009413A1 (es) 2000-04-12

Family

ID=10802813

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970105209A AR009413A1 (es) 1996-11-11 1997-11-10 Un compuesto, el cual es un derivado de distamicina benzoheterociclico, su utilizacion, un procedimiento para producirlo y una composicionfarmaceutica que lo comprende

Country Status (11)

Country Link
US (1) US6153642A (es)
EP (1) EP0937070B1 (es)
JP (1) JP2001504109A (es)
AR (1) AR009413A1 (es)
AU (1) AU5121698A (es)
CA (1) CA2271299A1 (es)
DE (1) DE69726593T2 (es)
ES (1) ES2212138T3 (es)
GB (1) GB9623522D0 (es)
WO (1) WO1998021202A1 (es)
ZA (1) ZA979997B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806692D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
DE10080190D2 (de) * 1999-02-04 2002-01-24 Joern Bullerdiek Mittel zur Prävention und/oder Behandlung einer Gewebeveränderung mesenchymalen Ursprungs
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
IT1318696B1 (it) * 2000-09-15 2003-08-27 Pharmacia & Upjohn Spa Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale.
GB0029004D0 (en) 2000-11-28 2001-01-10 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
WO2002101073A2 (en) * 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc. Aryl-benzimidazole compounds having antiinfective activity
WO2002101007A2 (en) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc Antipathogenic benzamide compounds
JP2005505508A (ja) 2001-06-13 2005-02-24 ジーンソフト ファーマシューティカルズ インコーポレイテッド 抗感染活性を有するベンゾチオフェン化合物
ITTO20010633A1 (it) * 2001-07-02 2003-01-02 Univ Ferrara Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a.
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
GB0130868D0 (en) 2001-12-24 2002-02-06 Univ Strathclyde New compounds
EP1539151B1 (en) 2002-08-02 2009-03-18 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
EP1556035A4 (en) 2002-09-20 2006-09-13 Genelabs Tech Inc NEW AROMATIC COMPOUNDS WITH ANTIMYCOTIC OR ANTIBACTERIAL EFFECT
AU2003287160A1 (en) * 2002-10-15 2004-05-04 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
AU2003285958A1 (en) 2002-10-25 2004-05-25 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
CA2508769A1 (en) 2002-12-10 2004-06-24 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
DE102006026764A1 (de) * 2006-06-09 2007-12-13 Comsort Gmbh Verfahren zum Ausschleusen von auf einem Sortiertisch einer Fördervorrichtung angeordnetem Stückgut sowie Sortiertisch und Vorrichtung zum Transportieren und Vereinzeln von Stückgut
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
CN102807540A (zh) * 2012-09-06 2012-12-05 无锡万全医药技术有限公司 一种新的5-氨基苯并呋喃-2-甲酸的制备方法
CN104845967B (zh) 2015-04-15 2020-12-11 苏州新海生物科技股份有限公司 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
WO2018047148A1 (en) 2016-09-12 2018-03-15 Novartis Ag Compounds for the inhibition of mirna
WO2020242719A2 (en) * 2019-05-01 2020-12-03 The University Of North Carolina At Chapel Hill Inhibitors of rna-binding proteins, compositions thereof, and therapeutic uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
IT1262921B (it) * 1992-01-10 1996-07-22 Federico Arcamone Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono
IT1271456B (it) * 1993-03-01 1997-05-28 Menarini Farma Ind Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
GB9514993D0 (en) * 1995-07-21 1995-09-20 Pharmacia Spa Site specific phenyl nitrogen mustards

Also Published As

Publication number Publication date
EP0937070B1 (en) 2003-12-03
ES2212138T3 (es) 2004-07-16
EP0937070A1 (en) 1999-08-25
ZA979997B (en) 1998-05-25
US6153642A (en) 2000-11-28
DE69726593T2 (de) 2004-11-18
WO1998021202A1 (en) 1998-05-22
AU5121698A (en) 1998-06-03
GB9623522D0 (en) 1997-01-08
DE69726593D1 (de) 2004-01-15
CA2271299A1 (en) 1998-05-22
JP2001504109A (ja) 2001-03-27

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