CN1970007A - Capsule for improving sexual function for men - Google Patents
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Abstract
Disclosed is a capsule for improving sex functions which is prepared from yohimbine, ginkgo extract, gen-seng extract, epimedium extract, wolferry fruit extract, arginine, zinc gluconate, nicotinic acid, lycopersicin, vitamin A, vitamin E and vitamin C.
Description
One, technical field: the invention belongs to the functional health-care food technical field, relate in particular to the health food that processes with raw materials such as Yohimbine, Folium Ginkgo, Radix Ginseng, Herba Epimedii, Fructus Lycii, arginine, lycopene, zinc, nicotinic acid, vitamin A, vitamin E, vitamin Cs.
Two, background technology: the health food that the present invention processes with raw materials such as Yohimbine, Folium Ginkgo, Radix Ginseng, Herba Epimedii, Fructus Lycii, arginine, lycopene, trace element, vitamin.This product has functions such as the sexual impotence of control, premature ejaculation, hyposexuality, sexual function improving, delay aging, spermatogenesis, control are sterile, resisting fatigue disease.Also really can not treat sexual impotence in the market, the natural drug of sexual dysfunction and delay aging occurs, studying this product can be and provide a kind of novel health food to suffering from sexual impotence, sexual dysfunction, hypokinetic male, with the popular sexual impotence of preventing and treating of existing market, the old and feeble health food of delay is compared, and this product is the natural new product with unique effects.
Three, summary of the invention: the function of male erection problem, the English ED that is called for short is commonly called as sexual impotence, is the common disease of adult male.Along with the development of society, people's live and work pressure increases, and its sickness rate also presents ascendant trend.Male's sickness rate in 40-70 year is the sickness rate of male below 52%, 40 years old about 10% according to investigations, wherein the complete sexual impotence 10% of severe.In among the state-owned 300,000,000 male adults, have nearly that 8,000 ten thousand male suffer from sexual dysfunction, the age is in the majority with thirty or forty years and old people, especially brain overwork person, and be engaged in mental work neural in tension middle aged white collar, the high risk group family of sexual dysfunction especially for a long time.The present invention makes a kind of health food at this high risk group family development.This product has the sexual impotence of control, premature ejaculation, hyposexuality, sexual function improving, delay aging, spermatogenesis, prevents and treats functions such as male infertility, resisting fatigue.This product is a hard capsule, does not have any abnormal flavour, taking convenience.
Four, composition of raw materials: 6 kilograms-11 kilograms of 2 kilograms-4 kilograms of Yohimbines, 6 kilograms-8 kilograms of Folium Ginkgo extract, 3 kilograms-5 kilograms of Radix Ginseng extracts, 20 kilograms-50 kilograms of Herba Epimedii extracts, 30 kilograms-60 kilograms of Fructus Lycii extracts, 50 kilograms-double centner of arginine, zinc gluconate, 0.2 kilogram-0.5 kilogram of lycopene, vitamin
A10 milligrams-40 milligrams, vitamin
E1.5-3 kilograms of kilograms, 1 kilogram-2 kilograms in nicotinic acid, vitamin
C8 kilograms-12 kilograms.
Five: technical scheme
(1), Yohimbine (yohimbine), this product is the Apocynaceae Radix Rauvolfiae, a kind of natural plant composition-Yohimbine that extracts in the plants such as Rauvolfia yunnanensis.The treatment sexual impotence is had unique effect, is to be loaded onto so far that Yohimbine is the most effective natural plant composition of treatment sexual impotence.
Pharmacological action: the treatment sexual impotence: Yohimbine is α one an adrenoceptor blocker, by blocking-up maincenter α one adrenoceptor, makes the central sympathetic activation, and stimulates erection.Yohimbine can also improve the ball testosterone levels, excites sexual desires, and is erection.It is reported that to treating psychological erection disturbance effective percentage be 46%.
According to external, Yohimbine (α one beta blocker), erection relies on spongy body small artery blood vessel exactly, the main mechanism of action of Yohimbine is to act on cavernous body of penis small artery blood vessel, increase the cavernous body of penis blood flow, directly act on the spongy body vascular smooth muscle, make erection more special effectively for a long time, effect is approximate with U.S.'s " viagra ".With Yohimbine 43% erection problem there is significant curative effect according to external experiment is single.
(3) Folium Ginkgo extract (Ginkgo bilobalenf exatract) is Ginkgoaceae plant Ginkgo biloba leaf extract.The property flat, sweet in the mouth, hardship, puckery.Functions such as having astringes the lung relievings asthma, removing dampness, increase blood vessels flow, microcirculation improvement, blood pressure lowering, blood fat reducing, inhibition thrombosis are impelled thromboembolism, and improve significantly dysmnesia and good defying age, antibiotic, sexual function improving.
Chemical constituent; Semen Ginkgo mainly contains flavone compound, Semen Ginkgo lactone, Semen Ginkgo polysaccharide, terpenoid fat chemical compound, bioactive ingredients such as various trace elements.
Pharmacological action: 1, blood vessel dilating, blood flow increasing: Folium Ginkgo extract contains flavone compound, can cause the guinea pig isolated heart coronary vasodilation, and can obviously expand the cerebrovascular of anesthetized cat, Canis familiaris L., cerebral blood flow increasing amount and coronary artery blood flow, its mechanism of action is that total flavones has the obvious suppression effect to the Angiotensin-Converting activity, shrinks blood flow increasing thereby suppress small artery.Other has the expansible cavernous body of penis smooth muscle of report Ginkgo total flavones small artery, increases the penile blood flow amount, can obviously improve erection kinetic energy, makes erection, sexual function improving.Folium Ginkgo can also improve the blood circulation of body tissue's organ pipe in addition, comprising penis.It is reported that several all backs of administration 50% property kinetic energy impaired patients improves.Itself and Yohimbine, that nicotinic acid share effect is better.
2, blood viscosity lowering, accelerate blood flow rate: Semen Ginkgo extrac can make the erythrocyte aggregation effect reduce, and blood flow rate is accelerated, and the energy vasodilator, blood viscosity lowering.
3, strong smart effect: Folium Ginkgo extract has the effect of strong essence, because Semen Ginkgo has been rich in lysine, and lysine is the important component that forms sperm, also has the reinforcing the kidney and supporting YANG Spermatogenic action.
4, anti-hypoxia: Folium Ginkgo extract not only can change blood flowing characteristic, and can improve hypoxia-bearing capability.Energy metabolism was relevant when its mechanism of action may and be improved anoxia with the cerebral blood flow increasing amount.
5, anxiety: this product the treatment rat nervous with anxiety experiment in, present certain anxiety activity, Semen Ginkgo lactone or Folium Ginkgo extract are the effective ingredient of angst resistance effect.
6, slow down aging: flavone base parent nucleus contains reproducibility hydroxyl functional group in the Folium Ginkgo, can directly bring into play antioxidation, can remove free radical, regulate superoxide dismutase, the activity of antioxidases such as catalase, slow down the pathologic lipid peroxidation, tangible anti peroxidation of lipid damaging action is arranged, therefore can slow down aging.
Semen Ginkgo extrac also has the memory of promotion, improves effects such as brain function, blood fat reducing, blood pressure lowering, anti-inflammatory, antibacterial antiviral in addition.
(3) Radix Ginseng extract (Renshen extpact), Radix Ginseng is the root of Araliaceae Radix Ginseng.The property flat, sweet in the mouth, little hardship, have strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid and inducing sedation of the mind to increase intelligence, palpitation with fear insomnia, sexual impotence cold womb, heart failure, resisting fatigue, improve substance metabolism, promotion hematopoietic function, mediator's yin-yang, QI and blood balance etc.
Chemical constituent: Radix Ginseng contains compositions such as 29 kinds of Saponins, protein, polypeptide class, aminoacid, enzyme, monosaccharide, oligosaccharide, polysaccharide, organic acid, alkaloids.
Pharmacological action: 1, promote protein synthesis: Radix Ginseng can make the male rat protein synthesis strengthen, and can correct male Mus and promote proteinic synthetic because of the hungry liver DNA (deoxyribonucleic acid) that goes out to see reduces.
2, stimulating central nervous system: Radix Ginseng energy stimulating central nervous system, male's sexual excitation is subjected to sympathetic innervation, and Radix Ginseng can make sympathetic activation, improves the sensitivity of genital region to mechanical irritation, increase sexual excitation degree and each preceding position muscular contraction force of ejaculation, impel erection.
3, strengthen hemopoietic function: Radix Ginseng and extract thereof have stimulation and protective effect to the hemopoietic function of bone marrow, can make normal and anemia animal erythrocyte number, and leukocyte count and hemoglobin content increase; Radix Ginseng can be by increasing bone marrow deoxysaccharide nucleic acid, ribonucleic acid, and synthesizing of protein and lipid promotes the medullary cell mitosis, stimulates hemopoietic function of bone marrow.
4, promote hypophysis one interrenal system function: Radix Ginseng can make adrenal gland's hypertrophy normal and excision one side adrenal gland rat, makes the rat Eosinophilia, and vitamin C and cholesterol reduce in the adrenal cortex, and thyroliberin increases in the urine.The total Saponin of Radix Ginseng irritates stomach or lumbar injection all can increase the 17-hydroxy-11-dehydrocorticosterone secretion.
5, strengthen in branch must system: mainly by strengthening hypophysis one adrenal cortex function system, Radix Ginseng must function also have potentiation to dividing in other to the Radix Ginseng anti-stress effect.Radix Ginseng extract can strengthen the release of the insulin that glucose perfusion pancreas in rat causes.The panoxadiol adds in the perfusion; can make the rat adrenal gland discharge the catecholamines medium increases; can quicken the estrous appearance of teenage female mice and increase ovary and uterus weight for the mouse stomach Radix Ginseng total saponins; promptly have the promotion gonadotropic Effect, Radix Ginseng decoction reduces the normalization effect that makes it to old rats serum thyroxine and corticosterone level.Ginsenoside's intramuscular injection can obviously increase the content of estradiol in the rat plasma in old age.Radix Ginseng can promote and strengthen the mating ability of male rat, makes castration the mating phenomenon occur, makes the female Mus of castration intensive estrogen action occur, and rabbit spermatozoa in testis quantity increases, and vigor strengthens.
6, sexual function improving: the ginsenoside can effectively promote DNA and RNA synthetic, regulates organism endocrine, inspires enthusiasm and improves human body energy, strengthens adrenal gland and gonad function, promotes gonadotropic Effect, improves sperm quality and testosterone concentration, sexual function improving.Deficiency of kidney-QI weak person's sexual disorder is improved.
Radix Ginseng is singly used clinically or is treated sexual impotence with other medicines compatibilities such as Herba Epimedii and Fructus Lycii in addition.
7, arrhythmia: ginsenoside's rat heart rate that can slow down, have the rat ventricular effect that stronger antioxidation barium brings out, the tachycardia of its generation there is stronger role of correcting.
8, resisting fatigue: Radix Ginseng all can strengthen the mobility of necton under the different water temperatures in the different approaches administration, prolongs swimming time.Also obviously the acute weight loading of prolong rats is forced swimming time.
9, antioxidation, the ginsenoside can significantly suppress mouse brain, and the lipid peroxidation in the hepatic tissue improves superoxide dismutase and peroxidase activity in the erythrocyte, and lipofuscin in rat cerebral cortex and the liver is generated significant inhibitory effect.
10, defying age, Radix Ginseng can promote human embryo lung (HEL) or fibrocyte propagation at advanced age, and activity of monoamine oxidase is reduced, and make and " do not divide " cell transformation among the senile cell group and be " division " cell, make the cell division cycle shortening.
In addition, Radix Ginseng extract also has the brain function of improvement, protection cardiac muscle, blood pressure lowering, blood fat reducing, mutation, anti-stress, multiple pharmacological effect such as antibiotic, anticancer.
(4) Herba Epimedii (riyanghuo extract), this product is a Berberidaceae plant Herba Epimedii, arrow leaf Herba Epimedii, Wushan Herba Epimedii, herbs such as pubescence Herba Epimedii, Korea's Herba Epimedii.Warm in nature, acrid in the mouth.Have invigorating the liver and kidney, supporing yang benefit essence, the phoenix of dispelling except that temperature, heart tonifying.Be used for impotence and seminal emission, the muscles and bones flaccidity is soft, Mental fatigue is forgetful, neurasthenia etc.
Chemical constituent; Mainly contain flavonoid, alkaloid, icariin, the new glycosides of Herba Epimedii, volatile oil, plant sterol, gentle matter, fatty acid (Palmic acid, hard cured acid, linoleic acid) etc.
Pharmacological action: 1, promote gonad function: branch must system's kinetic energy in the gonad axis that Herba Epimedii can strengthen hypothalamus---hypophysis---.Keep male penis normal erection and maintenance function, except male's biorgan and mental status normally, also depending in hypothalamus-hypophysis-gonad axis branch must system, water decoction is irritated stomach, can significantly increase the weight of blood plasma testosterone content and testis anus flesh, and can obviously promote testis tissue hypertrophy and secretion, can improve hypophysis for rat oral gavage reactivity and the corpus luteum that corpus luteum generates releasing hormone generated plain reactivity, obviously increase antepituitary, the weight in ovary and uterus improves the ovary chorion and promotes sex gland hormones/interstitialcellstimulating hormone (ICSH) receptor-specific adhesion.
Other has report, and the water logging agent can promote gonepoiesis, and 20-40mg/ intraperitoneal administration can increase weight such as mice prostate seminal vesicle, and decoct 0.3ml/ only can show the increase blood plasma testosterone content in 10 days, to promoting that sexual function has obvious effect.
2, enhancing property kinetic energy: the traditional Chinese medical science is thought, its acrid in the mouth of Herba Epimedii, sweet, warm in nature, goes into the Liver and kidney warp, has hard muscles and bones, beneficial vital essence blood, mends functions such as waist knee joint, heart tonifying power.Can be used for impotence, sterile frequent micturition, premature ejaculation, seminal emission, it belongs to the key medicine of helping property of the kidney invigorating, modern pharmacological research is found, Herba Epimedii glycoside, deoxidation methyl Herba Epimedii glycoside, Herba Epimedii extract have the androgenic effect of enhancing, its effectiveness even be better than Hippocampus and Gecko, can make the smart amount of seminal concentration increase Herba Epimedii and can also promote hypophysis secretion growth hormone, improve old people's insufficiency of kidney-YANG symptom.According to another report the Herba Epimedii stem and leaf contain Herba Epimedii glycoside and volatilization by, confirm that after deliberation Herba Epimedii has the effect of androgen sample, it is by gonepoiesis, makes seminal vesicle be full of behind the seminal fluid conversely sensation nerve again, thereby excites libido and cause erection.Herba Epimedii is mainly used in the treatment reproductive system clinically.
Report again in addition, alcohol extract directly adds does not influence the NO generation in the culture fluid of endothelial cell, can increase animal semen secretion, sensation nerve for the mouse gavaging Herba Epimedii, indirect excitation libido and have the excessive effect of urging, libido became stronger after laboratory animal was taken Herba Epimedii.Alcohol extract 120 minutes was gathered the generation that serum can promote NO in 180 minutes, and the effect peak was at 120 minutes, and icariin can obviously improve cGMP concentration in the cavernous body of penis.Strengthen cavernous body of penis smooth muscle relaxation effect, improve the erection ability.
3, antidepressant: confirm through zoopery that according to Nanjing University's school of life and health sciences the extract of warming and recuperating the kidney-YANG medicine Herba Epimedii has certain antidepressant effect.
Studies show that Herba Epimedii total flavones and icariin have the multiple biological activity relevant with antidepressant, as improving sleep, releive pressure and fatigue etc.
Research worker is introduced, and monoamine oxidase, MAO (MAO) is the important metabolic enzyme of monoamine neurotransmitter, suppresses the treatment that MAO-A and MAO-B activity help depression and be afraid of golden gloomy disease.
Originally studies show that, the Herba Epimedii extract can significantly suppress mouse brain and hepatic tissue MAO-A and MAO-B activity, prompting Herba Epimedii extract might be by suppressing the MAO activity, reduce the monoamine neurotransmitter metabolism, improve the cerebral tissue neurotransmitter levels and reach antidepressant purpose, MAO is a lipid peroxidation product, is one of sign of radical damage, it is too high also often to observe the interior MAO level of patients with depression body clinically, and some antidepressants can significantly reduce the MAO level.The Herba Epimedii extract can reverse MAO level rising in the depressed animal model, shows that the Herba Epimedii extract might improve depressed desperate behavior because of the degree that weakens radical pair neural tissue injury.
4, arteriosclerosis: the Herba Epimedii total flavones, can cell shrinkage appear induction of vascular smooth muscle cell proliferation model (IL-I stimulation), and nuclear disappears, and the after birth protuberance forms typical cells and transfers the morphological change of dying, and DNA doubts the visible AP of gel electrophoresis peak broadening and increases.
5, raise immunity: the Herba Epimedii total flavones can make sheep red blood cell (SRBC) immune serum hemolysin level improve, promote spleen antibody-producting cell quantity to increase, and can improve lymhocyte transformation rate, raise immunity strengthens the Turnover of Mouse Peritoneal Macrophages phagocytic function.Herba Epimedii improves exogenous corticosterone to the hematochezia brain, and---hypophysis---adrenal gland---thymus axle form suppresses with dynamic, significantly improves spleen antibody and generates and the serum antibody level, and can significantly promote lymphocyte transformation.
6, heart tonifying: the Herba Epimedii decoct can make Bufo siccus exsomatize or obviously strengthen at the systemic heart myocardial contraction, and the rabbit cardiac muscular tension is obviously increased.
7, the anti-blood of doubting: the Herba Epimedii total flavones can reduce rabbit whole blood viscosity and suppress the formation of erythrocytic gathering and external thrombus.The Herba Epimedii water decoction can obviously reduce the inductive platelet aggregation rate of healthy people ADP, can promote the depolymerization of part experimenter platelet, reduces healthy people's whole blood viscosity, accelerates blood circulation.
8, antioxidation: the Herba Epimedii flavone is irritated stomach, can significantly recover the function of D one galactose aging model mice T and bone-marrow-derived lymphocyte breeder reaction, obviously improve the activity of the total superoxide dismutase of mouse liver, reduce the hepatic tissue lipid peroxide and form, the lipofuscin that reduces tissues such as conscience forms.
9, osteoporosis: Herba Epimedii can significantly improve the DNA (deoxyribonucleic acid) synthetic ratio of animal, promotes the medullary cell DNA (deoxyribonucleic acid) synthetic.The Herba Epimedii extracting solution has the activity that suppresses osteoclast, promotes osteoblastic function again simultaneously, and calcified bone is formed to be increased, and not only can prevent the osteoporosis of rat due to the castration, can prevent that also the bone amount that hormone causes from reducing.
In addition, Herba Epimedii also has coronary blood flow increasing, resists myocardial ischemia, arrhythmia, blood pressure lowering, blood fat reducing, blood sugar lowering, protection brain, anti-inflammatory, antibacterial, antiviral, the anti-ageing effect of waiting for a long time.
(5) Fructus Lycii (Lycium barbarnm extraat), Fructus Lycii is the sub-mature fruit of matrimony vine of solanaceae plant.Property is put down, sweet in the mouth.Have invigorating the liver and kidney, promoting generation of vital essence and blood makes eye bright, lung moistening, beauty treatment, functions such as fat-reducing
Chemical constituent, the Fructus Lycii main component has polysaccharide, aminoacid, Folium hydrangeae strigosae alkali, carotene, vitamin B
1, vitamin B
2, various trace elements such as multivitamin such as vitamin C, nicotinic acid and manganese, chromium, zinc, copper, magnesium, calcium, germanium, cobalt, ferrum.
Pharmacological action: 1, protection reproductive system, achievement in research of HSPH of Wuhan University show that lycium barbarum polysaccharide can produce protective effect to the reproductive system that is damaged by effect " hypothalamus---hypophysis---gonad " this axis.
Experiment shows that lycium barbarum polysaccharide promotes hypophysis secreted glandular hormone by the gonadotropin effect, and " hypothalamus-hypophysis-gonad " this axis is produced the multilamellar regulating action, impels the spermatogenesis process unimpeded normal with testis sexual cell growth.
2, sexual function improving: Fructus Lycii has invigorating the liver and kidney, promoting generation of vital essence and blood, supporing yang function.No matter be that insufficiency of kidney-YANG, deficiency of the kidney yin all have certain effect, Fructus Lycii extract also has the effect of short gonad function, and plasma testosterone level is significantly raise, and property kinetic energy is gone down, and sexual impotence plays an important role.
3, enhancing immunity: Fructus Lycii is a medicine-food two-purpose food, and the Fructus Lycii polysaccharide has to strengthen exempts from power, and antitumor action can strengthen the cell anti-cancer function selectively.Lycium barbarum polysaccharide can strengthen natural killer cell and lymphocyte vigor, promotes interleukin to generate, and strengthens monocytic immune vigor.The Fructus Lycii polysaccharide also has antimutagenic effect, when mutation produces genetic damage and cell mutation, can repair damaged cell and recover its normal function.
4, defying age: Fructus Lycii has the rejuvenation effect, and showing as to stimulate gonad and endocrine, strengthens hormonal secretion, strengthens the physiological function of brain function and neurocyte.The toxin phenomenon occurs accumulating in the blood though can avoid people's age growth, thereby keep the normal function of each tissue in the body.But Fructus Lycii polysaccharide antagonism free radical peroxidase activity strengthens superoxide dismutase and glutathione peroxidase vigor, thereby the damage that alleviates the radical pair body has the effect of defying age.
5, resisting fatigue: Fructus Lycii can be improved hydroxyproline concentration, thereby improves muscular strength, and anti-fatigue ability is strengthened.
6, the liver protecting: Fructus Lycii extract has certain effect to hepatoprotective and fatty liver.Reason is that Fructus Lycii contains a kind of effective ingredient-Folium hydrangeae strigosae alkali, and it is effective to the treatment liver.Pharmacological research shows that Folium hydrangeae strigosae alkali has the fat of inhibition to deposit, and promotes the effect of liver cell regeneration in hepatocyte.Concerning the liver patient, the Folium hydrangeae strigosae alkali in the Fructus Lycii can prevent too much fat stores in the liver, and lipotropic effect is arranged, and chlorophyll contained in the Fructus Lycii also helps the liver detoxification effect, can also increase and improve liver function simultaneously.Chronic hepatitis patients, especially fatty liver patient.
In addition, Fructus Lycii also has and makes eye bright, improves looks, blood fat reducing, multiple pharmacological effect such as blood sugar lowering.
(6) arginine (Arginine), arginine is people's concrete conditions in the establishment of a specific crime essential amino acids, also is to keep hypophysis normal function essential amino acids.Three United States Medicine experts obtained this annual Nobel Prize because of finding relevant arginine important physiological function in 1998.The winner has found very little magical signaling molecule-an oxidation oxygen.Arginine is a nitric oxide, creatine, and stupid alanine, glutamate, Glu etc. have the precursor substance of important physiological function.Arginine and ornithine.Stupid alanine and other neuro chemistry essence one work, and can synthesize and secrete the growth hormone of hypophysis.
Physiological function: 1, promotion growth hormone secretion, arginine is to keep hypophysis, and the normal function essential amino acids is in close relations with growth hormone, and arginine synthesizes and secretion hypophysis growth hormone, growth hormone secretion during mainly because of its energy hypnotic.
2, blood vessel dilating: the arginine kidney tonifying, essence replenishing, help to regulate antiotasis, the vascular relaxing factor of anticoagulant is nitric oxide production synthetic, helps the minimizing blood vessel injury.
Arginine is endogenic nitric oxide precursors material.The most important blood circulation that acts on of nitric oxide.U.S. scientist discovers nitric oxide energy blood vessel dilating, and nitric oxide mainly results from the blood vessel endothelium layer, and this is a confluent monolayer cells that is positioned at tunica intima, and it can be expanded in the smooth muscle of blood vessel, distends the blood vessels.
3, prevent and treat sexual impotence: arginine is precursors of neurotransmitters materials such as endogenous nitric oxide, and nitric oxide can promote erection.The proof nitric oxide is a signaling molecule at present, the male is in the erection process, at first be the sexual stimulus signal to be sent to the neural blood vessel system by chemical mediators such as nitric oxide by brain, make the interior smooth muscle of cavernous body of penis loose, small artery vasodilation, spongy body blood flow and pressure sharply increase, add the fibrous elasticity tissue contracts of penis, stop small artery blood backflow in the spongy body smooth muscle, erection is congested expands thereby make, and makes erection strong.
United States Medicine expert Ignarro is discovered, because therefore nitric oxide energy blood vessel dilating also can act on the blood vessel in the penis, makes the strong sexual impotence for the treatment of of penis.Use this effect, the medicine " viagra " that world-famous pharmacy corporation Pfizer researchs and develops out treatment impotence just contains the arginine composition, but because it has magical curative effect to the treatment sexual impotence, and supplied and should ask.
4, control is sterile: the arginine the kidney invigorating and essence nourishing, increase the mankind spermatozoon number, and in seminal fluid, contain abundant arginine.As the arginine shortage sexual maturity is delayed, the sperm secretion reduces, and arginine is the main component of smart source protein matter.And 80% be to plant the protein key element thus to constitute in the seminal fluid, the quality and quantity that improves spermatid is had very great help.Therefore arginine has significant curative effect to treatment andropathy and infertility.
5, enhancing immunity: arginine can increase thymic weight, promotes the maturation and the differentiation of thymus medium-sized lymphocyte and the growth of CD cell and bone marrow and lymphocyte CD cell.Arginine can also stimulate in patient's peripheral vessels monocyte to antigen and fissional reaction, increases phagocyte, raise immunity.
In addition, smart chloric acid also has functions such as resisting fatigue.
(7) zinc (Zn), zinc is the trace element that body weight for humans is wanted.Mainly be present in skeleton, tooth, testis, the adrenal gland, skin, in the organ pipes such as muscle, especially with retina, choroid, prostate is for the highest.Zinc relates to each aspect of organism intracellular metabolite, comprises transcribing and duplicating of hereditary material, and is closely related with health and disease.Zinc still is the cofactors of 100 plurality of enzymes, also is protein, the constituent of hormone and nucleotide.
Physiological function: 1, promotion property organ pipe and sexual function are grown, and zinc can guarantee secondary feature of male and the growth of female reproduction phase.The human body zinc deficiency can make hypophysis cerebri discharge the promoting sexual gland hormone minimizing, causes sexual maturity to delay, the gonad atrophy, and hypogonadism, at the growth of people's spermatogenic cell, the adjusting of reproductive function also has great importance.The intravital zinc content of people mainly is distributed in testis, epididymis and prostate and seminal fluid, especially the highest with zinc content in the seminal fluid, zinc enters sperm in a large number before spermioteleosis, both guaranteed the generation of sperm, also keep the normal condition of seminal fluid source epithelium, so what of zinc content in the seminal fluid influence the key factor of sperm quantity and quality most, thereby promotion property organ pipe and gonad development.
2, promote hormone secretion: zinc all has effect in the generation of some testosterone in storage and the secretion, to the reaction generation significant impact of receptor usefulness and target cell.Zinc and reproductive system metabolic activity are closely related, and it can keep normal sexual function, to the growth of people's spermatogenic cell, maturation.Activate with function course and also participate in directly.Zinc content for a long time, the spermatogenesis ability is active, during zinc deficiency, testis dwindles, sperm number reduces, testosterone levels descends, sexual hypofunction.
3, sexual function improving: zinc and reproductive physiology and sexual function relation are very close.It can keep normal sexual function, and to the growth of people's spermatogenic cell, maturation activates with function and also participates in directly.Have enough zinc could guarantee to be highly sexed in the human body, sexual function and reproductive performance are just healthy.Zinc deficiency can cause motility of sperm to descend, sexual hypofunction, and zinc deficiency also can cause impotence.
4, control is sterile: the reason that causes infertility is numerous, has found that under study for action the zinc element in the seminal fluid has significant impact to fertility.For example zinc can stimulate sperm to breathe, and promotes motility of sperm, also has the effect of anti-pathogenic microorganism.The protection sperm is avoided invasion and attack, keeps sperm membrane stability and integrity, and prevents that sperm from disintegrating too early, and utilizing with combining of ovary increases the chance of becoming pregnant.With after the zinc treatment, sperm number is increased clinically, vigor improves, and recovers fertility.
5, enhancing immunity: zinc and immunologic function relation are very close.It participates in cellular immunization and humoral immunization process directly.Zinc has the effect that promotes lymphopoiesis and movable function, to keeping epithelial tissue and mucous membrane tissue is normal, the intrusion of defense against bacterial virus.Zinc deficiency can make atrophy of thymus gland, and the thymus secretion reduces the weight saving of spleen etc.The T cell quantity reduces, and antibody production descends, lymphocytophthisis, and the neutrophilic granulocyte chemotactic is suppressed, thereby causes resistance to descend, and immunologic function goes down.In addition, zinc also has the promotion growth promoter, promotes diet, functions such as slow down aging.
(8) nicotinic acid (Nicotinicacid) has another name called nicotinic acid, VPP.The major physiological activity exists with the nicotiamide form in vivo.Nicotinic acid extensively is present in the animal vegetable tissue, as animal livers, and kidney, the yeast equal size is more.The required nicotinic acid part of body can be formed by the tryptophan transformation, so tryptophan is the precursor of nicotinic acid.
Nicotinic acid has very high stability, and is survivable under acid, alkali, light and heating condition, and it is the most stable to belong to all vitamins.Nicotinic acid belongs to water soluble vitamins, and is soluble in water.
Physiological function: 1, nicotinic acid is the coenzyme composition: nicotinic acid is nadide and coenzyme II constituent, and at carbohydrate, the anti-and proteinic energy of fat discharges and plays a major role, and is the person that passs hydrogen of redox reaction, is the donor and the receptor of oxygen.Nicotinic acid has vitamin B
6, pantothenic acid and biotin exist down, nicotinic acid participates in fat, protein and DNA are synthetic.Nicotinic acid plays an important role in cholesterol chemical compound synthetic in addition, can reduce body inner cholesterol level.
2, synthetic hormone: nicotinic acid and adrenocortical hormone, thyroxine, insulin equally are synthetic hormones, estrogen, Progesterone, the indispensable material of testosterone.
3, expansion small artery blood vessel: the expansible cavernous body of penis small artery of nicotinic acid blood vessel, accelerate blood circulation, promote penis hyperemia, improve the nerve conduction function, it is loose to strengthen the spongy body smooth muscle, helps erection.In addition, the same Yohimbine of nicotinic acid, Semen Ginkgo extrac is with using better effects if.
4, fatigue alleviating, nicotinic acid are played the part of the crucial role that standing for a long while in vivo, and it participates in important biological metabolism in the body, and as sugar, the energy after fat and protein are absorbed by the body discharges.If there is not competent nicotinic acid in the body, a lot of important foodstuffs courses of processing will delay and stop in the body, and energy supply descends, and the people is tired easily,, this shows that nicotinic acid is the modern indispensable vitamin of pressure under heavy.Nicotinic acid also has resisting oxygen lack in addition.
(9) lycopene (Lycopeoe), lycopene is important carotenoid, belongs to the tetraterpenes chemical compound, is made up of 11 conjugation and two non-conjugated-carbon two strandss.Mainly be present in the plants such as Fructus Lycopersici esculenti, Citrullus vulgaris, Fructus psidii guajavae immaturus,, claim lycopene owing to be from Fructus Lycopersici esculenti, to extract the earliest.Lycopene belongs to fat-soluble carotenoid, does not have the vitamin A activity.
Physiological function: 1, antioxidation: lycopene is the cancellation singlet oxygen and the free radical of all discoveries up to now, antioxidation, the carotenoid that defying age is the strongest, its antioxidant effect is α one vitamin E100 times, lycopene has significant elimination free radical and stronger oxidation resistance, is that present occurring in nature exists antioxidation and the strongest material of defying age ability.
2, improve male fecundity: medical research shows, lycopene can effectively be treated male infertility, research worker is randomly drawed 30 ages the male infertility patient of 23-45 between year, every day 2 oral lycopenes, each 2 milligrams, continue to measure in three months their sperm concentration, mobility and form, found that, their sperm concentration and motility of sperm are improved significantly, 30 patients' sperm concentration has improved, and almost 3/4ths patients' sperm rises, and 63% patient's wife is conceived after experiment.The minister N of urinary system organ pipe portion of the full Hindu medicine in India New Delhi Science Institute, Gupta publish thesis and point out according to another report, male patient to patient's azoospermia and the general power disease of sperm motility awards lycopene, every day 2 times, each 2 milligrams, the intravital sperm quantity of patient after three months, mobility and sperm morphology all have apparent improvement, improve mankind spermatozoon quantity simultaneously and the vigor effect is remarkable.
3, control prostatosis: the concentration of lycopene in male testical and prostate is higher, but it is lower in suffering from the males of infertility, the lycopene of discovering before this determines prostatic health, and why prostatic lesion is difficult to cure clinically.Find that according to modern scientific research prostatic variation is not a kind of disease, but old and feeble syndrome.Up-to-date medical evidence.Contain a kind of a large amount of active factors-lycopene in the prostate, this active factors is determining the normal performance of prostate physiological function.Therefore lycopene has obvious curative effects to prostatitic treatment.Lycopene also has the effect of the carcinoma of prostate of preventing and treating in addition.
4, prevent and treat osteoporosis: prove that according to the up-to-date clinical trial of Canada the natural lycopene complex prevents bone-loss and promotes the active effect of bone sprout cell.Toronto STMichael hospital and University of Toronto find that in joint study lycopene has the effect that promotes the skeleton growth and form and promote the growth of bone sprout cell.Another research has shown that also tomato red have broken osteocyte formation and the active effect of destroying that stop, and this explanation lycopene can prevent osteoporosis.
In addition, lycopene, also have defying age, anti-angiocardiopathy, enhancing immunity, function such as anticancer.
(10) vitamin A (VitA) has another name called retinol.Be by 20 carbon and 40 unsaturated-unit's alcohol that carbon atom constitutes.Comprise vitamin A (retinol), vitamin A
2(dehydroretinal) and vitamin A
3They all are to have the active chemical compound of natural vitamin A for (tretinoins), and vitamin A has two kinds, and a kind of retinol is initial vitamin A form, only is present in the animal food; Another kind is a beta-carotene, and β-Radix Dauci Sativae is the precursor of vitamin A, absorbs the back and change retinol in human body, and it mainly is present in some plant foods, has the same physiological action of vitamin A.Vitamin A belongs to fatsoluble vitamin, and is water insoluble.
It is the complete essential chemical compound of vision, growth, cell differentiation and propagation, reproduction and immune system that vitamin A is one group.
Physiology kinetic energy: 1, keep the normal growth and the differentiation of epithelial tissue: epithelial tissue spreads all over whole body, the epithelial tissue of respiratory tract, digestive tract, urinary system, gonad and other body of gland, and normal differentiation all needs the participation of vitamin A.Vitamin A is to epithelial normal formation, grows and keep to have a very important role.During shortage, epithelial tissue atrophy, drying, hypertrophy and keratinization cause xerosis cutis, follicular keratosis, and alopecia can cause xerophthalmia to eyes, even blind.
2, keep normal fertility and reproductive function: vitamin A is a kind of trace element of wide spectrum physiological action, affects the genesis and development of a plurality of histoorgans.The effect of vitamin A aspect physiological function is relevant with the influence of its reproductive system epithelial tissue.In feedstuff, add a spot of retinol or tretinoin, can make the rat that loses reproductive performance recover normal reproductive function.
3, sexual function improving: its major function of vitamin A is to promote proteinic synthesizing, and for the male provides the spermatogenesis raw material, promotes to increase spermatogenesis, improves the mobility of sperm, and vitamin A also can promote testicualr development.And have the anti-infection ability that strengthens gonad, tie up characteristic functions, the effect of delay function aging.Can influence male testis tissue during vitamin A deficiency and produce spermatocyte, deferent duct epithelium degeneration testicular weight descends, and seminal vesicle diminishes, the prostate keratinization, and the male ovary A that is deficient in vitamin influences androgenic normal secretion.
4, improve immunity: studies show that the serum vitamin
ABe remarkable positive correlation between level and periphery T cell percent and the lymhocyte transformation rate.Cell culture shows the vitamin of physiological concentration
AGeneration to lymphocyte antibody has obvious facilitation.Vitamin
ACan obviously increase the thymic weight of rat, lung phagocyte number also strengthens its phagocytic function, and is immune moderator.
Vitamin in addition
AAlso have and keep normal vision, promote skeleton development, prevent multiple function such as cardiovascular and cerebrovascular disease and computer syndrome and antitumor etc.
(11), vitamin
E(Vit E) has another name called Vitamin E, i.e. α, β, γ and δ-Vitamin E, and α, β, γ and δ-triolefin Vitamin E is called vitamin with family system for 8 kinds
E, wherein the biological activity of α-Vitamin E is the strongest.Vitamin
EBelong to fatsoluble vitamin, water insoluble.To the oxygen sensitivity, be easy to oxidation and destroy, particularly under illumination, heat, alkali condition, can quicken its oxidation, comparatively stable under acid oxygen free condition.Vitamin
EIt is a kind of broad-spectrum anti-oxidizing compounds.
Physiological function: 1, antioxidation, vitamin E are a kind of very strong antioxidants, avoid the infringement of free radical at the protection cell membrane.Brain cell contains a large amount of unsaturated fatty acids, vitamin
ECan prevent that unsaturated fatty acid is oxidized, thereby the normal activity and the metabolism of protection brain cell prevent brain oxidation decline.Vitamin
ECan also block the lipid peroxidation free chain reaction, prevent that biomembrane (comprising cell membrane, organelle film) cytoskeleton and other proteinic sulfydryl from avoiding the attack of free radical and oxidant, keep the integrity of film.
2, sexual function improving.Studies show that vitamin
ECan impel the short gonad secretion of antepituitary, cell is hyperfunction, and the gonad secretion increases, and promotes the generation and the activity of sperm, varian function enhancing, vitamin
ERegulate the effect of gonad and prolongation sperm life.Vitamin
EAnd vitamin
AAll can improve blood circulation, improve the especially mobility of genitals position blood capillary of blood capillary, raise libido.Vitamin
EAlso have the mankind spermatozoon of stimulation and produce, promote the efficient of heart and male's sexuality.The delay deterioration.Be deficient in vitamin
ECan cause sexual hypofunction.Famine can cause penis to be degenerated and atrophy, and sex hormones secretion reduces and the forfeiture reproductive performance.Animal experiment shows that male mouse is deficient in vitamin
E, testis is degenerated, and can not form eupyrene sperm.
3, allaying tiredness and pressure; In the health diet seminar of holding June 6 calendar year 2001, pressure fatigue and vitamin
EDoctor Pu Sili points out from american dish; Current research shows, " polyphagia contains the antioxidative natural food to easing off the pressure, and fatigue alleviating has remarkable effect ".Antioxidant strengthens the human immune system by the control free radical.Free radical is the unstable factor of oxygen.The more insulting important fat of meeting, thereby infringement human body cell.Vitamin
E, vitamin
CAnd vitamin
ADeng antioxidant, can control these free radicals, protection human immune system, thereby ease people psychology and physiological pressure.Now people drop in nervous work and other and the affairs physically and mentally, and have ignored logical diet, and this also is a common problem of high rhythm life.Vitamin
ETo easing off the pressure, fatigue alleviating has very big effect.
4, improve immunity: vitamin
ETo keeping normal immune function.Very important for lymphocytic function especially, immunocyte is very responsive to the infringement of radical reaction, the vitamin of body
EChanged condition can make the reactivity of immunocyte change.Considerable evidence shows that old and feeble with immunity degradation, old people Yi Fa infects and tumor.Vitimin supplement
E, can make delayed state response tuerculoderma rate improve the lymphocyte transformation test increased activity.
5, defying age: vitamin
ECan blocking-up and old and feeble relevant oxidation chain reaction.Geriatric animals awards vitamin
EAfter can eliminate cell lipofuscin such as cerebral tissue, and can improve skin elasticity, gonad atrophy, delay aging, hypomnesis.Can also improve simultaneously the activity of enzyme, raise immunity, thereby delaying senility process.
In addition, vitamin
EAlso has the control cardiovascular and cerebrovascular disease, functions such as diabetic complication and antitumor.
(12) vitamin
C(Vit C) has another name called ascorbic acid, is the natural materials that extensively exists in fruit and the thin dish.Vitamin
CBe a kind of simple six carbon compounds, occurring in nature has two kinds of forms, i.e. reduced form ascorbic acid and oxidized form hydroascorbic acid, and the both has physiologically active, all can be done by body is sharp.Vitamin
CSoluble in water, should not under high temperature and alkali condition, process.
Physiological function: 1, participate in biosynthesis: vitamin
CThe cofactors that acts on substrate and enzyme in vivo in the digestion process participates in multiple important biosynthetic process, comprise collagen protein, carnitine, the metabolism of the synthetic and tyrosine of other neurotransmitter and peptide hormone etc., some enzyme require vitamin could keep the activity of height.Vitamin
CTherefore reproducibility with height has anti-oxidation function.It can reduce superoxides hydroxyl, hypochlorous acid and other activating oxide and other antioxidant and eliminate free radical and block fatty peroxidating.
2, maintenance function: vitamin
CEffect be to reduce the seminal fluid cohesive force, favourable seminal concentration liquefaction, genetic DNA passes through vitamin in the sperm sexual cell
CAnti-oxidation function is protected, if gene are destroyed, it is consequently infertile to cause sperm fertilizing ability to weaken.Vitamin
CKeep sexual cell function and regeneration, keep male sexual function and restorative function plays an important role.Studies show that the male is deficient in vitamin
CCan damage sperm quantity and quality, this means that smoking man's reproductive performance is lower than the normal person.Once the someone studied and thought, a large amount of smoking meetings cause male's libido to descend even sexual impotence occurs.In fact except the smoking meeting cause arteria penis narrow, may make vitamin in the body with the smoking meeting
CThe a large amount of loss is correlated with.
Three, resisting fatigue: studies show that vitamin
CHuman body produces free radical in the time of can neutralizing motion, comes to harm to prevent body tissue, and can promote the recovery of function of human body.The athlete absorbs vitamin
CCan significantly alleviate strenuous exercise's muscle pain, accelerate the recovery of muscle strength.Vitamin
CAlso the oxygen-supplying amount in enhancing body feels relief the people, and strength is abundant, and is full of vitality.
4, improve immunity: studies show that vitamin in the human plasma
CLevel is relevant with phagocytic activity of leukocytes.Vitamin
CCan pass through antioxidation, improve immunity, vitamin
CCan promote the secretion of prostate and lymph fluid, make body produce interferon and antivirin, thereby play immunity and antivirus action, improve the control ability of body tissue, help to synthesize and to regulate lymphocytic prostaglandin.
5, anti-flu: studies confirm that the high dose vitamin
CCan improve leukocytic chemotactic and have a liking for the bacterium effect, strengthen lymphocyte and macrophage function, thereby improve Abwehrkraft des Koepers, effectively reduce flu and take place, discover vitamin in the tissue blood of infection simultaneously
CContent obviously reduce, therefore flu is taken the high dose vitamin in early days
C, can obviously shorten the course of disease and reduce the flu order of severity.U.S. expert studies have shown that, every day 1000 milligrams of left and right sides vitamin
CCan make flu descend 45%, the course of disease shortens 60%.Vitamin
CCan link up respiratory apparatus and blood circulation promoting, preventing respiratory infects, and increases the unnecessary oxidation of body, reduces flu and takes place.
Vitamin
CExcept above-mentioned functions, also have reduce gallbladder because of alcohol, prevention of arterial is atherosis, safeguard health of heart, protection cardiovascular and cerebrovascular vessel, functions such as The Maintenance Of Skin Health.
In sum, this product has the sexual impotence of control, premature ejaculation, hyposexuality, sexual function improving, delay aging, spermatogenesis, prevents and treats functions such as infertility, resisting fatigue.
Processing technology is:
Allotment mixes: earlier with lycopene, and vitamin
A, vitamin
EMixing stirs well, then in arginine, zinc gluconate, nicotinic acid, vitamin
CMixing stirs well, again in Yohimbine, and Folium Ginkgo extract, Radix Ginseng extract, Herba Epimedii extract, Fructus Lycii extract mix, and stir.
2, capsule is filled: with the raw material that stirs, send into filling machine raw material is filled in the capsule.
3, seal: populated capsule is sealed by quality standard.
4, test package: the capsule that will seal mouthful is through after the assay was approved, pack formal product.
It is that all raw materials in the prescription are mixed the operation that stirs respectively by its physicochemical property that allotment mixes, and this operation gets even raw mix, and it is that the raw material that preceding operation stirs is filled into operation in the capsule that capsule is filled.It is the operation that the product that preceding operation makes is sealed that capsule seals, and this operation is in order to prevent that material component leakage and capsule in the capsule from scattering.This operation gets finished capsule product.Test package be finished product that preceding operation is made by national standard, become the process of formal product through packing after the assay was approved.
Six, quality standard:
1, physical and chemical index:
Yohimbine g/600g 0.84
Semen Ginkgo is carried sour thing g/100g 3.4
Radix Ginseng extract g/100g 0.21
Herba Epimedii extract g/100g 2.1
Fructus Lycii extract g/100g 2.1
Arginine g/100g 46
Zinc g/100g 4.6
Nicotinic acid g/100g 0.63
Lycopene g/100g 0.17
Vitamin
AMg/100g 17
Vitamin
EG/100g 0.63
Vitamin
CG/100g 4.2
2, instructions of taking: every mouthful of three each 1-5 gram one after each meals.
3, incompatibility crowd, kidney patient, mental patient, children, women.
Seven, the specific embodiment:
Embodiment: 2 kilograms of Yohimbines, 8 kilograms of Folium Ginkgo extract, 5 kilograms of Radix Ginseng extracts, 50 kilograms of Herba Epimedii extracts, 50 kilograms of Fructus Lycii extracts, arginine double centner, 11 kilograms of zinc gluconate, 1.5 kilograms in nicotinic acid, 0.4 kilogram of lycopene, vitamin
A40 milligrams, vitamin
E1.5 kilogram, vitamin
C10 kilograms.
Lycopene, vitamin
A, vitamin
EMixing and stirring, then with arginine, zinc gluconate, nicotinic acid, vitamin
CMixing and stirring, again with Yohimbine, Folium Ginkgo extract, Radix Ginseng extract, Herba Epimedii extract, wolfberry fruit extract mix, and send into filling machine after stirring, the mixed material that then will stir is filled in the hard capsule, for not avoiding material composition leakage and raw material in the capsule to shed, capsule to be sealed, this operation gets finished capsule product, by national touchstone after the assay was approved, packing becomes formal product.
Claims (2)
1, the capsule for improving sexual function for men processing technology stirs for allocating, mixing, capsule is filled, capsule seals, test package gets formal product,
2, process conditions are: 2 kilograms of Yohimbines, 8 kilograms of Folium Ginkgo extract, 5 kilograms of Radix Ginseng extracts, 50 kilograms of Herba Epimedii extracts, 50 kilograms of wolfberry fruit extracts, arginine double centner, 11 kilograms of zinc gluconate, 1.5 kilograms in nicotinic acid, 0.4 kilogram of lycopene, vitamin
A40 milligrams, vitamin
E1.5 kilogram, vitamin
C10 kilograms of grades, allotment mix, and stir, and send into filling machine material is filled in the capsule, then capsule is sealed finished product, be packaged into formal product after the assay was approved.
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| CN 200610080085 CN1970007A (en) | 2006-05-11 | 2006-05-11 | Capsule for improving sexual function for men |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610080085 CN1970007A (en) | 2006-05-11 | 2006-05-11 | Capsule for improving sexual function for men |
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ID=38111155
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| CN101595986A (en) * | 2009-05-01 | 2009-12-09 | 苟春虎 | Male functional capsule |
| CN101322555B (en) * | 2008-06-17 | 2012-05-02 | 苟春虎 | Tibetan medicine capsule for strengthening vitality |
| CN102894421A (en) * | 2011-07-24 | 2013-01-30 | 江西食方食坊中药食品有限公司 | Tomato-medlar beverage for prostate disease prevention, and preparation method thereof |
| CN103040001A (en) * | 2012-12-20 | 2013-04-17 | 苏州天南星生物科技有限公司 | New resource food |
| WO2013163928A1 (en) * | 2012-05-02 | 2013-11-07 | Zhang Fengfan | Complex amino-acid composition and preparation for treating male infertility, impotence and premature ejaculation |
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| CN101595986A (en) * | 2009-05-01 | 2009-12-09 | 苟春虎 | Male functional capsule |
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| WO2013163928A1 (en) * | 2012-05-02 | 2013-11-07 | Zhang Fengfan | Complex amino-acid composition and preparation for treating male infertility, impotence and premature ejaculation |
| CN103040001A (en) * | 2012-12-20 | 2013-04-17 | 苏州天南星生物科技有限公司 | New resource food |
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| CN104366119A (en) * | 2014-11-28 | 2015-02-25 | 广西商大科技有限公司 | Premix improving sexual desire of service boars |
| CN107412312A (en) * | 2017-07-06 | 2017-12-01 | 孙冠辰 | A kind of male health-care composition for treating erectile dysfunction |
| CN110693885A (en) * | 2018-07-09 | 2020-01-17 | 成都百裕制药股份有限公司 | Pharmaceutical composition for preventing or treating sexual dysfunction and use thereof |
| CN110613124A (en) * | 2019-09-18 | 2019-12-27 | 孙启城 | Health food containing L-carnitine and astaxanthin |
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